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This review explores the role of acetamide group in enhancing drug-like properties, including solubility, membrane permeability, and metabolic stability. Acetamide moieties are frequently found in a variety of pharmacologically active compounds, such as enzyme inhibitors, anticancer agents, and anti-inflammatory drugs, where they contribute to crucial interactions at the biological target site. Additionally, the incorporation of acetamido structures into lead compounds has been shown to improve binding affinity and pharmacokinetic profiles. Recent advances in synthetic methodologies have further facilitated the incorporation of acetamido group in drug design. In this article we mainly focus on synthesis, biological activity and mechanism of action of acetamido containing FDA approved drugs. This article aims to highlight the versatility and continued relevance of acetamido as a key functional group in the discovery and optimization of modern pharmaceuticals.<\/jats:p>","DOI":"10.3389\/fchem.2026.1830482","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:36:14Z","timestamp":1786116974000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["FDA approved drug containing acetamide group- a mini review"],"prefix":"10.3389","volume":"14","author":[{"given":"Sandeep","family":"Bindra","sequence":"first","affiliation":[{"name":"Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research (AcSIR)","place":["Ghaziabad, India"]},{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham","place":["Kochi, Kerala, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetana","family":"Amrodiya","sequence":"additional","affiliation":[{"name":"Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research (AcSIR)","place":["Ghaziabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham","place":["Kochi, Kerala, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Della Grace","family":"Thomas Parambi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jouf University","place":["Sakaka, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sharda University, Knowledge Park III","place":["Greater Noida, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseer","family":"Maliyakkal","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Operations, College of Applied Medical Sciences, Khamis Mushait, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasha Momo H.","family":"Anal","sequence":"additional","affiliation":[{"name":"Natural Products and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research (AcSIR)","place":["Ghaziabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijo","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham","place":["Kochi, Kerala, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"B1","volume-title":"Organic Syntheses","year":"1923"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.3390\/molecules28145389","article-title":"New acetamide-sulfonamide-containing scaffolds: antiurease activity screening, structure-activity relationship, kinetics mechanism, molecular docking, and MD simulation studies","volume":"28","author":"Ahmad","year":"2023","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1007\/s13738-021-02172-5","article-title":"Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates","volume":"18","author":"Al-Ostoot","year":"2021","journal-title":"J. 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