{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:54:12Z","timestamp":1781589252497,"version":"3.54.5"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    Accurate detection and localization of early-stage breast cancer represent the cornerstone for improving cancer cure rates and extending patient survival. However, selecting therapeutic regimens characterized by high efficacy and minimal side effects remains a formidable clinical challenge. Combining these two goals is now feasible with the innovation and progress of nanomaterials. Herein, we designed and synthesized a novel nanomaterial PDA@Fe-BTC@ MnO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles (PFMPP NPs) for breast cancer. The MnO\n                    <jats:sub>2<\/jats:sub>\n                    and Fe-BTC units confer tumor-microenvironment (TME)-responsive T\n                    <jats:sub>1<\/jats:sub>\n                    \/T\n                    <jats:sub>2<\/jats:sub>\n                    dual-mode magnetic resonance imaging (MRI)capability. For therapy, the Fe-BTC structure mediates chemodynamic therapy (CDT) via the Fenton-like reaction, generating cytotoxic reactive oxygen species (ROS). Simultaneously, the MnO\n                    <jats:sub>2<\/jats:sub>\n                    component catalyzes H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition to relieve tumor hypoxia and consumes reduced glutathione (GSH) to protect ROS from clearance. Furthermore, PFMPP NPs exhibit strong photothermal conversion under 808\u00a0nm near-infrared light, permitting direct tumor ablation via photothermal therapy (PTT). The localized heating also enhances the Fenton-like reaction, yielding more ROS and thereby enabling enhanced combined therapeutic efficacy. This integrated strategy provides a feasible approach for theranostic applications in breast cancer.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2026.1831059","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:39:10Z","timestamp":1781588350000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Core-shell structured nanomaterials in dual-modal magnetic resonance imaging guided antitumor effect via combined treatment"],"prefix":"10.3389","volume":"14","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhai","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Sciences","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Sciences","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/medicina56010015","article-title":"Tumor microenvironment","volume":"56","author":"Arneth","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"26931","DOI":"10.1038\/s41598-025-12644-w","article-title":"Detection of breast cancer using machine learning and explainable artificial intelligence","volume":"15","author":"Arravalli","year":"2025","journal-title":"Sci. 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