{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:41Z","timestamp":1783491521443,"version":"3.55.0"},"reference-count":180,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    The growing scientific interest in medicinal and nutritionally valuable plants has highlighted the importance of\n                    <jats:italic>Trigonella foenum-graecum<\/jats:italic>\n                    (fenugreek), a species widely recognized for its diverse phytochemical, nutritional, and pharmacological significance. This member of the legume family is an annual self-pollinating herb widely cultivated across Mediterranean, Asian, African, and other regions due to its adaptability to different climatic conditions and its ability to fix atmospheric nitrogen. It is also traditionally used in culinary and medicinal traditional practices, particularly as spice and functional food ingredients. This review provides an updated overview of the botanical characteristics, geographical distribution, cultivation conditions, phytochemical composition, nutritional value, and biological activities of the plant, with particular emphasis on recent advances in nanoformulations, biomedical applications, hemocompatibility, and recent pharmacological advances. The seeds and leaves contain proteins, dietary fibers, minerals, vitamins, and various bioactive compounds such as saponins, flavonoids, alkaloids, polyphenols, and galactomannans, which have been reported to exhibit antioxidant, antidiabetic, anti-inflammatory, anticancer, antilipidemic, antimicrobial effects, as well as low hemolytic activity. By integrating recent findings on fenugreek characteristics, phytochemistry, and biological activities, this review provides an updated perspective on its scientific relevance and ethnobotanical applications.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2026.1849521","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:56:35Z","timestamp":1783490195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical evaluation, nutritional and pharmacological values of Trigonella foenum-graecum plant: a comprehensive review"],"prefix":"10.3389","volume":"14","author":[{"given":"Bayansulu","family":"Otegenova","sequence":"first","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulzat","family":"Berganayeva","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bates","family":"Kudaibergenova","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Szyd\u0142owska-Czerniak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Applied Spectroscopy, Faculty of Chemistry, Nicolaus Copernicus University in Toru\u0144","place":["Toru\u0144, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adewale Olufunsho","family":"Adeloye","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]},{"name":"Department of Chemistry, College of Science, Engineering and Technology (CSET), University of South Africa","place":["Florida, South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moldyr","family":"Dyusebaeva","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Bari","family":"Shah","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]},{"name":"Research Center for Medicinal Plants, Al-Farabi Kazakh National University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4740","DOI":"10.1039\/d0ra08836f","article-title":"Ecological HPLC method for analyzing an antidiabetic drug in real rat plasma samples and studying the effects of concurrently administered fenugreek extract on its pharmacokinetics","volume":"11","author":"Abdelwahab","year":"2021","journal-title":"RSC Adv."},{"key":"B2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/cosmetics12010021","article-title":"Fenugreek as a potential active ingredient for the development of innovative cosmetic formulation","volume":"12","author":"Abdennebi","year":"2025","journal-title":"Cosmetics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/14888386.2006.9712808","article-title":"Fenugreek: an \u201cold world\u201d crop for the \u201cnew world.\u201d","volume":"7","author":"Acharya","year":"2006","journal-title":"Biodiversity"},{"key":"B4","doi-asserted-by":"publisher","first-page":"100252","DOI":"10.1016\/j.scenv.2025.100252","article-title":"Highlighting phytoconstituents of Trigonella foenum-graecum (fenugreek) seeds as multi-targeted inhibitors of common cancer receptors and subsequently optimizing its sequential extraction to develop an oral nutraceutical","volume":"10","author":"Adhikary","year":"2025","journal-title":"Sustain. 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