{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:59:35Z","timestamp":1790175575051,"version":"4.1.0"},"reference-count":222,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    Lysosomes are degradative, metabolic and signaling organelles in central nervous system (CNS) cells and play essential roles in neural homeostasis, injury responses and disease progression. Changes in lysosomal function are required for neurons, microglia, astrocytes and oligodendrocyte-lineage cells to adapt to proteotoxic stress, lipid overload, mitochondrial damage and inflammatory stimulation. Therefore, lysosomal activity in the CNS is regulated by diverse chemical and cellular cues, including luminal acidification, hydrolase maturation, ion transport, membrane integrity, lipid handling and transcriptional lysosome biogenesis. Here, we summarize current knowledge of lysosomal organization and function in neural cells, including lysosomal membrane signaling, vacuolar H\n                    <jats:sup>+<\/jats:sup>\n                    -ATPase (V-ATPase)-dependent acidification, ion and redox regulation, lysosomal membrane quality control, and metabolic recycling of proteins, lipids, glycans and damaged organelles. We then survey pathological lysosomal remodeling in spinal cord injury, traumatic brain injury, Alzheimer\u2019s disease, Parkinson\u2019s disease and related neurological disorders. Across these conditions, lysosomal remodeling may initially support cargo clearance and stress adaptation, but becomes maladaptive when degradative capacity, membrane repair or lipid-processing ability fails to meet cellular demand. Finally, we discuss lysosome-oriented therapeutic strategies for neural repair, including restoration of lysosomal acidification and hydrolase activity, transcription factor EB\/transcription factor E3 (TFEB\/TFE3)-mediated lysosomal biogenesis, regulation of lysosomal ion channels, enhancement of myelin lipid turnover, and lysosome-responsive nanomedicine. This Review highlights lysosomes as active organizers of CNS injury and repair rather than passive endpoints of degradation.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2026.1891677","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:34Z","timestamp":1790172214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lysosomes as chemical and metabolic organizers of central nervous system injury and repair"],"prefix":"10.3389","volume":"14","author":[{"given":"Tengfei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University","place":["Hangzhou, China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["Hangzhou, China"]},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deting","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University","place":["Hangzhou, China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["Hangzhou, China"]},{"name":"Heart Regeneration and Repair Key Laboratory of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Orthopedics Research Institute of Zhejiang University","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]},{"name":"Clinical Research Center of Motor System Disease of Zhejiang Province","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111480","DOI":"10.1016\/j.celrep.2022.111480","article-title":"Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death","volume":"41","author":"Aber","year":"2022","journal-title":"Cell Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1016\/j.molcel.2024.10.008","article-title":"mTORC1 activity licenses its own release from the lysosomal surface","volume":"84","author":"Acharya","year":"2024","journal-title":"Mol. Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"20220376","DOI":"10.1098\/rstb.2022.0376","article-title":"Retromer-dependent lysosomal stress in Parkinson\u2019s disease","volume":"379","author":"Alessi","year":"2024","journal-title":"Philos. Trans. R. Soc. Lond B Biol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/jmcb\/mjt022","article-title":"The lysosome: from waste bag to potential therapeutic target","volume":"5","author":"Appelqvist","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.tins.2024.07.003","article-title":"White matter damage and degeneration in traumatic brain injury","volume":"47","author":"Armstrong","year":"2024","journal-title":"Trends Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e129719","DOI":"10.1172\/jci.insight.129719","article-title":"Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies","volume":"4","author":"Arotcarena","year":"2019","journal-title":"JCI Insight"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/s41593-024-01749-6","article-title":"Oligodendroglial fatty acid metabolism as a central nervous system energy reserve","volume":"27","author":"Asadollahi","year":"2024","journal-title":"Nat. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.ymthe.2025.12.011","article-title":"AAV gene therapy for GBA1-related diseases","volume":"34","author":"Ayloo","year":"2026","journal-title":"Mol. Ther."},{"key":"B9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e49635","DOI":"10.1371\/journal.pone.0049635","article-title":"Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells","volume":"7","author":"Baltazar","year":"2012","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"6979","DOI":"10.1038\/s41467-024-51016-2","article-title":"Mitochondrial network reorganization and transient expansion during oligodendrocyte generation","volume":"15","author":"Bame","year":"2024","journal-title":"Nat. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1021\/acschemneuro.4c00617","article-title":"Microglial autophagic dysregulation in traumatic brain injury: molecular insights and therapeutic avenues","volume":"16","author":"Bano","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1","volume":"150","author":"Bar-Peled","year":"2012","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e2111506119","DOI":"10.1073\/pnas.2111506119","article-title":"Glycan degradation promotes macroautophagy","volume":"119","author":"Baudot","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"107742","DOI":"10.1016\/j.jbc.2024.107742","article-title":"Alpha-synuclein, autophagy-lysosomal pathway, and lewy bodies: mutations, propagation, aggregation, and the formation of inclusions","volume":"300","author":"Bayati","year":"2024","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2474796","DOI":"10.1080\/27694127.2025.2474796","article-title":"The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)","volume":"4","author":"Beckers","year":"2025","journal-title":"Autophagy Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s40478-023-01648-0","article-title":"A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons","volume":"11","author":"Beckers","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"102482","DOI":"10.1016\/j.ceb.2025.102482","article-title":"LRRK2, lysosome damage, and Parkinson\u2019s disease","volume":"93","author":"Bentley-DeSousa","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s40478-025-02131-8","article-title":"Pathobiology of the autophagy-lysosomal pathway in the Huntington\u2019s disease brain","volume":"13","author":"Berg","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41593-020-00757-6","article-title":"Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis","volume":"24","author":"Berghoff","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"eabb5077","DOI":"10.1126\/sciimmunol.abb5077","article-title":"Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation","volume":"5","author":"Berglund","year":"2020","journal-title":"Sci. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"107911","DOI":"10.1016\/j.jbc.2024.107911","article-title":"Lysosomal activity depends on TRPML1-mediated Ca(2+) release coupled to incoming vesicle fusions","volume":"300","author":"Bhattacharjee","year":"2024","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5073","DOI":"10.1038\/s41467-025-60402-3","article-title":"Endolysosomal processing of neuron-derived signaling lipids regulates autophagy and lipid droplet degradation in astrocytes","volume":"16","author":"Bhupana","year":"2025","journal-title":"Nat. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e202403116","DOI":"10.1083\/jcb.202403116","article-title":"Heterogeneity of late endosome\/lysosomes shown by multiplexed DNA-PAINT imaging","volume":"224","author":"Bond","year":"2025","journal-title":"J. Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1042\/bst20240087","article-title":"Mechanisms of lysosomal tubulation and sorting driven by LRRK2","volume":"52","author":"Bonet-Ponce","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"B26","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1080\/15548627.2015.1136769","article-title":"Nanoparticles restore lysosomal acidification defects: implications for parkinson and other lysosomal-related diseases","volume":"12","author":"Bourdenx","year":"2016","journal-title":"Autophagy"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1038\/s41467-022-31797-0","article-title":"Microglia coordinate cellular interactions during spinal cord repair in mice","volume":"13","author":"Brennan","year":"2022","journal-title":"Nat. Communications"},{"key":"B28","doi-asserted-by":"publisher","first-page":"102841","DOI":"10.1016\/j.conb.2024.102841","article-title":"Cell biology of Parkinson\u2019s disease: mechanisms of synaptic, lysosomal, and mitochondrial dysfunction","volume":"85","author":"Brooker","year":"2024","journal-title":"Curr. Opin. Neurobiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41586-025-08974-4","article-title":"Activation of lysosomal iron triggers ferroptosis in cancer","volume":"642","author":"Ca\u00f1eque","year":"2025","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1126\/science.aan4183","article-title":"Defective cholesterol clearance limits remyelination in the aged central nervous system","volume":"359","author":"Cantuti-Castelvetri","year":"2018","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6565","DOI":"10.3390\/ijms25126565","article-title":"Pathological functions of lysosomal ion channels in the central nervous system","volume":"25","author":"Cen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"216599","DOI":"10.1016\/j.canlet.2023.216599","article-title":"Emerging roles of lysosome homeostasis (repair, lysophagy and biogenesis) in cancer progression and therapy","volume":"584","author":"Chauhan","year":"2024","journal-title":"Cancer Lett."},{"key":"B33","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41420-024-01850-6","article-title":"From the regulatory mechanism of TFEB to its therapeutic implications","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"B34","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12264-024-01292-1","article-title":"Autophagy in oligodendrocyte lineage cells controls oligodendrocyte numbers and myelin integrity in an age-dependent manner","volume":"41","author":"Chen","year":"","journal-title":"Neurosci. Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3390\/biom15040525","article-title":"The emerging roles of vacuolar-type ATPase-Dependent lysosomal acidification in cardiovascular disease","volume":"15","author":"Chen","year":"","journal-title":"Biomolecules"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1083\/jcb.201711083","article-title":"Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons","volume":"217","author":"Cheng","year":"2018","journal-title":"J. Cell Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13024-025-00870-9","article-title":"Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases","volume":"20","author":"Choi","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"B38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3171\/spi.2007.6.3.255","article-title":"Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury","volume":"6","author":"Choo","year":"2007","journal-title":"J. Neurosurg. Spine"},{"key":"B39","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41556-025-01623-y","article-title":"Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer\u2019s disease","volume":"27","author":"Chou","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s41589-019-0308-4","article-title":"Covalent targeting of the vacuolar H(+)-ATPase activates autophagy via mTORC1 inhibition","volume":"15","author":"Chung","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00401-020-02193-z","article-title":"TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis","volume":"140","author":"Cignarella","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","article-title":"Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease","volume":"32","author":"Colacurcio","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1038\/s41467-021-21428-5","article-title":"Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia","volume":"12","author":"Colombo","year":"2021","journal-title":"Nat. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"5635","DOI":"10.1113\/jp285431","article-title":"Distinct ClC-6 and ClC-7 Cl(-) sensitivities provide insight into ClC-7\u2019s role in lysosomal Cl(-) homeostasis","volume":"601","author":"Coppola","year":"2023","journal-title":"J. Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1080\/15548627.2023.2267414","article-title":"ATG12-ATG5-TECPR1: an alternative E3-like complex utilized during the cellular response to lysosomal membrane damage","volume":"20","author":"Corkery","year":"2024","journal-title":"Autophagy"},{"key":"B47","doi-asserted-by":"publisher","first-page":"102544","DOI":"10.1016\/j.sbi.2023.102544","article-title":"Amino acid sensing and lysosomal signaling complexes","volume":"79","author":"Cui","year":"","journal-title":"Curr. Opin. Struct. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s41586-022-05652-7","article-title":"Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex","volume":"614","author":"Cui","year":"","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s00018-024-05419-5","article-title":"Lysosomal dysfunction in \u03b1-synuclein pathology: molecular mechanisms and therapeutic strategies","volume":"81","author":"Dai","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/s41593-024-01619-1","article-title":"Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration","volume":"27","author":"De Pace","year":"2024","journal-title":"Nat. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e199845","DOI":"10.1172\/jci199845","article-title":"Lysosomal homeostasis at the crossroads of neurodegeneration","volume":"136","author":"De Tito","year":"2026","journal-title":"J. Clin. Invest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1086895","DOI":"10.3389\/fncel.2023.1086895","article-title":"Autophagy and neurodegeneration: unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology","volume":"17","author":"Diab","year":"2023","journal-title":"Front. Cell Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1085\/jgp.201110596","article-title":"Lysosomal pH and analysis of the counter ion pathways that support acidification","volume":"137","author":"DiCiccio","year":"2011","journal-title":"J. Gen. Physiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/ncomms1037","article-title":"PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome","volume":"1","author":"Dong","year":"2010","journal-title":"Nat. Commun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"RP103137","DOI":"10.7554\/eLife.103137","article-title":"Small-molecule activation of TFEB alleviates Niemann-Pick disease type C via promoting lysosomal exocytosis and biogenesis","volume":"13","author":"Du","year":"2025","journal-title":"Elife"},{"key":"B57","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.chembiol.2025.02.003","article-title":"Mechanisms and functions of lysosomal lipid homeostasis","volume":"32","author":"Ebner","year":"2025","journal-title":"Cell Chem. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"E9115","DOI":"10.1073\/pnas.1812196115","article-title":"LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis","volume":"115","author":"Eguchi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B59","doi-asserted-by":"publisher","first-page":"7243","DOI":"10.3390\/jcm13237243","article-title":"Alpha-Synuclein and Microglia in parkinson\u2019s disease: from pathogenesis to therapeutic prospects","volume":"13","author":"Eo","year":"2024","journal-title":"J. Clin. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e2209177120","DOI":"10.1073\/pnas.2209177120","article-title":"Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer\u2019s disease","volume":"120","author":"Fairley","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.celrep.2019.06.013","article-title":"Neuronal soma-derived degradative lysosomes are continuously delivered to distal axons to maintain local degradation capacity","volume":"28","author":"Farfel-Becker","year":"2019","journal-title":"Cell Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e202305007","DOI":"10.1083\/jcb.202305007","article-title":"Not just protons: chloride also activates lysosomal acidic hydrolases","volume":"222","author":"Feng","year":"2023","journal-title":"J. Cell Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1038\/s41556-024-01523-7","article-title":"Spatial and functional separation of mTORC1 signalling in response to different amino acid sources","volume":"26","author":"Fernandes","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s11658-024-00633-2","article-title":"Lysosome quality control in health and neurodegenerative diseases","volume":"29","author":"Ferrari","year":"2024","journal-title":"Cell Mol. Biol. Lett."},{"key":"B65","article-title":"Genetic disorders of Glycan degradation","volume-title":"Essentials of Glycobiology","author":"Freeze","year":"2022"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.molcel.2024.02.029","article-title":"Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH","volume":"84","author":"Gahlot","year":"2024","journal-title":"Mol. Cell"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e2120404119","DOI":"10.1073\/pnas.2120404119","article-title":"Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P(2) and rapamycin","volume":"119","author":"Gan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.actbio.2022.11.015","article-title":"Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair","volume":"155","author":"Gao","year":"","journal-title":"Acta Biomater."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e14835","DOI":"10.1111\/cns.14835","article-title":"Therapeutic effects of exendin-4 on spinal cord injury via restoring autophagy function and decreasing necroptosis in neuron","volume":"30","author":"Gao","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s41467-024-46007-2","article-title":"A SPLICS reporter reveals [Formula: see text]-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation","volume":"15","author":"Giamogante","year":"2024","journal-title":"Nat. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"104591","DOI":"10.1016\/j.cellimm.2022.104591","article-title":"Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system","volume":"380","author":"Hammel","year":"2022","journal-title":"Cell Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer\u2019s disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1080\/15548627.2023.2167689","article-title":"Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes","volume":"19","author":"Hegdekar","year":"2023","journal-title":"Autophagy"},{"key":"B75","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","article-title":"Neuroinflammation in alzheimer disease","volume":"25","author":"Heneka","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.1038\/s41467-024-48151-1","article-title":"Structural basis for the intracellular regulation of ferritin degradation","volume":"15","author":"Hoelzgen","year":"2024","journal-title":"Nat. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1152\/physrev.00025.2023","article-title":"The ion channels of endomembranes","volume":"104","author":"Hu","year":"2024","journal-title":"Physiol. Rev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1593963","DOI":"10.3389\/fncel.2025.1593963","article-title":"Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies","volume":"19","author":"Huang","year":"2025","journal-title":"Front. Cell Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"eadg1925","DOI":"10.1126\/sciadv.adg1925","article-title":"Lysosomal dysfunction in Down syndrome and alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP \u03b2CTF","volume":"9","author":"Im","year":"2023","journal-title":"Sci. Adv."},{"key":"B81","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12964-025-02310-z","article-title":"Lysosomal targeting of liposomes with acidic pH and Cathepsin B induces protein aggregate clearance","volume":"23","author":"Jeon","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1080\/15548627.2021.1896906","article-title":"Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response","volume":"17","author":"Jeong","year":"2021","journal-title":"Autophagy"},{"key":"B83","doi-asserted-by":"publisher","first-page":"907","DOI":"10.3390\/gels9110907","article-title":"Application of injectable hydrogels as delivery systems in spinal cord injury","volume":"9","author":"Ji","year":"2023","journal-title":"Gels"},{"key":"B84","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.neuron.2025.01.019","article-title":"Neuronal autophagy in the control of synapse function","volume":"113","author":"Karpova","year":"2025","journal-title":"Neuron"},{"key":"B85","doi-asserted-by":"publisher","first-page":"8334","DOI":"10.1038\/s41467-024-52600-2","article-title":"USF2 and TFEB compete in regulating lysosomal and autophagy genes","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1093\/brain\/awy147","article-title":"Is Parkinson\u2019s disease a lysosomal disorder?","volume":"141","author":"Klein","year":"2018","journal-title":"Brain"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"B88","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/bioe.2025.0010","article-title":"Lysosomal ion channels and transporters: recent findings, therapeutic potential, and technical approaches","volume":"7","author":"Kondratskyi","year":"2025","journal-title":"Bioelectricity"},{"key":"B89","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1523\/jneurosci.2615-05.2006","article-title":"Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation","volume":"26","author":"Kotter","year":"2006","journal-title":"J. Neurosci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41586-025-09486-x","article-title":"PICALM Alzheimer\u2019s risk allele causes aberrant lipid droplets in microglia","volume":"646","author":"Kozlova","year":"2025","journal-title":"Nature"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1002\/prot.26723","article-title":"Microglial drivers of alzheimer\u2019s disease pathology: an evolution of diverse participating states","volume":"93","author":"Kuhn","year":"2025","journal-title":"Proteins"},{"key":"B93","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/s41467-024-44957-1","article-title":"DENND6A links Arl8b to a Rab34\/RILP\/dynein complex, regulating lysosomal positioning and autophagy","volume":"15","author":"Kumar","year":"2024","journal-title":"Nat. Commun."},{"key":"B94","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/wnr.0000000000002020","article-title":"Impaired autophagic flux in the human brain after traumatic brain injury","volume":"35","author":"Lang","year":"2024","journal-title":"Neuroreport"},{"key":"B95","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41556-018-0244-7","article-title":"The lysosome as a cellular centre for signalling, metabolism and quality control","volume":"21","author":"Lawrence","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","volume":"141","author":"Lee","year":"2010","journal-title":"Cell"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/j.celrep.2015.07.050","article-title":"Presenilin 1 maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-Mediated lysosome acidification","volume":"12","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1016\/j.jmb.2020.02.021","article-title":"\u03b22-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER-to-lysosome delivery of ClC-7","volume":"432","author":"Lee","year":"2020","journal-title":"J. Mol. Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer\u2019s disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"17513","DOI":"10.3390\/ijms242417513","article-title":"Abnormal cholesterol metabolism and lysosomal dysfunction induce age-related hearing loss by inhibiting mTORC1-TFEB-Dependent autophagy","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"24836","DOI":"10.1038\/s41598-024-75802-6","article-title":"Lysosomal Ca(2+) release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic\/lysosomal dysfunction in neurons","volume":"14","author":"Lei","year":"2024","journal-title":"Sci. Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"e74136","DOI":"10.7554\/eLife.74136","article-title":"Tonic inhibition of the chloride\/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance","volume":"11","author":"Leray","year":"2022","journal-title":"Elife"},{"key":"B103","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41419-019-1764-1","article-title":"cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"5364","DOI":"10.7150\/thno.72713","article-title":"Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"106282","DOI":"10.1016\/j.nbd.2023.106282","article-title":"The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage","volume":"186","author":"Li","year":"","journal-title":"Neurobiol. Dis."},{"key":"B106","doi-asserted-by":"publisher","first-page":"tkad018","DOI":"10.1093\/burnst\/tkad018","article-title":"Targeting neuronal mitophagy in ischemic stroke: an update","volume":"11","author":"Li","year":"","journal-title":"Burns Trauma"},{"key":"B107","doi-asserted-by":"publisher","first-page":"114840","DOI":"10.1016\/j.jconrel.2026.114840","article-title":"Cu(2+)-chelated epigallocatechin gallate nanoparticle-functionalized hydrogel promotes osteogenesis by inhibiting ferroptosis","volume":"394","author":"Li","year":"","journal-title":"J. Control Release"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.4103\/nrr.Nrr-d-24-01405","article-title":"Generation and clearance of myelin debris after spinal cord injury","volume":"21","author":"Li","year":"","journal-title":"Neural Regen. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/s12964-024-01761-0","article-title":"Axonal mitophagy in retinal ganglion cells","volume":"22","author":"Liang","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"B110","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/cells13010103","article-title":"Neuronal autophagy: regulations and implications in health and disease","volume":"13","author":"Li\u00e9nard","year":"2024","journal-title":"Cells"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e70919","DOI":"10.1002\/alz.70919","article-title":"ACLY regulates autolysosome acidification through tubulin acetylation-mediated assembly of V-ATPase subunits in Alzheimer\u2019s disease model mice","volume":"21","author":"Lin","year":"2025","journal-title":"Alzheimers Dement."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e1582","DOI":"10.1038\/cddis.2014.527","article-title":"Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-74063-3","article-title":"Nanozyme-engineered liners for proactive prevention of wear particle-induced osteolysis","author":"Liu","year":"2026","journal-title":"Nat. Commun."},{"key":"B114","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41582-019-0184-2","article-title":"The pro-remyelination properties of microglia in the central nervous system","volume":"15","author":"Lloyd","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"15452","DOI":"10.1021\/acsnano.3c09206","article-title":"Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic \u03b2-Cells under lipotoxic conditions","volume":"18","author":"Lo","year":"2024","journal-title":"ACS Nano"},{"key":"B116","doi-asserted-by":"publisher","first-page":"e14285","DOI":"10.1111\/acel.14285","article-title":"Age- and disease-related autophagy impairment in huntington disease: new insights from direct neuronal reprogramming","volume":"23","author":"Luo","year":"2024","journal-title":"Aging Cell"},{"key":"B117","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s40478-024-01791-2","article-title":"Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration","volume":"12","author":"Luo","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"B118","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13578-025-01357-2","article-title":"Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury","volume":"15","author":"Ma","year":"2025","journal-title":"Cell Biosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1038\/emboj.2013.171","article-title":"Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury","volume":"32","author":"Maejima","year":"2013","journal-title":"Embo J."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1091\/mbc.e06-10-0975","article-title":"Activation of microglia acidifies lysosomes and leads to degradation of alzheimer amyloid fibrils","volume":"18","author":"Majumdar","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"B122","doi-asserted-by":"publisher","first-page":"ra9","DOI":"10.1126\/scisignal.2004754","article-title":"The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris","volume":"7","author":"Martina","year":"2014","journal-title":"Sci. Signal"},{"key":"B123","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington\u2019s disease","volume":"13","author":"Martinez-Vicente","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00702-024-02774-2","article-title":"Current trends in basic research on Parkinson\u2019s disease: from mitochondria, lysosome to \u03b1-synuclein","volume":"131","author":"Matsui","year":"2024","journal-title":"J. Neural Transm. (Vienna)"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1080\/15548627.2015.1066957","article-title":"Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A\/SERCA-dependent autophagosome-lysosome fusion","volume":"11","author":"Mauvezin","year":"2015","journal-title":"Autophagy"},{"key":"B126","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and \u200bTFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-biochem-030222-102505","article-title":"The endo-lysosomal damage response","volume":"93","author":"Meyer","year":"2024","journal-title":"Annu. Rev. Biochem."},{"key":"B129","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev-physiol-012110-142317","article-title":"Lysosomal acidification mechanisms","volume":"74","author":"Mindell","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"106889","DOI":"10.1016\/j.nbd.2025.106889","article-title":"\u03b1-Synuclein pathology and mitochondrial dysfunction: toxic partners in Parkinson\u2019s disease","volume":"209","author":"Mingo","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"B131","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00018-025-05648-2","article-title":"Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5","volume":"82","author":"Montilla","year":"2025","journal-title":"Cell Mol. Life Sci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"e53529","DOI":"10.1371\/journal.pone.0053529","article-title":"The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E","volume":"8","author":"Namjoshi","year":"2013","journal-title":"PLoS One"},{"key":"B133","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.tcb.2022.04.012","article-title":"Non-canonical mTORC1 signaling at the lysosome","volume":"32","author":"Napolitano","year":"2022","journal-title":"Trends Cell Biol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.cell.2020.05.050","article-title":"Microglial remodeling of the extracellular matrix promotes synapse plasticity","volume":"182","author":"Nguyen","year":"2020","journal-title":"Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/s41580-024-00757-5","article-title":"Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases","volume":"25","author":"Nixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.3390\/ijms23042290","article-title":"Lysosomes at the crossroads of cell metabolism, cell cycle, and stemness","volume":"23","author":"Nowosad","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1038\/s41598-025-86991-z","article-title":"Glycosylated lysosomal membrane protein promotes tissue repair after spinal cord injury by reducing iron deposition and ferroptosis in microglia","volume":"15","author":"Ouyang","year":"2025","journal-title":"Sci. Rep."},{"key":"B138","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuron.2024.09.015","article-title":"Autophagy, aging, and age-related neurodegeneration","volume":"113","author":"Palmer","year":"2025","journal-title":"Neuron"},{"key":"B139","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1080\/15548627.2022.2069956","article-title":"Essential role of lysosomal Ca2+-mediated TFEB activation in mitophagy and functional adaptation of pancreatic \u03b2-cells to metabolic stress","volume":"18","author":"Park","year":"2022","journal-title":"Autophagy"},{"key":"B140","doi-asserted-by":"publisher","first-page":"102382","DOI":"10.1016\/j.ceb.2024.102382","article-title":"Disruptions in axonal lysosome transport and its contribution to neurological disease","volume":"89","author":"Paumier","year":"2024","journal-title":"Curr. Opinion Cell Biology"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1038\/s42003-025-09167-5","article-title":"Lipid accumulation in foam cells drives C1q-dependent synaptic loss and impairs motor function recovery after spinal cord injury","volume":"8","author":"Peng","year":"2025","journal-title":"Commun. Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"861202","DOI":"10.3389\/fncel.2022.861202","article-title":"Activated endolysosomal cation channel TRPML1 facilitates maturation of \u03b1-Synuclein-Containing autophagosomes","volume":"16","author":"Pollmanns","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"106588","DOI":"10.1016\/j.isci.2023.106588","article-title":"Modulation of microglial metabolism facilitates regeneration in demyelination","volume":"26","author":"Qin","year":"2023","journal-title":"iScience"},{"key":"B144","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1111\/jnc.16184","article-title":"Exploring the triad: VPS35, neurogenesis, and neurodegenerative diseases","volume":"168","author":"Qiu","year":"2024","journal-title":"J. Neurochem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12974-023-02866-y","article-title":"Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration","volume":"20","author":"Quick","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B146","doi-asserted-by":"publisher","first-page":"e99753","DOI":"10.15252\/embj.201899753","article-title":"ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival","volume":"37","author":"Radulovic","year":"2018","journal-title":"Embo J."},{"key":"B147","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41580-025-00873-w","article-title":"Lysosomal membrane homeostasis and its importance in physiology and disease","volume":"27","author":"Radulovic","year":"2026","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"107861","DOI":"10.1016\/j.phrs.2025.107861","article-title":"Liver X receptors: a therapeutic target in demyelinating disorders","volume":"219","author":"Richartz","year":"2025","journal-title":"Pharmacol. Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-pharmtox-051921-013755","article-title":"Lysosomal ion channels: what are they good for and are they druggable targets?","volume":"63","author":"Riederer","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"e202111077","DOI":"10.1083\/jcb.202111077","article-title":"Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis","volume":"221","author":"Roney","year":"2022","journal-title":"J. Cell Biol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1080\/15548627.2018.1535292","article-title":"Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration","volume":"15","author":"Rusmini","year":"2019","journal-title":"Autophagy"},{"key":"B152","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41419-025-08103-z","article-title":"Impairment of lysosomal quality control in huntington disease","volume":"16","author":"Rusmini","year":"2025","journal-title":"Cell Death Dis."},{"key":"B153","doi-asserted-by":"publisher","first-page":"105608","DOI":"10.1016\/j.nbd.2021.105608","article-title":"Myelin and Non-myelin debris contribute to foamy macrophage formation after spinal cord injury","volume":"163","author":"Ryan","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"B154","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/nn.4325","article-title":"Age-related myelin degradation burdens the clearance function of microglia during aging","volume":"19","author":"Safaiyan","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrm2745","article-title":"Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function","volume":"10","author":"Saftig","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"B157","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"B158","doi-asserted-by":"publisher","first-page":"951","DOI":"10.4103\/1673-5374.382247","article-title":"Autophagy in neuroinflammation after traumatic brain injury","volume":"19","author":"Sarkar","year":"2024","journal-title":"Neural Regen. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"key":"B160","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.tcb.2019.08.008","article-title":"Lysosomes: signaling hubs for metabolic sensing and longevity","volume":"29","author":"Savini","year":"2019","journal-title":"Trends Cell Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1016\/j.neuron.2024.06.029","article-title":"Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes","volume":"112","author":"Scheiblich","year":"2024","journal-title":"Neuron"},{"key":"B162","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/s1474-4422(23)00247-8","article-title":"Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer\u2019s disease","volume":"22","author":"Schlepckow","year":"2023","journal-title":"Lancet Neurol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.1038\/s41467-019-13572-w","article-title":"TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK\u03b2\/VPS34 pathway","volume":"10","author":"Scotto Rosato","year":"2019","journal-title":"Nat. Commun."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/emboj.2012.32","article-title":"A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB","volume":"31","author":"Settembre","year":"2012","journal-title":"Embo J."},{"key":"B165","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s11011-025-01739-y","article-title":"Rewiring brain immunity: targeting microglial metabolism for neuroprotection in neurodegenerative disorders","volume":"40","author":"Shokr","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1089\/neu.2007.0302","article-title":"The extent of myelin pathology differs following contusion and transection spinal cord injury","volume":"24","author":"Siegenthaler","year":"2007","journal-title":"J. Neurotrauma"},{"key":"B167","doi-asserted-by":"publisher","first-page":"101203","DOI":"10.1016\/j.crmeth.2025.101203","article-title":"Real-time pH imaging of macrophage lysosomes using the pH-sensitive probe ApHID","volume":"5","author":"Sol\u00e9-Dom\u00e8nech","year":"2025","journal-title":"Cell Rep. Methods"},{"key":"B168","doi-asserted-by":"publisher","first-page":"jcs259875","DOI":"10.1242\/jcs.259875","article-title":"The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system","volume":"136","author":"Somogyi","year":"2023","journal-title":"J. Cell Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"10211","DOI":"10.1074\/jbc.M113.506246","article-title":"2-Hydroxypropyl-\u03b2-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy","volume":"289","author":"Song","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40035-020-00196-0","article-title":"The emerging roles of vacuolar-type ATPase-dependent lysosomal acidification in neurodegenerative diseases","volume":"9","author":"Song","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"B171","doi-asserted-by":"publisher","first-page":"100872","DOI":"10.1016\/j.jlr.2025.100872","article-title":"Lipid and lipoprotein metabolism in microglia: alzheimer\u2019s disease mechanisms and interventions","volume":"66","author":"Sprenger","year":"2025","journal-title":"J. Lipid Res."},{"key":"B172","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev-physiol-030212-183702","article-title":"Chloride in vesicular trafficking and function","volume":"75","author":"Stauber","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s00401-024-02810-1","article-title":"Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway","volume":"148","author":"Sweeney","year":"2024","journal-title":"Acta Neuropathol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41586-022-05164-4","article-title":"A phosphoinositide signalling pathway mediates rapid lysosomal repair","volume":"609","author":"Tan","year":"2022","journal-title":"Nature"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1022754","DOI":"10.3389\/fncel.2022.1022754","article-title":"A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system","volume":"16","author":"Tewari","year":"2022","journal-title":"Front. Cell Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/s41593-024-01714-3","article-title":"Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice","volume":"27","author":"Tewari","year":"2024","journal-title":"Nat. Neurosci."},{"key":"B177","doi-asserted-by":"publisher","first-page":"217024","DOI":"10.1016\/j.canlet.2024.217024","article-title":"Lysosomal exocytosis: from cell protection to protumoral functions","volume":"597","author":"Trojani","year":"2024","journal-title":"Cancer Lett."},{"key":"B178","doi-asserted-by":"publisher","first-page":"101341","DOI":"10.1016\/j.plipres.2025.101341","article-title":"The balancing act between lipid droplets and lysosomes for membrane functionality in age-related neurodegeneration and inflammation","volume":"99","author":"Tsap","year":"2025","journal-title":"Prog. Lipid Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.tins.2021.12.004","article-title":"Lysosomal dysfunction in neurodegeneration: emerging concepts and methods","volume":"45","author":"Udayar","year":"2022","journal-title":"Trends Neurosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol. Cell"},{"key":"B181","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/s41593-022-01240-0","article-title":"A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer\u2019s disease models","volume":"26","author":"van Lengerich","year":"2023","journal-title":"Nat. Neurosci."},{"key":"B182","doi-asserted-by":"publisher","first-page":"111591","DOI":"10.1016\/j.celrep.2022.111591","article-title":"The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris","volume":"41","author":"Vanherle","year":"2022","journal-title":"Cell Rep."},{"key":"B183","doi-asserted-by":"publisher","first-page":"e2121609119","DOI":"10.1073\/pnas.2121609119","article-title":"Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration","volume":"119","author":"Vest","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B184","doi-asserted-by":"publisher","first-page":"e202209077","DOI":"10.1083\/jcb.202209077","article-title":"A PI(3,5)P2 reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes","volume":"222","author":"Vines","year":"2023","journal-title":"J. Cell Biol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"108043","DOI":"10.1016\/j.pharmthera.2021.108043","article-title":"Functional hydrogels as therapeutic tools for spinal cord injury: new perspectives on immunopharmacological interventions","volume":"234","author":"Walsh","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"B186","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B187","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41593-023-01494-2","article-title":"TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy","volume":"27","author":"Wang","year":"","journal-title":"Nat. Neurosci."},{"key":"B188","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/15548627.2023.2276639","article-title":"CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction","volume":"20","author":"Wang","year":"","journal-title":"Autophagy"},{"key":"B189","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12967-025-06095-0","article-title":"Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-\u03baB signaling: evidence from integrated single-cell and spatial transcriptomic analysis","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"B190","doi-asserted-by":"publisher","first-page":"tkad051","DOI":"10.1093\/burnst\/tkad051","article-title":"Broadening horizons: ferroptosis as a new target for traumatic brain injury","volume":"12","author":"Wei","year":"2024","journal-title":"Burns Trauma"},{"key":"B191","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41419-024-06423-0","article-title":"Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control","volume":"15","author":"Wible","year":"2024","journal-title":"Cell Death Dis."},{"key":"B192","doi-asserted-by":"publisher","first-page":"e202208155","DOI":"10.1083\/jcb.202208155","article-title":"ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution","volume":"222","author":"Wu","year":"2023","journal-title":"J. Cell Biol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"eadq6038","DOI":"10.1126\/sciadv.adq6038","article-title":"Reducing microglial lipid load enhances \u03b2 amyloid phagocytosis in an Alzheimer\u2019s disease mouse model","volume":"11","author":"Wu","year":"2025","journal-title":"Sci. Adv."},{"key":"B194","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12974-025-03490-8","article-title":"Cholesterol in the CNS: functions, recycling and remyelination","volume":"22","author":"Wuerch","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"B195","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41419-023-05786-0","article-title":"Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways","volume":"14","author":"Xie","year":"2023","journal-title":"Cell Death Dis."},{"key":"B196","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev-physiol-021014-071649","article-title":"Lysosomal physiology","volume":"77","author":"Xu","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"e70044","DOI":"10.1002\/jcp.70044","article-title":"Lysosomal repair in health and disease","volume":"240","author":"Xun","year":"2025","journal-title":"J. Cell Physiol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.tcb.2023.01.001","article-title":"Lysosomal quality control: molecular mechanisms and therapeutic implications","volume":"33","author":"Yang","year":"2023","journal-title":"Trends Cell Biol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1093\/hmg\/ddx001","article-title":"Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and alzheimer model mice","volume":"26","author":"Yang","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B200","doi-asserted-by":"publisher","first-page":"341448","DOI":"10.1016\/j.aca.2023.341448","article-title":"Ratiometric visualization of lysosomal pH fluctuations during autophagy by two-photon carbonized polymer dots-based probe","volume":"1271","author":"Yao","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"B201","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1161\/strokeaha.124.049745","article-title":"FTY720 modulating microglia-mediated cholesterol recycling via TREM2 promotes remyelination following ischemic damage","volume":"56","author":"Yu","year":"","journal-title":"Stroke"},{"key":"B202","doi-asserted-by":"publisher","first-page":"107129","DOI":"10.1016\/j.nbd.2025.107129","article-title":"Altered APP trafficking drives amyloidogenic processing in primary neurons from the App(NL-F) knock-in mouse model of Alzheimer\u2019s disease","volume":"216","author":"Yu","year":"","journal-title":"Neurobiol. Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s11357-023-00923-1","article-title":"Endocytosis and Alzheimer\u2019s disease","volume":"46","author":"Zadka","year":"2024","journal-title":"Geroscience"},{"key":"B204","doi-asserted-by":"publisher","first-page":"e1801511","DOI":"10.1002\/adhm.201801511","article-title":"Degradable nanoparticles restore lysosomal pH and autophagic flux in lipotoxic pancreatic beta cells","volume":"8","author":"Zeng","year":"2019","journal-title":"Adv. Healthc. Mater"},{"key":"B205","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1038\/s41467-023-38165-6","article-title":"Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease","volume":"14","author":"Zeng","year":"2023","journal-title":"Nat. Commun."},{"key":"B206","doi-asserted-by":"publisher","first-page":"8633","DOI":"10.1523\/jneurosci.0556-12.2012","article-title":"A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2","volume":"32","author":"Zhang","year":"2012","journal-title":"J. Neurosci."},{"key":"B207","doi-asserted-by":"publisher","first-page":"134465","DOI":"10.1016\/j.cej.2021.134465","article-title":"Enhancement of motor functional recovery using immunomodulatory extracellular vesicles-loaded injectable thermosensitive hydrogel post spinal cord injury","volume":"433","author":"Zhang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"B208","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.molcel.2023.06.004","article-title":"Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel","volume":"83","author":"Zhang","year":"","journal-title":"Mol. Cell"},{"key":"B209","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1080\/15548627.2022.2108252","article-title":"Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis","volume":"19","author":"Zhang","year":"","journal-title":"Autophagy"},{"key":"B210","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12974-024-03056-0","article-title":"LXR agonism for CNS diseases: promises and challenges","volume":"21","author":"Zhang","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"B211","doi-asserted-by":"publisher","first-page":"1584577","DOI":"10.3389\/fimmu.2025.1584577","article-title":"Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"104979","DOI":"10.1016\/j.neures.2025.104979","article-title":"Traumatic brain injury and Alzheimer\u2019s disease related neurodegenerative diseases: insights from animal models","volume":"221","author":"Zhao","year":"2025","journal-title":"Neurosci. Res."},{"key":"B213","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1016\/j.molcel.2024.04.018","article-title":"Autophagy preferentially degrades non-fibrillar polyQ aggregates","volume":"84","author":"Zhao","year":"2024","journal-title":"Mol. Cell"},{"key":"B214","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1038\/s42255-025-01379-7","article-title":"Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke","volume":"7","author":"Zhao","year":"2025","journal-title":"Nat. Metab."},{"key":"B215","doi-asserted-by":"publisher","first-page":"0135","DOI":"10.34133\/research.0135","article-title":"Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury","volume":"6","author":"Zheng","year":"2023","journal-title":"Res. (Wash D C)"},{"key":"B216","doi-asserted-by":"publisher","first-page":"eadk6084","DOI":"10.1126\/sciadv.adk6084","article-title":"Engineered MgO nanoparticles for cartilage-bone synergistic therapy","volume":"10","author":"Zheng","year":"2024","journal-title":"Sci. Adv."},{"key":"B217","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.4103\/nrr.Nrr-d-24-00112","article-title":"Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets","volume":"20","author":"Zheng","year":"2025","journal-title":"Neural Regen. Res."},{"key":"B218","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41419-024-06540-w","article-title":"Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."},{"key":"B219","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41419-020-03032-5","article-title":"Lysosomal quality control of cell fate: a novel therapeutic target for human diseases","volume":"11","author":"Zhu","year":"2020","journal-title":"Cell Death Dis."},{"key":"B220","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"key":"B221","doi-asserted-by":"publisher","first-page":"1775841","DOI":"10.3389\/fimmu.2026.1775841","article-title":"Focusing on microglial mitochondria-lysosome crosstalk and neuroinflammation underlying depression: from molecular pathways to potential therapeutic interventions","volume":"17","author":"Zou","year":"2026","journal-title":"Front. Immunol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1016\/j.molcel.2024.10.009","article-title":"mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes","volume":"84","author":"Zwakenberg","year":"2024","journal-title":"Mol. Cell"}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2026.1891677\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:03:36Z","timestamp":1790172216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2026.1891677\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":222,"alternative-id":["10.3389\/fchem.2026.1891677"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2026.1891677","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"1891677"}}