{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:03:38Z","timestamp":1789625018427,"version":"build-2803163510"},"reference-count":227,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>In recent times, permeation of nanotechnology to modern medicine has revolutionized transformation, especially in the case of cancer diagnosis and therapy, positioning nanomedicine as a key pillar of next-generation healthcare. Tuning the physicochemical properties of nanoparticles such as size, morphology, and surface charge, enables controlled targeted drug delivery, increased cellular uptake and controlled therapeutic release. Nanomedicine-based platforms can improve certain drawbacks associated with conventional therapies including poor aqueous solubility, unfavorable pharmacokinetics, systemic toxicity and low bioavailability for specific therapeutic agents. While consistent tumor-specific accumulation, intratumoral heterogeneity, drug resistance, and long-term therapeutic outcomes remains challenging and highly formulation- and patient-dependent. This review paper besides, focussing on individual nanocarrier classes or specific therapeutic modalities, also provide an integrated and critical perspective on next-generation nanomedicine by connecting nanocarrier design with tumor-specific accumulation, intracellular trafficking, stimuli-responsive drug release, combination therapy and clinical translation. Recent advances in polymeric, lipid-based, inorganic, biological, and hybrid nanocarriers are systematically discussed, with particular stress on surface engineering, ligand-mediated targeting, multifunctional delivery systems and nanoengineered cancer medicine. The potential of these platforms for elevating therapeutic precision, overcoming biological barriers, multidrug resistance and enabling site-specific delivery is critically studied. In addition, major translational challenges, including large-scale fabrication, reproducibility, long-term safety, regulatory barriers, and nanotoxicological concerns are also addressed. Finally, emerging directions involving personalized nanomedicine, combination therapies, and artificial intelligence-assisted nanoparticle design are highlighted to provide perspectives toward safer, more effective, and patient-concentrated cancer therapy.<\/jats:p>","DOI":"10.3389\/fchem.2026.1920337","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:31:23Z","timestamp":1789623083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Next-generation nanomedicine for cancer therapy: advances, challenges, and future perspectives"],"prefix":"10.3389","volume":"14","author":[{"given":"Biswajit","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Chemistry, Assam University","place":["Silchar, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Assam University","place":["Silchar, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Pandey","sequence":"additional","affiliation":[{"name":"Departement of Microbiology, Assam University","place":["Silchar, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chira R.","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Assam University","place":["Silchar, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.addr.2007.03.005","article-title":"RNAi therapeutics: principles, prospects and challenges","volume":"59","author":"Aagaard","year":"2007","journal-title":"Adv. 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