{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:09:45Z","timestamp":1789711785252,"version":"4.0.1"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>The direct C\u2013H trifluoroacetylation of electron-deficient nitrogen heterocycles remains a longstanding challenge with conventional reagents, owing to the inherent instability of the trifluoroacetyl radical and its polarity mismatch with electron-deficient substrates. Here, a novel method for the trifluoroacetylation of electron-deficient nitrogen heterocycles has been developed; under visible-light irradiation, the protocol operates without the need for cumbersome substrate pre-functionalization, expensive catalysts, transition metals, or additional additives. This approach enables the efficient trifluoroacetylation of diverse substrates, including pyridine, quinoline, quinoxalinone, chromone, and azauracil, and exhibits broad functional group tolerance and versatility, rendering it highly suitable for the late-stage functionalization of various bioactive molecules. By overcoming the polarity-mismatch limitation, this strategy addresses the longstanding challenge of direct C\u2013H trifluoroacetylation of electron-deficient nitrogen heterocycles and aligns with the principles of sustainable chemistry.<\/jats:p>","DOI":"10.3389\/fchem.2026.1957846","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:39:21Z","timestamp":1789709961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Visible-light-induced trifluoroacetylation reaction of electron-deficient nitrogen heterocycles"],"prefix":"10.3389","volume":"14","author":[{"given":"Yanshu","family":"Li","sequence":"first","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangzhen","family":"An","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]},{"name":"National Engineering Research Center of Low Carbon Processing and Utilization of Forest Biomass, Nanjing Forestry University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuren","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]},{"name":"Henan Fluorine-Based New Materials Technology Co., Ltd.","place":["Jiaozuo, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences, Henan University","place":["Kaifeng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]},{"name":"Institute of Chemistry, Henan Academy of Sciences","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11486","DOI":"10.1021\/acs.joc.5c00987","article-title":"Visible-light-driven trifluoroacetylation of azauracils","volume":"90","author":"An","year":"2025","journal-title":"J. Org. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1021\/acs.chemrev.2c00478","article-title":"Photocatalytic late-stage C-H functionalization","volume":"123","author":"Bellotti","year":"2023","journal-title":"Chem. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4342","DOI":"10.1038\/s41467-021-24671-y","article-title":"Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles","volume":"12","author":"Chang","year":"2021","journal-title":"Nat. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4499","DOI":"10.1039\/d2cc06887g","article-title":"Radical-mediated remote migration of quinoxalinones","volume":"59","author":"Chang","year":"2023","journal-title":"Chem. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1039\/b510795d","article-title":"Fluorescence modulation in anion sensing by introducing intramolecular H-bonding interactions in host-guest adducts","volume":"14","author":"Chung","year":"2006","journal-title":"Chem. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1039\/C5DT03091A","article-title":"Synthesis, structure and adsorption properties of lanthanide\u2013organic frameworks with pyridine-3,5-bis(phenyl-4-carboxylate)","volume":"45","author":"Cui","year":"2016","journal-title":"Dalton Trans."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e202308732","DOI":"10.1002\/anie.202308732","article-title":"Access to trifluoromethylketones from alkyl bromides and trifluoroacetic anhydride by photocatalysis","volume":"62","author":"Du","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"B8","doi-asserted-by":"publisher","first-page":"377","DOI":"10.2174\/1568026620666200908162311","article-title":"Indole alkaloids, synthetic dimers and hybrids with potential in vivo anticancer activity","volume":"21","author":"Feng","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e202318377","DOI":"10.1002\/anie.202318377","article-title":"Review and theoretical analysis of fluorinated radicals in direct CAr-H functionalization of (hetero)arenes","volume":"63","author":"Fernandes","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5978","DOI":"10.1002\/ejoc.201901049","article-title":"One-pot and reducible-functional-group-tolerant synthesis of \u03b1-Aryl- and \u03b1-Heteroaryl-\u03b1-Trifluoromethyl alcohols via tandem trifluoroacetylation and MPV type reduction","volume":"2019","author":"Funabiki","year":"2019","journal-title":"Eur. J. Org. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"11530","DOI":"10.1021\/jacs.3c04294","article-title":"Hydrotrifluoroacetylation of alkenes via designer masked acyl reagents","volume":"145","author":"Han","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7258","DOI":"10.1021\/acs.jmedchem.5b00482","article-title":"6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives as novel d-Amino acid oxidase inhibitors","volume":"58","author":"Hin","year":"2015","journal-title":"J. Med. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s11426-024-2496-5","article-title":"Combination of photocatalytic proton-coupled electron transfer and spin-center shift: direct C-H benzylation of N-heteroarenes with benzaldehydes in continuous-flow","volume":"68","author":"Hou","year":"2025","journal-title":"Sci. China Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1039\/d5ob01848j","article-title":"Cu@g-C3N4 heterojunction-catalyzed visible-light-driven direct C\u2013H alkylation of heterocycles","volume":"24","author":"Ji","year":"2026","journal-title":"Org. Biomol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1081\/ncn-200055695","article-title":"Synthesis and biological activity of some unsaturated 6-azauracil acyclonucleosides","volume":"24","author":"Kabbaj","year":"2005","journal-title":"Nucleosides Nucleotides and Nucleic Acids"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1016\/S0040-4039(00)00378-6","article-title":"New catalytic oxidation of trifluoromethyl carbinols by a ruthenium(II) complex","volume":"41","author":"Kesavan","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/s41586-021-03637-6","article-title":"A radical approach for the selective C-H borylation of azines","volume":"595","author":"Kim","year":"2021","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/cbdv.201100285","article-title":"Synthesis and evaluation of 6-Aza-2\u2032-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis","volume":"9","author":"Koegler","year":"2012","journal-title":"Chem. and Biodivers."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1039\/C5CC09518B","article-title":"3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability","volume":"52","author":"Kumar","year":"2016","journal-title":"Chem. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nchem.2523","article-title":"Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions","volume":"8","author":"Lee","year":"2016","journal-title":"Nat. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e202400423","DOI":"10.1002\/ejoc.202400423","article-title":"Introduction of difluoromethyl through radical pathways","volume":"27","author":"Li","year":"2024","journal-title":"Eur. J. Org. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.2147\/DDDT.S214157","article-title":"Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor","volume":"14","author":"Li","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6861","DOI":"10.1039\/D2QO01498J","article-title":"NHPI-catalyzed electrochemical C\u2013H alkylation of indoles with alcohols to access di(indolyl)methanes via radical coupling","volume":"9","author":"Li","year":"2022","journal-title":"Org. Chem. Front."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1021\/acs.orglett.4c00238","article-title":"Photoredox-catalyzed hydroacylation of azobenzenes with carboxylic acids","volume":"26","author":"Li","year":"2024","journal-title":"Org. Lett."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1038\/s41929-025-01457-9","article-title":"Illuminating the transformation of photocatalysts in light-driven organic synthesis","volume":"8","author":"Li","year":"2025","journal-title":"Nat. Catal."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e23587","DOI":"10.1002\/anie.202523587","article-title":"Hydroxyl radicals unlock strong C(sp3)\u2013Si bonds: photocatalytic alkylation and silacycle engineering","volume":"65","author":"Li","year":"2026","journal-title":"Angew. Chem. Int. Ed."},{"key":"B27","doi-asserted-by":"publisher","first-page":"6040","DOI":"10.1021\/jacs.2c01116","article-title":"Catalytic asymmetric construction of axially and centrally chiral heterobiaryls by minisci reaction","volume":"144","author":"Liang","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1021\/jo500840s","article-title":"[Bmim]PF6-Promoted ligandless suzuki\u2013miyaura coupling reaction of potassium aryltrifluoroborates in water","volume":"79","author":"Liu","year":"","journal-title":"J. Org. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1039\/C3GC42182A","article-title":"A highly efficient and recyclable ligand-free protocol for the suzuki coupling reaction of potassium aryltrifluoroborates in water","volume":"16","author":"Liu","year":"","journal-title":"Green Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jorganchem.2013.09.026","article-title":"A simple and efficient protocol for suzuki coupling reactions of aryl chlorides and aryl bromides in aqueous DMF","volume":"749","author":"Liu","year":"","journal-title":"J. Organomet. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10637-024-01451-1","article-title":"Radiosensitization effect of quinoline-indole-schiff base derivative 10E on non-small cell lung cancer cells in vitro and in tumor xenografts","volume":"42","author":"Liu","year":"2024","journal-title":"Invest. New Drugs"},{"key":"B32","doi-asserted-by":"publisher","first-page":"9197","DOI":"10.1039\/d0cs00604a","article-title":"Recent progress on selective deconstructive modes of halodifluoromethyl and trifluoromethyl-containing reagents","volume":"49","author":"Ma","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1021\/acs.joc.5c02904","article-title":"Visible-light photoredox-catalyzed alkylation\/1,2-aryl migration of allylic alcohols with malonic esters leading to \u03b4-keto esters","volume":"91","author":"Ma","year":"2025","journal-title":"J. Org. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"8476","DOI":"10.1039\/D1CC03624F","article-title":"Base-catalysed 18F-labelling of trifluoromethyl ketones. Application to the synthesis of 18F-labelled neutrophil elastase inhibitors","volume":"57","author":"Meyer","year":"2021","journal-title":"Chem. Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1016\/S0040-4020(01)93049-2","article-title":"Nucleophilic character of alkyl radicals\u2014Ii: selective alkylation of pyridine, quinoline and acridine by hydroperoxides and oxaziranes","volume":"26","author":"Minisci","year":"1970","journal-title":"Tetrahedron"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/cmdc.201700333","article-title":"Trifluoromethyl oxetanes: synthesis and evaluation as a tert-Butyl isostere","volume":"12","author":"Mukherjee","year":"2017","journal-title":"ChemMedChem"},{"key":"B37","doi-asserted-by":"publisher","first-page":"104253","DOI":"10.1016\/j.isci.2022.104253","article-title":"Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer","volume":"25","author":"Niu","year":"2022","journal-title":"iScience"},{"key":"B38","doi-asserted-by":"publisher","first-page":"13284","DOI":"10.1021\/acs.joc.4c01416","article-title":"A general radical functionalization of Quinoxalin-2(1H)-ones via a donor-acceptor inversion strategy","volume":"89","author":"Niu","year":"2024","journal-title":"J. Org. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1126\/science.adi1557","article-title":"Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF","volume":"381","author":"Patel","year":"2023","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"18255","DOI":"10.1021\/acs.joc.5c02498","article-title":"Semiheterogeneous intrinsic CoS2-Photoredox\/Cp2Fe dual-catalyzed synthesis of selenylated phenanthrene","volume":"90","author":"Peng","year":"2025","journal-title":"J. Org. Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"13666","DOI":"10.1002\/anie.201900977","article-title":"Recent advances in minisci-type reactions","volume":"58","author":"Proctor","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5791","DOI":"10.1039\/D4QO01339E","article-title":"Decatungstate-photocatalyzed radical addition of C(sp3)\u2013H to azauracils","volume":"11","author":"Qiao","year":"2024","journal-title":"Org. Chem. Front."},{"key":"B43","doi-asserted-by":"publisher","first-page":"9077","DOI":"10.1021\/acs.orglett.6c02556","article-title":"Visible light-induced N-Phenylbenzo[c]phenothiazine-Catalyzed \u03b1-C(sp3)\u2013H phosphonylation of secondary amines via intramolecular 1,5-HAT","volume":"28","author":"Qiao","year":"2026","journal-title":"Org. Lett."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9476","DOI":"10.1021\/jo801737c","article-title":"Trifluoromethyl ketones from enolizable carboxylic acids via enediolate trifluoroacetylation\/decarboxylation","volume":"73","author":"Reeves","year":"2008","journal-title":"J. Org. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"114807","DOI":"10.1016\/j.ejmech.2022.114807","article-title":"Rational design of metabolically stable HDAC inhibitors: an overhaul of trifluoromethyl ketones","volume":"244","author":"Riddhidev","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1002\/anie.202000414","article-title":"Analysis of an active deformylation mechanism of 5-Formyl-deoxycytidine (fdC) in stem cells","volume":"59","author":"Schoen","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1039\/D0CS01366H","article-title":"Reactive intermediates for interactome mapping","volume":"50","author":"Seath","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"8848","DOI":"10.1021\/acs.orglett.4c03288","article-title":"Light-driven N-Heterocyclic carbene-catalyzed multi-component reaction for the synthesis of \u03b2-Amino ketones","volume":"26","author":"Shi","year":"2024","journal-title":"Org. Lett."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1039\/D2GC04843D","article-title":"Semi-heterogeneous g-C3N4\/NaI dual catalytic C\u2013C bond formation under visible light","volume":"25","author":"Song","year":"2023","journal-title":"Green Chem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1021\/acs.orglett.3c00890","article-title":"Trifluoromethylations of (hetero)arenes and polarized alkenes using trifluoroacetic anhydride under photoredox catalysis","volume":"25","author":"Song","year":"2023","journal-title":"Org. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"6840","DOI":"10.1021\/acs.joc.6c00085","article-title":"Recyclable Cs2AgBiBr6 for photocatalytic synthesis of cyanomethylated oxindoles","volume":"91","author":"Song","year":"2026","journal-title":"J. Org. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5659","DOI":"10.1039\/d2sc01241c","article-title":"A general electron donor-acceptor complex for photoactivation of arenes via thianthrenation","volume":"13","author":"Sun","year":"2022","journal-title":"Chem. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1021\/jm4017625","article-title":"Rings in drugs","volume":"57","author":"Taylor","year":"2014","journal-title":"J. Med. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3382\/ps.0680489","article-title":"Diclazuril, a new broad spectrum anticoccidial drug in chickens.: 1. Dose titration studies and pilot floor pen trials","volume":"68","author":"Vanparijs","year":"1989","journal-title":"Poult. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/1097-0142(197204)29:4<1057::Aid-cncr2820290455>3.0.Co;2-q","article-title":"6-Azauridine in combination chemotherapy of childhood acute myelocytic leukemia","volume":"29","author":"Walters","year":"1972","journal-title":"Cancer"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1039\/c8gc01534a","article-title":"Transition-metal-free oxidative cyclization of N-propargyl ynamides: stereospecific construction of linear polycyclic N-heterocycles","volume":"20","author":"Wang","year":"2018","journal-title":"Green Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.1021\/acs.chemrev.3c00158","article-title":"Electrochemical late-stage functionalization","volume":"123","author":"Wang","year":"2023","journal-title":"Chem. Rev."},{"key":"B58","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1080\/14740338.2024.2348614","article-title":"Comparison of safety of acetaminophen and ibuprofen in minors: based on the FAERS database","volume":"24","author":"Wang","year":"2025","journal-title":"Expert Opin. Drug Saf."},{"key":"B59","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.1021\/acs.orglett.5c01350","article-title":"C3\u2013H trifluoroacetylation of quinolines and pyridines: access to heteroaryl ketones, carboxylic acids, and amides","volume":"27","author":"Wang","year":"2025","journal-title":"Org. Lett."},{"key":"B60","doi-asserted-by":"publisher","first-page":"10812","DOI":"10.1039\/D5CC02744F","article-title":"Visible-light induced 1,2-dicarbofunctionalization of alkenes with quinoxalin-2(1H)-ones and malonic esters","volume":"61","author":"Wang","year":"2025","journal-title":"Chem. Commun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1021\/acs.orglett.5c05211","article-title":"Nickel-catalyzed regioselective hydroalkynylation of nitrogen heterocycle-tethered unactivated alkenes","volume":"28","author":"Wang","year":"2026","journal-title":"Org. Lett."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1055\/s-0036-1591971","article-title":"Synthesis of aryl trifluoromethyl ketones","volume":"50","author":"Wu","year":"2018","journal-title":"Synthesis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5972","DOI":"10.1039\/D5SC08495D","article-title":"Heterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines","volume":"17","author":"Xiang","year":"2026","journal-title":"Chem. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e202405186","DOI":"10.1002\/anie.202405186","article-title":"A general photoactive H-Bonding EDA complex model drives the selective hydrothiolation and hydroxysulfenylation of carbonyl activated alkenes","volume":"63","author":"Yan","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"B65","doi-asserted-by":"publisher","first-page":"16403","DOI":"10.1021\/acs.joc.5c01813","article-title":"Synergistic photocatalysis of acridinium salts and pyridine N-Oxides for \u03b1-Aminoalkylation with N-Methylsulfonamides","volume":"90","author":"Yang","year":"2025","journal-title":"J. Org. Chem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.1021\/acs.joc.6c00202","article-title":"Visible-light-induced Oximo-Thioesterification of alkenes with tert-butyl nitrite and thioacids leading to \u03b1-Thioester oximes","volume":"91","author":"Yang","year":"2026","journal-title":"J. Org. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5196","DOI":"10.1021\/acs.orglett.4c01780","article-title":"Iodine(III)-Mediated trifluoroacetylation of a C(sp2)\u2013H or C(sp)\u2013H bond with masked trifluoroacyl reagents","volume":"26","author":"Ye","year":"2024","journal-title":"Org. Lett."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1126\/science.abg0781","article-title":"Sequential C-F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts","volume":"371","author":"Yu","year":"2021","journal-title":"Science"},{"key":"B69","doi-asserted-by":"publisher","first-page":"111776","DOI":"10.1016\/j.cclet.2025.111776","article-title":"Decatungstate-photocatalyzed heterogeneous direct benzylation of N-heterocycles with benzaldehydes","volume":"37","author":"Zeng","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"B70","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1248\/bpb.b20-00021","article-title":"Dehydrocholic acid ameliorates sodium taurocholate-induced acute biliary pancreatitis in mice","volume":"43","author":"Zhang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"B71","doi-asserted-by":"publisher","first-page":"22487","DOI":"10.1002\/anie.202109235","article-title":"Radical trifluoroacetylation of alkenes triggered by a visible-light-promoted C-O bond fragmentation of trifluoroacetic anhydride","volume":"60","author":"Zhang","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"B72","doi-asserted-by":"publisher","first-page":"116457","DOI":"10.1016\/j.bmc.2021.116457","article-title":"Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design","volume":"50","author":"Zhang","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e202116190","DOI":"10.1002\/anie.202116190","article-title":"A carbene strategy for progressive (deutero)Hydrodefluorination of fluoroalkyl ketones","volume":"61","author":"Zhang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e202318344","DOI":"10.1002\/anie.202318344","article-title":"Decarboxylative radical sulfilimination via photoredox, copper, and br\u00f8nsted base catalysis","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.6023\/cjoc202505025","article-title":"Iron-photocatalytic decarboxylative functionalization based on ligand-to-metal charge transfer","volume":"45","author":"Zhang","year":"2025","journal-title":"Chin. J. Org. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"5819","DOI":"10.1039\/d6ob00896h","article-title":"When dowd\u2013beckwith reaction meets photocatalysis","volume":"24","author":"Zhang","year":"2026","journal-title":"Org. Biomol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"111834","DOI":"10.1016\/j.cclet.2025.111834","article-title":"Visible-light-promoted multi-component carbene transfer reactions of diazo compounds via ring-opening of cyclic ethers","volume":"37","author":"Zhao","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.6023\/cjoc202510017","article-title":"Recent advances in functionalization of 6-Azauracils via radical reactions","volume":"46","author":"Zheng","year":"2026","journal-title":"Chin. J. Org. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1021\/acs.chemrev.5b00392","article-title":"Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II-III clinical trials of major pharmaceutical companies: new structural trends and therapeutic areas","volume":"116","author":"Zhou","year":"2016","journal-title":"Chem. Rev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1021\/jacs.3c12150","article-title":"Divergent synthesis of fluoroalkyl ketones through controlling the reactivity of organoboronate complexes","volume":"146","author":"Zhou","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.4314\/tjpr.v21i9.29","article-title":"Effects of the combination of loxoprofen sodium and sodium hyaluronate on osteoarthritis and knee function","volume":"21","author":"Zou","year":"2022","journal-title":"Trop. J. Pharm. Res."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2026.1957846\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:39:22Z","timestamp":1789709962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2026.1957846\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":81,"alternative-id":["10.3389\/fchem.2026.1957846"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2026.1957846","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"article-number":"1957846"}}