{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:03:39Z","timestamp":1789596219906,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["621-2110-5238"],"award-info":[{"award-number":["621-2110-5238"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2015.00093","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T15:29:45Z","timestamp":1450798185000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The Gut Microbiota Reduces Colonization of the Mesenteric Lymph Nodes and IL-12-Independent IFN-\u03b3 Production During Salmonella Infection"],"prefix":"10.3389","volume":"5","author":[{"given":"Mar\u00eda","family":"Fern\u00e1ndez-Santoscoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf A.","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Yrlid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Cardell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"B\u00e4ckhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.immuni.2012.04.011","article-title":"Commensal bacteria calibrate the activation threshold of innate antiviral immunity","volume":"37","author":"Abt","year":"2012","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/nature07240","article-title":"ATP drives lamina propria Th17 cell differentiation","volume":"455","author":"Atarashi","year":"2008","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.immuni.2014.01.003","article-title":"The Cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria","volume":"40","author":"Behnsen","year":"2014","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.chom.2009.06.005","article-title":"Gut commensal bacteria direct a protective immune response against Toxoplasma gondii","volume":"6","author":"Benson","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrmicro2546","article-title":"Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis","volume":"9","author":"Bevins","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","volume":"13","author":"Buffie","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.pharmthera.2011.01.012","article-title":"The gut microbiome as therapeutic target","volume":"130","author":"Cani","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"B8","first-page":"77","article-title":"Commensal bacteria shape intestinal immune system development","volume":"71","author":"Cash","year":"2005","journal-title":"ASM News"},{"key":"B9","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1128\/IAI.72.1.468-477.2004","article-title":"Role of neutrophils in murine salmonellosis","volume":"72","author":"Cheminay","year":"2004","journal-title":"Infect. Immun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut immune maturation depends on colonization with a host-specific microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nm.2087","article-title":"Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity","volume":"16","author":"Clarke","year":"2010","journal-title":"Nat. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/sj.icb.7100007","article-title":"Salmonella, the host and disease: a brief review","volume":"85","author":"Coburn","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/IAI.65.2.630-635.1997","article-title":"Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitica","volume":"65","author":"Conlan","year":"1997","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1189\/jlb.0503249","article-title":"Expression and regulation of antimicrobial peptides in the gastrointestinal tract","volume":"75","author":"Cunliffe","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"B15","first-page":"116","article-title":"Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells","volume-title":"Nature","author":"Diehl","year":"2013"},{"key":"B16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/MOG.0b013e3282f2b0e8","article-title":"Gastrointestinal microbiology enters the metagenomics era","volume":"24","author":"Frank","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.immuni.2012.05.020","article-title":"Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota","volume":"37","author":"Ganal","year":"2012","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e35988","DOI":"10.1371\/journal.pone.0035988","article-title":"Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice","volume":"7","author":"Haag","year":"2012","journal-title":"PLoS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2008.08.009","article-title":"Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses","volume":"29","author":"Hall","year":"2008","journal-title":"Immunity"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1126\/science.1187703","article-title":"Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris","volume":"328","author":"Hayes","year":"2010","journal-title":"Science"},{"key":"B21","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.4049\/jimmunol.156.9.3321","article-title":"Salmonella typhimurium aroA\u2212 infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-\u03b1\u03b2 cells and IFN-\u03b3 in bacterial clearance independent of intracellular location","volume":"156","author":"Hess","year":"1996","journal-title":"J. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.coi.2011.03.001","article-title":"Regulation of innate and adaptive immunity by the commensal microbiota","volume":"23","author":"Jarchum","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/ni.2608","article-title":"Control of pathogens and pathobionts by the gut microbiota","volume":"14","author":"Kamada","year":"2013","journal-title":"Nat. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1126\/science.1210718","article-title":"Successful transmission of a retrovirus depends on the commensal microbiota","volume":"334","author":"Kane","year":"2011","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.2337\/db13-0844","article-title":"Assessing the human gut microbiota in metabolic diseases","volume":"62","author":"Karlsson","year":"2013","journal-title":"Diabetes"},{"key":"B27","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.immuni.2011.12.011","article-title":"Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense","volume":"36","author":"Kinnebrew","year":"2012","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-309059","article-title":"Antibiotics promote inflammation through the translocation of native commensal colonic bacteria","author":"Knoop","year":"2015a","journal-title":"Gut"},{"key":"B29","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/mi.2014.58","article-title":"Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon","volume":"8","author":"Knoop","year":"2015b","journal-title":"Mucosal Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1126\/science.1211057","article-title":"Intestinal microbiota promote enteric virus replication and systemic pathogenesis","volume":"334","author":"Kuss","year":"2011","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.chom.2011.10.004","article-title":"Role of the commensal microbiota in normal and pathogenic host immune responses","volume":"10","author":"Littman","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B32","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.chom.2012.01.017","article-title":"Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut","volume":"11","author":"Liu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.chom.2007.06.010","article-title":"Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae","volume":"2","author":"Lupp","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","article-title":"An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system","volume":"122","author":"Mazmanian","year":"2005","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-3-540-93864-4_8","article-title":"Tracking the dynamics of Salmonella specific T Cell responses","volume":"334","author":"Moon","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B37","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1128\/IAI.61.10.4248-4253.1993","article-title":"Role of gamma interferon in late stages of murine salmonellosis","volume":"61","author":"Muotiala","year":"1993","journal-title":"Infect. Immun."},{"key":"B38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/IAI.60.2.450-454.1992","article-title":"Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection","volume":"60","author":"Nauciel","year":"1992","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature12503","article-title":"Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens","volume":"502","author":"Ng","year":"2013","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.2508","article-title":"Parasite-induced Th1 cells and intestinal dysbiosis cooperate in IFN-\u03b3-dependent elimination of paneth cells","volume":"14","author":"Raetz","year":"2013","journal-title":"Nat. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"522","DOI":"10.4161\/gmic.32155","article-title":"Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites","volume":"5","author":"Reynolds","year":"2014","journal-title":"Gut Microbes"},{"key":"B42","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.4049\/jimmunol.178.9.5789","article-title":"Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection","volume":"178","author":"Rydstr\u00f6m","year":"2007","journal-title":"J. Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1002\/eji.200939483","article-title":"Monocyte and neutrophil recruitment during oral Salmonella infection is driven by MyD88-derived chemokines","volume":"39","author":"Rydstr\u00f6m","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.immuni.2011.02.016","article-title":"Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands","volume":"34","author":"Shi","year":"2011","journal-title":"Immunity"},{"key":"B46","doi-asserted-by":"publisher","first-page":"626827","DOI":"10.1155\/2008\/626827","article-title":"Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk","volume":"2008","author":"Srikanth","year":"2008","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1371\/journal.pbio.0050244","article-title":"Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota","volume":"5","author":"Stecher","year":"2007","journal-title":"PLoS Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1189\/jlb.0708413","article-title":"Salmonella induces death of CD8\u03b1+ dendritic cells but not CD11cintCD11b+ inflammatory cells in vivo via MyD88 and TNFR1","volume":"85","author":"Sundquist","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"B49","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1128\/IAI.67.4.1992-2000.1999","article-title":"Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system","volume":"67","author":"Talham","year":"1999","journal-title":"Infect. Immun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional interactions between the gut microbiota and host metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.chom.2013.09.012","article-title":"Microbial modulation of energy availability in the colon regulates intestinal transit","volume":"14","author":"Wichmann","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B52","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature09415","article-title":"Gut inflammation provides a respiratory electron acceptor for Salmonella","volume":"467","author":"Winter","year":"2010","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.4049\/jimmunol.169.8.4475","article-title":"Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice","volume":"169","author":"Yang","year":"2002","journal-title":"J. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"108","DOI":"10.4049\/jimmunol.169.1.108","article-title":"Antigen presentation capacity and cytokine production by murine splenic dendritic cell subsets upon Salmonella encounter","volume":"169","author":"Yrlid","year":"2002","journal-title":"J. Immunol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T07:47:29Z","timestamp":1692172049000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fcimb.2015.00093\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3389\/fcimb.2015.00093","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}