{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:24:12Z","timestamp":1790727852942,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2016.00177","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T03:43:56Z","timestamp":1480995836000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["ExsE Is a Negative Regulator for T3SS Gene Expression in Vibrio alginolyticus"],"prefix":"10.3389","volume":"6","author":[{"given":"Jinxin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yeh","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa H.","family":"Orfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Qun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Call","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannetsy J.","family":"Avillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.vetmic.2009.03.015","article-title":"Vibrios as causal agents of zoonoses","volume":"140","author":"Austin","year":"2010","journal-title":"Vet. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.annder.2007.04.010","article-title":"Cutaneous ulceration after an octopus bite: infection due to Vibrio alginolyticus, an emerging pathogen","volume":"135","author":"Campanelli","year":"2008","journal-title":"Ann. Dermatol. Venereol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1080\/08927010902964578","article-title":"Phenotypic and genetic differences between opaque and translucent colonies of Vibrio alginolyticus","volume":"25","author":"Chen","year":"2009","journal-title":"Biofouling"},{"key":"B4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s10096-002-0726-0","article-title":"Vibrio alginolyticus as the cause of pleural empyema and bacteremia in an immunocompromised patient","volume":"21","author":"Chien","year":"2002","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nrmicro1526","article-title":"The type III secretion injectisome","volume":"4","author":"Cornelis","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1365-2958.2004.04128.x","article-title":"A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system","volume":"53","author":"Dasgupta","year":"2004","journal-title":"Mol. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1099\/mic.0.059931-0","article-title":"Vibrio parahaemolyticus ExsE is requisite for initial adhesion and subsequent type III secretion system 1-dependent autophagy in HeLa cells","volume":"158","author":"Erwin","year":"2012","journal-title":"Microbiology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1046\/j.1365-2958.1997.4891851.x","article-title":"ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury","volume":"25","author":"Finck-Barbancon","year":"1997","journal-title":"Mol. Microbiol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/JB.164.2.918-921.1985","article-title":"Positive selection procedure for entrapment of insertion sequence elements in gram-negative bacteria","volume":"164","author":"Gay","year":"1985","journal-title":"J. Bacteriol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrmicro2199","article-title":"The type III secretion system of Pseudomonas aeruginosa: infection by injection","volume":"7","author":"Hauser","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"B11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants","volume":"62","author":"Hueck","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1574-6968.2010.02066.x","article-title":"Transcription of Vibrio parahaemolyticus T3SS1 genes is regulated by a dual regulation system consisting of the ExsACDE regulatory cascade and H-NS","volume":"311","author":"Kodama","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e2783","DOI":"10.3791\/2783","article-title":"In vitro assay of bacterial adhesion onto mammalian epithelial cells","author":"Letourneau","year":"2011","journal-title":"J. Vis. Exp."},{"key":"B14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B15","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(03)12659-1","article-title":"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae","volume":"361","author":"Makino","year":"2003","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1046\/j.1365-2958.2002.03228.x","article-title":"ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon","volume":"46","author":"Mccaw","year":"2002","journal-title":"Mol. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7235","DOI":"10.1128\/jb.174.22.7235-7244.1992","article-title":"Cloning of a metalloprotease gene involved in the virulence mechanism of Vibrio anguillarum","volume":"174","author":"Milton","year":"1992","journal-title":"J. Bacteriol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1128\/jb.178.5.1310-1319.1996","article-title":"Flagellin A is essential for the virulence of Vibrio anguillarum","volume":"178","author":"Milton","year":"1996","journal-title":"J. Bacteriol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0378-1119(91)90007-X","article-title":"A series of wide-host-range low-copy-number vectors that allow direct screening for recombinants","volume":"97","author":"Morales","year":"1991","journal-title":"Gene"},{"key":"B20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.mimet.2005.01.013","article-title":"Enhanced swarming of bacteria on agar plates containing the surfactant Tween 80","volume":"62","author":"Niu","year":"2005","journal-title":"J. Microbiol. Methods"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2014.00001","article-title":"Transcriptome analysis of Vibrio parahaemolyticus in type III secretion system 1 inducing conditions","volume":"4","author":"Nydam","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"8006","DOI":"10.1073\/pnas.0503005102","article-title":"ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa","volume":"102","author":"Rietsch","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1152\/physiol.00011.2005","article-title":"Type III secretion: more systems than you think","volume":"20","author":"Troisfontaines","year":"2005","journal-title":"Physiology (Bethesda)."},{"key":"B24","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/1471-2180-9-S1-S2","article-title":"Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology","volume":"9","author":"Tseng","year":"2009","journal-title":"BMC Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1128\/IAI.00664-07","article-title":"Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system","volume":"75","author":"Urbanowski","year":"2007","journal-title":"Infect. Immun."},{"key":"B26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/IAI.67.2.914-920.1999","article-title":"Regulation of ExoS production and secretion by Pseudomonas aeruginosa in response to tissue culture conditions","volume":"67","author":"Vallis","year":"1999","journal-title":"Infect. Immun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1365-2958.2006.05412.x","article-title":"Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system","volume":"62","author":"Yahr","year":"2006","journal-title":"Mol. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1099\/mic.0.040626-0","article-title":"The type III secretion system of Vibrio alginolyticus induces rapid apoptosis, cell rounding and osmotic lysis of fish cells","volume":"156","author":"Zhao","year":"2010","journal-title":"Microbiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00203-010-0646-9","article-title":"Autophagy is induced by the type III secretion system of Vibrio alginolyticus in several mammalian cell lines","volume":"193","author":"Zhao","year":"2011","journal-title":"Arch. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"260","DOI":"10.4161\/viru.1.4.12318","article-title":"Regulation of type III secretion system 1 gene expression in Vibrio parahaemolyticus is dependent on interactions between ExsA, ExsC, and ExsD","volume":"1","author":"Zhou","year":"2010","journal-title":"Virulence"},{"key":"B31","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1365-2958.2008.06326.x","article-title":"Type III secretion system 1 genes in Vibrio parahaemolyticus are positively regulated by ExsA and negatively regulated by ExsD","volume":"69","author":"Zhou","year":"2008","journal-title":"Mol. Microbiol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2016.00177\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T19:21:42Z","timestamp":1601234502000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2016.00177\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,6]]},"references-count":31,"URL":"https:\/\/doi.org\/10.3389\/fcimb.2016.00177","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,6]]}}}