{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:35:29Z","timestamp":1785893729675,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171573"],"award-info":[{"award-number":["81171573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370192"],"award-info":[{"award-number":["31370192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2013FA024"],"award-info":[{"award-number":["2013FA024"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["2014FB191"],"award-info":[{"award-number":["2014FB191"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2016.00192","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T03:54:55Z","timestamp":1482292495000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["The Preferential Infection of Astrocytes by Enterovirus 71 Plays a Key Role in the Viral Neurogenic Pathogenesis"],"prefix":"10.3389","volume":"6","author":[{"given":"Min","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longding","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jns.2011.03.009","article-title":"Enterovirus 71 meningoencephalitis complicating rituximab therapy","volume":"305","author":"Ahmed","year":"2011","journal-title":"J. Neurol. Sci."},{"issue":"Pt 2","key":"B2","first-page":"257","article-title":"An ultrastructural study of the phagocytic activity of astrocytes in adult rat brain","volume":"188","author":"Al-Ali","year":"1996","journal-title":"J. Anat."},{"key":"B3","first-page":"619","article-title":"Astrocyte-neuron signaling in the brain\u2013implications for disease","volume":"7","author":"Araque","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1128\/JVI.01798-07","article-title":"Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD\/SCID mouse infection model","volume":"82","author":"Arita","year":"2008","journal-title":"J. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/10454411950060020301","article-title":"Complement biosynthesis in the central nervous system","volume":"6","author":"Barnum","year":"1995","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: a perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1471-4892(01)00122-9","article-title":"Chemokines in the brain: neuroimmunology and beyond","volume":"2","author":"Biber","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group","volume":"31","author":"Chan","year":"2000","journal-title":"Clin. Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0140-6736(98)24031-1","article-title":"Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease","volume":"352","author":"Chang","year":"1998","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1099\/vir.0.19423-0","article-title":"A murine oral enterovirus 71 infection model with central nervous system involvement","volume":"85","author":"Chen","year":"2004","journal-title":"J. Gen. Virol."},{"key":"B11","volume-title":"The Guideance to Experimental Animal Welfare and Ethical Treatment.","author":"China","year":"2006"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0361-9230(01)00527-5","article-title":"Glial cell abnormalities in major psychiatric disorders: the evidence and implications","volume":"55","author":"Cotter","year":"2001","journal-title":"Brain Res. Bull."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1128\/JVI.74.14.6570-6580.2000","article-title":"Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis","volume":"74","author":"Egger","year":"2000","journal-title":"J. Virol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"14753","DOI":"10.1073\/pnas.1217563110","article-title":"Transgenic mouse model for the study of enterovirus 71 neuropathogenesis","volume":"110","author":"Fujii","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B16","first-page":"226","article-title":"Characteristics of a human diploid cell line, KMB-17","volume":"3","author":"Guo","year":"1981","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"B17","doi-asserted-by":"publisher","first-page":"R712","DOI":"10.1016\/S0960-9822(00)00708-9","article-title":"Neuroglial networks: neurons and glia talk to each other","volume":"10","author":"Haydon","year":"2000","journal-title":"Curr. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1056\/NEJM199909233411302","article-title":"Neurologic complications in children with enterovirus 71 infection","volume":"341","author":"Huang","year":"1999","journal-title":"N Engl. J. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1365-2559.2004.01930.x","article-title":"Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker","volume":"45","author":"Jiang","year":"2004","journal-title":"Histopathology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1034\/j.1600-0404.2000.101002116.x","article-title":"Cerebrospinal fluid C3 and C4 indexes in immunological disorders of the central nervous system","volume":"101","author":"Jongen","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1128\/JVI.06103-11","article-title":"A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection","volume":"86","author":"Khong","year":"2012","journal-title":"J. Virol."},{"key":"B22","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1182\/blood.V88.8.3010.bloodjournal8883010","article-title":"P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells","volume":"88","author":"Laszik","year":"1996","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1086\/345905","article-title":"Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system","volume":"36","author":"Lin","year":"2003","journal-title":"Clin. Infect Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.virol.2010.12.058","article-title":"Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection","volume":"412","author":"Liu","year":"2011","journal-title":"Virology"},{"key":"B25","first-page":"1690","article-title":"Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans","volume":"77","author":"Mastorakos","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B26","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1096\/fasebj.7.13.8405808","article-title":"Astrocytes in infectious and immune-mediated diseases of the central nervous system","volume":"7","author":"Mucke","year":"1993","journal-title":"FASEB J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1128\/JCM.01394-06","article-title":"Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand-foot-and-mouth disease","volume":"45","author":"Ooi","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0960-5428(96)00018-6","article-title":"Immunoregulatory role of neurotransmitters","volume":"6","author":"Qiu","year":"1996","journal-title":"Adv. Neuroimmunol."},{"key":"B29","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/j.1600-6143.2005.00873.x","article-title":"Local complement C3 expression is upregulated in humoral and cellular rejection of renal allografts","volume":"5","author":"Serins\u00f6z","year":"2005","journal-title":"Am. J. Transplant"},{"key":"B31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fnins.2014.00315","article-title":"Inflammasomes in neuroinflammation and changes in brain function: a focused review","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1038\/emi.2013.44","article-title":"EV71-infected CD14(+) cells modulate the immune activity of T lymphocytes in rhesus monkeys","volume":"2","author":"Wang","year":"2013","journal-title":"Emerg. Microbes Infect."},{"key":"B33","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s12250-010-3102-8","article-title":"A comparison of the biological characteristics of EV71 C4 subtypes from different epidemic strains","volume":"25","author":"Wang","year":"2010","journal-title":"Virol. Sin."},{"key":"B34","doi-asserted-by":"publisher","first-page":"876241","DOI":"10.1155\/2012\/876241","article-title":"Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis","volume":"2012","author":"Wang","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1086\/520149","article-title":"Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications","volume":"29","author":"Wang","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/nrmicro1284","article-title":"Host and virus determinants of picornavirus pathogenesis and tropism","volume":"3","author":"Whitton","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.2174\/138161208785740090","article-title":"CNS immune surveillance and neuroinflammation: endocannabinoids keep control","volume":"14","author":"Wolf","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1542\/peds.109.2.e26","article-title":"Cardiopulmonary manifestations of fulminant enterovirus 71 infection","volume":"109","author":"Wu","year":"2002","journal-title":"Pediatrics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.humpath.2009.01.015","article-title":"Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study","volume":"40","author":"Yang","year":"2009","journal-title":"Hum. Pathol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e51996","DOI":"10.1371\/journal.pone.0051996","article-title":"Enterovirus 71-Induced neurological disorders in young gerbils, meriones unguiculatus: development and application of a neurological disease model","volume":"7","author":"Yao","year":"2012","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.virusres.2014.05.006","article-title":"Histopathological features and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection","volume":"189","author":"Yu","year":"2014","journal-title":"Virus Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e79648","DOI":"10.1371\/journal.pone.0079648","article-title":"The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes","volume":"8","author":"Yue","year":"2013","journal-title":"PLoS ONE"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/labinvest.2011.82","article-title":"Pathogenesis study of enterovirus 71 infection in rhesus monkeys","volume":"91","author":"Zhang","year":"2011","journal-title":"Lab. Inves."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2016.00192\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T03:57:24Z","timestamp":1601265444000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2016.00192\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":43,"URL":"https:\/\/doi.org\/10.3389\/fcimb.2016.00192","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}