{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:47:36Z","timestamp":1777344456753,"version":"3.51.4"},"reference-count":49,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00073","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T23:54:26Z","timestamp":1489622066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus"],"prefix":"10.3389","volume":"7","author":[{"given":"Veronika","family":"Urbanov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Hajdu\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"H\u00f6nig Mondekov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"\u0160\u00edma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Kop\u00e1\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.femsim.2004.07.012","article-title":"Sensitivity of Borrelia genospecies to serum complement from different animals and human: a host-pathogen relationship","volume":"43","author":"Bhide","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jip.2006.05.006","article-title":"A comparison of Chryseobacterium indologenes pathogenicity to the soft tick Ornithodoros moubata and hard tick Ixodes ricinus","volume":"93","author":"Buresova","year":"2006","journal-title":"J. Invertebr. Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1159\/000328851","article-title":"Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system","volume":"3","author":"Buresova","year":"2011","journal-title":"J. Innate Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.dci.2008.09.011","article-title":"IrAM-An \u03b12-macroglobulin from the hard tick Ixodes ricinus: characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes","volume":"33","author":"Buresova","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"B5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.7043737","article-title":"Lyme disease-a tick-borne spirochetosis?","volume":"216","author":"Burgdorfer","year":"1982","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature13965","article-title":"Transferred interbacterial antagonism genes augment eukaryotic innate immune function","volume":"518","author":"Chou","year":"2015","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0092-8674(00)80298-6","article-title":"Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice","volume":"89","author":"Coleman","year":"1997","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1001205","DOI":"10.1371\/journal.ppat.1001205","article-title":"Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent","volume":"6","author":"Dai","year":"2010","journal-title":"PLoS Pathog."},{"key":"B9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.chom.2009.10.006","article-title":"Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent","volume":"6","author":"Dai","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6938","DOI":"10.2741\/3200","article-title":"Overview: ticks as vectors of pathogens that cause disease in humans and animals","volume":"13","author":"de la Fuente","year":"2008","journal-title":"Front. Biosci."},{"key":"B11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding","volume":"53","author":"De Silva","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pt.2012.12.001","article-title":"Complement evasion by Borrelia burgdorferi: it takes three to tango","volume":"29","author":"De Taeye","year":"2013","journal-title":"Trends Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1172\/JCI39401","article-title":"Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks","volume":"119","author":"Dunham-Ems","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fcimb.2013.00026","article-title":"Interaction of the tick immune system with transmitted pathogens","volume":"3","author":"Hajdusek","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1603\/0022-2585(2008)45[732:TDOBBS]2.0.CO;2","article-title":"Transmission dynamics of Borrelia burgdorferi s.s. during the key third day of feeding by nymphal Ixodes scapularis (Acari: Ixodidae)","volume":"45","author":"Hojgaard","year":"2008","journal-title":"J. Med. Entomol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1603\/0022-2585-38.1.99","article-title":"Contrasts in tick innate immune responses to Borrelia burgdorferi challenge: immunotolerance in Ixodes scapularis versus immunocompetence in Dermacentor variabilis (Acari: Ixodidae)","volume":"38","author":"Johns","year":"2001","journal-title":"J. Med. Entomol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1603\/0022-2585-37.2.265","article-title":"Response of the tick Dermacentor variabilis (Acari: Ixodidae) to hemocoelic inoculation of Borrelia burgdorferi (Spirochetales)","volume":"37","author":"Johns","year":"2000","journal-title":"J. Med. Entomol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2004","journal-title":"Parasitology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/978-1-4419-5638-5_9","article-title":"Tick as a model for the study of a primitive complement system","volume":"710","author":"Kopacek","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2217\/fmb.12.121","article-title":"Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector","volume":"8","author":"Kung","year":"2013","journal-title":"Future Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1645\/0022-3395(2000)086[1223:ACSOMA]2.0.CO;2","article-title":"A comparative study of mammalian and reptilian alternative pathway of complement-mediated killing of the Lyme disease spirochete (Borrelia burgdorferi)","volume":"86","author":"Kuo","year":"2000","journal-title":"J. Parasitol."},{"key":"B22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0966-842X(01)02298-3","article-title":"Host association of Borrelia burgdorferi sensu lato\u2013the key role of host complement","volume":"10","author":"Kurtenbach","year":"2002","journal-title":"Trends Microbiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/S0966-842X(01)02298-3","article-title":"Serum complement sensitivity as a key factor in Lyme disease ecology","volume":"66","author":"Kurtenbach","year":"1998","journal-title":"Infect Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/embor.2011.177","article-title":"Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands","volume":"12","author":"Liu","year":"2011","journal-title":"EMBO Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1633","DOI":"10.1371\/journal.pone.0001633","article-title":"Clocking the Lyme spirochete","volume":"3","author":"Malawista","year":"2008","journal-title":"PLoS ONE"},{"key":"B26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1673\/031.007.5801","article-title":"Phagocytosis of the Lyme disease spirochete, Borrelia burgdorferi, by cells from the ticks, Ixodes scapularis and Dermacentor andersoni, infected with an endosymbiont, Rickettsia peacockii","volume":"7","author":"Mattila","year":"2007","journal-title":"J. Insect Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.immuni.2005.05.006","article-title":"In vivo identification of novel regulators and conserved pathways of phagocytosis","volume":"23","author":"Moita","year":"2005","journal-title":"A. gambiae. Immunity"},{"key":"B28","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev.en.40.010195.001253","article-title":"Cellular and molecular interrelationships between ticks and prokaryotic tick-borne pathogens","volume":"40","author":"Munderloh","year":"1995","journal-title":"Annu. Rev. Entomol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.pt.2015.03.010","article-title":"Tick microbiome: the force within","volume":"31","author":"Narasimhan","year":"2015","journal-title":"Trends Parasitol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.chom.2007.06.001","article-title":"A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector","volume":"2","author":"Narasimhan","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e14743","DOI":"10.1371\/journal.pone.0014743","article-title":"Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections","volume":"6","author":"Nehme","year":"2011","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cell.2004.10.027","article-title":"TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi","volume":"119","author":"Pal","year":"2004","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e12318","DOI":"10.7554\/eLife.12318","article-title":"Acquisition of exogenous haem is essential for tick reproduction","volume":"5","author":"Perner","year":"2016","journal-title":"Elife"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"S191","DOI":"10.1017\/S0031182003004694","article-title":"Lyme borreliosis in Europe and North America","volume":"129","author":"Piesman","year":"2004","journal-title":"Parasitology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"Radolf","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host","volume":"436","author":"Ramamoorthi","year":"2005","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/jmedent\/24.2.201","article-title":"Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae)","volume":"24","author":"Ribeiro","year":"1987","journal-title":"J. Med. Entomol."},{"key":"B39","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0145-305X(96)00023-7","article-title":"Phagocytes from both vertebrate and invertebrate species use \u201ccoiling\u201d phagocytosis","volume":"20","author":"Rittig","year":"1996","journal-title":"Dev. Comp. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.chom.2011.06.010","article-title":"A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent","volume":"10","author":"Schuijt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B41","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1046\/j.1198-743x.2001.00282.x","article-title":"Routine diagnosis of Borrelia burgdorferi (sensu lato) infections using a real-time PCR assay","volume":"7","author":"Schwaiger","year":"2001","journal-title":"Clin. Microbiol. Infect"},{"key":"B42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.chom.2016.06.001","article-title":"Cross-species interferon signaling boosts microbicidal activity within the tick vector","volume":"20","author":"Smith","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B43","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/jmedent\/43.1.61","article-title":"Kinetics of Borrelia burgdorferi infection in larvae of refractory and competent tick vectors","volume":"43","author":"Soares","year":"2006","journal-title":"J. Med. Entomol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","article-title":"Lyme borreliosis","volume":"379","author":"Stanek","year":"2012","journal-title":"Lancet"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1371\/journal.pbio.0040004","article-title":"Identification of Drosophila gene products required for phagocytosis of Candida albicans","volume":"4","author":"Stroschein-Stevenson","year":"2006","journal-title":"PLoS Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1089\/vbz.2015.1847","article-title":"Sensitivity of lyme borreliosis spirochetes to serum complement of regular zoo animals: potential reservoir competence of some exotic vertebrates","volume":"16","author":"Ticha","year":"2016","journal-title":"Vector Borne Zoonotic Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.dci.2014.05.016","article-title":"IrFC - an Ixodes ricinus injury-responsive molecule related to Limulus Factor C","volume":"46","author":"Urbanova","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.dci.2014.09.004","article-title":"Thioester-containing proteins of the tick Ixodes ricinus: gene expression, response to microbial challenge and their role in phagocytosis of the yeast Candida albicans","volume":"48","author":"Urbanova","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1002079","DOI":"10.1371\/journal.ppat.1002079","article-title":"Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph","volume":"7","author":"Zhang","year":"2011","journal-title":"PLoS Pathog."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00073\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T16:17:09Z","timestamp":1568909829000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00073\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":49,"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00073","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,16]]}}}