{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:08:21Z","timestamp":1793117301090,"version":"4.5.0"},"reference-count":95,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00160","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T04:36:23Z","timestamp":1493613383000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":117,"title":["With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia"],"prefix":"10.3389","volume":"7","author":[{"suffix":"PhD","given":"Roger D.","family":"Pechous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00011-005-0062-9","article-title":"Mechanisms of cell death induced by the neutrophil antimicrobial peptides \u03b1-defensins and LL-37","volume":"55","author":"Aarbiou","year":"2006","journal-title":"Inflamm. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S1567-5769(01)00189-8","article-title":"Lactoferrin immunomodulation of DTH response in mice","volume":"2","author":"Actor","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.lfs.2004.01.028","article-title":"High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome","volume":"75","author":"Ashitani","year":"2004","journal-title":"Life Sci."},{"key":"B4","doi-asserted-by":"crossref","first-page":"L336","DOI":"10.1152\/ajplung.2001.281.2.L336","article-title":"Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats","volume":"281","author":"Auten","year":"2001","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1165\/ajrcmb.26.4.4708","article-title":"Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung","volume":"26","author":"Auten","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1083\/jcb.39.2.286","article-title":"Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. I. Histochemical staining of bone marrow smears","volume":"39","author":"Bainton","year":"","journal-title":"J. Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1083\/jcb.39.2.299","article-title":"Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. II. Cytochemistry and electron microscopy of bone marrow cells","volume":"39","author":"Bainton","year":"","journal-title":"J. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1189\/jlb.1005560","article-title":"The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system","volume":"80","author":"Barlow","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1164\/rccm.200907-1128OC","article-title":"Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier","volume":"181","author":"Bdeir","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cub.2006.01.056","article-title":"An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps","volume":"16","author":"Beiter","year":"2006","journal-title":"Curr. Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1126\/science.289.5482.1185","article-title":"Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase","volume":"289","author":"Belaaouaj","year":"2000","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/nm0598-615","article-title":"Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis","volume":"4","author":"Belaaouaj","year":"1998","journal-title":"Nat. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5115","DOI":"10.4049\/jimmunol.1300522","article-title":"Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation","volume":"191","author":"Bhowmick","year":"2013","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1016\/j.ijid.2012.06.006","article-title":"Understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective versus deleterious inflammatory response in pneumonia","volume":"17","author":"Bordon","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.it.2007.06.002","article-title":"Neutrophil granules: a library of innate immunity proteins","volume":"28","author":"Borregaard","year":"2007","journal-title":"Trends Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1005126","DOI":"10.1371\/journal.ppat.1005126","article-title":"Extracellular adenosine protects against Streptococcus pneumoniae lung infection by regulating pulmonary neutrophil recruitment","volume":"11","author":"Bou Ghanem","year":"2015","journal-title":"PLoS Pathog."},{"key":"B17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12931-016-0449-x","article-title":"Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium","volume":"17","author":"Boxio","year":"2016","journal-title":"Respir. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cell.2013.06.013","article-title":"A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection","volume":"154","author":"Brandes","year":"2013","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrmicro1710","article-title":"Beneficial suicide: why neutrophils die to make NETs","volume":"5","author":"Brinkmann","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/BF02256548","article-title":"Neutrophil elastase induces IL-8 synthesis by lung epithelial cells via the mitogen-activated protein kinase pathway","volume":"11","author":"Chen","year":"2004","journal-title":"J. Biomed. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature11042","article-title":"Infection regulates pro-resolving mediators that lower antibiotic requirements","volume":"484","author":"Chiang","year":"2012","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"35466","DOI":"10.1038\/srep35466","article-title":"S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin","volume":"6","author":"Cohen","year":"2016","journal-title":"Sci Rep"},{"key":"B24","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1164\/rccm.200406-808OC","article-title":"Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study","volume":"171","author":"Confalonieri","year":"2005","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1128\/IAI.00832-08","article-title":"Neutrophil recruitment to the lungs during bacterial pneumonia","volume":"77","author":"Craig","year":"2009","journal-title":"Infect. Immun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1182\/asheducation-2000.1.303","article-title":"Inherited neutrophil disorders: molecular basis and new therapies","volume":"2000","author":"Dinauer","year":"2000","journal-title":"Hematol. Am. Soc. Hematol. Educ. Progr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1189\/jlb.0609382","article-title":"Human defensins and LL-37 in mucosal immunity","volume":"87","author":"Doss","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1385\/IR:31:2:075","article-title":"Pulmonary defense and the human cathelicidin hCAP-18\/LL-37","volume":"31","author":"Fahy","year":"2005","journal-title":"Immunol. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/ni.2109","article-title":"Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils","volume":"12","author":"Galli","year":"2011","journal-title":"Nat. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/BF01487042","article-title":"The importance of neutrophils in resistance to pneumococcal pneumonia in adult and neonatal mice","volume":"20","author":"Garvy","year":"1996","journal-title":"Inflammation"},{"key":"B31","doi-asserted-by":"crossref","first-page":"G705","DOI":"10.1152\/ajpgi.2001.281.3.G705","article-title":"Neutrophil-mediated epithelial injury during transmigration: role of elastase","volume":"281","author":"Ginzberg","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B32","volume-title":"Neutrophils in Acute Bacterial Pneumonia","author":"Gomez","year":"2012"},{"key":"B33","first-page":"215","article-title":"Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function","volume":"5","author":"Good","year":"1968","journal-title":"Semin. Hematol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.1128\/IAI.05593-11","article-title":"Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice","volume":"79","author":"Hahn","year":"2011","journal-title":"Infect. Immun."},{"key":"B36","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","article-title":"Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1164\/rccm.201203-0508OC","article-title":"CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin","volume":"187","author":"Ichikawa","year":"2013","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.1128\/IAI.72.12.7247-7256.2004","article-title":"Transcriptional profiling of lipopolysaccharide-induced acute lung injury","volume":"72","author":"Jeyaseelan","year":"2004","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1165\/rcmb.2005-0063OC","article-title":"Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium","volume":"32","author":"Jeyaseelan","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.177.1.538","article-title":"Toll\/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa","volume":"177","author":"Jeyaseelan","year":"2006","journal-title":"J. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1172\/JCI110149","article-title":"In vivo damage of rat lungs by oxygen metabolites","volume":"67","author":"Johnson","year":"1981","journal-title":"J. Clin. Invest."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.2741\/2964","article-title":"The role of the multifunctional peptide LL-37 in host defense","volume":"13","author":"Kai-Larsen","year":"2008","journal-title":"Front. Biosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1164\/ajrccm.161.6.9904047","article-title":"Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters","volume":"161","author":"Kawabata","year":"2000","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe","volume":"77","author":"Klebanoff","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1124\/pr.110.002733","article-title":"Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases","volume":"62","author":"Korkmaz","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"18073","DOI":"10.1073\/pnas.1008737107","article-title":"In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation","volume":"107","author":"Kreisel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00075198-200102000-00001","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"key":"B49","first-page":"252","article-title":"Lactoferrin: a general review","volume":"80","author":"Levay","year":"1995","journal-title":"Haematologica"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD-0018-2015","article-title":"The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole","author":"Levine","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"B51","doi-asserted-by":"publisher","first-page":"16171","DOI":"10.1021\/bi00049a032","article-title":"Nonisotropic enzyme\u2013inhibitor interactions: a novel nonoxidative mechanism for quantum proteolysis by human neutrophils","volume":"34","author":"Liou","year":"1995","journal-title":"Biochemistry"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1172\/JCI0217302","article-title":"Neutrophils and lung injury: getting it right","volume":"110","author":"Martin","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B53","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.immuni.2010.07.009","article-title":"CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection","volume":"33","author":"Mei","year":"2010","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/cc11442","article-title":"Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice","volume":"16","author":"Meng","year":"2012","journal-title":"Crit Care"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.4049\/jimmunol.0804187","article-title":"Dying and necrotic neutrophils are anti-inflammatory secondary to the release of \u03b1-defensins","volume":"183","author":"Miles","year":"2009","journal-title":"J. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1371\/journal.pmed.0030076","article-title":"Lung infection\u2013a public health priority","volume":"3","author":"Mizgerd","year":"2006","journal-title":"PLoS Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1056\/NEJMra074111","article-title":"Acute lower respiratory tract infection","volume":"358","author":"Mizgerd","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1164\/rccm.201206-1063PP","article-title":"Respiratory infection and the impact of pulmonary immunity on lung health and disease","volume":"186","author":"Mizgerd","year":"2012","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"19327","DOI":"10.18632\/oncotarget.8451","article-title":"Capsules of virulent pneumococcal serotypes enhance formation of neutrophil extracellular traps during in vivo pathogenesis of pneumonia","volume":"7","author":"Moorthy","year":"2016","journal-title":"Oncotarget"},{"key":"B60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.moh.0000190113.31027.d5","article-title":"Neutrophil granule contents in the pathogenesis of lung injury","volume":"13","author":"Moraes","year":"2006","journal-title":"Curr. Opin. Hematol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.it.2009.07.007","article-title":"Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?","volume":"30","author":"M\u00fcller","year":"2009","journal-title":"Trends Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am. J. Pathol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Publ. Group"},{"key":"B64","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1136\/gut.43.2.232","article-title":"A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits","volume":"43","author":"Osman","year":"1998","journal-title":"Gut"},{"key":"B66","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J. Cell Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e02302","DOI":"10.1128\/mBio.02302-14","article-title":"In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation","volume":"6","author":"Pechous","year":"2015","journal-title":"MBio"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e1003679","DOI":"10.1371\/journal.ppat.1003679","article-title":"Early host cell targets of Yersinia pestis during primary pneumonic plague","volume":"9","author":"Pechous","year":"2013","journal-title":"PLoS Pathog."},{"key":"B69","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"Pham","year":"2006","journal-title":"Nat. Publ. Group"},{"key":"B70","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3389\/fimmu.2016.00311","article-title":"Neutrophil extracellular traps in pulmonary diseases: too much of a good thing?","volume":"7","author":"Porto","year":"2016","journal-title":"Front. Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1146\/annurev-physiol-021014-071937","article-title":"Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling","volume":"77","author":"Quinton","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/416291a","article-title":"Killing activity of neutrophils is mediated through activation of proteases by K+ flux","volume":"416","author":"Reeves","year":"2002","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s11908-016-0516-y","article-title":"Relevant cytokines in the management of community-acquired pneumonia","volume":"18","author":"Rendon","year":"2016","journal-title":"Curr. Infect. Dis. Rep."},{"key":"B74","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.idc.2009.04.003","article-title":"Severe community-acquired pneumonia","volume":"23","author":"Restrepo","year":"2009","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e32366","DOI":"10.1371\/journal.pone.0032366","article-title":"Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones","volume":"7","author":"Saffarzadeh","year":"2012","journal-title":"PLoS ONE"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e1004327","DOI":"10.1371\/journal.ppat.1004327","article-title":"Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species","volume":"10","author":"Sahoo","year":"2014","journal-title":"PLoS Pathog."},{"key":"B77","doi-asserted-by":"publisher","first-page":"L508","DOI":"10.1152\/ajplung.00076.2004","article-title":"Differential effects of alpha- and beta-defensin on cytokine production by cultured human bronchial epithelial cells","volume":"288","author":"Sakamoto","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/01.ASN.0000040751.83734.D1","article-title":"Membrane expression of proteinase 3 is genetically determined","volume":"14","author":"Schreiber","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"a016311","DOI":"10.1101\/cshperspect.a016311","article-title":"Lipid mediators in the resolution of inflammation","volume":"7","author":"Serhan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1084\/jem.20020760","article-title":"Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals","volume":"196","author":"Serhan","year":"2002","journal-title":"J. Exp. Med."},{"key":"B81","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.4049\/jimmunol.152.8.4087","article-title":"Pulmonary epithelial cells facilitate TNF-alpha-induced neutrophil chemotaxis. A role for cytokine networking","volume":"152","author":"Smart","year":"","journal-title":"J. Immunol."},{"key":"B82","first-page":"L238","article-title":"TNF-alpha-induced transendothelial neutrophil migration is IL-8 dependent","volume":"266","author":"Smart","year":"","journal-title":"Am. J. Physiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1183\/09031936.00173207","article-title":"Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein","volume":"32","author":"Soehnlein","year":"2008","journal-title":"Eur. Respir. J."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.4049\/jimmunol.0900688","article-title":"Human neutrophils kill Streptococcus pneumoniae via serine proteases","volume":"183","author":"Standish","year":"2009","journal-title":"J. Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"e01530","DOI":"10.1128\/mBio.01530-15","article-title":"Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague","volume":"6","author":"Stasulli","year":"2015","journal-title":"MBio."},{"key":"B86","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1165\/rcmb.2008-0157OC","article-title":"Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-\u03baB-, and p53-dependent pathway","volume":"41","author":"Suzuki","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.4049\/jimmunol.166.5.3355","article-title":"Early recruitment of neutrophils determines subsequent T1\/T2 host responses in a murine model of Legionella pneumophila pneumonia","volume":"166","author":"Tateda","year":"2001","journal-title":"J. Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1074-7613(00)80173-9","article-title":"Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G","volume":"12","author":"Tkalcevic","year":"2000","journal-title":"Immunity"},{"key":"B89","doi-asserted-by":"publisher","first-page":"L999","DOI":"10.1152\/ajplung.00211.2005","article-title":"Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins","volume":"289","author":"Usatyuk","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1172\/JCI0213572","article-title":"Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis","volume":"109","author":"Vandivier","year":"2002","journal-title":"J. Clin. Invest."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1164\/ajrccm.150.5.7952574","article-title":"Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs","volume":"150","author":"Wang","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1462-5822.2006.00857.x","article-title":"Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps","volume":"9","author":"Wartha","year":"2007","journal-title":"Cell Microbiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/417091a","article-title":"Neutrophil elastase targets virulence factors of enterobacteria","volume":"417","author":"Weinrauch","year":"2002","journal-title":"Nature"},{"key":"B94","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1165\/rcmb.4890","article-title":"Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase","volume":"30","author":"Witherden","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.pupt.2011.08.001","article-title":"In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia","volume":"24","author":"Yamada","year":"2011","journal-title":"Pulm. Pharmacol. Ther."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00160\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:37:02Z","timestamp":1692787022000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00160\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":95,"alternative-id":["10.3389\/fcimb.2017.00160"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00160","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,1]]},"article-number":"160"}}