{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:02:07Z","timestamp":1792677727754,"version":"4.5.0"},"reference-count":27,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R21AI111058-01A1"],"award-info":[{"award-number":["1R21AI111058-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00260","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T03:53:40Z","timestamp":1497930820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Genetic Characterization of Coenzyme A Biosynthesis Reveals Essential Distinctive Functions during Malaria Parasite Development in Blood and Mosquito"],"prefix":"10.3389","volume":"7","author":[{"given":"Robert J.","family":"Hart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanah","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S. I.","family":"Aly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1111\/j.1462-5822.2010.01441.x","article-title":"Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice","volume":"12","author":"Aly","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1146\/annurev.micro.091208.073403","article-title":"Malaria parasite development in the mosquito and infection of the mammalian host","volume":"63","author":"Aly","year":"2009","journal-title":"Annu. Rev. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1073\/pnas.72.6.2456","article-title":"Coenzyme A requirement of malaria parasites: enzymes of coenzyme A biosynthesis in normal duck erythrocytes and erythrocytes infected with Plasmodium lophurae","volume":"72","author":"Brohn","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1042\/BST20140096","article-title":"Physiological roles of the pantothenate kinases","volume":"42","author":"Dansie","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00024","article-title":"Antiplasmodial mode of action of Pantothenamides: pantothenate kinase serves as a Metabolic activator not as a target","author":"de Villiers","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nchembio.1912","article-title":"Metabolism: jump-starting CoA biosynthesis","volume":"11","author":"de Villiers","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"33518","DOI":"10.1038\/srep33518","article-title":"Genetic characterization of Plasmodium Putative Pantothenate Kinase genes reveals their essential role in malaria parasite transmission to the mosquito","volume":"6","author":"Hart","year":"","journal-title":"Sci. Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1242\/bio.016352","article-title":"Plasmodium AdoMetDC\/ODC bifunctional enzyme is essential for male sexual stage development and mosquito transmission","volume":"5","author":"Hart","year":"","journal-title":"Biol. Open"},{"key":"B9","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1038\/srep05665","article-title":"Plasmodium yoelii Vitamin B5 Pantothenate transporter candidate is essential for parasite transmission to the mosquito","volume":"4","author":"Hart","year":"2014","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0021-9258(17)43491-0","article-title":"Turnover of the 4\u2032-phosphopantetheine prosthetic group of acyl carrier protein","volume":"259","author":"Jackowski","year":"1984","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.molbiopara.2005.09.007","article-title":"High efficiency transfection of Plasmodium berghei facilitates novel selection procedures","volume":"145","author":"Janse","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1005734","DOI":"10.1371\/journal.ppat.1005734","article-title":"A putative small solute transporter is responsible for the secretion of g377 and trap-containing secretory vesicles during Plasmodium gamete egress and sporozoite motility","volume":"12","author":"Kehrer","year":"2016","journal-title":"PLoS Pathog."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1128\/ecosal.3.6.3.4","article-title":"Biosynthesis of pantothenic acid and coenzyme, A","author":"Leonardi","year":"2007","journal-title":"EcoSal Plus"},{"key":"B14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.plipres.2005.04.001","article-title":"Coenzyme A: back in action","volume":"44","author":"Leonardi","year":"2005","journal-title":"Prog. Lipid Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.chembiol.2010.06.006","article-title":"Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate\/allosteric regulatory domain","volume":"17","author":"Leonardi","year":"2010","journal-title":"Chem. Biol."},{"key":"B16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0021-9258(17)30973-0","article-title":"Coenzyme for acetylation, a pantothenic acid derivative","volume":"167","author":"Lipmann","year":"","journal-title":"J. Biol. Chem."},{"key":"B17","first-page":"272","article-title":"Chemistry and distribution of the coenzyme for acetylation (coenzyme A)","volume":"6","author":"Lipmann","year":"","journal-title":"Fed. Proc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-62703-026-7_7","article-title":"Transfection of rodent malaria parasites","volume":"923","author":"Philip","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrm.2016.110","article-title":"Coenzyme A: to make it or uptake it?","volume":"17","author":"Sibon","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1128\/AAC.49.11.4649-4657.2005","article-title":"A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites","volume":"49","author":"Spry","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1574-6976.2007.00093.x","article-title":"Coenzyme A biosynthesis: an antimicrobial drug target","volume":"32","author":"Spry","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e54974","DOI":"10.1371\/journal.pone.0054974","article-title":"Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated","volume":"8","author":"Spry","year":"2013","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.2174\/187152610791163390","article-title":"Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy","volume":"10","author":"Spry","year":"2010","journal-title":"Infect. Disord. Drug Targets"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1006094","DOI":"10.1371\/journal.ppat.1006094","article-title":"Stage-specific changes in Plasmodium metabolism required for differentiation and adaptation to different host and vector environments","volume":"12","author":"Srivastava","year":"2016","journal-title":"PLoS Pathog."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1073\/pnas.72.5.1834","article-title":"Coezyme A requirement of malaria parasites: effects of coenzyme A precursors on extracellular development in vitro of Plasmodium lophurae","volume":"72","author":"Trager","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.bmc.2005.09.021","article-title":"Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors","volume":"14","author":"Virga","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.chembiol.2007.01.013","article-title":"Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis","volume":"14","author":"Zhang","year":"2007","journal-title":"Chem. Biol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00260\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:44:53Z","timestamp":1692845093000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00260\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":27,"alternative-id":["10.3389\/fcimb.2017.00260"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00260","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]},"article-number":"260"}}