{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:37:20Z","timestamp":1791405440616,"version":"4.3.3"},"reference-count":39,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00277","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T03:52:36Z","timestamp":1498017156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague"],"prefix":"10.3389","volume":"7","author":[{"given":"Ayelet","family":"Zauberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Vagima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Tidhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Aftalion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Rotem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor","family":"Chitlaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinon","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuelle","family":"Mamroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0147-619X(81)90019-6","article-title":"Essential virulence determinants of different Yersinia species are carried on a common plasmid","volume":"5","author":"Ben-Gurion","year":"1981","journal-title":"Plasmid"},{"key":"B2","first-page":"89","article-title":"Plague around the world","volume":"91","author":"Bertherat","year":"2016","journal-title":"Wkly. Epidemiol. Rec."},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mib.2015.07.005","article-title":"Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections","volume":"27","author":"Bruhn","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S1286-4579(01)01412-5","article-title":"The Yersinia high-pathogenicity island: an iron-uptake island","volume":"3","author":"Carniel","year":"2001","journal-title":"Microbes Infect."},{"key":"B5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00253-010-2550-2","article-title":"Iron uptake and metabolism in pseudomonads","volume":"86","author":"Cornelis","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1004359","DOI":"10.1371\/journal.ppat.1004359","article-title":"The effects of vaccination and immunity on bacterial infection dynamics in vivo","volume":"10","author":"Coward","year":"2014","journal-title":"PLoS Pathog."},{"key":"B8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.32607\/20758251-2015-7-1-102-108","article-title":"Selective protective potency of Yersinia pestis DeltanlpD Mutants","volume":"7","author":"Dentovskaya","year":"2015","journal-title":"Acta Nat."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0004162","DOI":"10.1371\/journal.pntd.0004162","article-title":"Complete protection against pneumonic and bubonic plague after a single oral vaccination","volume":"9","author":"Derbise","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/infdis\/jiw357","article-title":"Alterations in systemic extracellular heme and hemopexin are associated with adverse clinical outcomes in ugandan children with severe malaria","volume":"214","author":"Elphinstone","year":"2016","journal-title":"J. Infect. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1038\/emi.2012.34","article-title":"Plague vaccines: current developments and future perspectives","volume":"1","author":"Feodorova","year":"2012","journal-title":"Emerg. Microbes Infect."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7620","DOI":"10.1016\/j.vaccine.2007.08.055","article-title":"A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs","volume":"25","author":"Feodorova","year":"2007","journal-title":"Vaccine"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1111\/j.1365-2958.1992.tb01446.x","article-title":"Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102 kb of chromosomal DNA which is flanked by a repetitive element","volume":"6","author":"Fetherston","year":"1992","journal-title":"Mol. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1128\/IAI.72.2.908-915.2004","article-title":"Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates","volume":"72","author":"Flashner","year":"2004","journal-title":"Infect. Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"P98","DOI":"10.1186\/1475-2859-5-S1-P98","article-title":"Production and purification of high molecular weight oligomers of Yersinia pestis F1 capsular antigen released by high cell density culture of recombinant Escherichia coli cells carrying the caf1 operon","volume":"5","author":"Holtzman","year":"2006","journal-title":"Microb. Cell Factor."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1001\/jama.283.17.2281","article-title":"Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense","volume":"283","author":"Inglesby","year":"2000","journal-title":"JAMA"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16669","DOI":"10.1073\/pnas.0607898104","article-title":"Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract","volume":"104","author":"Lane","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"51r","DOI":"10.1126\/scitranslmed.3001118","article-title":"A central role for free heme in the pathogenesis of severe sepsis","volume":"2","author":"Larsen","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.1137195","article-title":"A plasminogen-activating protease specifically controls the development of primary pneumonic plague","volume":"315","author":"Lathem","year":"2007","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6866","DOI":"10.1016\/j.vaccine.2011.07.059","article-title":"T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague","volume":"29","author":"Levy","year":"2011","journal-title":"Vaccine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1093\/infdis\/jiw290","article-title":"Adjunctive corticosteroid treatment against yersinia pestis improves bacterial clearance, immunopathology, and survival in the mouse model of bubonic plague","volume":"214","author":"Levy","year":"2016","journal-title":"J. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/infdis\/jiu049","article-title":"Transferrin iron starvation therapy for lethal bacterial and fungal infections","volume":"210","author":"Lin","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1126\/science.1214935","article-title":"Disease tolerance as a defense strategy","volume":"335","author":"Medzhitov","year":"2012","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.virol.2015.03.032","article-title":"Live attenuated vaccines: historical successes and current challenges","volume":"480","author":"Minor","year":"2015","journal-title":"Virology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1128\/IAI.00602-13","article-title":"Sequestration and scavenging of iron in infection","volume":"81","author":"Parrow","year":"2013","journal-title":"Infect. Immun."},{"key":"B26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis\u2013etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"27609","DOI":"10.1074\/jbc.M110.154930","article-title":"Human transferrin confers serum resistance against Bacillus anthracis","volume":"285","author":"Rooijakkers","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"eaai8371","DOI":"10.1126\/sciimmunol.aai8371","article-title":"IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections","volume":"2","author":"Sakamoto","year":"2017","journal-title":"Sci. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.1073\/pnas.0509544103","article-title":"Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague","volume":"103","author":"Sebbane","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.1128\/IAI.68.6.3787-3791.2000","article-title":"Characterization of an anticryptococcal protein isolated from human serum","volume":"68","author":"Sridhar","year":"2000","journal-title":"Infect. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e7023","DOI":"10.1371\/journal.pone.0007023","article-title":"The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague","volume":"4","author":"Tidhar","year":"2009","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"16020","DOI":"10.1038\/npjvaccines.2016.20","article-title":"Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague","volume":"1","author":"Tiner","year":"2016","journal-title":"npj Vaccines"},{"key":"B33","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1517\/14712598.4.6.965","article-title":"Yersinia pestis (plague) vaccines","volume":"4","author":"Titball","year":"2004","journal-title":"Expert Opin. Biol. Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1004893","DOI":"10.1371\/journal.ppat.1004893","article-title":"Circumventing Y. pestis virulence by early recruitment of neutrophils to the lungs during pneumonic plague","volume":"11","author":"Vagima","year":"2015","journal-title":"PLoS Pathog"},{"key":"B35","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3389\/fimmu.2016.00602","article-title":"Plague vaccine development: current research and future trends","volume":"7","author":"Verma","year":"2016","journal-title":"Front. Immunol."},{"key":"B36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.70.3.245","article-title":"Studies on immunization against plague. V. Multiplication and persistence of virulent and avirulent Pasteurella pestis in mice and guinea pigs","volume":"70","author":"Walker","year":"1953","journal-title":"J. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jama.1975.03240130021018","article-title":"Nutritional immunity. Host's attempt to withold iron from microbial invaders","volume":"231","author":"Weinberg","year":"1975","journal-title":"JAMA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e83560","DOI":"10.1371\/journal.pone.0083560","article-title":"YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected]","volume":"8","author":"Zauberman","year":"2013","journal-title":"PLoS ONE"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e5938","DOI":"10.1371\/journal.pone.0005938","article-title":"Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague","volume":"4","author":"Zauberman","year":"2009","journal-title":"PLoS ONE"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00277\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T21:10:40Z","timestamp":1750367440000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00277\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":39,"alternative-id":["10.3389\/fcimb.2017.00277"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00277","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]},"article-number":"277"}}