{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:07:17Z","timestamp":1791846437238,"version":"4.3.4"},"reference-count":104,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1107001"],"award-info":[{"award-number":["APP1107001"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00351","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T03:42:10Z","timestamp":1501818130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":206,"title":["Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles"],"prefix":"10.3389","volume":"7","author":[{"suffix":"Fleetwood","given":"Andrew J.","family":"Fleetwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man K.S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Singleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Achuthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"O'Brien-Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Dashper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.mib.2013.04.004","article-title":"Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection","volume":"16","author":"Aachoui","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/oxfordjournals.jbchem.a021937","article-title":"Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease","volume":"123","author":"Abe","year":"1998","journal-title":"J. Biochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"37643","DOI":"10.1038\/srep37643","article-title":"Nucleoside-diphosphate-kinase of P. gingivalis is secreted from epithelial cells in the absence of a leader sequence through a pannexin-1 interactome","volume":"6","author":"Atanasova","year":"2016","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4161\/auto.2828","article-title":"Autophagy: a highway for Porphyromonas gingivalis in endothelial cells","volume":"2","author":"Belanger","year":"2006","journal-title":"Autophagy"},{"key":"B5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/cmi.2016.11","article-title":"Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals","volume":"14","author":"Bezbradica","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2249.2009.03972.x","article-title":"Expression and regulation of the NALP3 inflammasome complex in periodontal diseases","volume":"157","author":"Bostanci","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1399-302X.2009.00544.x","article-title":"Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque","volume":"24","author":"Byrne","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1074\/jbc.273.12.6611","article-title":"Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion","volume":"273","author":"Calkins","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.4049\/jimmunol.1201053","article-title":"Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential","volume":"189","author":"Carrion","year":"2012","journal-title":"J. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0151967","DOI":"10.1371\/journal.pone.0151967","article-title":"Differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens","volume":"11","author":"Cecil","year":"2016","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/cmi.12089","article-title":"Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor\/NADPH-oxidase signalling and contributes to persistence","volume":"15","author":"Choi","year":"2013","journal-title":"Cell. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"14274","DOI":"10.1074\/jbc.M115.685792","article-title":"Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels","volume":"291","author":"Cordes","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.archoralbio.2007.04.008","article-title":"Relationship between lactate dehydrogenase activity in saliva and oral health status","volume":"52","author":"De La Pena","year":"2007","journal-title":"Arch. Oral Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1128\/MMBR.00031-09","article-title":"Virulence and immunomodulatory roles of bacterial outer membrane vesicles","volume":"74","author":"Ellis","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation","volume":"15","author":"Everts","year":"2014","journal-title":"Nat. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood-2012-03-419747","article-title":"Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells","volume":"120","author":"Everts","year":"2012","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3389\/fimmu.2014.00203","article-title":"Metabolic control of dendritic cell activation and function: recent advances and clinical implications","volume":"5","author":"Everts","year":"2014","journal-title":"Front. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1111\/j.1462-5822.2006.00751.x","article-title":"Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages","volume":"8","author":"Fink","year":"2006","journal-title":"Cell. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1189\/jlb.1108702","article-title":"GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling","volume":"86","author":"Fleetwood","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5245","DOI":"10.4049\/jimmunol.178.8.5245","article-title":"Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation","volume":"178","author":"Fleetwood","year":"2007","journal-title":"J. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.1074\/jbc.M115.645572","article-title":"Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage urokinase plasminogen activator system: implications for periodontitis","volume":"290","author":"Fleetwood","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype","volume":"289","author":"Freemerman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/ni.3509","article-title":"Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense","volume":"17","author":"Garaude","year":"2016","journal-title":"Nat. Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.4049\/jimmunol.1501612","article-title":"Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication","volume":"196","author":"Gleeson","year":"2016","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1600-0765.1989.tb00865.x","article-title":"Prevalence of Bacteroides forsythus and Bacteroides gingivalis in subgingival plaque of prosthodontically treated patients on short recall","volume":"24","author":"Gmur","year":"1989","journal-title":"J. Periodont. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/omi.12134","article-title":"Spheres of influence: Porphyromonas gingivalis outer membrane vesicles","volume":"31","author":"Gui","year":"2016","journal-title":"Mol. Oral Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S1349-0079(11)80006-X","article-title":"Immune evasion strategies of Porphyromonas gingivalis","volume":"53","author":"Hajishengallis","year":"2011","journal-title":"J. Oral Biosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/omi.12065","article-title":"The inflammophilic character of the periodontitis-associated microbiota","volume":"29","author":"Hajishengallis","year":"2014","journal-title":"Mol. Oral Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cyto.2008.11.005","article-title":"Porphyromonas gingivalis culture supernatants differentially regulate interleukin-1beta and interleukin-18 in human monocytic cells","volume":"45","author":"Hamedi","year":"2009","journal-title":"Cytokine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cmet.2012.04.023","article-title":"The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism","volume":"15","author":"Haschemi","year":"2012","journal-title":"Cell Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0123448","DOI":"10.1371\/journal.pone.0123448","article-title":"Functional advantages of Porphyromonas gingivalis vesicles","volume":"10","author":"Ho","year":"2015","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.4049\/jimmunol.0800909","article-title":"Critical role of apoptotic speck protein containing a caspase recruitment domain (ASC) and NLRP3 in causing necrosis and ASC speck formation induced by Porphyromonas gingivalis in human cells","volume":"182","author":"Huang","year":"2009","journal-title":"J. Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.immuni.2016.09.016","article-title":"Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation","volume":"45","author":"Huang","year":"2016","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e70210","DOI":"10.1371\/journal.pone.0070210","article-title":"P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation","volume":"8","author":"Hung","year":"2013","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1601-0825.2010.01708.x","article-title":"NO production in RAW264 cells stimulated with Porphyromonas gingivalis extracellular vesicles","volume":"17","author":"Imayoshi","year":"2011","journal-title":"Oral Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1902\/jop.2007.060218","article-title":"Comparison of curet and paper point sampling of subgingival bacteria as analyzed by real-time polymerase chain reaction","volume":"78","author":"Jervoe-Storm","year":"2007","journal-title":"J. Periodontol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"B44","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.micinf.2015.03.010","article-title":"Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase","volume":"17","author":"Johnson","year":"2015","journal-title":"Microbes Infect."},{"key":"B45","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/imr.12287","article-title":"Pyroptotic cell death defends against intracellular pathogens","volume":"265","author":"Jorgensen","year":"2015","journal-title":"Immunol. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/cmi.12435","article-title":"Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation","volume":"17","author":"Jung","year":"2015","journal-title":"Cell. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1124\/mol.104.004366","article-title":"Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors","volume":"66","author":"Kadowaki","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1038\/cddis.2011.6","article-title":"Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin","volume":"2","author":"Kelk","year":"2011","journal-title":"Cell Death Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1902\/jop.2000.71.5.760","article-title":"A rapid DNA probe method for detection of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans","volume":"71","author":"Komiya","year":"2000","journal-title":"J. Periodontol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1182\/blood-2009-10-249540","article-title":"Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation","volume":"115","author":"Krawczyk","year":"2010","journal-title":"Blood"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1101\/gad.1299905","article-title":"Bacterial outer membrane vesicles and the host-pathogen interaction","volume":"19","author":"Kuehn","year":"2005","journal-title":"Genes Dev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.4049\/jimmunol.1103426","article-title":"Defining GM-CSF\u2013and macrophage-CSF\u2013dependent macrophage responses by in vitro models","volume":"188","author":"Lacey","year":"2012","journal-title":"J. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e0158629","DOI":"10.1371\/journal.pone.0158629","article-title":"Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis","volume":"11","author":"Lam","year":"2016","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/MMBR.62.4.1244-1263.1998","article-title":"Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis","volume":"62","author":"Lamont","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B55","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1128\/IAI.63.10.3878-3885.1995","article-title":"Porphyromonas gingivalis invasion of gingival epithelial cells","volume":"63","author":"Lamont","year":"1995","journal-title":"Infect. Immun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"B57","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bone.2006.09.003","article-title":"Macrophage lineage phenotypes and osteoclastogenesis\u2013complexity in the control by GM-CSF and TGF-beta","volume":"40","author":"Lari","year":"2007","journal-title":"Bone"},{"key":"B58","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1600-0757.2009.00329.x","article-title":"Metal uptake in host-pathogen interactions: role of iron in Porphyromonas gingivalis interactions with host organisms","volume":"52","author":"Lewis","year":"2010","journal-title":"Periodontol. 2000"},{"key":"B59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/mbo3.221","article-title":"Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis","volume":"4","author":"Mantri","year":"2015","journal-title":"Microbiologyopen"},{"key":"B60","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/j.1365-2958.2006.05272.x","article-title":"Special delivery: vesicle trafficking in prokaryotes","volume":"61","author":"Mashburn-Warren","year":"2006","journal-title":"Mol. Microbiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"22893","DOI":"10.1074\/jbc.R113.486464","article-title":"How metabolism generates signals during innate immunity and inflammation","volume":"288","author":"McGettrick","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase-1-induced pyroptotic cell death","volume":"243","author":"Miao","year":"2011","journal-title":"Immunol. Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.celrep.2016.12.047","article-title":"Porphyromonas gingivalis promotes unrestrained type I interferon production by dysregulating TAM signaling via MYD88 degradation","volume":"18","author":"Mizraji","year":"2017","journal-title":"Cell Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.celrep.2015.05.046","article-title":"mTORC1-induced HK1-dependent glycolysis regulates NLRP3 inflammasome activation","volume":"12","author":"Moon","year":"2015","journal-title":"Cell Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1159\/000363338","article-title":"Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1beta secretion","volume":"6","author":"Morandini","year":"2014","journal-title":"J. Innate Immun."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e95137","DOI":"10.1371\/journal.pone.0095137","article-title":"A novel approach for purification and selective capture of membrane vesicles of the periodontopathic bacterium, Porphyromonas gingivalis: membrane vesicles bind to magnetic beads coated with epoxy groups in a noncovalent, species-specific manner","volume":"9","author":"Nakao","year":"2014","journal-title":"PLoS ONE"},{"key":"B68","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1096\/fj.15-279398","article-title":"Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage","volume":"30","author":"Nemeth","year":"2016","journal-title":"FASEB J."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages","volume":"113","author":"Netea","year":"2009","journal-title":"Blood"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1128\/IAI.68.5.2704-2712.2000","article-title":"Serum immunoglobulin G (IgG) and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis in adult periodontitis","volume":"68","author":"O'Brien-Simpson","year":"2000","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1128\/IAI.01038-08","article-title":"Porphyromonas gingivalis RgpA-Kgp proteinase-adhesin complexes penetrate gingival tissue and induce proinflammatory cytokines or apoptosis in a concentration-dependent manner","volume":"77","author":"O'Brien-Simpson","year":"2009","journal-title":"Infect. Immun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O'Neill","year":"2016","journal-title":"J. Exp. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/1471-2180-13-155","article-title":"Porphyromonas gingivalis downregulates the immune response of fibroblasts","volume":"3","author":"Palm","year":"2013","journal-title":"BMC Microbiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1128\/IAI.00862-13","article-title":"Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection","volume":"82","author":"Park","year":"2014","journal-title":"Infect. Immun."},{"key":"B76","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.micpath.2003.07.002","article-title":"Porphyromonas gingivalis induces murine macrophage foam cell formation","volume":"35","author":"Qi","year":"2003","journal-title":"Microb. Pathog."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3252","DOI":"10.1074\/jbc.M608328200","article-title":"The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor","volume":"282","author":"Raje","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1177\/0022034515593465","article-title":"A dual role for P2X7 receptor during Porphyromonas gingivalis infection","volume":"94","author":"Ramos-Junior","year":"2015","journal-title":"J. Dent. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/mi.2015.44","article-title":"Strain- and host species-specific inflammasome activation, IL-1beta release, and cell death in macrophages infected with uropathogenic Escherichia coli","volume":"9","author":"Schaale","year":"2016","journal-title":"Mucosal Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"5667","DOI":"10.1128\/IAI.01140-05","article-title":"Gingipains from Porphyromonas gingivalis W83 synergistically disrupt endothelial cell adhesion and can induce caspase-independent apoptosis","volume":"74","author":"Sheets","year":"2006","journal-title":"Infect. Immun."},{"key":"B82","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e1004215","DOI":"10.1371\/journal.ppat.1004215","article-title":"Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation","volume":"10","author":"Slocum","year":"2014","journal-title":"PLoS Pathog."},{"key":"B84","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1006\/mpat.1999.0287","article-title":"Outer membrane vesicles of Porphyromonas gingivalis inhibit IFN-gamma-mediated MHC class II expression by human vascular endothelial cells","volume":"27","author":"Srisatjaluk","year":"1999","journal-title":"Microb. Pathog."},{"key":"B86","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1399-302X.2008.00467.x","article-title":"The host cytokine response to Porphyromonas gingivalis is modified by gingipains","volume":"24","author":"Stathopoulou","year":"2009","journal-title":"Oral Microbiol. Immunol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"32791","DOI":"10.1074\/jbc.M112.401737","article-title":"Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis","volume":"287","author":"Taxman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.4049\/jimmunol.177.7.4252","article-title":"Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways","volume":"177","author":"Taxman","year":"2006","journal-title":"J. Immunol."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3791\/53424","article-title":"Metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis","author":"Van den Bossche","year":"2015","journal-title":"J. Vis. Exp"},{"key":"B91","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"Van den Bossche","year":"2016","journal-title":"Cell Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2016.04.015","article-title":"Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation","volume":"165","author":"Vanaja","year":"2016","journal-title":"Cell"},{"key":"B93","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1021\/pr401227e","article-title":"Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors","volume":"13","author":"Veith","year":"2014","journal-title":"J. Proteome Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1128\/IAI.01390-15","article-title":"Porphyromonas gingivalis outer membrane vesicles induce selective tumor necrosis factor tolerance in a toll-like receptor 4- and mTOR-dependent manner","volume":"84","author":"Waller","year":"2016","journal-title":"Infect. Immun."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1111\/j.1462-5822.2008.01185.x","article-title":"Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages","volume":"10","author":"Wang","year":"2008","journal-title":"Cell. Microbiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"ra11","DOI":"10.1126\/scisignal.2000697","article-title":"Microbial hijacking of complement-toll-like receptor crosstalk","volume":"3","author":"Wang","year":"2010","journal-title":"Sci. Signal."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.4049\/jimmunol.179.4.2349","article-title":"Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages","volume":"179","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1189\/jlb.1108689","article-title":"The generation and properties of human macrophage populations from hemopoietic stem cells","volume":"85","author":"Way","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1002\/pmic.200700543","article-title":"Quantitative proteomics of intracellular Porphyromonas gingivalis","volume":"7","author":"Xia","year":"2007","journal-title":"Proteomics"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2217\/fmb.15.63","article-title":"Biogenesis and function of Porphyromonas gingivalis outer membrane vesicles","volume":"10","author":"Xie","year":"2015","journal-title":"Future Microbiol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12084","article-title":"The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity","volume":"69","author":"Yilmaz","year":"2015","journal-title":"Periodontol. 2000"},{"key":"B103","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/j.1462-5822.2009.01390.x","article-title":"ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis","volume":"12","author":"Yilmaz","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"5694","DOI":"10.4049\/jimmunol.0901030","article-title":"Targeting of DC-SIGN on human dendritic cells by minor fimbriated Porphyromonas gingivalis strains elicits a distinct effector T cell response","volume":"183","author":"Zeituni","year":"2009","journal-title":"J. Immunol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00351\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T05:17:18Z","timestamp":1602652638000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00351\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,4]]},"references-count":104,"alternative-id":["10.3389\/fcimb.2017.00351"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00351","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,4]]},"article-number":"351"}}