{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:24:54Z","timestamp":1780331094362,"version":"3.54.1"},"reference-count":85,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2016-79892-P"],"award-info":[{"award-number":["BFU2016-79892-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["201440E098"],"award-info":[{"award-number":["201440E098"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00360","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T03:44:23Z","timestamp":1502250263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Vaccinomics Approach to the Identification of Candidate Protective Antigens for the Control of Tick Vector Infestations and Anaplasma phagocytophilum Infection"],"prefix":"10.3389","volume":"7","author":[{"given":"Marinela","family":"Contreras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Alberdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel G.","family":"Fern\u00e1ndez De Mera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Krull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ard","family":"Nijhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"De La Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3109\/1354750X.2015.1123354","article-title":"The potential of lipocalin-2\/NGAL as biomarker for inflammatory and metabolic diseases","volume":"20","author":"Abella","year":"2015","journal-title":"Biomarkers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.ttbdis.2015.07.001","article-title":"Infection of Ixodes spp. tick cells with different Anaplasma phagocytophilum isolates induces the inhibition of apoptotic cell death","volume":"6","author":"Alberdi","year":"2015","journal-title":"Ticks Tick Borne Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fcimb.2016.00020","article-title":"Tissue-specific signatures in the transcriptional response to Anaplasma phagocytophilum infection of Ixodes scapularis and Ixodes ricinus tick cell lines","volume":"6","author":"Alberdi","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1756-3305-7-42","article-title":"Tick capillary feeding for the study of proteins involved in tick-pathogen interactions as potential antigens for the control of tick infestation and pathogen infection","volume":"7","author":"Antunes","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1086\/516529","article-title":"Antigenic diversity of granulocytic Ehrlichia isolates from humans in Wisconsin and New York and a horse in California","volume":"176","author":"Asanovich","year":"1997","journal-title":"J. Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1128\/IAI.00194-13","article-title":"Anaplasma phagocytophilum inhibits apoptosis and promotes cytoskeleton rearrangement for infection of tick cells","volume":"81","author":"Ayll\u00f3n","year":"2013","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1005120","DOI":"10.1371\/journal.pgen.1005120","article-title":"Systems biology of tissue-specific response to Anaplasma phagocytophilum reveals differentiated apoptosis in the tick vector Ixodes scapularis","volume":"11","author":"Ayll\u00f3n","year":"2015","journal-title":"PLoS Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.idc.2015.02.007","article-title":"Human granulocytic anaplasmosis","volume":"29","author":"Bakken","year":"2015","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e6047","DOI":"10.1371\/journal.pone.0006047","article-title":"The role of salivary and intestinal complement system inhibitors in the midgut protection of triatomines and mosquitoes","volume":"4","author":"Barros","year":"2009","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e3941","DOI":"10.1371\/journal.pone.0003941","article-title":"Ixodes ricinus tick lipocalins: identification, cloning, phylogenetic analysis and biochemical characterization","volume":"3","author":"Beaufays","year":"2008","journal-title":"PLoS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.pt.2007.07.009","article-title":"Tick cell lines: tools for tick and tick-borne disease research","volume":"23","author":"Bell-Sakyi","year":"2007","journal-title":"Trends Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1051\/acarologia\/20122068","article-title":"Laboratory artificial infection of hard ticks: a tool for the analysis of tick-borne pathogen transmission","volume":"52","author":"Bonnet","year":"2012","journal-title":"Acarologia."},{"key":"B14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/15592294.2016.1163460","article-title":"Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis","volume":"11","author":"Cabezas-Cruz","year":"2016","journal-title":"Epigenetics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fcimb.2017.00023","article-title":"Anaplasma phagocytophilum infection subverts carbohydrate metabolic pathways in the tick vector, Ixodes scapularis","volume":"7","author":"Cabezas-Cruz","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B16","first-page":"1830","article-title":"Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum","volume":"22","author":"Cabezas-Cruz","year":"","journal-title":"Front. Biosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jcpa.2014.08.001","article-title":"Innate resistance to tuberculosis in man, cattle and laboratory animal models: nipping disease in the bud?","volume":"151","author":"Cassidy","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bbcan.2012.03.008","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"Chakraborty","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B19","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.pt.2015.10.002","article-title":"Sialomes and mialomes: a systems-biology view of tick tissues and tick-host interactions","volume":"32","author":"Chmela\u0159","year":"2016","journal-title":"Trends Parasitol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fcimb.2017.00307","article-title":"Anaplasma phagocytophilum MSP4 and HSP70 proteins are involved in interactions with host cells during pathogen infection","volume":"7","author":"Contreras","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/978-1-4939-3389-1_19","article-title":"Vaccinomics approach to tick vaccine development","volume":"1404","author":"Contreras","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1400","DOI":"10.1371\/journal.pone.0001400","article-title":"Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus","volume":"3","author":"Couvreur","year":"2008","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1186\/s12864-015-1981-7","article-title":"Integration of Ixodes ricinus genome sequencing with transcriptome and proteome annotation of the na\u00efve midgut","volume":"6","author":"Cramaro","year":"2015","journal-title":"BMC Genomics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2583.2006.00710.x","article-title":"Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins","volume":"16","author":"Daix","year":"2007","journal-title":"Insect Mol. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.ttbdis.2016.01.014","article-title":"De novo assembly and annotation of the salivary gland transcriptome of Rhipicephalus appendiculatus male and female ticks during blood feeding","volume":"7","author":"de Castro","year":"2016","journal-title":"Ticks Tick Borne Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fcimb.2017.00114","article-title":"Tick-pathogen interactions and vector competence: identification of molecular drivers for tick-borne diseases","volume":"7","author":"de la Fuente","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1586\/14760584.2015.1076339","article-title":"Tick vaccines: current status and future directions","volume":"14","author":"de la Fuente","year":"2015","journal-title":"Expert Rev. Vaccines."},{"key":"B28","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/pim.12339","article-title":"Strategies for new and improved vaccines against ticks and tick-borne diseases","volume":"38","author":"de la Fuente","year":"","journal-title":"Parasite Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fcimb.2016.00103","article-title":"Tick genome assembled: new opportunities for research on tick-host-pathogen interactions","volume":"6","author":"de la Fuente","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.tim.2015.12.001","article-title":"Anaplasma phagocytophilum uses common strategies for infection of ticks and vertebrate hosts","volume":"24","author":"de la Fuente","year":"","journal-title":"Trends. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1005488","DOI":"10.1371\/journal.ppat.1005488","article-title":"Tick-host-pathogen interactions: conflict and cooperation","volume":"12","author":"de la Fuente","year":"","journal-title":"PLoS. Pathog."},{"key":"B32","doi-asserted-by":"publisher","first-page":"5923","DOI":"10.1016\/j.vaccine.2013.10.049","article-title":"Vaccinomics, the new road to tick vaccines","volume":"31","author":"de la Fuente","year":"2013","journal-title":"Vaccine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fcimb.2015.00061","article-title":"Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives","volume":"5","author":"Dugat","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1099\/00207713-51-6-2145","article-title":"Reorganization of the genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions subjective synonyms of Ehrlichia phagocytophila","volume":"51","author":"Dumler","year":"2001","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"675898","DOI":"10.1155\/2013\/675898","article-title":"The emerging role of complement lectin pathway in trypanosomatids: molecular bases in activation, genetic deficiencies, susceptibility to infection, and complement system-based therapeutics","volume":"3","author":"Evans-Osses","year":"2013","journal-title":"Sci. World J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.pneurobio.2015.06.005","article-title":"From the periphery to the brain: Lipocalin-2, a friend or foe?","volume":"131","author":"Ferreira","year":"2015","journal-title":"Prog Neurobiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/path.1700630103","article-title":"Studies on the infectious agent of tick-borne fever in sheep","volume":"63","author":"Foggie","year":"1951","journal-title":"J. Path. Bact."},{"key":"B38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.exppara.2016.03.002","article-title":"Inhibition of the classical pathway of the complement system by saliva of Amblyomma cajennense (Acari: Ixodidae)","volume":"164","author":"Franco","year":"2016","journal-title":"Exp. Parasitol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/1755-0998.12298","article-title":"Transcriptome sequence divergence between Lyme disease tick vectors, Ixodes scapularis and Ixodes ricinus. Genomic Resources Notes","volume":"14","author":"Contreras","year":"2014","journal-title":"Mol. Ecol. Resour."},{"key":"B40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0368-1742(32)80025-1","article-title":"Tick-borne fever","volume":"45","author":"Gordon","year":"1932","journal-title":"J. Comp. Path."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10507","DOI":"10.1038\/ncomms10507","article-title":"Genomic insights into the Ixodes scapularis tick vector of Lyme disease","volume":"7","author":"Gulia-Nuss","year":"2016","journal-title":"Nat. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"10498","DOI":"10.1073\/pnas.1202588109","article-title":"Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2","volume":"109","author":"H\u00e9ja","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e0004323","DOI":"10.1371\/journal.pntd.0004323","article-title":"Ixodes scapularis tick saliva proteins sequentially secreted every 24 h during blood feeding","volume":"10","author":"Kim","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ttbdis.2012.01.004","article-title":"Sheep experimentally-infected with a human isolate of Anaplasma phagocytophilum serve as a host for infection of Ixodes scapularis","volume":"3","author":"Kocan","year":"2012","journal-title":"Ticks Tick Borne Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"9103","DOI":"10.1038\/srep09103","article-title":"Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host","volume":"5","author":"Kotsyfakis","year":"2015","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ps.1293","article-title":"An in vitro feeding assay to test acaricides for control of hard ticks","volume":"63","author":"Kr\u00f6ber","year":"2007","journal-title":"Pest Manag. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13071-017-2000-4","article-title":"Optimization of an artificial tick feeding assay for Dermacentor reticulatus","author":"Krull","year":"2017","journal-title":"Parasit. Vectors"},{"key":"B48","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1006\/jipa.1996.0050","article-title":"Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis","volume":"67","author":"Kurtti","year":"1996","journal-title":"J. Inv. Path."},{"key":"B49","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1006\/expr.1999.4456","article-title":"Ixodes ticks: serum species sensitivity of anticomplement activity","volume":"93","author":"Lawrie","year":"1999","journal-title":"Exp. Parasitol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.molimm.2004.07.001","article-title":"Investigation of the mechanisms of anti-complement activity in Ixodes ricinus ticks","volume":"42","author":"Lawrie","year":"2005","journal-title":"Mol. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0076-6879(96)66011-X","article-title":"Applications of network BLAST server","volume":"266","author":"Madden","year":"1996","journal-title":"Meth. Enzymol."},{"key":"B52","first-page":"1131","article-title":"Tick histamine-binding proteins and related lipocalins: potential as therapeutic agents","volume":"6","author":"Mans","year":"2005","journal-title":"Curr. Opin. Investig. Drugs."},{"key":"B53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.vetpar.2016.08.005","article-title":"TSGP4 from Ornithodoros moubata: molecular cloning, phylogenetic analysis and vaccine efficacy of a new member of the lipocalin clade of cysteinyl leukotriene scavengers","volume":"227","author":"Manzano-Rom\u00e1n","year":"2016","journal-title":"Vet. Parasitol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"e79787","DOI":"10.1371\/journal.pone.0079787","article-title":"Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum promastigotes","volume":"8","author":"Mendes-Sousa","year":"2013","journal-title":"PLoS ONE"},{"key":"B55","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.1016\/j.vaccine.2013.09.037","article-title":"Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection","volume":"31","author":"Merino","year":"2013","journal-title":"Vaccine"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.vaccine.2012.12.073","article-title":"Control of multiple arthropod vector infestations with subolesin\/akirin vaccines","volume":"31","author":"Moreno-Cid","year":"2013","journal-title":"Vaccine"},{"key":"B57","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1128\/JCM.37.8.2518-2524.1999","article-title":"Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture","volume":"37","author":"Munderloh","year":"1999","journal-title":"J. Clin. Microbiol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0167-4838(00)00168-0","article-title":"Tick histamine-binding proteins: lipocalins with a second binding cavity","volume":"1482","author":"Paesen","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"B59","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks","volume":"36","author":"Ribeiro","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ttbdis.2016.08.011","article-title":"An insight into the sialome of Hyalomma excavatum","volume":"8","author":"Ribeiro","year":"2017","journal-title":"Ticks Tick Borne Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.imbio.2007.10.009","article-title":"Ficolins: novel pattern recognition molecules of the innate immune response","volume":"213","author":"Runza","year":"2008","journal-title":"Immunobiology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.chom.2011.06.010","article-title":"A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the Lyme disease agent","volume":"10","author":"Schuijt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1074\/mcp.M114.039289","article-title":"A systems level analysis reveals transcriptomic and proteomic complexity in Ixodes ricinus midgut and salivary glands during early attachment and feeding","volume":"13","author":"Schwarz","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1096\/fj.13-232140","article-title":"De novo Ixodes ricinus salivary gland transcriptome analysis using two next-generation sequencing methodologies","volume":"27","author":"Schwarz","year":"2013","journal-title":"FASEB J."},{"key":"B65","first-page":"2033","article-title":"Anaplasma","volume-title":"Molecular Medical Microbiology, 2nd Edn","author":"Severo","year":"2015"},{"key":"B66","doi-asserted-by":"publisher","first-page":"14401","DOI":"10.1038\/ncomms14401","article-title":"Infection-derived lipids elicit an immune deficiency circuit in arthropods","volume":"8","author":"Shaw","year":"2017","journal-title":"Nat. Commun."},{"key":"B67","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ttbdis.2015.12.014","article-title":"Multienzyme degradation of host serum albumin in ticks","volume":"7","author":"Sojka","year":"2015","journal-title":"Ticks Tick Borne Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fcimb.2013.00031","article-title":"Anaplasma phagocytophilum\u2013a widespread multi-host pathogen with highly adaptive strategies","volume":"3","author":"Stuen","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13028-015-0131-1","article-title":"Lambs immunized with an inactivated variant of Anaplasma phagocytophilum","volume":"7","author":"Stuen","year":"2015","journal-title":"Acta Vet. Scand."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e0169053","DOI":"10.1371\/journal.pone.0169053","article-title":"Establishment of an artificial tick feeding system to study Theileria lestoquardi infection","volume":"11","author":"Tajeri","year":"2016","journal-title":"PLoS ONE"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1111\/j.1462-5822.2007.00908.x","article-title":"Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection","volume":"9","author":"Thomas","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13071-017-2081-0","article-title":"A new method for in vitro feeding of Rhipicephalus australis (formerly Rhipicephalus microplus) larvae: a valuable tool for tick vaccine development","author":"Trentelman","year":"2017","journal-title":"Parasit. Vectors"},{"key":"B73","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1365-2583.2007.00742.x","article-title":"Biochemical and functional characterization of Salp20, an Ixodes scapularis tick salivary protein that inhibits the complement pathway","volume":"16","author":"Tyson","year":"2007","journal-title":"Insect Mol. Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.4049\/jimmunol.180.6.3964","article-title":"A novel mechanism of complement inhibition unmasked by a tick salivary protein that binds to properdin","volume":"180","author":"Tyson","year":"2008","journal-title":"J. Immunol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s13071-014-0491-9","article-title":"Antihistamine response: a dynamically refined function at the host-tick interface","volume":"7","author":"Vald\u00e9s","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B76","doi-asserted-by":"publisher","first-page":"32372","DOI":"10.1038\/srep32372","article-title":"Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection","volume":"6","author":"Vald\u00e9s","year":"2016","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"18717","DOI":"10.1074\/jbc.M001486200","article-title":"Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis","volume":"275","author":"Valenzuela","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1074\/mcp.M115.051938","article-title":"Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells","volume":"14","author":"Villar","year":"","journal-title":"Mol. Cell. Proteomics"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e0137237","DOI":"10.1371\/journal.pone.0137237","article-title":"Identification and characterization of Anaplasma phagocytophilum proteins involved in infection of the tick vector, Ixodes scapularis","volume":"10","author":"Villar","year":"","journal-title":"PLoS ONE"},{"key":"B80","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1186\/s13071-016-1747-3","article-title":"The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis","volume":"9","author":"Villar","year":"2016","journal-title":"Parasit. Vectors"},{"key":"B81","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/14789450.2017.1284590","article-title":"Applying proteomics to tick vaccine development: where are we?","volume":"14","author":"Villar","year":"2017","journal-title":"Expert Rev. Proteomics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e89564","DOI":"10.1371\/journal.pone.0089564","article-title":"A systems biology approach to the characterization of stress response in Dermacentor reticulatus tick unfed larvae","volume":"9","author":"Villar","year":"2014","journal-title":"PLoS ONE"},{"key":"B83","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1089\/vbz.2015.1901","article-title":"An Ixodes ricinus tick salivary lectin pathway inhibitor protects Borrelia burgdorferi sensu lato from human complement","volume":"16","author":"Wagemakers","year":"2016","journal-title":"Vector Borne Zoonotic Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1186\/s13071-015-1210-x","article-title":"Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis","volume":"8","author":"Weisheit","year":"2015","journal-title":"Parasit. Vectors"},{"key":"B85","first-page":"457","article-title":"Acquired resistance to ticks. III. Cobra venom factor and the resistance response","volume":"32","author":"Wikel","year":"1977","journal-title":"Immunology"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00360\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T14:42:51Z","timestamp":1602686571000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00360\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":85,"alternative-id":["10.3389\/fcimb.2017.00360"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00360","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]},"article-number":"360"}}