{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:40:25Z","timestamp":1790671225665,"version":"4.1.0"},"reference-count":73,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01 AI065545"],"award-info":[{"award-number":["2R01 AI065545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["1010265"],"award-info":[{"award-number":["1010265"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/86670\/2012"],"award-info":[{"award-number":["SFRH\/BD\/86670\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00438","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T04:17:48Z","timestamp":1507609068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Characterization of the Growth of Chlamydia trachomatis in In Vitro-Generated Stratified Epithelium"],"prefix":"10.3389","volume":"7","author":[{"given":"Ana T.","family":"Nogueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rey A.","family":"Carabeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The chlamydial developmental cycle: figure 1","volume":"29","author":"AbdelRahman","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1128\/IAI.72.8.4751-4762.2004","article-title":"Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway","volume":"72","author":"Al-Younes","year":"2004","journal-title":"Infect. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/aji.12230","article-title":"The structure of the human vaginal stratum corneum and its role in immune defense","volume":"71","author":"Anderson","year":"2014","journal-title":"Am. J. Reprod. Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1242\/jcs.02733","article-title":"Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis","volume":"119","author":"Beatty","year":"2006","journal-title":"J. Cell Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1128\/IAI.00129-08","article-title":"Late endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63","volume":"76","author":"Beatty","year":"2008","journal-title":"Infect. Immun."},{"key":"B6","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1126\/science.7008197","article-title":"Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness","volume":"211","author":"Bell","year":"1981","journal-title":"Science"},{"key":"B7","first-page":"673","article-title":"Epithelial cells immortalized by human papillomaviruses have premalignant characteristics in organotypic culture","volume":"138","author":"Blanton","year":"1991","journal-title":"Am. J. Pathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1046\/j.1523-1747.1999.00545.x","article-title":"Reconstruction of a human skin equivalent using a spontaneously transformed keratinocyte cell line (HaCaT)","volume":"112","author":"Boelsma","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J. Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.1073\/pnas.1131289100","article-title":"Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion","volume":"100","author":"Carabeo","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B11","volume-title":"Cell Biology: A Laboratory Handbook","author":"Celis","year":"2006"},{"key":"B12","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s004410050598","article-title":"Regulation of differentiation and keratin 10 expression by all-trans retinoic acid during the estrous cycle in the rat vaginal epithelium","volume":"284","author":"Chateau","year":"1996","journal-title":"Cell Tissue Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1128\/AAC.05975-11","article-title":"Three-dimensional human skin equivalent as a tool to study Acinetobacter baumannii colonization","volume":"56","author":"de Breij","year":"2012","journal-title":"Antimicrob. Agents Chemother"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1002092","DOI":"10.1371\/journal.ppat.1002092","article-title":"The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites","volume":"7","author":"Derr\u00e9","year":"2011","journal-title":"PLoS Pathog"},{"key":"B15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10616-007-9076-1","article-title":"In vitro culture conditions to study keratinocyte differentiation using the HaCaT cell line","volume":"54","author":"Deyrieux","year":"2007","journal-title":"Cytotechnology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1111\/tra.12002","article-title":"Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum","volume":"13","author":"Dumoux","year":"2012","journal-title":"Traffic"},{"key":"B17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1289\/ehp.8980109","article-title":"Molecular biology of keratinocyte differentiation","volume":"80","author":"Eckert","year":"1989","journal-title":"Environ. Health Perspect."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1016\/j.bbamcr.2013.06.010","article-title":"Cell death by cornification","volume":"1833","author":"Eckhart","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/1523-1747.ep12550377","article-title":"Localization and composition of lipids in neonatal mouse stratum granulosum and stratum corneum","volume":"73","author":"Elias","year":"1979","journal-title":"J. Invest. Dermatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/1523-1747.ep12687968","article-title":"Mammalian epidermal barrier layer lipids: composition and influence on structure","volume":"69","author":"Elias","year":"1977","journal-title":"J. Invest. Dermatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0163-4453(82)92479-3","article-title":"Chlamydial infection of the human cervix\u2013an ultrastructural study","volume":"4","author":"Evans","year":"1982","journal-title":"J. Infect."},{"key":"B22","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1083\/jcb.111.6.2807","article-title":"Epidermal differentiation: the bare essentials","volume":"111","author":"Fuchs","year":"1990","journal-title":"J. Cell Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/0092-8674(80)90094-X","article-title":"Changes in keratin gene expression during terminal differentiation of the keratinocyte","volume":"19","author":"Fuchs","year":"1980","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nrg758","article-title":"Getting under the skin of epidermal morphogenesis","volume":"3","author":"Fuchs","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"B25","doi-asserted-by":"crossref","first-page":"168s","DOI":"10.1111\/1523-1747.ep12541032","article-title":"Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo","volume":"81","author":"Fusenig","year":"1983","journal-title":"J. Invest. Dermatol."},{"key":"B26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/jcp.36.5.539","article-title":"Transferrin receptors in human tissues: their distribution and possible clinical relevance","volume":"36","author":"Gatter","year":"1983","journal-title":"J. Clin. Pathol."},{"key":"B27","first-page":"493","article-title":"Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast","volume":"17","author":"Green","year":"1977","journal-title":"Prog. Clin. Biol. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.addr.2011.01.005","article-title":"Skin tissue engineering\u2014in vivo and in vitro applications","volume":"63","author":"Groeber","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B29","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/j.1460-2075.1996.tb00433.x","article-title":"Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane","volume":"15","author":"Hackstadt","year":"1996","journal-title":"EMBO J."},{"key":"B30","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1073\/pnas.92.11.4877","article-title":"Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion","volume":"92","author":"Hackstadt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/IAI.12.1.211-220.1975","article-title":"Competition between Chlamydia psittaci and L cells for host isoleucine pools: a limiting factor in chlamydial multiplication","volume":"12","author":"Hatch","year":"1975","journal-title":"Infect. Immun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","article-title":"Calcium regulation of growth and differentiation of mouse epidermal cells in culture","volume":"19","author":"Hennings","year":"1980","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/978-1-62703-601-6_17","article-title":"3D-tissue model for herpes simplex virus-1 infections","volume":"1064","author":"Hogk","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5456","DOI":"10.1016\/j.febslet.2006.08.039","article-title":"Epidermal sphingolipids: metabolism, function, and roles in skin disorders","volume":"580","author":"Holleran","year":"2006","journal-title":"FEBS Lett"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1099\/jmm.0.032169-0","article-title":"Differences in Chlamydia trachomatis growth rates in human keratinocytes among lymphogranuloma venereum reference strains and clinical isolates","volume":"60","author":"Joubert","year":"2011","journal-title":"J. Med. Microbiol"},{"key":"B36","first-page":"571","article-title":"Time correlation of commitment to calcium-induced apoptosis and terminal differentiation in human ectocervical keratinocytes in suspension cultures","volume":"8","author":"Kikuchi","year":"1997","journal-title":"Cell Growth Differ."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e54022","DOI":"10.1371\/journal.pone.0054022","article-title":"Chlamydia Induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model","volume":"8","author":"Knowlton","year":"2013","journal-title":"PLoS ONE"},{"key":"B38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.15585\/mmwr.mm6603a3","article-title":"Prevalence of pelvic inflammatory disease in sexually experienced women of reproductive age \u2014 United States, 2013\u20132014","volume":"66","author":"Kreisel","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly. Rep"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e52494","DOI":"10.1371\/journal.pone.0052494","article-title":"Keratinocytes propagated in serum-free, feeder-free culture conditions fail to form stratified epidermis in a reconstituted skin model","volume":"8","author":"Lamb","year":"2013","journal-title":"PLoS ONE"},{"key":"B40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0022-2275(20)38006-8","article-title":"Human epidermal lipids: characterization and modulations during differentiation","volume":"24","author":"Lampe","year":"1983","journal-title":"J. Lipid Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4110\/in.2015.15.1.16","article-title":"Immune cells in the female reproductive tract","volume":"15","author":"Lee","year":"2015","journal-title":"Immune Netw"},{"key":"B42","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1783\/147118906776276440","article-title":"Relationship of cervical ectopy to chlamydia infection in young women","volume":"32","author":"Lee","year":"2006","journal-title":"J. Fam. Plan. Reprod. Heal. Care"},{"key":"B43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fcimb.2014.00071","article-title":"Morphologic and molecular evaluation of Chlamydia trachomatis growth in human endocervix reveals distinct growth patterns","volume":"4","author":"Lewis","year":"2014","journal-title":"Front. Cell. Infect. Microbiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"50682","DOI":"10.18632\/oncotarget.9330","article-title":"The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"B45","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1046\/j.1523-1747.2001.01349.x","article-title":"Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation","volume":"116","author":"Maas-Szabowski","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"B46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4049\/jimmunol.83.5.529","article-title":"Persistent infection of HeLa cells with Meningopneumonitis virus","volume":"83","author":"Manire","year":"1959","journal-title":"J. Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00418-008-0435-6","article-title":"The human keratins: biology and pathology","volume":"129","author":"Moll","year":"2008","journal-title":"Histochem. Cell Biol"},{"key":"B48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1099\/00221287-132-4-1055","article-title":"Interaction of Chlamydia trachomatis with human genital epithelium in culture","volume":"132","author":"Moorman","year":"1986","journal-title":"Microbiology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"875","DOI":"10.2307\/1294708","article-title":"A model for studying the biology of parasitism: Chlamydia psittaci and Mouse Fibroblasts (L Cells)","volume":"19","author":"Moulder","year":"1969","journal-title":"Bioscience"},{"key":"B51","first-page":"269","article-title":"Investigation of microtrauma after sexual intercourse","volume":"29","author":"Norvell","year":"1984","journal-title":"J. Reprod. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fmicb.2010.00112","article-title":"A functional slow recycling pathway of transferrin is required for growth of Chlamydia","volume":"1","author":"Ouellette","year":"2010","journal-title":"Front. Microbiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e16783","DOI":"10.1371\/journal.pone.0016783","article-title":"Chlamydia species-dependent differences in the growth requirement for lysosomes","volume":"6","author":"Ouellette","year":"2011","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1067\/mob.2000.108857","article-title":"Epithelial cell layer thickness and immune cell populations in the normal human vagina at different stages of the menstrual cycle","volume":"183","author":"Patton","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fimmu.2014.00041","article-title":"Three-dimensional human skin models to understand Staphylococcus aureus skin colonization and infection","volume":"5","author":"Popov","year":"2014","journal-title":"Front. Immunol."},{"key":"B56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(75)80001-8","article-title":"Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells","volume":"6","author":"Rheinwald","year":"1975","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1000664","DOI":"10.1371\/journal.ppat.1000664","article-title":"Inclusion biogenesis and reactivation of persistent Chlamydia trachomatis requires host cell sphingolipid biosynthesis","volume":"5","author":"Robertson","year":"2009","journal-title":"PLoS Pathog."},{"key":"B58","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1432-0436.1989.tb00812.x","article-title":"Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones","volume":"40","author":"Ryle","year":"1989","journal-title":"Differentiation"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J. Cell Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1523-1747.2000.00935.x","article-title":"Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis","volume":"114","author":"Schaller","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1523-1747.1999.00524.x","article-title":"Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts","volume":"112","author":"Schoop","year":"1999","journal-title":"J. Invest. Dermatol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/nrm3175","article-title":"Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis","volume":"12","author":"Simpson","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.122.2.417","article-title":"Mutual induction of growth factor gene expression by epidermal-dermal cell interaction","volume":"122","author":"Smola","year":"1993","journal-title":"J. Cell Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/infdis\/jis244","article-title":"Staphylococcus aureus activation of caspase 1\/calpain signaling mediates invasion through human keratinocytes","volume":"205","author":"Soong","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1046\/j.1523-1747.1999.00573.x","article-title":"Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation","volume":"112","author":"Stark","year":"1999","journal-title":"J. Invest. Dermatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1251\/bpo72","article-title":"Organotypic cocultures as skin equivalents: a complex and sophisticated in vitro system","volume":"6","author":"Stark","year":"2004","journal-title":"Biol. Proced. Online"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.1073\/pnas.78.7.4097","article-title":"Characterization of a class of cationic proteins that specifically interact with intermediate filaments","volume":"78","author":"Steinert","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.2741\/E679","article-title":"Autophagy in epithelial homeostasis and defense","volume":"5","author":"Sukseree","year":"2013","journal-title":"Front. Biosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2147\/IDR.S12715","article-title":"Management of Chlamydia trachomatis genital tract infection: screening and treatment challenges","volume":"4","author":"Taylor","year":"2011","journal-title":"Infect. Drug Resist"},{"key":"B70","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1349-7006.1994.tb02088.x","article-title":"Growth and differentiation properties of normal and transformed human keratinocytes in organotypic culture","volume":"85","author":"Tsunenaga","year":"1994","journal-title":"Jpn. J. Cancer Res."},{"key":"B71","volume-title":"Global Incidence and Prevalence of Selected Curable Sexually Transmitted Infections\u20132008","year":"2014"},{"key":"B72","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/1523-1747.ep12470400","article-title":"Skin lipid content during early fetal development","volume":"91","author":"Williams","year":"1988","journal-title":"J. Invest. Dermatol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"S88","DOI":"10.1086\/652394","article-title":"Chlamydia trachomatis persistence in vitro: an overview","volume":"201","author":"Wyrick","year":"2010","journal-title":"J. Infect. Dis."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00438\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T22:23:50Z","timestamp":1693088630000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00438\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,10]]},"references-count":73,"alternative-id":["10.3389\/fcimb.2017.00438"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00438","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,10]]},"article-number":"438"}}