{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:59:04Z","timestamp":1788404344265,"version":"build-2803163510"},"reference-count":107,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2008\/053570-0"],"award-info":[{"award-number":["2008\/053570-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/26450-2"],"award-info":[{"award-number":["2013\/26450-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/11513-1"],"award-info":[{"award-number":["2014\/11513-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["INCT-EM\/CNPq 573959\/2008-0"],"award-info":[{"award-number":["INCT-EM\/CNPq 573959\/2008-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["MOBIARVE\/USP 12.1.17661.1.7"],"award-info":[{"award-number":["MOBIARVE\/USP 12.1.17661.1.7"]}],"id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00476","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T04:36:44Z","timestamp":1511239004000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Analysis of the Salivary Gland Transcriptome of Unfed and Partially Fed Amblyomma sculptum Ticks and Descriptive Proteome of the Saliva"],"prefix":"10.3389","volume":"7","author":[{"given":"Eliane","family":"Esteves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra R.","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa A.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adne A.","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco B.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Labruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"S\u00e1-Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M. C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a C.","family":"Foga\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.vetpar.2014.11.007","article-title":"Immunoprotective potential of a Rhipicephalus (Boophilus) microplus metalloprotease","volume":"207","author":"Ali","year":"2015","journal-title":"Vet. Parasitol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1186\/1471-2164-11-450","article-title":"An insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus","volume":"11","author":"Anatriello","year":"2010","journal-title":"BMC Genomics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1186\/1471-2164-9-552","article-title":"Exploring the mialome of ticks: an annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae)","volume":"9","author":"Anderson","year":"2008","journal-title":"BMC Genomics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1196\/annals.1374.044","article-title":"Brazilian spotted fever: a case series from an endemic area in southeastern Brazil: clinical aspects","volume":"1078","author":"Angerami","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1046\/j.1432-1327.1999.00406.x","article-title":"Primary structure and properties of the cathepsin G\/chymotrypsin inhibitor from the larval hemolymph of Apis mellifera","volume":"262","author":"Bania","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.vetpar.2011.11.026","article-title":"Expression profiling, gene silencing and transcriptional networking of metzincin metalloproteases in the cattle tick, Rhipicephalus (Boophilus) microplus","volume":"186","author":"Barnard","year":"2012","journal-title":"Vet. Parasitol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/nar\/28.1.263","article-title":"The Pfam protein families database","volume":"28","author":"Bateman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"B11","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1645\/0022-3395(2000)086[0516:IAMCOA]2.0.CO;2","article-title":"Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland","volume":"86","author":"Bergman","year":"2000","journal-title":"J. Parasitol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1017\/S0031182004006468","article-title":"Tick salivary glands: function, physiology and future","volume":"129","author":"Bowman","year":"2004","journal-title":"Parasitology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0960-9822(99)80312-1","article-title":"A missing metabolic pathway in the cattle tick Boophilus microplus","volume":"9","author":"Braz","year":"1999","journal-title":"Curr. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3201\/eid1705.101530","article-title":"Rickettsia rickettsii transmission by a lone star tick, North Carolina","volume":"17","author":"Breitschwerdt","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0147966","DOI":"10.1371\/journal.pone.0147966","article-title":"Temporal gene expression analysis and RNA silencing of single and multiple members of gene family in the lone star tick Amblyomma americanum","volume":"11","author":"Bullard","year":"2016","journal-title":"PLoS ONE"},{"key":"B16","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/arch.21118","article-title":"Characterization of a new Kunitz-type serine protease inhibitor from the hard tick Rhipicephalus hemaphysaloides","volume":"84","author":"Cao","year":"2013","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1128\/IAI.00362-10","article-title":"A Kunitz protease inhibitor from Dermacentor variabilis, a vector for spotted fever group rickettsiae, limits Rickettsia montanensis invasion","volume":"79","author":"Ceraul","year":"2011","journal-title":"Infect. Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.1128\/IAI.00866-08","article-title":"Functional characterization and novel rickettsiostatic effects of a Kunitz-type serine protease inhibitor from the tick Dermacentor variabilis","volume":"76","author":"Ceraul","year":"2008","journal-title":"Infect. Immun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/BF00694580","article-title":"Fat body is the site of vitellogenin synthesis in the soft tick, Ornithodoros moubata","volume":"155","author":"Chinzei","year":"1994","journal-title":"J. Comp. Physiol. B"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1016\/j.jprot.2012.04.026","article-title":"Tick salivary secretion as a source of antihemostatics","volume":"75","author":"Chmelar","year":"2012","journal-title":"J. Proteomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.pt.2015.10.002","article-title":"Sialomes and mialomes: a systems-biology view of tick tissues and tick-host interactions","volume":"32","author":"Chmelar","year":"","journal-title":"Trends Parasitol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.pt.2016.01.004","article-title":"All for one and one for all on the tick-host battlefield","volume":"32","author":"Chmelar","year":"","journal-title":"Trends Parasitol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3389\/fcimb.2017.00216","article-title":"Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction","volume":"7","author":"Chmelar","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1473-3099(07)70261-X","article-title":"Rocky Mountain spotted fever","volume":"7","author":"Dantas-Torres","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.pt.2012.07.003","article-title":"Ticks and tick-borne diseases: a one health perspective","volume":"28","author":"Dantas-Torres","year":"2012","journal-title":"Trends Parasitol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1111\/j.1742-4658.2008.06308.x","article-title":"A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus","volume":"275","author":"Decrem","year":"2008","journal-title":"FEBS J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1056\/NEJMoa050043","article-title":"Rocky Mountain spotted fever from an unexpected tick vector in Arizona","volume":"353","author":"Demma","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1084\/jem.20072689","article-title":"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity","volume":"205","author":"D\u00e9ruaz","year":"2008","journal-title":"J. Exp. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"B31","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.peptides.2005.07.013","article-title":"Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases","volume":"27","author":"Foga\u00e7a","year":"2006","journal-title":"Peptides"},{"key":"B32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.dci.2003.08.001","article-title":"Cysteine-rich antimicrobial peptides of the cattle tick Boophilus microplus: isolation, structural characterization and tissue expression profile","volume":"28","author":"Foga\u00e7a","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0006-291X(03)00857-X","article-title":"Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis","volume":"305","author":"Francischetti","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1160\/TH03-11-0715","article-title":"Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis","volume":"91","author":"Francischetti","year":"2004","journal-title":"Thromb. Haemost."},{"key":"B35","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1160\/TH04-09-0566","article-title":"Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis","volume":"94","author":"Francischetti","year":"","journal-title":"Thromb. Haemost."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.ibmb.2005.05.007","article-title":"The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae)","volume":"35","author":"Francischetti","year":"","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.2741\/3363","article-title":"The role of saliva in tick feeding","volume":"14","author":"Francischetti","year":"2009","journal-title":"Front. Biosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1182\/blood-2001-12-0237","article-title":"Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa\/tissue factor complex","volume":"99","author":"Francischetti","year":"2002","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"27250","DOI":"10.1074\/jbc.M704706200","article-title":"Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus","volume":"282","author":"Frauenschuh","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e77388","DOI":"10.1371\/journal.pone.0077388","article-title":"Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector","volume":"8","author":"Galletti","year":"2013","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1186\/1756-3305-7-430","article-title":"The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq","volume":"7","author":"Garcia","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B42","doi-asserted-by":"publisher","first-page":"D314","DOI":"10.1093\/nar\/gkm939","article-title":"KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007","volume":"36","author":"Gracy","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fcimb.2013.00026","article-title":"Interaction of the tick immune system with transmitted pathogens","volume":"3","author":"Hajdu\u0161ek","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B44","first-page":"41","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume-title":"Nucleic Acids Symposium Series","author":"Hall","year":"1999"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5021","DOI":"10.1016\/j.bmc.2005.04.085","article-title":"The chemistry and biology of mucin-type O-linked glycosylation","volume":"13","author":"Hang","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.cbpb.2006.12.008","article-title":"Molecular characterization and comparative study of 6 salivary gland metalloproteases from the hard tick, Haemaphysalis longicornis","volume":"147","author":"Harnnoi","year":"2007","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/07924259.1999.9652369","article-title":"Localization of vitellogenin production in the blacklegged tick, Ixodes scapularis (Acari: Ixodidae)","volume":"35","author":"James","year":"1999","journal-title":"Invertebr. Reprod. Dev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/bioinformatics\/8.3.275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Comput. Appl. Biosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2004","journal-title":"Parasitology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/glycob\/cwh151","article-title":"Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites","volume":"15","author":"Julenius","year":"2005","journal-title":"Glycobiology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0131292","DOI":"10.1371\/journal.pone.0131292","article-title":"An insight into the sialome of the lone star tick, Amblyomma americanum, with a glimpse on its time dependent gene expression","volume":"10","author":"Karim","year":"2015","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e28525","DOI":"10.1371\/journal.pone.0028525","article-title":"A deep insight into the sialotranscriptome of the gulf coast tick, Amblyomma maculatum","volume":"6","author":"Karim","year":"2011","journal-title":"PLoS ONE"},{"key":"B53","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fcimb.2013.00043","article-title":"Tick salivary compounds: their role in modulation of host defences and pathogen transmission","volume":"3","author":"Kazim\u00edrov\u00e1","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1017\/S0031182000000950","article-title":"Boophilus microplus: the effect of histamine on the attachment of cattle-tick larvae\u2013studies in vivo and in vitro","volume":"80","author":"Kemp","year":"1980","journal-title":"Parasitology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0004323","DOI":"10.1371\/journal.pntd.0004323","article-title":"Ixodes scapularis tick saliva proteins sequentially secreted every 24 h during blood feeding","volume":"10","author":"Kim","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1365-2567.2008.02890.x","article-title":"Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis","volume":"126","author":"Konnai","year":"2009","journal-title":"Immunology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jprot.2015.07.005","article-title":"Modulation of host immunity by tick saliva","volume":"128","author":"Kot\u00e1l","year":"2015","journal-title":"J. Proteomics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e0003754","DOI":"10.1371\/journal.pntd.0003754","article-title":"Deep sequencing analysis of the Ixodes ricinus haemocytome","volume":"9","author":"Kotsyfakis","year":"","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B59","doi-asserted-by":"publisher","first-page":"9103","DOI":"10.1038\/srep09103","article-title":"Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host","volume":"5","author":"Kotsyfakis","year":"","journal-title":"Sci. Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1749-6632.2009.04516.x","article-title":"Ecology of rickettsia in South America","volume":"1166","author":"Labruna","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0304-4017(01)00387-9","article-title":"Risk factors to tick infestations and their occurrence on horses in the state of Sao Paulo, Brazil","volume":"97","author":"Labruna","year":"2001","journal-title":"Vet. Parasitol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1096\/fj.03-1154fje","article-title":"A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum","volume":"18","author":"Lai","year":"2004","journal-title":"FASEB J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1016\/S0965-1748(02)00162-5","article-title":"Binding and storage of heme by vitellin from the cattle tick, Boophilus microplus","volume":"32","author":"Logullo","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ibmb.2007.09.003","article-title":"Comparative sialomics between hard and soft ticks: implications for the evolution of blood-feeding behavior","volume":"38","author":"Mans","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/nar\/30.1.281","article-title":"CDD: a database of conserved domain alignments with links to domain three-dimensional structure","volume":"30","author":"Marchler-Bauer","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fcimb.2017.00129","article-title":"The distinct transcriptional response of the midgut of Amblyomma sculptum and Amblyomma aureolatum ticks to Rickettsia rickettsii correlates to their differences in susceptibility to infection","volume":"7","author":"Martins","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/1471-2164-11-363","article-title":"The expression of genes coding for distinct types of glycine-rich proteins varies according to the biology of three metastriate ticks, Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus and Amblyomma cajennense","volume":"11","author":"Maruyama","year":"2010","journal-title":"BMC Genomics"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.ijpara.2014.07.003","article-title":"Proteomics informed by transcriptomics identifies novel secreted proteins in Dermacentor andersoni saliva","volume":"44","author":"Mudenda","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ttbdis.2013.11.004","article-title":"Reassessment of the taxonomic status of Amblyomma cajennense () with the description of three new species, Amblyomma tonelliae n. sp., Amblyomma interandinum n. sp. and Amblyomma patinoi n. sp., and reinstatement of Amblyomma mixtum, and Amblyomma sculptum (Ixodida: Ixodidae). ticks and tick-borne diseases","author":"Nava","year":"2014"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.ibmb.2004.07.002","article-title":"Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva","volume":"34","author":"Nene","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/S0020-7519(02)00159-5","article-title":"AvGI, an index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatum","volume":"32","author":"Nene","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/protein\/10.1.1","article-title":"Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"B74","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ttbdis.2013.05.001","article-title":"Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine","volume":"4","author":"Oliveira","year":"2013","journal-title":"Ticks Tick Borne Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2915.2003.00459.x","article-title":"Seasonal dynamics of the cayenne tick, Amblyomma cajennense on horses in Brazil","volume":"17","author":"Oliveira","year":"2003","journal-title":"Med. Vet. Entomol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1756-3305-6-16","article-title":"Vector-borne helminths of dogs and humans in Europe","volume":"6","author":"Otranto","year":"2013","journal-title":"Parasit. Vectors"},{"key":"B77","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S1097-2765(00)80359-7","article-title":"Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure","volume":"3","author":"Paesen","year":"1999","journal-title":"Mol. Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1017\/S0031182000050617","article-title":"In vitro feeding of Dermacentor andersoni (Stiles): effects of histamine and other mediators","volume":"86","author":"Paine","year":"1983","journal-title":"Parasitology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1093\/molbev\/msv093","article-title":"Comparative genomics reveals the origins and diversity of arthropod immune systems","volume":"32","author":"Palmer","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"B81","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0304-4017(01)00650-1","article-title":"The sex ratio of Amblyomma cajennense (Acari: Ixodidae) with notes on the male feeding period in the laboratory","volume":"105","author":"Pinter","year":"2002","journal-title":"Vet. Parasitol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.dci.2012.10.005","article-title":"Structure and function of invertebrate Kunitz serine protease inhibitors","volume":"39","author":"Ranasinghe","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks","volume":"36","author":"Ribeiro","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.0962-1075.2004.00503.x","article-title":"AnoXcel: an Anopheles gambiae protein database","volume":"13","author":"Ribeiro","year":"2004","journal-title":"Insect Mol. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0020-7519(05)80012-8","article-title":"The role of the fat body, midgut and ovary in vitellogenin production and vitellogenesis in the female tick, Dermacentor variabilis","volume":"22","author":"Rosell","year":"1992","journal-title":"Int. J. Parasitol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1385\/1-59259-192-2:365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1046\/j.0962-1075.2001.00311.x","article-title":"A high affinity serotonin- and histamine-binding lipocalin from tick saliva","volume":"11","author":"Sangamnatdej","year":"2002","journal-title":"Insect Mol. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.biochi.2004.09.010","article-title":"Boophilus microplus tick larvae, a rich source of Kunitz type serine proteinase inhibitors","volume":"86","author":"Sasaki","year":"2004","journal-title":"Biochimie"},{"key":"B89","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/nar\/28.1.231","article-title":"SMART: a web-based tool for the study of genetically mobile domains","volume":"28","author":"Schultz","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B90","doi-asserted-by":"publisher","first-page":"34735","DOI":"10.1074\/jbc.M109.016410","article-title":"Structure and mode of action of microplusin, a copper II chelating antimicrobial peptide from the cattle tick Rhipicephalus (Boophilus) Microplus","volume":"284","author":"Silva","year":"2009","journal-title":"J. Biol. Chem"},{"key":"B91","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1574-6968.2011.02386.x","article-title":"Effects of microplusin, a copper-chelating antimicrobial peptide, against Cryptococcus neoformans","volume":"324","author":"Silva","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"B92","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fcimb.2017.00281","article-title":"The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission","volume":"7","author":"\u0160imo","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.vetpar.2008.12.010","article-title":"Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense","volume":"161","author":"Souza","year":"2009","journal-title":"Vet. Parasitol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fcimb.2013.00027","article-title":"Ecology, biology and distribution of spotted-fever tick vectors in Brazil","volume":"3","author":"Szab\u00f3","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0014-4894(69)90130-1","article-title":"Boophilus microplus: antihistaminic and tranquilizing drugs and cattle resistance","volume":"26","author":"Tatchell","year":"1969","journal-title":"Exp. Parasitol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-2105-4-41","article-title":"The COG database: an updated version includes eukaryotes","volume":"4","author":"Tatusov","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"B98","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/0020-1790(91)90113-S","article-title":"Vitellogenin synthesis, processing and hormonal regulation in the tick, Ornithodoros parkeri (ACARI: ARGASIDAE)","volume":"21","author":"Taylor","year":"1991","journal-title":"Insect Biochem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0304-4017(01)00573-8","article-title":"Reduced oviposition of Boophilus microplus feeding on sheep vaccinated with vitellin","volume":"103","author":"Tellam","year":"2002","journal-title":"Vet. Parasitol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ibmb.2007.01.004","article-title":"Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration","volume":"37","author":"Thompson","year":"2007","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e94831","DOI":"10.1371\/journal.pone.0094831","article-title":"Proteomic analysis of cattle tick Rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged females","volume":"9","author":"Tirloni","year":"2014","journal-title":"PLoS ONE"},{"key":"B102","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1242\/jeb.205.18.2843","article-title":"Exploring the sialome of the tick Ixodes scapularis","volume":"205","author":"Valenzuela","year":"2002","journal-title":"J. Exp. Biol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1365-3024.2010.01203.x","article-title":"Evasin-3-like anti-chemokine activity in salivary gland extracts of ixodid ticks during blood-feeding: a new target for tick control","volume":"32","author":"Vancov\u00e1","year":"2010","journal-title":"Parasite Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1086\/518145","article-title":"Rickettsiae and rickettsial infections: the current state of knowledge","volume":"45","author":"Walker","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"B105","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13659-015-0069-z","article-title":"A novel trypsin inhibitor-like cysteine-rich peptide from the frog Lepidobatrachus laevis containing proteinase inhibiting activity","volume":"5","author":"Wang","year":"2015","journal-title":"Nat. Prod. Bioprospect"},{"key":"B106","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/00034983.1982.11687525","article-title":"Histamine content of tick attachment sites and the effects of H1 and H2 histamine antagonists on the expression of resistance","volume":"76","author":"Wikel","year":"1982","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"B107","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-1-4832-2734-4.50017-6","article-title":"Evolutionary divergence and convergence in proteins","volume-title":"Evolving Genes and Proteins","author":"Zuckerkandl","year":"1965"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00476\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T20:30:47Z","timestamp":1719606647000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00476\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":107,"alternative-id":["10.3389\/fcimb.2017.00476"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00476","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,21]]},"article-number":"476"}}