{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:35:19Z","timestamp":1776447319256,"version":"3.51.2"},"reference-count":82,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/BI\/25\/015\/2012(BIF)"],"award-info":[{"award-number":["BT\/BI\/25\/015\/2012(BIF)"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["F.4-1\/2006(BSR)\/7-326\/2011(BSR)"],"award-info":[{"award-number":["F.4-1\/2006(BSR)\/7-326\/2011(BSR)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["UGC-BSR faculty fellow"],"award-info":[{"award-number":["UGC-BSR faculty fellow"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00498","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T04:26:58Z","timestamp":1512448018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Exploring the Anti-quorum Sensing and Antibiofilm Efficacy of Phytol against Serratia marcescens Associated Acute Pyelonephritis Infection in Wistar Rats"],"prefix":"10.3389","volume":"7","author":[{"given":"Ramanathan","family":"Srinivasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramar","family":"Mohankumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunachalam","family":"Kannappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veeramani","family":"Karthick Raja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govindaraju","family":"Archunan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunmugiah","family":"Karutha Pandian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandasamy","family":"Ruckmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arumugam","family":"Veera Ravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.18875\/2375-6713.1.105","article-title":"Bacterial biofilm: dispersal and inhibition strategies","volume":"1","author":"Abdel-Aziz","year":"2014","journal-title":"SaJ Biotechnol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000054028","article-title":"The role of RsmA in the regulation of swarming motility in Serratia marcescens","volume":"8","author":"Ang","year":"2001","journal-title":"J. Biomed. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.fct.2015.12.010","article-title":"RIFM fragrance ingredient safety assessment, \u03b1-Ionone, CAS Registry Number 127-41-3","volume":"97","author":"Api","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3389\/fmicb.2015.00832","article-title":"Development of a biofilm inhibitor molecule against multidrug resistant Staphylococcus aureus associated with gestational urinary tract infections","volume":"6","author":"Balamurugan","year":"2015","journal-title":"Front Microbiol."},{"key":"B5","first-page":"111","article-title":"A survey on urinary tract infections associated with the three most common uropathogenic bacteria","volume":"5","author":"Behzadi","year":"2010","journal-title":"Maedica"},{"key":"B6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/laban0411-111","article-title":"Urethral catheterization of the female rat","volume":"40","author":"Brown","year":"2011","journal-title":"Lab. Anim"},{"key":"B7","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jmii.2011.11.007","article-title":"Proteus mirabilis urinary tract infection and bacteremia: risk factors, clinical presentation, and outcomes","volume":"45","author":"Chen","year":"2012","journal-title":"J. Microbiol. Immunol. Infect"},{"key":"B8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.11604\/pamj.2017.26.134.7827","article-title":"Antibiogram profile of uropathogens isolated at Bahir Dar Regional Health Research Laboratory Centre, Northwest Ethiopia","volume":"26","author":"Derbie","year":"2017","journal-title":"Pan. Afr. Med. J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1128\/IAI.01682-14","article-title":"Serratia marcescens ShlA pore-forming toxin is responsible for early induction of autophagy in host cells and is transcriptionally regulated by RcsB","volume":"82","author":"Di Venanzio","year":"2014","journal-title":"Infect. Immun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1365-2958.1996.tb02495.x","article-title":"Involvement of N-acyl-l-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens","volume":"20","author":"Eberl","year":"1996","journal-title":"Mol. Microbiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0378-1135(87)90090-3","article-title":"Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink","volume":"13","author":"Elsheikh","year":"1987","journal-title":"Vet Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0891-5520(03)00005-9","article-title":"Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costs","volume":"17","author":"Foxman","year":"2003","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B13","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1128\/IAI.01822-14","article-title":"Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia","volume":"83","author":"Gonz\u00e1lez-Juarbe","year":"2015","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1128\/JB.00352-10","article-title":"PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules","volume":"193","author":"Gristwood","year":"2011","journal-title":"J. Bacteriol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0255-0857.108715","article-title":"Multiple virulence factors regulated by quorum sensing may help in establishment and colonisation of urinary tract by Pseudomonas aeruginosa during experimental urinary tract infection","volume":"31","author":"Gupta","year":"","journal-title":"Ind. J. Med. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10753-013-9650-y","article-title":"Quorum sensing signal molecules produced by Pseudomonas aeruginosa cause inflammation and escape host factors in murine model of urinary tract infection","volume":"36","author":"Gupta","year":"","journal-title":"Inflammation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s10482-016-0755-9","article-title":"Rhl quorum sensing affects the virulence potential of Pseudomonas aeruginosa in an experimental urinary tract infection","volume":"109","author":"Gupta","year":"2016","journal-title":"Antonie Leeuwenhoek"},{"key":"B18","doi-asserted-by":"publisher","first-page":"456463","DOI":"10.1155\/2015\/456463","article-title":"Effect of tyrosol and farnesol on virulence and antibiotic resistance of clinical isolates of Pseudomonas aeruginosa","volume":"2015","author":"Hassan Abdel-Rhman","year":"2015","journal-title":"BioMed. Res. Int"},{"key":"B19","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1099\/00222615-46-11-903","article-title":"Serratia marcescens","volume":"46","author":"Hejazi","year":"1997","journal-title":"J. Med. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1099\/00221287-146-10-2395","article-title":"Quantification of biofilm structures by the novel computer program COMSTAT","volume":"146","author":"Heydorn","year":"2000","journal-title":"Microbiology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1139\/y72-069","article-title":"Fate of 14 C-phytoI Administered Orally to Sheep","volume":"50","author":"Hidiroglou","year":"1972","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1128\/jb.170.9.4141-4146.1988","article-title":"Genetic analysis of extracellular proteins of Serratia marcescens","volume":"170","author":"Hines","year":"1988","journal-title":"J. Bacteriol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0076-6879(67)11047-1","article-title":"[45] Glycopeptides","volume":"11","author":"Hirs","year":"1967","journal-title":"Methods Enzymol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1046\/j.1365-2958.2002.03117.x","article-title":"The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescens","volume":"45","author":"Horng","year":"2002","journal-title":"Mol. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1128\/AAC.44.1.156-163.2000","article-title":"Development of a long-term ascending urinary tract infection mouse model for antibiotic treatment studies","volume":"44","author":"Hvidberg","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1128\/AAC.49.5.1770-1774.2005","article-title":"Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus","volume":"49","author":"Inoue","year":"2005","journal-title":"Antimicrob. Agents Chemother"},{"key":"B27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jip.2014.02.001","article-title":"Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori","volume":"117","author":"Ishii","year":"2014","journal-title":"J Invertebr Pathol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cbi.2015.07.010","article-title":"Phytol in a pharma-medico-stance","volume":"240","author":"Islam","year":"2015","journal-title":"Chem. Biol. Interact"},{"key":"B29","doi-asserted-by":"publisher","first-page":"R561","DOI":"10.1016\/j.cub.2007.04.050","article-title":"Bacterial swarming: a re-examination of cell-movement patterns","volume":"17","author":"Kaiser","year":"2007","journal-title":"Curr. Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.micpath.2017.07.016","article-title":"Antibiofilm activity of Vetiveria zizanioides root extract against methicillin-resistant Staphylococcus aureus","volume":"110","author":"Kannappan","year":"2017","journal-title":"Microb. Pathog"},{"key":"B31","first-page":"381","article-title":"Community acquired quinolone-resistant Escherichia coli pyelonephritis complicated with multiple renal abscesses: a case report","volume":"16","author":"Katsiari","year":"2012","journal-title":"Hippokratia."},{"key":"B32","doi-asserted-by":"publisher","first-page":"DC01","DOI":"10.7860\/JCDR\/2014\/8772.4919","article-title":"Urinary tract infection: aetiology and antimicrobial resistance pattern in infants from A Tertiary Care Hospital in North India","volume":"8","author":"Kaur","year":"2014","journal-title":"J. Clin. Diagn. Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1128\/IAI.01239-06","article-title":"Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2","volume":"75","author":"Kida","year":"2007","journal-title":"Infect. Immun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e3678","DOI":"10.3791\/3678","article-title":"Investigating intestinal inflammation in DSS-induced model of IBD","author":"Kim","year":"2012","journal-title":"J. Vis. Exp."},{"key":"B35","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.diagmicrobio.2013.04.006","article-title":"Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea","volume":"76","author":"Kim","year":"2013","journal-title":"Diagn. Microbiol. Infect. Dis"},{"key":"B36","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1177\/0897190016679760","article-title":"A case of septic shock due to Serratia marcescens pyelonephritis and bacteremia in a patient receiving empagliflozin","volume":"30","author":"Kufel","year":"2016","journal-title":"J. Pharm. Pract."},{"key":"B37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/ki.2009.183","article-title":"Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection","volume":"76","author":"Kumar","year":"2009","journal-title":"Kidney Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1093\/emboj\/cdg159","article-title":"Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening","volume":"22","author":"Kurz","year":"2003","journal-title":"EMBO J"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1128\/JB.01582-06","article-title":"Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent","volume":"189","author":"Labbate","year":"2007","journal-title":"J. Bacteriol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/j.1469-0691.2011.03703.x","article-title":"EUCAST expert rules in antimicrobial susceptibility testing","volume":"19","author":"Leclercq","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"B41","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.diagmicrobio.2005.04.012","article-title":"Prevalence of decreased susceptibility to carbapenems among Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii and investigation of carbapenemases","volume":"52","author":"Lee","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1080\/10715762.2016.1241395","article-title":"Phytol has antibacterial property by inducing oxidative stress response in Pseudomonas aeruginosa","volume":"50","author":"Lee","year":"2016","journal-title":"Free Radic Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1476-8518-4-6","article-title":"Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses","volume":"4","author":"Lim","year":"2006","journal-title":"J. Immune Based Ther. Vaccines"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1128\/IAI.00661-10","article-title":"RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens","volume":"78","author":"Lin","year":"2010","journal-title":"Infect Immun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jmii.2013.04.003","article-title":"A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan","volume":"47","author":"Liou","year":"2014","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"B46","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1159\/000025483","article-title":"Role of flhDC in the expression of the nuclease gene nucA, cell division and flagellar synthesis in Serratia marcescens","volume":"7","author":"Liu","year":"2000","journal-title":"J. Biomed. Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"135625","DOI":"10.1155\/2008\/135625","article-title":"Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes","volume":"2008","author":"Loria","year":"2008","journal-title":"Mediat. Inflamm."},{"key":"B48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1128\/IAI.40.1.113-119.1983","article-title":"Importance of serratia protease in the pathogenesis of experimental Serratia marcescens pneumonia","volume":"40","author":"Lyerly","year":"1983","journal-title":"Infect Immun"},{"key":"B49","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1177\/0192623308330789","article-title":"Phytol-induced hepatotoxicity in mice","volume":"37","author":"Mackie","year":"2009","journal-title":"Toxicol. Pathol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1016\/j.fct.2009.11.012","article-title":"Fragrance material review on phytol","volume":"48","author":"McGinty","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1097\/00004630-199609000-00003","article-title":"Endothelin-1, interleukin-6, and interleukin-8 levels increase in patients with burns","volume":"17","author":"McMillen","year":"1996","journal-title":"J. Burn. Care Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jiph.2009.08.003","article-title":"Urinary tract infections caused by Pseudomonas aeruginosa: a minireview","volume":"2","author":"Mittal","year":"2009","journal-title":"J. Infect. Public Health."},{"key":"B53","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1464-410X.1987.tb04573.x","article-title":"An ecological study of infected urinary stone genesis in an animal model","volume":"59","author":"Nickel","year":"1987","journal-title":"BJU Int."},{"key":"B54","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.resmic.2010.03.002","article-title":"Bacillus pumilus of Palk Bay origin inhibits quorum-sensing-mediated virulence factors in Gram-negative bacteria","volume":"161","author":"Nithya","year":"2010","journal-title":"Res. Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.2169\/internalmedicine.42.1144","article-title":"A patient with E. coli-induced pyelonephritis and sepsis who transiently exhibited symptoms associated with primary biliary cirrhosis","volume":"42","author":"Ohno","year":"2003","journal-title":"Intern. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"10177","DOI":"10.1007\/s00253-013-4704-5","article-title":"Prevention of quorum-sensing-mediated biofilm development and virulence factors production in Vibrio spp. by curcumin","volume":"97","author":"Packiavathy","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1080\/08927014.2014.972386","article-title":"Phenol, 2, 4-bis (1, 1-dimethylethyl) of marine bacterial origin inhibits quorum sensing mediated biofilm formation in the uropathogen Serratia marcescens","volume":"30","author":"Padmavathi","year":"2014","journal-title":"Biofouling"},{"key":"B59","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1080\/14786419.2014.945088","article-title":"In vitro anti-quorum sensing activity of phytol","volume":"29","author":"Pejin","year":"2015","journal-title":"Nat. Prod. Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1080\/14786419.2013.869692","article-title":"Further in vitro evaluation of antiradical and antimicrobial activities of phytol","volume":"28","author":"Pejin","year":"2014","journal-title":"Nat. Prod. Res"},{"key":"B61","first-page":"933","article-title":"Diagnosis and management of acute pyelonephritis in adults","volume":"71","author":"Ramakrishnan","year":"2005","journal-title":"Am. Fam. Physician"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1128\/JB.187.10.3477-3485.2005","article-title":"Biofilm formation and sloughing in Serratia marcescens are controlled by quorum sensing and nutrient cues","volume":"187","author":"Rice","year":"2005","journal-title":"J. Bacteriol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1365-3024.1994.tb00346.x","article-title":"Possible role of nitric oxide in malarial immunosuppression","volume":"16","author":"Rockett","year":"1994","journal-title":"Parasite Immunol."},{"key":"B64","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1128\/IAI.67.11.5854-5862.1999","article-title":"Contribution of quorum sensing to the virulence of pseudomonas aeruginosa in burn wound infections","volume":"67","author":"Rumbaugh","year":"1999","journal-title":"Infect. Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jss.2003.08.009","article-title":"Cytokine induction by the P. aeruginosa quorum sensing system during thermal injury","volume":"116","author":"Rumbaugh","year":"2004","journal-title":"J. Surg. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1055\/s-0030-1250119","article-title":"Anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp in mice","volume":"77","author":"Ryu","year":"2011","journal-title":"Planta Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijmm.2015.11.002","article-title":"Divalent flagellin immunotherapy provides homologous and heterologous protection in experimental urinary tract infections in mice","volume":"306","author":"Sabharwal","year":"2016","journal-title":"Int. J. Med. Microbiol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.ijantimicag.2014.11.008","article-title":"Azithromycin and ciprofloxacin: a possible synergistic combination against Pseudomonas aeruginosa biofilm-associated urinary tract infections","volume":"45","author":"Saini","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B69","doi-asserted-by":"publisher","first-page":"ftv038","DOI":"10.1093\/femspd\/ftv038","article-title":"Interference of quorum sensing in urinary pathogen Serratia marcescens by Anethum graveolens","volume":"73","author":"Salini","year":"2015","journal-title":"Pathog. Dis"},{"key":"B70","doi-asserted-by":"publisher","first-page":"949452","DOI":"10.1155\/2013\/949452","article-title":"Antinociceptive and antioxidant activities of phytol in vivo and in vitro models","volume":"2013","author":"Santos","year":"2013","journal-title":"Neurosci. J"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21691401.2017.1391822","article-title":"Phytol-loaded PLGA nanoparticle as a modulator of Alzheimer's toxic A\u03b2 peptide aggregation and fibrillation associated with impaired neuronal cell function","author":"Sathya","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e57634","DOI":"10.1371\/journal.pone.0057634","article-title":"A Serratia marcescens PigP homolog controls prodigiosin biosynthesis, swarming motility and hemolysis and is regulated by cAMP-CRP and HexS","volume":"8","author":"Shanks","year":"2013","journal-title":"PLoS ONE"},{"key":"B73","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/1471-2180-9-261","article-title":"The hemolytic and cytolytic activities of Serratia marcescens phospholipase A (PhlA) depend on lysophospholipid production by PhlA","volume":"9","author":"Shimuta","year":"2009","journal-title":"BMC Microbiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijfoodmicro.2016.08.021","article-title":"Morin inhibits biofilm production and reduces the virulence of Listeria monocytogenes-An in vitro and in vivo approach","volume":"237","author":"Sivaranjani","year":"2016","journal-title":"Int. J. Food Microbiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.resmic.2013.10.005","article-title":"ManA is regulated by RssAB signaling and promotes motility in Serratia marcescens","volume":"165","author":"Soo","year":"2014","journal-title":"Res. Microbiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.jep.2016.10.017","article-title":"Piper betle and its bioactive metabolite phytol mitigates quorum sensing mediated virulence factors and biofilm of nosocomial pathogen Serratia marcescens in vitro","volume":"193","author":"Srinivasan","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-017-0971-y","article-title":"Inhibition of quorum sensing-dependent biofilm and virulence genes expression in environmental pathogen Serratia marcescens by petroselinic acid","author":"Srinivasan","year":"","journal-title":"Antonie van Leeuwenhoek."},{"key":"B78","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.micpath.2017.07.001","article-title":"In vitro antibiofilm efficacy of Piper betle against quorum sensing mediated biofilm formation of luminescent Vibrio harveyi","volume":"110","author":"Srinivasan","year":"","journal-title":"Microb. Pathog"},{"key":"B79","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.1128\/JCM.41.10.4726-4732.2003","article-title":"Extended epidemic of nosocomial urinary tract infections caused by Serratia marcescens","volume":"41","author":"Su","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/08927014.2015.1137289","article-title":"Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis","volume":"32","author":"Vadekeetil","year":"2016","journal-title":"Biofouling"},{"key":"B81","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1074\/jbc.272.12.7617","article-title":"Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite a potential additional mechanism of nitric oxide-dependent toxicity","volume":"272","author":"Van Der Vliet","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B82","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/BF02067111","article-title":"The role of mediators in the response to thermal injury","volume":"16","author":"Youn","year":"1992","journal-title":"World J. Surg."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00498\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T19:18:37Z","timestamp":1603480717000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00498\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,5]]},"references-count":82,"alternative-id":["10.3389\/fcimb.2017.00498"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00498","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,5]]},"article-number":"498"}}