{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:48:26Z","timestamp":1790711306528,"version":"4.1.0"},"reference-count":115,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["12-CSP-C03-065"],"award-info":[{"award-number":["12-CSP-C03-065"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2017.00536","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T04:36:35Z","timestamp":1515645395000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Differential Effects of Iron, Zinc, and Copper on Dictyostelium discoideum Cell Growth and Resistance to Legionella pneumophila"],"prefix":"10.3389","volume":"7","author":[{"given":"Simona","family":"Buracco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Peracino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Andreini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Bozzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e26325","DOI":"10.1371\/journal.pone.0026325","article-title":"Minimal functional sites allow a classification of zinc sites in proteins","volume":"6","author":"Andreini","year":"2011","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00775-008-0404-5","article-title":"Metal ions in biological catalysis: from enzyme databases to general principles","volume":"13","author":"Andreini","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1189\/jlb.0206079","article-title":"Macrophage nutriprive antimicrobial mechanisms","volume":"79","author":"Appelberg","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/jn\/120.12.1692","article-title":"Respiratory burst and candidacidal activity of peritoneal macrophages are impaired in copper-deficient rats","volume":"120","author":"Babu","year":"1990","journal-title":"J. Nutr."},{"key":"B5","first-page":"1137","article-title":"A novel bioassay for evaluating soil bio-hazards using Dictyostelium as biosensor: validation and application to the Bio-Bio project","volume":"17","author":"Balbo","year":"2008","journal-title":"Fresenius Environ. Bull."},{"key":"B6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/AEM.64.1.279-286.1998","article-title":"Production of respirable vesicles containing live Legionella pneumophila cells by two Acanthamoeba spp","volume":"64","author":"Berk","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00775-016-1335-1","article-title":"The Yin and Yang of copper during infection","volume":"21","author":"Besold","year":"2016","journal-title":"J. Biol. Inorg. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.jnutbio.2015.08.002","article-title":"Cellular sensing and transport of metal ions: implications in micronutrient homeostasis","volume":"26","author":"Bird","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.autrev.2014.11.008","article-title":"Zinc and its role in immunity and inflammation","volume":"14","author":"Bonaventura","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.chom.2011.08.006","article-title":"Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages","volume":"10","author":"Botella","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B11","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.tim.2012.01.005","article-title":"Metallobiology of host-pathogen interactions: an intoxicating new insight","volume":"20","author":"Botella","year":"2012","journal-title":"Trends Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1937-6448(08)01206-9","article-title":"Phagocytosis and host\u2013pathogen interactions in dictyostelium with a look at macrophages","volume":"271","author":"Bozzaro","year":"2008","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fcimb.2013.00050","article-title":"Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum","volume":"3","author":"Bozzaro","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"942","DOI":"10.2174\/138945011795677782","article-title":"The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens","volume":"12","author":"Bozzaro","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"B15","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/978-1-62703-161-5_26","article-title":"Dictyostelium host response to legionella infection: strategies and assays","volume":"954","author":"Bozzaro","year":"","journal-title":"Methods Mol. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbpa.2013.12.021","article-title":"Recent developments in copper and zinc homeostasis in bacterial pathogens","volume":"19","author":"Braymer","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fcimb.2017.00282","article-title":"Nramp1 and NrampB contribute to resistance against francisella in Dictyostelium","volume":"7","author":"Brenz","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3304","DOI":"10.1242\/jcs.173153","article-title":"Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux","volume":"128","author":"Buracco","year":"2015","journal-title":"J. Cell Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7831","DOI":"10.1021\/ja010059l","article-title":"Fluorescent Sensors for Zn 2+ based on a Fluorescein platform: synthesis, properties and intracellular distribution","volume":"123","author":"Burdette","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"B20","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1006\/bbrc.2002.6463","article-title":"Occurrence of {Cu-ATPase} in Dictyostelium: possible role in resistance to copper","volume":"291","author":"Burlando","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"20858","DOI":"10.1074\/jbc.R116.742023","article-title":"Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface","volume":"291","author":"Capdevila","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev.micro.61.080706.093305","article-title":"Evolution of intracellular pathogens","volume":"62","author":"Casadevall","year":"2008","journal-title":"Annu. Rev. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/978-1-4614-0106-3_19","article-title":"Nutritional immunity: homology modeling of Nramp metal import","volume":"946","author":"Cellier","year":"2012","journal-title":"Adv. Exp. Med. Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fcimb.2013.00108","article-title":"Competition for zinc binding in the host-pathogen interaction","volume":"3","author":"Cerasi","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fcimb.2014.00003","article-title":"Pathogenic adaptations to host-derived antibacterial copper","volume":"4","author":"Chaturvedi","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1126\/science.1094226","article-title":"Legionella effectors that promote nonlytic release from protozoa","volume":"303","author":"Chen","year":"2004","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2217\/fmb.15.21","article-title":"An update on iron acquisition by Legionella pneumophila: new pathways for siderophore uptake and ferric iron reduction","volume":"10","author":"Cianciotto","year":"2015","journal-title":"Future Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"C726","DOI":"10.1152\/ajpcell.00541.2007","article-title":"Insights into Zn2+ homeostasis in neurons from experimental and modeling studies","volume":"294","author":"Colvin","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mib.2008.05.005","article-title":"Eat, kill or die: when amoeba meets bacteria","volume":"11","author":"Cosson","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1139\/o06-193","article-title":"Recent progress in structure\u2013function analyses of Nramp proton-dependent metal-ion transporters","volume":"84","author":"Courville","year":"2006","journal-title":"Biochem. Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1073\/pnas.1121286109","article-title":"The protein SdhA maintains the integrity of the Legionella-containing vacuole","volume":"109","author":"Creasey","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"18954","DOI":"10.1074\/jbc.R115.647099","article-title":"The role of copper and zinc toxicity in innate immune defense against bacterial pathogens","volume":"290","author":"Djoko","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1039\/c1mt00107h","article-title":"Copper toxicity and the origin of bacterial resistance\u2014new insights and applications","volume":"3","author":"Dupont","year":"2011","journal-title":"Metallomics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s00248-013-0189-0","article-title":"The rise of pathogens: predation as a factor driving the evolution of human pathogens in the environment","volume":"65","author":"Erken","year":"2013","journal-title":"Microb. Ecol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1099\/mic.0.27111-0","article-title":"Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum","volume":"150","author":"Fajardo","year":"2004","journal-title":"Microbiology"},{"key":"B36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/JCM.10.4.437-441.1979","article-title":"Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila","volume":"10","author":"Feeley","year":"1979","journal-title":"J. Clin. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"R877","DOI":"10.1016\/j.cub.2011.09.040","article-title":"Copper: an essential metal in biology","volume":"21","author":"Festa","year":"2011","journal-title":"Curr. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1039\/C3MT00283G","article-title":"Selectivity and specificity of small molecule fluorescent dyes\/probes used for the detection of Zn2+ and Ca2+ in cells","volume":"6","author":"Figueroa","year":"2014","journal-title":"Metallomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00394-011-0256-6","article-title":"Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels","volume":"51","author":"Fiorito","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.febslet.2004.09.084","article-title":"A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium","volume":"577","author":"Fischer","year":"2004","journal-title":"FEBS Lett."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1182\/blood-2003-02-0425","article-title":"Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane","volume":"102","author":"Forbes","year":"2003","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1073\/pnas.74.5.2157","article-title":"A defined minimal medium for axenic strains of Dictyostelium discoideum","volume":"74","author":"Franke","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nprot.2008.212","article-title":"Dictyostelium discoideum: a model host to measure bacterial virulence","volume":"4","author":"Froquet","year":"2008","journal-title":"Nat. Protoc."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.MCHD-0050-2016","article-title":"Evolution of cell-autonomous effector mechanisms in macrophages versus non-immune cells","volume":"4","author":"Gaudet","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"18377","DOI":"10.1074\/jbc.M109.001503","article-title":"Severe zinc depletion of Escherichia coli","volume":"284","author":"Graham","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1128\/CMR.17.2.413-433.2004","article-title":"Microorganisms resistant to free-living amoebae","volume":"17","author":"Greub","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1111\/j.1462-5822.2007.00993.x","article-title":"Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection","volume":"9","author":"Hagedorn","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1046\/j.1462-5822.2000.00044.x","article-title":"Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella","volume":"2","author":"H\u00e4gele","year":"2000","journal-title":"Cell. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/mmi.13483","article-title":"A role for copper in protozoan grazing \u2013 two billion years selecting for bacterial copper resistance","volume":"102","author":"Hao","year":"2016","journal-title":"Mol Microbiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/j.1462-2920.2007.01238.x","article-title":"Environmental predators as models for bacterial pathogenesis","volume":"9","author":"Hilbi","year":"2007","journal-title":"Environ. Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/cmi.12235","article-title":"The natural alternative: protozoa as cellular models for Legionella infection","volume":"16","author":"Hoffmann","year":"2014","journal-title":"Cell. Microbiol."},{"key":"B52","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.158.4.1319","article-title":"Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes","volume":"158","author":"Horwitz","year":"1983","journal-title":"J. Exp. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2958.2004.04109.x","article-title":"Disruption of the peroxisomal citrate synthase CshA affects cell growth and multicellular development in Dictyostelium discoideum","volume":"53","author":"Huang","year":"2004","journal-title":"Mol. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"28121","DOI":"10.1074\/jbc.R114.588814","article-title":"The mismetallation of enzymes during oxidative stress","volume":"289","author":"Imlay","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1152\/physrev.00035.2014","article-title":"The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism","volume":"95","author":"Kambe","year":"2015","journal-title":"Physiol. Rev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1472-6793-4-4","article-title":"Detecting and minimizing zinc contamination in physiological solutions","volume":"4","author":"Kay","year":"2004","journal-title":"BMC Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.cbpa.2009.11.008","article-title":"Nutritional immunity beyond iron: a role for manganese and zinc","volume":"14","author":"Kehl-Fie","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0168-6445(03)00052-4","article-title":"Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria","volume":"27","author":"Kehres","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s00775-006-0150-5","article-title":"Zinc-buffering capacity of a eukaryotic cell at physiological pZn","volume":"11","author":"Krezel","year":"2006","journal-title":"J. Biol. Inorg. Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1006\/excr.1994.1269","article-title":"Specific induction by zinc of Dictyostelium stalk cell differentiation","volume":"214","author":"Kubohara","year":"1994","journal-title":"Exp. Cell Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1365-2672.2009.04208.x","article-title":"The role of biofilms and protozoa in Legionella pathogenesis: implications for drinking water","volume":"107","author":"Lau","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cbi.2004.12.004","article-title":"Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity","volume":"151","author":"Letelier","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"B63","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fcimb.2013.00091","article-title":"Manganese acquisition and homeostasis at the host-pathogen interface","volume":"3","author":"Lisher","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/j.1462-5822.2005.00528.x","article-title":"Dynamic properties of Legionella-containing phagosomes in Dictyostelium amoebae","volume":"7","author":"Lu","year":"2005","journal-title":"Cell Microbiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3945\/an.112.003038","article-title":"Zinc biochemistry: from a single zinc enzyme to a key element of life","volume":"4","author":"Maret","year":"2013","journal-title":"Adv. Nutr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6772","DOI":"10.1093\/emboj\/20.23.6772","article-title":"Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis","volume":"20","author":"M\u00fcller-Taubenberger","year":"2001","journal-title":"EMBO J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1111\/j.1462-5822.2010.01529.x","article-title":"The struggle for iron - a metal at the host-pathogen interface","volume":"12","author":"Nairz","year":"2010","journal-title":"Cell Microbiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.cub.2013.04.034","article-title":"Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions","volume":"23","author":"Nasser","year":"2013","journal-title":"Curr. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/bies.950140708","article-title":"Streamer F mutants and chemotaxis of Dictyostelium","volume":"14","author":"Newell","year":"1992","journal-title":"Bioessays"},{"key":"B70","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/imr.12265","article-title":"Mycobacteria, metals, and the macrophage","volume":"264","author":"Neyrolles","year":"2015","journal-title":"Immunol. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1128\/IAI.01306-15","article-title":"Iron limitation triggers early egress by the intracellular bacterial pathogen Legionella pneumophila","volume":"84","author":"O'Connor","year":"2016","journal-title":"Infect. Immun."},{"key":"B72","doi-asserted-by":"crossref","first-page":"616S","DOI":"10.1093\/jn\/131.2.616S","article-title":"Iron and its relation to immunity and infectious disease","volume":"131","author":"Oppenheimer","year":"2001","journal-title":"J. Nutr."},{"key":"B73","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.bbagen.2008.09.010","article-title":"Iron overload following red blood cell transfusion and its impact on disease severity","volume":"1790","author":"Ozment","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuron.2011.07.019","article-title":"Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse","volume":"71","author":"Pan","year":"2011","journal-title":"Neuron"},{"key":"B75","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1006\/plas.1999.1391","article-title":"Variables controlling the expression level of exogenous genes in Dictyostelium","volume":"41","author":"Pang","year":"1999","journal-title":"Plasmid"},{"key":"B76","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1021\/bi300752r","article-title":"Mechanisms of mammalian iron homeostasis","volume":"51","author":"Pantopoulos","year":"2012","journal-title":"Biochemistry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.hoc.2015.11.003","article-title":"Iron deficiency anemia: problems in diagnosis and prevention at the population level","volume":"30","author":"Pasricha","year":"2016","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1242\/jcs.072124","article-title":"Phosphoinositides differentially regulate bacterial uptake and Nramp1-induced resistance to Legionella infection in Dictyostelium","volume":"123","author":"Peracino","year":"2010","journal-title":"J. Cell Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1242\/jcs.116210","article-title":"The Nramp (Slc11) proteins regulate development, resistance to pathogenic bacteria and iron homeostasis in Dictyostelium discoideum","volume":"126","author":"Peracino","year":"2013","journal-title":"J. Cell Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1600-0854.2005.00356.x","article-title":"Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in bacterial infection","volume":"7","author":"Peracino","year":"2006","journal-title":"Traffic"},{"key":"B81","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fcimb.2013.00090","article-title":"Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence","volume":"3","author":"Porcheron","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1111\/1462-2920.12604","article-title":"IroT\/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages","volume":"17","author":"Portier","year":"2015","journal-title":"Environ. Microbiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jtemb.2014.09.002","article-title":"Impact of the discovery of human zinc deficiency on health","volume":"28","author":"Prasad","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1126\/science.7244654","article-title":"Copper deficiency suppresses the immune response of mice","volume":"213","author":"Prohaska","year":"1981","journal-title":"Science"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1111\/j.1462-5822.2008.01219.x","article-title":"The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole","volume":"10","author":"Ragaz","year":"2008","journal-title":"Cell Microbiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1078\/0171-9335-00215","article-title":"Membrane sorting in the endocytic and phagocytic pathway of Dictyostelium discoideum","volume":"80","author":"Ravanel","year":"2001","journal-title":"Eur. J. Cell Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"5659","DOI":"10.1128\/IAI.70.10.5659-5669.2002","article-title":"Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection","volume":"70","author":"Robey","year":"2002","journal-title":"Infect. Immun."},{"key":"B88","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1099\/00221287-115-2-289","article-title":"Genetics of aggregation pattern mutations in the cellular slime mould Dictyostelium discoideum","volume":"115","author":"Ross","year":"1979","journal-title":"J. Gen. Microbiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.tube.2011.12.006","article-title":"Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload","volume":"92","author":"Rowland","year":"2012","journal-title":"Tuberculosis"},{"key":"B90","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jinorgbio.2011.11.024","article-title":"Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function","volume":"107","author":"Rubino","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/j.1469-0691.2009.03011.x","article-title":"Free-living amoebae, a training field for macrophage resistance of mycobacteria","volume":"15","author":"Salah","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"B92","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1039\/C5MT90021B","article-title":"Metals in infectious diseases and nutritional immunity","volume":"7","author":"Skaar","year":"2015","journal-title":"Metallomics"},{"key":"B93","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1078\/1438-4221-00177","article-title":"Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum","volume":"291","author":"Skriwan","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/j.1600-0854.2012.01358.x","article-title":"Mycobacteria and the intraphagosomal environment: take it with a pinch of salt(s)!","volume":"13","author":"Soldati","year":"2012","journal-title":"Traffic"},{"key":"B95","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S0966-842X(00)01852-7","article-title":"Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host-pathogen interactions","volume":"8","author":"Solomon","year":"2000","journal-title":"Trends Microbiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0140-6736(13)60437-7","article-title":"Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial","volume":"382","author":"Soofi","year":"2013","journal-title":"Lancet"},{"key":"B97","doi-asserted-by":"publisher","first-page":"e00049","DOI":"10.1042\/BSR20130014","article-title":"Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper","volume":"33","author":"Stafford","year":"2013","journal-title":"Biosci. Rep."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2017.08.004","article-title":"Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics","author":"Steiner","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.semcdb.2010.11.003","article-title":"Pathogen-host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens","volume":"22","author":"Steinert","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1387\/ijdb.072389ns","article-title":"Expression of zinc transporter family genes in Dictyostelium","volume":"52","author":"Sunaga","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0753-3322(03)00081-7","article-title":"Trace elements in human physiology and pathology: zinc and metallothioneins","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"B102","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-62703-161-5_14","article-title":"Analysis of legionella infection by flow cytometry","volume":"954","author":"Tiaden","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.micpath.2014.07.009","article-title":"Amoebae as a tool to isolate new bacterial species, to discover new virulence factors and to study the host\u2013pathogen interactions","volume":"77","author":"Tosetti","year":"2014","journal-title":"Microb. Pathog."},{"key":"B104","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1600-0854.2008.00851.x","article-title":"Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases","volume":"10","author":"Urwyler","year":"2009","journal-title":"Traffic"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1093\/bioinformatics\/btw238","article-title":"MetalPredator: a web server to predict iron-sulfur cluster binding proteomes","volume":"32","author":"Valasatava","year":"2016","journal-title":"Bioinformatics"},{"key":"B106","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.immuni.2013.09.006","article-title":"Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival","volume":"39","author":"Vignesh","year":"2013","journal-title":"Immunity"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.4049\/jimmunol.174.3.1491","article-title":"Elemental analysis of Mycobacterium avium-, Mycobacterium tuberculosis-, and Mycobacterium smegmatis-containing phagosomes indicates pathogen-induced microenvironments within the host cell's endosomal system","volume":"174","author":"Wagner","year":"2005","journal-title":"J. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nature08300","article-title":"Metalloproteins and metal sensing","volume":"460","author":"Waldron","year":"2009","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1365-2958.2010.07273.x","article-title":"CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis","volume":"77","author":"Ward","year":"2010","journal-title":"Mol. Microbiol."},{"key":"B110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bj1190171","article-title":"Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture","volume":"119","author":"Watts","year":"1970","journal-title":"Biochem. J."},{"key":"B111","doi-asserted-by":"publisher","first-page":"e00839","DOI":"10.1128\/mBio.00839-13","article-title":"Live-cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection","volume":"5","author":"Weber","year":"2014","journal-title":"MBio"},{"key":"B112","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1286-4579(00)00281-1","article-title":"Modulation of intramacrophage iron metabolism during microbial cell invasion","volume":"2","author":"Weinberg","year":"2000","journal-title":"Microbes Infect."},{"key":"B113","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cmi.2017.01.018","article-title":"Role of divalent metals in infectious disease susceptibility and outcome","volume":"24","author":"Weiss","year":"2017","journal-title":"Clin. Microbiol. Infect"},{"key":"B114","doi-asserted-by":"publisher","first-page":"33949","DOI":"10.1074\/jbc.M109.070201","article-title":"A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity","volume":"284","author":"White","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B115","doi-asserted-by":"publisher","first-page":"e1000822","DOI":"10.1371\/journal.ppat.1000822","article-title":"Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector","volume":"6","author":"Xu","year":"2010","journal-title":"PLoS Pathog."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00536\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T13:10:57Z","timestamp":1603631457000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fcimb.2017.00536\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":115,"alternative-id":["10.3389\/fcimb.2017.00536"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2017.00536","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]},"article-number":"536"}}