{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:25:26Z","timestamp":1779161126928,"version":"3.51.4"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31230073"],"award-info":[{"award-number":["No. 31230073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2018.00189","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T04:29:21Z","timestamp":1528172961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Hepatic Metabolomics Investigation in Acute and Chronic Murine Toxoplasmosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Xiao-Qing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany M.","family":"Elsheikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Si","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Xue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1128\/IAI.01373-10","article-title":"Impact of Salmonella infection on host hormone metabolism revealed by metabolomics","volume":"79","author":"Antunes","year":"2011","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.dnarep.2013.04.010","article-title":"The role of DNA repair in brain related disease pathology","volume":"12","author":"Canugovi","year":"2013","journal-title":"DNA repair (Amst)"},{"key":"B3","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1242\/jcs.115.15.3049","article-title":"Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii","volume":"115","author":"Charron","year":"2002","journal-title":"J. Cell Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"31221","DOI":"10.1074\/jbc.M404232200","article-title":"Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii","volume":"279","author":"Chaudhary","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s13071-017-2282-6","article-title":"Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis","volume":"10","author":"Chen","year":"2017","journal-title":"Parasite Vectors"},{"key":"B6","doi-asserted-by":"publisher","first-page":"25599","DOI":"10.18632\/oncotarget.16108","article-title":"Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection","volume":"8","author":"Cong","year":"2017","journal-title":"Oncotarget"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1091\/mbc.e02-12-0830","article-title":"Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge","volume":"14","author":"Coppens","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1083\/jcb.149.1.167","article-title":"Toxoplasma gondii exploits host low-density lipoprotein receptor- mediated endocytosis for cholesterol acquisition","volume":"149","author":"Coppens","year":"2000","journal-title":"J. Cell Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.1994.14.313","article-title":"Human indoleamine 2,3-dioxygenase inhibits Toxoplasma gondii growth in fibroblast cells","volume":"14","author":"Dai","year":"1994","journal-title":"J. Interferon Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1046\/j.1365-2567.1998.00553.x","article-title":"Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron","volume":"94","author":"Dimier","year":"1998","journal-title":"Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.exppara.2012.05.006","article-title":"Kinetics of parasite burdens in blood and tissues during murine toxoplasmosis","volume":"131","author":"Djurkovi\u0107-Djakovi\u0107","year":"2012","journal-title":"Exp. Parasitol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","article-title":"Metabolism and functions of glutathione in brain","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog Neurobiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","article-title":"The history of Toxoplasma gondii\u2013the first 100 years","volume":"55","author":"Dubey","year":"2008","journal-title":"J. Eukaryot. Microbiol."},{"key":"B14","volume-title":"Toxoplasmosis of Animals and Man","author":"Dubey","year":"1988"},{"key":"B15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1550-7408.1976.tb03836.x","article-title":"Feline toxoplasmosis from acutely infected mice and the development of Toxoplasma cysts","volume":"23","author":"Dubey","year":"1976","journal-title":"J. Protozool"},{"key":"B16","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","article-title":"Immune response and immunopathology during toxoplasmosis","volume":"34","author":"Dupont","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.puhe.2007.08.009","article-title":"Congenital toxoplasmosis: priorities for further health promotion action","volume":"122","author":"Elsheikha","year":"2008","journal-title":"Public Health"},{"key":"B18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/QCO.0000000000000265","article-title":"Toxoplasma gondii infection and schizophrenia: an inter-kingdom communication perspective","volume":"29","author":"Elsheikha","year":"2016","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1781","DOI":"10.1371\/journal.pntd.0001781","article-title":"The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway","volume":"6","author":"Fiorillo","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ijpara.2003.12.001","article-title":"Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation","volume":"34","author":"Fox","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.prostaglandins.2011.08.004","article-title":"Regulation of inflammation in cancer by eicosanoids","volume":"96","author":"Greene","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0152022","DOI":"10.1371\/journal.pone.0152022","article-title":"Proteomic profiling of Mouse liver following acute Toxoplasma gondii infection","volume":"11","author":"He","year":"","journal-title":"PLoS ONE"},{"key":"B23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s13071-016-1716-x","article-title":"Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection","volume":"9","author":"He","year":"","journal-title":"Parasit. Vectors"},{"key":"B24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.vetpar.2006.05.008","article-title":"Comparison of detection methods for Toxoplasma gondii in naturally and experimentally infected swine","volume":"141","author":"Hill","year":"2006","journal-title":"Vet. Parasitol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2008.08.026","article-title":"Metabolic phenotyping in health and disease","volume":"134","author":"Holmes","year":"2008","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.chom.2010.01.008","article-title":"Eating at the table of another: metabolomics of host-parasite interactions","volume":"7","author":"Kafsack","year":"2010","journal-title":"Cell Host Microbe."},{"key":"B27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.4049\/jimmunol.178.2.641","article-title":"Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation","volume":"178","author":"Levick","year":"2007","journal-title":"J. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.vetpar.2008.07.007","article-title":"Alterations of concentrations of calcium and arachidonic acid and agglutinations of microfilaments in host cells during Toxoplasma gondii invasion","volume":"157","author":"Li","year":"2008","journal-title":"Vet. Parasitol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.exppara.2017.02.018","article-title":"Toxoplasma growth in vitro is dependent on exogenous tyrosine and is independent of AAH2 even in tyrosine-limiting conditions","volume":"176","author":"Marino","year":"2017","journal-title":"Exp. Parasitol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"25843","DOI":"10.1074\/jbc.R200009200","article-title":"De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway","volume":"277","author":"Merrill","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0176700","DOI":"10.1371\/journal.pone.0176700","article-title":"Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results","volume":"12","author":"Milovanovi\u0107","year":"2017","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1600-065X.2010.00992.x","article-title":"Immunology of Toxoplasma gondii","volume":"240","author":"Munoz","year":"2011","journal-title":"Immunol. Rev"},{"key":"B33","doi-asserted-by":"publisher","first-page":"20811","DOI":"10.1038\/srep20811","article-title":"Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging","volume":"6","author":"Naemat","year":"2016","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1128\/IAI.01115-07","article-title":"Modulation of the host cell proteome by the intracellular apicomplexan parasite Toxoplasma gondii","volume":"76","author":"Nelson","year":"2008","journal-title":"Infect. Immun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.1128\/IAI.00947-15","article-title":"Global metabolomic analysis of a mammalian host infected with Bacillus anthracis","volume":"83","author":"Nguyen","year":"2015","journal-title":"Infect. Immun."},{"key":"B36","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","article-title":"\u2018Metabonomics\u2019: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"29","author":"Nicholson","year":"1999","journal-title":"Xenobiotica"},{"key":"B37","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1073\/pnas.81.3.908","article-title":"Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan","volume":"81","author":"Pfefferkorn","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B38","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1186\/1471-2164-15-806","article-title":"Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection","volume":"15","author":"Pittman","year":"2014","journal-title":"BMC Genomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4957","DOI":"10.1074\/jbc.M111.310144","article-title":"Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii","volume":"287","author":"Ramakrishnan","year":"2012","journal-title":"J. Biol. Chem"},{"key":"B40","first-page":"5047","article-title":"Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells","volume":"59","author":"Rizzo","year":"1999","journal-title":"Cancer Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s00394-013-0586-7","article-title":"Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study","volume":"53","author":"Rosa","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"B42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0014-4894(82)90094-7","article-title":"Toxoplasma gondii: purine synthesis and salvage in mutant host cells and parasites","volume":"53","author":"Schwartzman","year":"1982","journal-title":"Exp. Parasitol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1645\/GE-179R","article-title":"Endogenous polyamine levels in macrophages is sufficient to support growth of Toxoplasma gondii","volume":"90","author":"Seabra","year":"2004","journal-title":"J. Parasitol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1021\/pr101054m","article-title":"1H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis","volume":"10","author":"Shin","year":"2011","journal-title":"J. Proteome Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1128\/IAI.70.2.859-868.2002","article-title":"Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1","volume":"70","author":"Silva","year":"2002","journal-title":"Infect. Immun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1574-6976.2011.00305.x","article-title":"Mechanisms of Toxoplasma gondii persistence and latency","volume":"36","author":"Sullivan","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1189\/jlb.0208104","article-title":"The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease","volume":"84","author":"Tait","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0005140","DOI":"10.1371\/journal.pntd.0005140","article-title":"Metabolomics identifies multiple candidate biomarkers to diagnose and stage human african trypanosomiasis","volume":"10","author":"Vincent","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/S0140-6736(67)90235-8","article-title":"Two cases of hepatitis due to Toxoplasma gondii","volume":"290","author":"Vischer","year":"1967","journal-title":"Lancet"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1056\/NEJM197905103001907","article-title":"Acute granulomatous hepatitis in the course of acquired toxoplasmosis","volume":"300","author":"Weitberg","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12859-017-1579-y","article-title":"metaX: a flexible and comprehensive software for processing metabolomics data","volume":"18","author":"Wen","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/jcp.55.8.637","article-title":"Fatal disseminated toxoplasmosis in a toxoplasma seropositive liver transplant recipient","volume":"55","author":"Wendum","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1021\/pr050364w","article-title":"High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B","volume":"5","author":"Yang","year":"2006","journal-title":"J. Proteome Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/gigascience\/gix036","article-title":"Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals","volume":"6","author":"Zhong","year":"2017","journal-title":"Gigascience"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0139635","DOI":"10.1371\/journal.pone.0139635","article-title":"Global metabolomic profiling of mice brains following experimental infection with the cyst-forming Toxoplasma gondii","volume":"10","author":"Zhou","year":"2015","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"19557","DOI":"10.1038\/srep19557","article-title":"Metabolomic profiling of mice serum during toxoplasmosis progression using liquid chromatography-mass spectrometry","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00189\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:59:47Z","timestamp":1661389187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00189\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,5]]},"references-count":56,"alternative-id":["10.3389\/fcimb.2018.00189"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2018.00189","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,5]]},"article-number":"189"}}