{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:06:46Z","timestamp":1792667206965,"version":"4.5.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["254434"],"award-info":[{"award-number":["254434"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["244830"],"award-info":[{"award-number":["244830"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN206316"],"award-info":[{"award-number":["IN206316"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2018.00226","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T07:01:20Z","timestamp":1530687680000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["Entamoeba histolytica Induce Signaling via Raf\/MEK\/ERK for Neutrophil Extracellular Trap (NET) Formation"],"prefix":"10.3389","volume":"8","author":[{"given":"Zayda","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"D\u00edaz-God\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar R.","family":"Alem\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Uribe-Querol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Carrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rosales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1128\/IAI.05730-11","article-title":"Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps","volume":"80","author":"Abi Abdallah","year":"2012","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"142643","DOI":"10.1155\/2016\/2908034","article-title":"Differential use of human neutrophil Fc\u03b3 receptors for inducing neutrophil extracellular trap formation","volume":"2016","author":"Alem\u00e1n","year":"","journal-title":"J. Immunol. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2016.00277","article-title":"Transforming growth factor-\u03b2-activated kinase 1 is required for human Fc\u03b3RIIIb-induced neutrophil extracellular trap formation","volume":"7","author":"Alem\u00e1n","year":"","journal-title":"Front. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.4049\/jimmunol.1300261","article-title":"IgA enhances NETosis and release of neutrophil extracellular traps by polymorphonuclear cells via Fc\u03b1 receptor I","volume":"192","author":"Aleyd","year":"2014","journal-title":"J. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fimmu.2013.00045","article-title":"NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury","volume":"4","author":"Almyroudis","year":"2013","journal-title":"Front. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bbrc.2013.12.007","article-title":"Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation","volume":"443","author":"Arai","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4522","DOI":"10.1128\/IAI.73.8.4522-4529.2005","article-title":"Resistance to intestinal Entamoeba histolytica infection is conferred by innate immunity and Gr-1+ cells","volume":"73","author":"Asgharpour","year":"2005","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0158979","DOI":"10.1371\/journal.pone.0158979","article-title":"Entamoeba histolytica trophozoites and lipopeptidophosphoglycan trigger human neutrophil extracellular traps","volume":"11","author":"\u00c1vila","year":"2016","journal-title":"PLos ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.4049\/jimmunol.1400478","article-title":"Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via Fc\u03b3RIIIB and Mac-1","volume":"193","author":"Behnen","year":"2014","journal-title":"J. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2009-05-221606","article-title":"Restoration of NET formation by gene therapy in CGD controls aspergillosis","volume":"114","author":"Bianchi","year":"2009","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.freeradbiomed.2015.10.398","article-title":"Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species","volume":"89","author":"Bj\u00f6rnsdottir","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00281-013-0384-6","article-title":"Molecular mechanisms regulating NETosis in infection and disease","volume":"35","author":"Branzk","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/ni.2987","article-title":"Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens","volume":"15","author":"Branzk","year":"2014","journal-title":"Nat. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3389\/fimmu.2012.00413","article-title":"Automatic quantification of in vitro NET formation","volume":"3","author":"Brinkmann","year":"2013","journal-title":"Front. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1724","DOI":"10.3791\/1724","article-title":"Neutrophil extracellular traps: how to generate and visualize them","volume":"36","author":"Brinkmann","year":"2010","journal-title":"J. Vis. Exp."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.4049\/jimmunol.1202671","article-title":"An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans","volume":"190","author":"Byrd","year":"2013","journal-title":"J. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e1283386","DOI":"10.1080\/21688370.2017.1283386","article-title":"Entamoeba histolytica: host parasite interactions at the colonic epithelium","volume":"5","author":"Cornick","year":"2017","journal-title":"Tissue Barriers"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.12688\/f1000research.9691.1","article-title":"Recent advances in understanding neutrophils","volume":"5","author":"Deniset","year":"2014","journal-title":"F1000Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1189\/jlb.4A0615-261RR","article-title":"Neutrophil extracellular traps release induced by Leishmania: role of PI3K\u03b3, ERK, PI3K\u03c3, PKC, and [Ca2+]","volume":"100","author":"DeSouza-Vieira","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"B21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0035-9203(78)90144-X","article-title":"A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba","volume":"72","author":"Diamond","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fcimb.2018.00184","article-title":"Entamoeba histolytica trophozoites induce a rapid non-classical NETosis mechanism independent of NOX2-derived reactive oxygen species and PAD4 activity","volume":"8","author":"D\u00edaz-God\u00ednez","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1089\/sur.2008.011","article-title":"Polymorphonuclear neutrophil infiltration intensity as consequence of Entamoeba histolytica density in amebic colitis","volume":"10","author":"Dickson-Gonzalez","year":"2009","journal-title":"Surg. Infect."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.4049\/jimmunol.153.3.1254","article-title":"Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression","volume":"153","author":"Dransfield","year":"1994","journal-title":"J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/imr.12447","article-title":"Priming of the neutrophil respiratory burst: role in host defense and inflammation","volume":"273","author":"El-Benna","year":"2016","journal-title":"Immunol. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1128\/CMR.13.2.318-331.2000","article-title":"Pathogenesis of intestinal amebiasis: from molecules to disease","volume":"13","author":"Espinosa-Cantellano","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1365-3024.2011.01333.x","article-title":"Absence of CD38 delays arrival of neutrophils to the liver and innate immune response development during hepatic amoebiasis by Entamoeba histolytica","volume":"33","author":"Estrada-Figueroa","year":"2011","journal-title":"Parasite Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.4049\/jimmunol.1000893","article-title":"Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps","volume":"185","author":"Gabriel","year":"2010","journal-title":"J. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.4049\/jimmunol.178.5.3048","article-title":"Transmembrane mutations to Fc\u03b3RIIA alter its association with lipid rafts: implications for receptor signaling","volume":"178","author":"Garc\u00eda-Garc\u00eda","year":"2007","journal-title":"J. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1189\/jlb.72.1.107","article-title":"Phosphatidylinositol 3-kinase and extracellular signal-regulated kinase are recruited for Fc receptor-mediated phagocytosis during monocyte to macrophage differentiation","volume":"72","author":"Garc\u00eda-Garc\u00eda","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e50410","DOI":"10.3791\/50410","article-title":"A simple and efficient method to detect nuclear factor activation in human neutrophils by flow cytometry","volume":"74","author":"Garc\u00eda-Garc\u00eda","year":"2013","journal-title":"J. Vis. Exp."},{"key":"B34","doi-asserted-by":"publisher","first-page":"32088","DOI":"10.3402\/ljm.v11.32088","article-title":"Prevalence of Entamoeba histolytica, Giardia lamblia, and Cryptosporidium spp. in Libya: 2000-2015","volume":"11","author":"Ghenghesh","year":"2016","journal-title":"Libyan J. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/978-1-62703-845-4_20","article-title":"Induction and quantification of neutrophil extracellular traps","volume":"1124","author":"Gonzalez","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimar\u00e3es-Costa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e97088","DOI":"10.1371\/journal.pone.0097088","article-title":"Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A","volume":"9","author":"Gupta","year":"2014","journal-title":"PLoS ONE"},{"key":"B38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nchembio.496","article-title":"Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation","volume":"7","author":"Hakkim","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.107.100214","article-title":"Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant","volume":"51","author":"Heum\u00fcller","year":"2008","journal-title":"Hypertension"},{"key":"B40","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/exd.13125","article-title":"Interindividual variation of NETosis in healthy donors: introduction and application of a refined method for extracellular trap quantification","volume":"25","author":"Hoffmann","year":"2016","journal-title":"Exp. Dermatol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1189\/jlb.3AB0815-379RR","article-title":"Nicotine induces neutrophil extracellular traps","volume":"100","author":"Hosseinzadeh","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e1004929","DOI":"10.1371\/journal.ppat.1004929","article-title":"Rapid sequestration of Leishmania mexicana by neutrophils contributes to the development of chronic lesion","volume":"11","author":"Hurrell","year":"2015","journal-title":"PLoS Pathog."},{"key":"B43","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0014-4894(02)00021-8","article-title":"Entamoeba histolytica: immunohistochemical study of hepatic amoebiasis in mouse. Neutrophils and nitric oxide as possible factors of resistance","volume":"101","author":"Jarillo-Luna","year":"2002","journal-title":"Exp. Parasitol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e24437","DOI":"10.7554\/eLife.24437","article-title":"Diverse stimuli engage different neutrophil extracellular trap pathways","volume":"6","author":"Kenny","year":"2017","journal-title":"Elife"},{"key":"B45","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/jcb.24391","article-title":"Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils","volume":"114","author":"Keshari","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"41749","DOI":"10.1038\/srep41749","article-title":"Transcriptional firing helps to drive NETosis","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/icb.2011.60","article-title":"Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation","volume":"90","author":"Kim","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.autrev.2016.02.018","article-title":"A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes","volume":"15","author":"Kraaij","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1124\/jpet.112.202879","article-title":"Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs","volume":"345","author":"Lapponi","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nrm3979","article-title":"Regulation of RAF protein kinases in ERK signalling","volume":"16","author":"Lavoie","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"B53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","article-title":"The multifaceted functions of neutrophils","volume":"9","author":"Mayadas","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cub.2005.02.022","article-title":"Ras-independent activation of ERK signaling via the torso receptor tyrosine kinase is mediated by Rap1","volume":"15","author":"Mishra","year":"2005","journal-title":"Curr. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/cvr\/cvv159","article-title":"Intracellular signalling during neutrophil recruitment","volume":"107","author":"M\u00f3csai","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0165-2478(99)00041-3","article-title":"Regulation of production of soluble Fc gamma receptors type III in normal and pathological conditions","volume":"68","author":"Moldovan","year":"1999","journal-title":"Immunol. Lett."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1003489","DOI":"10.1371\/journal.ppat.1003489","article-title":"Host immune response to intestinal amebiasis","volume":"9","author":"Moonah","year":"2013","journal-title":"PLoS Pathog."},{"key":"B58","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.exppara.2010.03.005","article-title":"The immunopathogenesis of Entamoeba histolytica","volume":"126","author":"Mortimer","year":"2010","journal-title":"Exp. Parasitol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fimmu.2016.00175","article-title":"Immune response of amebiasis and immune evasion by Entamoeba histolytica","volume":"7","author":"Nakada-Tsukui","year":"2016","journal-title":"Front. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/ar3773","article-title":"Knotting the NETs: analyzing histone modifications in neutrophil extracellular traps","volume":"14","author":"Neeli","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"B61","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fimmu.2013.00038","article-title":"Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release","volume":"4","author":"Neeli","year":"2013","journal-title":"Front. Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000206974","article-title":"Regulation of extracellular chromatin release from neutrophils","volume":"1","author":"Neeli","year":"2009","journal-title":"J. Innate Immun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.yexmp.2006.09.005","article-title":"Late experimental amebic liver abscess in hamster is inhibited by cyclosporine and N-acetylcysteine","volume":"82","author":"Olivos-Garc\u00eda","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.it.2009.07.011.","article-title":"NETs: a new strategy for using old weapons","volume":"30","author":"Papayannopoulos","year":"2009","journal-title":"Trends. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1189\/jlb.0711387","article-title":"Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide","volume":"91","author":"Parker","year":"","journal-title":"J. Leukoc. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1189\/jlb.1211601","article-title":"Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus","volume":"92","author":"Parker","year":"","journal-title":"J. Leukoc. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.niox.2010.01.001","article-title":"Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation","volume":"22","author":"Patel","year":"2010","journal-title":"Nitric Oxide"},{"key":"B69","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2307\/3282753","article-title":"Pathogenesis of acute experimental amebic liver abscess in hamsters","volume":"77","author":"P\u00e9rez-Tamayo","year":"1991","journal-title":"J. Parasitol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.arcmed.2005.10.007","article-title":"Pathogenesis of acute experimental liver amebiasis","volume":"37","author":"P\u00e9rez-Tamayo","year":"2006","journal-title":"Arch. Med. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","article-title":"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus","volume":"185","author":"Pilsczek","year":"2010","journal-title":"J. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.4049\/jimmunol.0900906","article-title":"Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C","volume":"183","author":"Popa-Nita","year":"2009","journal-title":"J. Immunol."},{"key":"B73","first-page":"229","article-title":"The histopathology of acute intestinal amebiasis. A rectal biopsy study","volume":"60","author":"Prathap","year":"1970","journal-title":"Am. J. Pathol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1084\/jem.20131092","article-title":"\u03b22 integrin mediates hantavirus-induced release of neutrophil extracellular traps","volume":"211","author":"Raftery","year":"2014","journal-title":"J. Exp. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/cr.2010.150","article-title":"Neutrophil extracellular trap cell death requires both autophagy and superoxide generation","volume":"21","author":"Remijsen","year":"2011","journal-title":"Cell. Res."},{"key":"B76","unstructured":"Phosphatidylinositol 3-kinase mediates integrin-dependent NF-kB and MAPK activation through separate signaling pathways15791589 Reyes-ReyesM. MoraN. ZentellaA. RosalesC. J. Cell Sci.1142001"},{"key":"B77","doi-asserted-by":"publisher","first-page":"18302","DOI":"10.1038\/srep18302","article-title":"Classical ROS-dependent and early\/rapid ROS-independent release of neutrophil extracellular traps triggered by Leishmania parasites","volume":"5","author":"Rochael","year":"2015","journal-title":"Sci. Rep."},{"key":"B78","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.4049\/jimmunol.146.11.3937","article-title":"Two mechanisms for IgG Fc receptor-mediated phagocytosis by human neutrophils","volume":"146","author":"Rosales","year":"1991","journal-title":"J. Immunol."},{"key":"B79","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1016\/S0021-9258(18)42761-5","article-title":"Signal transduction by neutrophil IgG Fc receptors: dissociation of [Ca+2] rise from IP3","volume":"267","author":"Rosales","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B80","doi-asserted-by":"publisher","first-page":"9042851","DOI":"10.1155\/2017\/9042851","article-title":"Phagocytosis: a fundamental process in immunity","volume":"2017","author":"Rosales","year":"2017","journal-title":"BioMed Res. Int."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1182\/blood-2013-07-516484","article-title":"Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation","volume":"123","author":"Rossaint","year":"2014","journal-title":"Blood"},{"key":"B82","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2012.08.011","article-title":"LAT-independent Erk activation via Bam32-PLC-\u03b31-Pak1 complexes: GTPase-independent Pak1 activation","volume":"48","author":"Rouquette-Jazdanian","year":"2012","journal-title":"Mol. Cell"},{"key":"B83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/infdis\/154.1.19","article-title":"The interaction of human neutrophils and Entamoeba histolytica increases cytopathogenicity for liver cell monolayers","volume":"154","author":"Salata","year":"1986","journal-title":"J. Infect. Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"B85","doi-asserted-by":"publisher","first-page":"41011","DOI":"10.1074\/jbc.M003716200","article-title":"Ras-independent activation of the Raf\/MEK\/ERK pathway upon calcium-induced differentiation of keratinocytes","volume":"275","author":"Schmidt","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/S0016-5085(98)70023-X","article-title":"Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine","volume":"115","author":"Seydel","year":"1998","journal-title":"Gastroenterology"},{"key":"B87","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/IAI.65.9.3951-3953.1997","article-title":"Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice","volume":"65","author":"Seydel","year":"1997","journal-title":"Infect. Immun."},{"key":"B88","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.4049\/jimmunol.174.7.4279","article-title":"NADPH oxidase-derived reactive oxygen species-mediated activation of ERK1\/2 is required for apoptosis of human neutrophils induced by Entamoeba histolytica","volume":"174","author":"Sim","year":"2005","journal-title":"J. Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0157454","DOI":"10.1371\/journal.pone.0157454","article-title":"Neutrophil extracellular trap formation is independent of de novo gene expression","volume":"11","author":"Sollberger","year":"2016","journal-title":"PLoS ONE"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e0139569","DOI":"10.1371\/journal.pone.0139569","article-title":"Trypanosoma cruzi and its soluble antigens induce NET release by stimulating toll-like receptors","volume":"10","author":"Sousa-Rocha","year":"2015","journal-title":"PLoS ONE"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/sj.onc.1202527","article-title":"VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells","volume":"18","author":"Takahashi","year":"1999","journal-title":"Oncogene"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e0004125","DOI":"10.1371\/journal.pntd.0004125","article-title":"Prevalence of Cryptosporidium parvum\/hominis, Entamoeba histolytica and Giardia lamblia among young children with and without diarrhea in Dar es Salaam, Tanzania","volume":"9","author":"Tellevik","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B93","first-page":"112","article-title":"Inflammatory reaction in experimental hepatic amebiasis. An ultrastructural study","volume":"130","author":"Tsutsumi","year":"1988","journal-title":"Am. J. Pathol."},{"key":"B94","first-page":"81","article-title":"Cellular bases of experimental amebic liver abscess formation","volume":"117","author":"Tsutsumi","year":"1984","journal-title":"Am. J. Pathol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/j.1462-5822.2005.00659.x","article-title":"Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms","volume":"8","author":"Urban","year":"2006","journal-title":"Cell. Microbiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"6529","DOI":"10.1038\/s41598-017-06901-w","article-title":"Differential signalling and kinetics of neutrophil extracellular trap release revealed by quantitative live imaging","volume":"7","author":"van der Linden","year":"2017","journal-title":"Sci. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-3024.1998.00128.x","article-title":"Role of neutrophils in innate resistance to Entamoeba histolytica liver infection in mice","volume":"20","author":"Velazquez","year":"1998","journal-title":"Parasite Immunol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/pim.12332","article-title":"Entamoeba histolytica induces human neutrophils to form NETs","volume":"38","author":"Ventura-Juarez","year":"2016","journal-title":"Parasite Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s00281-012-0349-1","article-title":"The dynamic interdependence of amebiasis, innate immunity, and undernutrition","volume":"34","author":"Verkerke","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"B100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/clinids\/8.2.228","article-title":"Problems in recognition and diagnosis of amebiasis: estimation of the global magnitude of morbidity and mortality","volume":"8","author":"Walsh","year":"1986","journal-title":"Rev. Infect. Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/B978-0-12-416618-9.00013-3","article-title":"Methods to monitor ROS production by fluorescence microscopy and fluorometry","volume":"542","author":"Wojtala","year":"2014","journal-title":"Methods Enzymol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat. Med."},{"key":"B103","unstructured":"Neutrophil extracellular traps (NETs) - formation and implications277284 ZawrotniakM. Rapala-KozikM. 23819131Acta Biochim. Pol.602013"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00226\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T14:24:39Z","timestamp":1693751079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00226\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":103,"alternative-id":["10.3389\/fcimb.2018.00226"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2018.00226","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]},"article-number":"226"}}