{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:35:13Z","timestamp":1787628913198,"version":"build-2736575974"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2018.00287","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T05:06:40Z","timestamp":1534828000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["The Key Role of c-Fos for Immune Regulation and Bacterial Dissemination in Brucella Infected Macrophage"],"prefix":"10.3389","volume":"8","author":[{"given":"Huynh T.","family":"Hop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Arayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran X. N.","family":"Huy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha W. B.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son H.","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WonGi","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man H.","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong H.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.4049\/jimmunol.169.6.3155","article-title":"Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice","volume":"169","author":"Abel","year":"2002","journal-title":"J. Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cell.2011.01.031","article-title":"TLR signaling is required for Salmonella typhimurium virulence","volume":"144","author":"Arpaia","year":"2011","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"20343","DOI":"10.1074\/jbc.M110.116988","article-title":"Helicobacter pylori induces ERK-dependent formation of a phosphor-c-Fos c-Jun activator protein 1 complex that cause apoptosis in macrophages","volume":"285","author":"Asim","year":"2010","journal-title":"J. Biol. Chem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1001262","DOI":"10.1371\/journal.ppat.1001262","article-title":"A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci","volume":"7","author":"Bewley","year":"2011","journal-title":"PLoS. Pathog."},{"key":"B5","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"Celli","year":"2003","journal-title":"J. Exp. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1186\/1471-2164-14-426","article-title":"Early transcriptional responses of internalization defective Brucella abortus mutants in professional phagocytes, RAW 264.7","volume":"14","author":"Cha","year":"2013","journal-title":"BMC Genomics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1128\/IAI.00050-11","article-title":"Proinflammatory caspase-2-mediated macrophage cell death induced by a rough attenuated Brucella suis strain","volume":"79","author":"Chen","year":"2011","journal-title":"Infect. Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e6830","DOI":"10.1371\/journal.pone.0006830","article-title":"Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus","volume":"4","author":"Chen","year":"2009","journal-title":"PLoS ONE."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/(SICI)1097-0320(19961201)25:4<381::AID-CYTO10>3.0.CO;2-R","article-title":"Double fluorescent flow cytometric assessment of bacterial internalization and binding by epithelial cells","volume":"25","author":"de Boer","year":"1996","journal-title":"Cytometry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1084\/jem.20031237","article-title":"Toll-like receptors induce a phagocytic gene program through p38","volume":"199","author":"Doyle","year":"2004","journal-title":"J. Exp. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1128\/IAI.71.3.1125-1133.2003","article-title":"Microarray analysis of mRNA levels from RAW 264.7 macrophages infected with Brucella abortus","volume":"71","author":"Eskra","year":"2003","journal-title":"Infect. Immun."},{"key":"B13","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/IAI.63.3.1130-1133.1995","article-title":"Interleukin-10 downregulates protective immunity to Brucella abortus","volume":"63","author":"Fernandes","year":"1995","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0008-6363(99)00220-5","article-title":"Alterations in c-fos expression, cell proliferation and apoptosis in pressure distended human saphenous vein","volume":"44","author":"Galea","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.4049\/jimmunol.1202817","article-title":"Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection","volume":"190","author":"Gomes","year":"2013","journal-title":"J. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1128\/IAI.68.1.342-351.2000","article-title":"In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells","volume":"68","author":"Gross","year":"2000","journal-title":"Infect. Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nature01603","article-title":"Microbial pathogenesis and cytoskeletal function","volume":"422","author":"Gruenheid","year":"2003","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4161\/sgtp.25604","article-title":"Functional role(s) of phagosomal Rab GTPases","volume":"4","author":"Gutierrez","year":"2013","journal-title":"Small GTPases"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.4049\/jimmunol.181.4.2651","article-title":"NF-kappaB activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophages","volume":"181","author":"Gutierrez","year":"2008","journal-title":"J. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.micpath.2017.10.029","article-title":"simultaneous RNA-seq based transcriptional profiling of intracellular Brucella abortus and B. abortus-infected murine macrophages","volume":"113","author":"Hop","year":"","journal-title":"Microb. Pathog."},{"key":"B21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3389\/fcimb.2017.00437","article-title":"Activation of NF-kB-mediated TNF-induced antimicrobial immunity is required for the efficient Brucella abortus clearance in RAW 264.7 cells","volume":"7","author":"Hop","year":"","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.1074\/jbc.M117.805556","article-title":"Interleukin 10 suppresses lysosome-mediated killing of Brucella abortus in cultured macrophages","volume":"293","author":"Hop","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/sj.emboj.7601511","article-title":"LAMP proteins are required for fusion of lysosomes with phagosomes","volume":"26","author":"Huynh","year":"2007","journal-title":"EMBO J."},{"key":"B24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/IAI.61.1.124-134.1993","article-title":"Effects of cytokines on intracellular growth of Brucella abortus","volume":"61","author":"Jiang","year":"1993","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/infdis\/jir765","article-title":"RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes","volume":"205","author":"Kim","year":"2012","journal-title":"J. Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1574-6968.2004.tb09546.x","article-title":"Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice","volume":"234","author":"Kim","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"B27","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1073\/pnas.0708110105","article-title":"Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"28049","DOI":"10.1074\/jbc.M113.491555","article-title":"Interplay between clathrin and Rab5 controls the early phagocytic trafficking and intracellular survival of Brucella abortus with HeLa cells","volume":"288","author":"Lee","year":"","journal-title":"J. Biol. Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1128\/IAI.00403-13","article-title":"Toll-like receptor 4-linked Janus kinase 2 signaling contributes to internalization of Brucella abortus by macrophages","volume":"81","author":"Lee","year":"","journal-title":"Infect. Immun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"24006","DOI":"10.1074\/jbc.M109.025528","article-title":"AP-1 activated by toll-like receptors regulates expression of IL-23 p19","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1128\/IAI.01316-06","article-title":"c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection","volume":"75","author":"Maruyama","year":"2007","journal-title":"Infect. Immun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/BF01309672","article-title":"Use of FITC-labeled influenza virus and flow cytometry to assess binding and internalization of virus by monocytes-macrophages and lymphocytes","volume":"130","author":"Nichols","year":"1993","journal-title":"Arch. Virol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/intimm\/dxg126","article-title":"Dominant negative effect of the c-fos family gene products on inducible NO synthase expression in macrophages","volume":"15","author":"Okada","year":"2003","journal-title":"Int. Immunol."},{"key":"B34","first-page":"985","article-title":"c-fos expression is required during all phases of the cell cycle during exponential cell proliferation","volume":"14","author":"Pai","year":"1994","journal-title":"Anticancer Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fcimb.2014.00023","article-title":"Brucella dissociation is essential for macrophage egress and bacterial dissemination","volume":"4","author":"Pei","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.mimet.2005.08.013","article-title":"Quantification of bacterial invasion into adherent cells by flow cytometry","volume":"65","author":"Pils","year":"2006","journal-title":"J. Microbiol. Methods."},{"key":"B37","doi-asserted-by":"publisher","first-page":"32247","DOI":"10.1038\/srep32247","article-title":"Role of Cathepsins in Mycobacterium tuberculosis survival in human macrophages","volume":"6","author":"Pires","year":"2016","journal-title":"Sci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1128\/MCB.16.1.211","article-title":"Induction of apoptosis by c-Fos protein","volume":"16","author":"Preston","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/intimm\/dxl004","article-title":"C-Fos suppresses systemic inflammatory response to endotoxin","volume":"18","author":"Ray","year":"2006","journal-title":"Int. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.micpath.2016.11.028","article-title":"Nocodazole treatment interrupted Brucella abortus invasion in RAW 264.7 cells, and successfully attenuated splenic proliferation with enhanced inflammatory response in mice","volume":"103","author":"Reyes","year":"2017","journal-title":"Microb. Pathog."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5712","DOI":"10.1128\/IAI.72.10.5712-5721.2004","article-title":"The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli","volume":"72","author":"Rivera-Marrero","year":"2004","journal-title":"Infect. Immun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1046\/j.1462-5822.2003.00263.x","article-title":"Macrophage signaling upon mycobacterial infection: the MAP kinases lead the way","volume":"5","author":"Schorey","year":"2003","journal-title":"Cell. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat. Cell. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"32585","DOI":"10.1074\/jbc.M100444200","article-title":"Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway","volume":"276","author":"Siegmund","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.4049\/jimmunol.179.8.5137","article-title":"Mycobacterium bovis bacillus Calmette-Guerin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages","volume":"179","author":"Soualhine","year":"2007","journal-title":"J. Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/j.1600-0854.2008.00718.x","article-title":"Brucella intracellular replication requires trafficking through the late endosomal\/lysosomal compartment","volume":"9","author":"Starr","year":"2008","journal-title":"Traffic"},{"key":"B47","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fmicb.2011.00054","article-title":"Lipopolysaccharide-deficient Brucella variants arise spontaneously during infection","volume":"2","author":"Turse","year":"2011","journal-title":"Front. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1186\/s12885-015-1866-9","article-title":"Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B-virus-related hepatocellular carcinoma via ERK1\/2 signaling","volume":"15","author":"Wang","year":"2015","journal-title":"BMC Cancer"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1003454","DOI":"10.1371\/journal.ppat.1003454","article-title":"CD4+ T cell-derived IL10 promotes Brucella abortus persistence via modulation of macrophage function","volume":"9","author":"Xavier","year":"2013","journal-title":"PLoS Pathog."},{"key":"B50","doi-asserted-by":"publisher","first-page":"9425","DOI":"10.1158\/0008-5472.CAN-07-1310","article-title":"C-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00287\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T01:51:51Z","timestamp":1604800311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00287\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":50,"alternative-id":["10.3389\/fcimb.2018.00287"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2018.00287","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,21]]},"article-number":"287"}}