{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:29:06Z","timestamp":1792805346267,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2018.00445","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T08:41:18Z","timestamp":1546591278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":101,"title":["Antifungal Activity of Coumarin Against Candida albicans Is Related to Apoptosis"],"prefix":"10.3389","volume":"8","author":[{"given":"Chang","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.bbamcr.2008.01.005","article-title":"Drug-induced apoptosis in yeast","volume":"1783","author":"Almeida","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/jbt.20288","article-title":"Coumarin A\/AA induces apoptosis-like cell death in HeLa cells mediated by the release of apoptosis-inducing factor","volume":"23","author":"\u00c1lvarez-Delgado","year":"2009","journal-title":"J. Biochem. Mol. Toxic."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1016\/j.ejmech.2011.05.044","article-title":"Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives","volume":"46","author":"Arshad","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cbi.2006.04.006","article-title":"Effects of isocoumarins isolated from Paepalanthus bromelioides on mitochondria: uncoupling, and induction\/inhibition of mitochondrial permeability transition","volume":"161","author":"C\u00e1lgarohelena","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"B5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/cdd.2009.219","article-title":"Apoptosis in yeast: triggers, pathways, subroutines","volume":"17","author":"Carmona-Gutierrez","year":"2010","journal-title":"Cell Death Differ."},{"key":"B6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ceca.2016.03.005","article-title":"Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast","volume":"60","author":"Carraro","year":"2016","journal-title":"Cell Calcium"},{"key":"B7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.biochi.2015.05.009","article-title":"Lycopene induces apoptosis in Candida albicans through reactive oxygen species production and mitochondrial dysfunction","volume":"115","author":"Choi","year":"2015","journal-title":"Biochimie"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/j.1471-8286.2005.01182.x","article-title":"Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation","volume":"21","author":"Chuang","year":"2007","journal-title":"Vivo"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.jinorgbio.2009.05.017","article-title":"Copper (II) complexes of coumarin-derived Schiff bases and their anti-Candida activity","volume":"103","author":"Creaven","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1086\/520192","article-title":"Nosocomial bloodstream infections in United States hospitals: a three-year analysis","volume":"29","author":"Edmond","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.mib.2011.06.001","article-title":"Mucosal biofilms of Candida albicans","volume":"14","author":"Ganguly","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.2174\/1568026618666171215100326","article-title":"Recent developments of coumarin hybrids as anti-fungal agents","volume":"17","author":"Hu","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.fgb.2014.08.012","article-title":"Role of TFP1 in vacuolar acidification, oxidative stress and filamentous development in Candida albicans","volume":"71","author":"Jia","year":"2014","journal-title":"Fungal Genet. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1016\/j.bbamcr.2015.08.005","article-title":"Tfp1 is required for ion homeostasis, fluconazole resistance and N-Acetylglucosamine utilization in Candida albicans","volume":"1853","author":"Jia","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4790","DOI":"10.3390\/molecules14114790","article-title":"Synthetic approaches and biological activities of 4-Hydroxycoumarin derivatives","volume":"14","author":"Jung","year":"2009","journal-title":"Molecules"},{"key":"B16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.fitote.2011.11.003","article-title":"A new antifungal coumarin from Clausena excavata","volume":"83","author":"Kumar","year":"2012","journal-title":"Fitoterapia"},{"key":"B17","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/cdd.2009.196","article-title":"Apoptosis and the yeast actin cytoskeleton","volume":"17","author":"Leadsham","year":"2010","journal-title":"Cell Death Differ."},{"key":"B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/10715762.2017.1407412","article-title":"Reactive oxygen species modulate itraconazole-induced apoptosis via mitochondrial disruption in Candida albicans","volume":"52","author":"Lee","year":"2017","journal-title":"Free Radic Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/jac\/dkh385","article-title":"Release of calcium from intracellular stores and subsequent uptake by mitochondria are essential for the candidacidal activity of an N-terminal peptide of human lactoferrin","volume":"54","author":"Lupetti","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"B20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbrc.2009.02.117","article-title":"Caspase-dependent and caspase-independent cell death pathways in yeast","volume":"382","author":"Madeo","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1083\/jcb.145.4.757","article-title":"Oxygen stress: a regulator of apoptosis in yeast","volume":"145","author":"Madeo","year":"1999","journal-title":"J. Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0038-1627456","article-title":"Nonalcoholic fatty liver disease in children","volume":"38","author":"Mann","year":"2018","journal-title":"Semin. Liver Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6918","DOI":"10.1074\/jbc.M805288200","article-title":"Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis","volume":"284","author":"Mirnikjoo","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B24","first-page":"4271","article-title":"Coumarin-based benzopyranone derivatives induced apoptosis in human lung (A549) cancer cells","volume":"32","author":"Musa","year":"2012","journal-title":"Anticancer Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbrc.2010.02.138","article-title":"Melittin induces apoptotic features in Candida albicans","volume":"394","author":"Park","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.bbamcr.2008.03.010","article-title":"Mitochondria-dependent apoptosis in yeast","volume":"1783","author":"Pereira","year":"2008","journal-title":"Biochim. Biophys. Acta."},{"key":"B27","doi-asserted-by":"publisher","first-page":"14327","DOI":"10.1073\/pnas.2332326100","article-title":"Apoptosis induced by environmental stresses and amphotericin B in Candida albicans","volume":"100","author":"Phillips","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.exger.2008.08.044","article-title":"Apoptotic death of ageing yeast","volume":"43","author":"Rockenfeller","year":"2008","journal-title":"Exp. Gerontol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e103039","DOI":"10.1371\/journal.pone.0103039","article-title":"In vivo efficacy of a synthetic coumarin derivative in a murine model of aspergillosis","volume":"9","author":"Singh","year":"2014","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cbi.2006.04.013","article-title":"The lysosomal-mitochondrial axis theory of postmitotic aging and cell death","volume":"163","author":"Terman","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"B32","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.tiv.2007.01.022","article-title":"Mechanism of action of coumarin and silver(I)-coumarin complexes against the pathogenic yeast Candida albicans","volume":"21","author":"Thati","year":"2007","journal-title":"Toxicol. Vitro"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1007\/s00253-017-8146-3","article-title":"Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans","volume":"101","author":"Tian","year":"","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.biocel.2017.02.006","article-title":"Nerol triggers mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS in Candida albicans","volume":"85","author":"Tian","year":"","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0022-1759(00)00233-7","article-title":"Flow cytometry of apoptotic cell death","volume":"243","author":"Vermes","year":"2000","journal-title":"J. Immunol. Methods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5614\/itbj.sci.2012.44.2.4","article-title":"Mechanism of action of coumarin against Candida albicans by SEM\/TEM Analysis","volume":"44","author":"Widodo","year":"2012","journal-title":"J. Math. Fun. Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.bbagen.2010.01.001","article-title":"Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway","volume":"1800","author":"Wu","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biocel.2016.09.008","article-title":"Silibinin triggers yeast apoptosis related to mitochondrial Ca2+ influx in Candida albicans","volume":"80","author":"Yun","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbagen.2016.12.026","article-title":"Role of potassium channels in chlorogenic acid-induced apoptotic volume decrease and cell cycle arrest in Candida albicans","volume":"1861","author":"Yun","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s10495-008-0278-6","article-title":"In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway","volume":"13","author":"Zhang","year":"2008","journal-title":"Apoptosis"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00445\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T08:41:20Z","timestamp":1546591280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00445\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":41,"alternative-id":["10.3389\/fcimb.2018.00445"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2018.00445","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"article-number":"445"}}