{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:33:00Z","timestamp":1775856780137,"version":"3.50.1"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2016YFD0500406"],"award-info":[{"award-number":["2016YFD0500406"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772736"],"award-info":[{"award-number":["31772736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502062"],"award-info":[{"award-number":["31502062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2018CFA070"],"award-info":[{"award-number":["2018CFA070"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007925","name":"Huazhong Agricultural University","doi-asserted-by":"publisher","award":["2662018PY032"],"award-info":[{"award-number":["2662018PY032"]}],"id":[{"id":"10.13039\/501100007925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2018.00448","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T05:09:22Z","timestamp":1547010562000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Transactivated Epidermal Growth Factor Receptor Recruitment of \u03b1-actinin-4 From F-actin Contributes to Invasion of Brain Microvascular Endothelial Cells by Meningitic Escherichia coli"],"prefix":"10.3389","volume":"8","author":[{"given":"Jiyang","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruicheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouman","family":"Amjad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S2468-1253(17)30394-1","article-title":"Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2-3 randomised trial","volume":"3","author":"Adams","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2165\/11593340-000000000-00000","article-title":"Acute bacterial meningitis in infants and children: epidemiology and management","volume":"13","author":"Agrawal","year":"2011","journal-title":"Paediatr. Drugs"},{"key":"B3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1210\/js.2016-1053","article-title":"EGFR induces E2F1-mediated corticotroph tumorigenesis","volume":"1","author":"Araki","year":"2017","journal-title":"J. Endocr. Soc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.18632\/genesandcancer.154","article-title":"Molecular insights: suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer","volume":"8","author":"Chandrasekaran","year":"2017","journal-title":"Genes Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.bbrc.2017.09.121","article-title":"Src-mediated ligand release-independent EGFR transactivation involves TGF-beta-induced Smad3 activation in mesangial cells","volume":"493","author":"Chen","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrm1962","article-title":"EGF-ERBB signalling: towards the systems level","volume":"7","author":"Citri","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fcimb.2016.00107","article-title":"Hijacking host cell highways: manipulation of the host actin cytoskeleton by obligate intracellular bacterial pathogens","volume":"6","author":"Colonne","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/nrmicro.2016.178","article-title":"A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers","volume":"15","author":"Coureuil","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/php.12727","article-title":"Silibinin treatment inhibits the growth of hedgehog inhibitor-resistant basal cell carcinoma cells via targeting EGFR-MAPK-Akt and hedgehog signaling","volume":"93","author":"Dheeraj","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/cmi.12099","article-title":"Neisseria gonorrhoeae breaches the apical junction of polarized epithelial cells for transmigration by activating EGFR","volume":"15","author":"Edwards","year":"2013","journal-title":"Cell. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/cmi.12110","article-title":"Klebsiella pneumoniae targets an EGF receptor-dependent pathway to subvert inflammation","volume":"15","author":"Frank","year":"2013","journal-title":"Cell. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/emboj\/16.7.1647","article-title":"ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling","volume":"16","author":"Graus-Porta","year":"1997","journal-title":"EMBO J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/nrneph.2016.91","article-title":"The epidermal growth factor receptor pathway in chronic kidney diseases","volume":"12","author":"Harskamp","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1349-7006.2007.00676.x","article-title":"Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands","volume":"99","author":"Higashiyama","year":"2008","journal-title":"Cancer Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1083\/jcb.200106148","article-title":"Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis","volume":"155","author":"Hoffmann","year":"2001","journal-title":"J. Cell Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"39481","DOI":"10.1074\/jbc.M110.164731","article-title":"Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization","volume":"285","author":"Hofman","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/B978-0-12-416673-8.00005-8","article-title":"Alpha-actinin 4 and tumorigenesis of breast cancer","volume":"93","author":"Hsu","year":"2013","journal-title":"Vitam. Horm."},{"key":"B18","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/IAI.67.5.2103-2109.1999","article-title":"Identification and characterization of an Escherichia coli invasion gene locus, ibeB, required for penetration of brain microvascular endothelial cells","volume":"67","author":"Huang","year":"1999","journal-title":"Infect. Immun."},{"key":"B19","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1128\/IAI.63.11.4470-4475.1995","article-title":"Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10","volume":"63","author":"Huang","year":"1995","journal-title":"Infect. Immun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-physiol-021014-071720","article-title":"ADAM proteases and gastrointestinal function","volume":"78","author":"Jones","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1462-5822.2006.00779.x","article-title":"FimH-mediated Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"9","author":"Khan","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0882-4010(03)00090-1","article-title":"Outer membrane protein A and cytotoxic necrotizing factor-1 use diverse signaling mechanisms for Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"35","author":"Khan","year":"2003","journal-title":"Microb. Pathog."},{"key":"B23","doi-asserted-by":"publisher","first-page":"15607","DOI":"10.1074\/jbc.M112224200","article-title":"Cytotoxic necrotizing factor-1 contributes to Escherichia coli K1 invasion of the central nervous system","volume":"277","author":"Khan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ijmm.2005.07.004","article-title":"Invasion processes of pathogenic Escherichia coli","volume":"295","author":"Kim","year":"2005","journal-title":"Int. J. Med. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"S220","DOI":"10.1086\/344284","article-title":"Strategy of Escherichia coli for crossing the blood-brain barrier","volume":"186","author":"Kim","year":"2002","journal-title":"J. Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nrn1103","article-title":"Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury","volume":"4","author":"Kim","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nrmicro1952","article-title":"Mechanisms of microbial traversal of the blood-brain barrier","volume":"6","author":"Kim","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S1473-3099(09)70306-8","article-title":"Acute bacterial meningitis in infants and children","volume":"10","author":"Kim","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1128\/ecosalplus.ESP-0015-2015","article-title":"Human meningitis-associated Escherichia coli","author":"Kim","year":"2016","journal-title":"EcoSal Plus"},{"key":"B30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/QCO.0b013e328337f49e","article-title":"New understandings on the pathophysiology of bacterial meningitis","volume":"23","author":"Koedel","year":"2010","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/82_2016_45","article-title":"Actin: structure, function, dynamics, and interactions with bacterial toxins","volume":"399","author":"K\u00fchn","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1091\/mbc.e16-01-0010","article-title":"The F-actin bundler alpha-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast","volume":"27","author":"Li","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.mce.2010.04.008","article-title":"EGF receptor activation by GPCRs: an universal pathway reveals different versions","volume":"331","author":"Liebmann","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.tcb.2006.10.008","article-title":"ErbB receptors: new insights on mechanisms and biology","volume":"16","author":"Linggi","year":"2006","journal-title":"Trends Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1186\/s12864-015-1890-9","article-title":"Genome analysis and in vivo virulence of porcine extraintestinal pathogenic Escherichia coli strain PCN033","volume":"16","author":"Liu","year":"2015","journal-title":"BMC Genomics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/tra.12508","article-title":"Escherichia coli K1 utilizes host macropinocytic pathways for invasion of brain microvascular endothelial cells","volume":"18","author":"Loh","year":"2017","journal-title":"Traffic"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1172\/JCI87406","article-title":"Epiregulin and EGFR interactions are involved in pain processing","volume":"127","author":"Martin","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1742-2094-9-154","article-title":"Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding","volume":"9","author":"Mart\u00edn","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1016\/S0140-6736(16)30654-7","article-title":"Acute bacterial meningitis in adults","volume":"388","author":"McGill","year":"2016","journal-title":"Lancet"},{"key":"B40","doi-asserted-by":"publisher","first-page":"36185","DOI":"10.1074\/jbc.M503941200","article-title":"Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway","volume":"280","author":"Mikami","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B41","first-page":"3651","article-title":"Anti-tumor effect of intravenous administration of CRM197 for triple-negative breast cancer therapy","volume":"36","author":"Nam","year":"2016","journal-title":"Anticancer Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1242\/jcs.03045","article-title":"alpha-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth","volume":"119","author":"Nyman-Huttunen","year":"2006","journal-title":"J. Cell Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","article-title":"The ErbB signaling network: receptor heterodimerization in development and cancer","volume":"19","author":"Olayioye","year":"2000","journal-title":"EMBO J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/cm.20007","article-title":"Alpha-actinin revisited: a fresh look at an old player","volume":"58","author":"Otey","year":"2004","journal-title":"Cell Motil. Cytoskeleton"},{"key":"B45","doi-asserted-by":"publisher","first-page":"26816","DOI":"10.1038\/srep26816","article-title":"Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e112794","DOI":"10.1371\/journal.pone.0112794","article-title":"N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain","volume":"9","author":"Raikwar","year":"2014","journal-title":"PLoS ONE"},{"key":"B47","doi-asserted-by":"publisher","first-page":"36769","DOI":"10.1074\/jbc.M007382200","article-title":"Phosphatidylinositol 3-kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"275","author":"Reddy","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.micinf.2005.07.012","article-title":"Role of Rac1 in Escherichia coli K1 invasion of human brain microvascular endothelial cells","volume":"8","author":"Rudrabhatla","year":"2006","journal-title":"Microbes Infect."},{"key":"B49","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S0092-8674(02)00966-2","article-title":"Ligand-induced, receptor-mediated dimerization and activation of EGF receptor","volume":"110","author":"Schlessinger","year":"2002","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.bbrc.2005.03.097","article-title":"Escherichia coli outer membrane protein A adheres to human brain microvascular endothelial cells","volume":"330","author":"Shin","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"50716","DOI":"10.1074\/jbc.M208830200","article-title":"Escherichia coli K1 internalization via caveolae requires caveolin-1 and protein kinase Calpha interaction in human brain microvascular endothelial cells","volume":"277","author":"Sukumaran","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1096\/fj.15-275586","article-title":"NHERF1 regulates actin cytoskeleton organization through modulation of alpha-actinin-4 stability","volume":"30","author":"Sun","year":"2016","journal-title":"FASEB J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/j.1462-5822.2011.01603.x","article-title":"Neisseria gonorrhoeae-induced transactivation of EGFR enhances gonococcal invasion","volume":"13","author":"Swanson","year":"2011","journal-title":"Cell. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.semcdb.2014.03.004","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) and proteolytic processing by a disintegrin and metalloproteinases (ADAM): a regulator of several pathways","volume":"28","author":"Taylor","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.2527\/jas.2015-9191","article-title":"Role of G protein-coupled receptors (GPCR), matrix metalloproteinases 2 and 9 (MMP2 and MMP9), heparin-binding epidermal growth factor-like growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (IGF-1R) in trenbolone acetate-stimulated bovine satellite cell proliferation","volume":"93","author":"Thornton","year":"2015","journal-title":"J. Anim. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"C909","DOI":"10.1152\/ajpcell.00113.2006","article-title":"Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis","volume":"291","author":"Triplett","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1005926","DOI":"10.1371\/journal.ppat.1005926","article-title":"Sphingosine 1-Phosphate activation of EGFR as a novel target for meningitic Escherichia coli penetration of the blood-brain barrier","volume":"12","author":"Wang","year":"2016","journal-title":"PLoS Pathog."},{"key":"B58","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1203\/00006450-200205000-0","article-title":"Role of OmpA and IbeB in Escherichia coli K1 invasion of brain microvascular endothelial cells in vitro and in vivo","volume":"51","author":"Wang","year":"2002","journal-title":"Pediatr. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3390\/ijms17010095","article-title":"Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research","volume":"17","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1053\/j.gastro.2008.12.059","article-title":"Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis","volume":"136","author":"Yan","year":"2009","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"38903","DOI":"10.1038\/srep38903","article-title":"Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli","volume":"6","author":"Yang","year":"","journal-title":"Sci. Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"63839","DOI":"10.18632\/oncotarget.11696","article-title":"Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier","volume":"7","author":"Yang","year":"","journal-title":"Oncotarget"},{"key":"B63","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12974-016-0734-0","article-title":"EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis","volume":"13","author":"Yang","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.jmb.2011.06.049","article-title":"Nonlinear viscoelasticity of actin transiently cross-linked with mutant alpha-actinin-4","volume":"411","author":"Yao","year":"2011","journal-title":"J. Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/35052073","article-title":"Untangling the ErbB signalling network","volume":"2","author":"Yarden","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1099\/mic.0.2008\/017988-0","article-title":"Differential expression of the polysialyl capsule during blood-to-brain transit of neuropathogenic Escherichia coli K1","volume":"154","author":"Zelmer","year":"2008","journal-title":"Microbiology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.micres.2016.02.002","article-title":"Effect of the glycosyltransferases on the capsular polysaccharide synthesis of Streptococcus suis serotype 2","volume":"185","author":"Zhang","year":"2016","journal-title":"Microbiol. Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1128\/IAI.00377-10","article-title":"Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through the phosphatidylinositol 3-kinase\/Akt signaling pathway","volume":"78","author":"Zhao","year":"2010","journal-title":"Infect. Immun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1128\/IAI.00624-10","article-title":"Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier","volume":"78","author":"Zhu","year":"","journal-title":"Infect. Immun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1128\/IAI.00336-10","article-title":"Prevention of Escherichia coli K1 penetration of the blood-brain barrier by counteracting the host cell receptor and signaling molecule involved in E. coli invasion of human brain microvascular endothelial cells","volume":"78","author":"Zhu","year":"","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"F459","DOI":"10.1152\/ajprenal.00473.2007","article-title":"Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells","volume":"294","author":"Zhuang","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00448\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T02:27:55Z","timestamp":1606012075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2018.00448\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,9]]},"references-count":71,"alternative-id":["10.3389\/fcimb.2018.00448"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2018.00448","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,9]]},"article-number":"448"}}