{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:53:32Z","timestamp":1790380412083,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00013","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:15:25Z","timestamp":1549322125000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Structural Integrity of Plasmid-Encoded Pgp3 Is Essential for Induction of Hydrosalpinx by Chlamydia muridarum"],"prefix":"10.3389","volume":"9","author":[{"given":"Yumeng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/(SICI)1098-0997(1998)6:4<163::AID-IDOG5>3.0.CO;2-6","article-title":"Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility","volume":"6","author":"Ault","year":"1998","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1097\/AOG.0b013e3182519326","article-title":"Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection","volume":"119","author":"Budrys","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e101634","DOI":"10.1371\/journal.pone.0101634","article-title":"Bioluminescence imaging of Chlamydia muridarum ascending infection in mice","volume":"9","author":"Campbell","year":"2014","journal-title":"PLoS ONE"},{"key":"B4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.micinf.2012.12.001","article-title":"Differences in infectivity and induction of infertility: a comparative study of Chlamydia trachomatis strains in the murine model","volume":"15","author":"Carmichael","year":"2013","journal-title":"Microbes Infect."},{"key":"B5","doi-asserted-by":"publisher","first-page":"6017","DOI":"10.1128\/JB.00847-10","article-title":"Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen","volume":"192","author":"Chen","year":"2010","journal-title":"J. Bacteriol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e95076","DOI":"10.1371\/journal.pone.0095076","article-title":"Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"22068","DOI":"10.1074\/jbc.M113.475012","article-title":"Structure of the Chlamydia trachomatis immunodominant antigen Pgp3","volume":"288","author":"Galaleldeen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.1128\/JB.00511-13","article-title":"Characterization of Chlamydia trachomatis plasmid-encoded open reading frames","volume":"195","author":"Gong","year":"2013","journal-title":"J. Bacteriol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s11307-014-0732-5","article-title":"In vivo whole animal body imaging reveals colonization of Chlamydia muridarum to the lower genital tract at early stages of infection","volume":"16","author":"Gupta","year":"2014","journal-title":"Mol. Imaging Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.contraception.2015.01.004","article-title":"Pathogenesis of fallopian tube damage caused by Chlamydia trachomatis infections","volume":"92","author":"Hafner","year":"2015","journal-title":"Contraception"},{"key":"B11","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1128\/IAI.00746-15","article-title":"Chlamydial plasmid-encoded virulence factor Pgp3 neutralizes the antichlamydial activity of human cathelicidin LL-37","volume":"83","author":"Hou","year":"2015","journal-title":"Infect. Immun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0124840","DOI":"10.1371\/journal.pone.0124840","article-title":"Plasmid-encoded Pgp5 is a significant contributor to Chlamydia muridarum induction of hydrosalpinx","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1128\/IAI.01543-13","article-title":"Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum","volume":"82","author":"Lei","year":"2014","journal-title":"Infect. Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1128\/JB.01161-13","article-title":"Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression","volume":"196","author":"Liu","year":"","journal-title":"J. Bacteriol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5327","DOI":"10.1128\/IAI.02576-14","article-title":"Plasmid-encoded Pgp3 is a major virulence factor for Chlamydia muridarum to induce hydrosalpinx in mice","volume":"82","author":"Liu","year":"","journal-title":"Infect. Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.micinf.2013.02.001","article-title":"Induction of protective immunity against Chlamydia muridarum intravaginal infection with the chlamydial immunodominant antigen macrophage infectivity potentiator","volume":"15","author":"Lu","year":"2013","journal-title":"Microbes Infect."},{"key":"B17","first-page":"1127","article-title":"Chlamydia trachomatis infections: screening, diagnosis, and management","volume":"86","author":"Mishori","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1128\/IAI.05022-11","article-title":"Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection","volume":"79","author":"Murthy","year":"2011","journal-title":"Infect. Immun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.4049\/jimmunol.179.6.4027","article-title":"Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease","volume":"179","author":"O'connell","year":"2007","journal-title":"J. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.1128\/IAI.00841-15","article-title":"Comparable genital tract infection, pathology, and immunity in rhesus macaques inoculated with wild-type or plasmid-deficient Chlamydia trachomatis serovar D","volume":"83","author":"Qu","year":"2015","journal-title":"Infect. Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1128\/IAI.01795-14","article-title":"Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection","volume":"82","author":"Ramsey","year":"2014","journal-title":"Infect. Immun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/2049-632X.12086","article-title":"Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model","volume":"70","author":"Sigar","year":"2014","journal-title":"Pathog. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1128\/IAI.01305-12","article-title":"Chlamydia trachomatis plasmid-encoded Pgp4 is a transcriptional regulator of virulence-associated genes","volume":"81","author":"Song","year":"2013","journal-title":"Infect. Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1128\/IAI.00154-15","article-title":"Chlamydia muridarum induction of glandular duct dilation in mice","volume":"83","author":"Sun","year":"2015","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.4049\/jimmunol.1001240","article-title":"A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans","volume":"185","author":"Wang","year":"2010","journal-title":"J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1084\/jem.193.8.935","article-title":"Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors","volume":"193","author":"Zhong","year":"2001","journal-title":"J. Exp. Med."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00013\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:15:27Z","timestamp":1549322127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00013\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":26,"alternative-id":["10.3389\/fcimb.2019.00013"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00013","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"article-number":"13"}}