{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:44:23Z","timestamp":1791841463021,"version":"4.3.4"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00117","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:19:06Z","timestamp":1556065146000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":155,"title":["The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation"],"prefix":"10.3389","volume":"9","author":[{"given":"Poshmaal","family":"Dhar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.immuni.2009.02.005","article-title":"The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA","volume":"30","author":"Allen","year":"2009","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3201\/eid0501.990104","article-title":"Campylobacter jejuni\u2013an emerging foodborne pathogen","volume":"5","author":"Altekruse","year":"1999","journal-title":"Emerg. Infect .Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1091\/mbc.11.3.819","article-title":"Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state","volume":"11","author":"Altschuler","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"347292","DOI":"10.1155\/2015\/347292","article-title":"Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells","volume":"2015","author":"Ba\u00f1os-Lara Mdel","year":"2015","journal-title":"Mediators Inflamm"},{"key":"B5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1136\/gut.42.2.227","article-title":"Interleukin 1 beta and tumour necrosis factor alpha Inhibit acid secretion in cultured rabbit parietal cells by multiple pathways","volume":"42","author":"Beales","year":"1998","journal-title":"Gut"},{"key":"B6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e00717","DOI":"10.1128\/mBio.00717-17","article-title":"Enteroaggregative Escherichia coli adherence fimbriae drive inflammatory cell recruitment via interactions with epithelial MUC1","volume":"8","author":"Boll","year":"2017","journal-title":"mBio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1477-7827-2-4","article-title":"MUC1: a multifunctional cell surface component of reproductive tissue epithelia","volume":"2","author":"Brayman","year":"2004","journal-title":"Reproduc. Biol. Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1080\/21505594.2017.1341021","article-title":"Mucin 1 protects against severe Streptococcus pneumoniae infection","volume":"8","author":"Dhar","year":"2017","journal-title":"Virulence"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6191","DOI":"10.1074\/jbc.M009449200","article-title":"A stat-responsive element in the promoter of the episialin\/MUC1 gene is involved in its overexpression in carcinoma cells","volume":"276","author":"Gaemers","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B11","first-page":"1071","article-title":"MUC6 gene polymorphism in healthy individuals and in gastric cancer patients from northern Portugal","volume":"6","author":"Garcia","year":"1997","journal-title":"Cancer Epidemiol. Biomarkers Prevent."},{"key":"B12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/2049-632X.12033","article-title":"Pseudomonas aeruginosa: new insights into pathogenesis and host defenses","volume":"67","author":"Gellatly","year":"2013","journal-title":"Pathog. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"20547","DOI":"10.1074\/jbc.M110.121319","article-title":"Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen","volume":"285","author":"Guang","year":"2010","journal-title":"J. Biol. Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/(SICI)1096-9888(199804)33:4<358::AID-JMS642>3.0.CO;2-3","article-title":"Localization of O-glycosylation sites of MUC1 tandem repeats by QTOF ESI mass spectrometry","volume":"33","author":"Hanisch","year":"1998","journal-title":"J. Mass Spectrometry."},{"key":"B15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1093\/glycob\/10.5.439","article-title":"MUC1: the polymorphic appearance of a human mucin","volume":"10","author":"Hanisch","year":"2000","journal-title":"Glycobiology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.physiol.70.113006.100659","article-title":"Structure and function of the cell surface (tethered) mucins","volume":"70","author":"Hattrup","year":"2008","journal-title":"Annu. Rev. Physiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1165\/ajrcmb.17.4.2253","article-title":"KL-6, a human MUC1 mucin, is chemotactic for human fibroblasts","volume":"17","author":"Hirasawa","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1R","DOI":"10.1093\/glycob\/11.2.1R","article-title":"Glycans as legislators of host-microbial interactions: spanning the spectrum from symbiosis to pathogenicity","volume":"11","author":"Hooper","year":"2001","journal-title":"Glycobiology."},{"key":"B19","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ppul.10044","article-title":"Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients","volume":"33","author":"Imai","year":"2002","journal-title":"Pediatr. Pulmonol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000324539","article-title":"Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: a sequential sputum analysis","volume":"82","author":"Ishikawa","year":"2011","journal-title":"Respiration."},{"key":"B21","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1582-4934.2001.tb00169.x","article-title":"Altered mucin expression in the gastrointestinal tract: a review","volume":"5","author":"Jass","year":"2001","journal-title":"J. Cell. Mol. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1165\/rcmb.2014-0018OC","article-title":"MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll\/IL-1 receptor-domain-containing adapter-inducing IFN-beta (TRIF) recruitment to Toll-like receptor 3","volume":"51","author":"Kato","year":"2014","journal-title":"Am. J. Respir. Cell. Mol. Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.4049\/jimmunol.1102405","article-title":"Membrane-tethered MUC1 mucin is phosphorylated by EGFR in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88","volume":"188","author":"Kato","year":"2012","journal-title":"J. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"L686","DOI":"10.1152\/ajplung.00423.2006","article-title":"Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling","volume":"293","author":"Kato","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1165\/rcmb.2015-0177OC","article-title":"Membrane-tethered MUC1 mucin counter-regulates the phagocytic activity of macrophages","volume":"54","author":"Kato","year":"2016","journal-title":"Am. J. Respir. Cell. Mol. Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1165\/rcmb.2008-0169TR","article-title":"MUC1 mucin: a peacemaker in the lung","volume":"39","author":"Kim","year":"2008","journal-title":"Am. J. Respir. Cell. Mol. Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s10156-005-0416-9","article-title":"The role of serum KL-6 measurement in common pediatric respiratory infections","volume":"12","author":"Kubota","year":"2006","journal-title":"J. Infect. Chemother"},{"key":"B28","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1165\/rcmb.2011-0142OC","article-title":"Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae","volume":"46","author":"Kyo","year":"2012","journal-title":"Am .J. Respir. Cell Mol. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"19321","DOI":"10.1074\/jbc.M703222200","article-title":"Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62","volume":"282","author":"Leng","year":"2007","journal-title":"J. Biol. Chem"},{"key":"B30","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bbrc.2004.01.075","article-title":"Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells","volume":"315","author":"Li","year":"2004","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"7216","DOI":"10.1128\/MCB.18.12.7216","article-title":"Interaction of glycogen synthase kinase 3beta with the DF3\/MUC1 carcinoma-associated antigen and beta-catenin","volume":"18","author":"Li","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"L558","DOI":"10.1152\/ajplung.00225.2009","article-title":"Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro","volume":"298","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"6061","DOI":"10.1074\/jbc.C000754200","article-title":"The c-Src tyrosine kinase regulates signaling of the human DF3\/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin","volume":"276","author":"Li","year":"","journal-title":"J. Biol. Chem"},{"key":"B34","doi-asserted-by":"publisher","first-page":"35239","DOI":"10.1074\/jbc.C100359200","article-title":"The epidermal growth factor receptor regulates interaction of the human DF3\/MUC1 carcinoma antigen with c-Src and beta-catenin","volume":"276","author":"Li","year":"","journal-title":"J. Biol. Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/nar\/19.2.297","article-title":"A single nucleotide polymorphism in an exon dictates allele dependent differential splicing of episialin mRNA","volume":"19","author":"Ligtenberg","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"18316","DOI":"10.1074\/jbc.M115.657114","article-title":"NEU1 sialidase regulates membrane-tethered mucin (MUC1) ectodomain ahesiveness for Pseudomonas aeruginosa and decoy receptor release","volume":"290","author":"Lillehoj","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"L751","DOI":"10.1152\/ajplung.00383.2001","article-title":"Identification of Pseudomonas aeruginosa. flagellin as an adhesin for Muc1 mucin","volume":"282","author":"Lillehoj","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1000617","DOI":"10.1371\/journal.ppat.1000617","article-title":"MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy","volume":"5","author":"Lind\u00e9n","year":"2009","journal-title":"PLoS Pathog."},{"key":"B39","doi-asserted-by":"publisher","first-page":"33325","DOI":"10.1074\/jbc.271.52.33325","article-title":"Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines","volume":"271","author":"Lloyd","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.4049\/jimmunol.176.7.3890","article-title":"Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice","volume":"176","author":"Lu","year":"2006","journal-title":"J. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nsmb1035","article-title":"Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin","volume":"13","author":"Macao","year":"2006","journal-title":"Nat. Struc. Mol. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","article-title":"Peptic ulcer disease","volume":"374","author":"Malfertheiner","year":"2009","journal-title":"Lancet."},{"key":"B43","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1038\/mi.2017.16","article-title":"The cell surface mucin MUC1 limits the severity of influenza A virus infection","volume":"10","author":"McAuley","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1172\/JCI26705","article-title":"MUC1 cell surface mucin is a critical element of the mucosal barrier to infection","volume":"117","author":"McAuley","year":"2007","journal-title":"J. Clin. Invest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1053\/j.gastro.2007.07.003","article-title":"Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis","volume":"133","author":"McGuckin","year":"2007","journal-title":"Gastroenterology."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e1001191","DOI":"10.1371\/journal.ppat.1001191","article-title":"Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4","volume":"6","author":"McNeela","year":"2010","journal-title":"PLoS Pathog."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1136\/gutjnl-2014-307175","article-title":"The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome","volume":"65","author":"Ng","year":"2016","journal-title":"Gut."},{"key":"B49","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/gene.2016.10","article-title":"The MUC1 mucin specifically inhibits activation of the NLRP3 inflammasome","volume":"17","author":"Ng","year":"2016","journal-title":"Genes Immunity"},{"key":"B50","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1164\/ajrccm.165.3.2107134","article-title":"Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases","volume":"165","author":"Ohnishi","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"B51","first-page":"47","article-title":"Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis","volume":"26","author":"Ohshimo","year":"2009","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis"},{"key":"B52","first-page":"4000","article-title":"Association of the DF3\/MUC1 breast cancer antigen with Grb2 and the Sos\/Ras exchange protein","volume":"55","author":"Pandey","year":"1995","journal-title":"Cancer Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/glycob\/cwj110","article-title":"N-Glycosylation of the MUC1 mucin in epithelial cells and secretions","volume":"16","author":"Parry","year":"2006","journal-title":"Glycobiology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1006\/bbrc.2001.4775","article-title":"Identification of MUC1 proteolytic cleavage sites in vivo","volume":"283","author":"Parry","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"31751","DOI":"10.1074\/jbc.274.45.31751","article-title":"The structure and assembly of secreted mucins","volume":"274","author":"Perez-Vilar","year":"1999","journal-title":"J. Biol. Chem"},{"key":"B56","doi-asserted-by":"publisher","first-page":"17616","DOI":"10.1074\/jbc.M200436200","article-title":"Protein kinase C delta regulates function of the DF3\/MUC1 carcinoma antigen in beta-catenin signaling","volume":"277","author":"Ren","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"14112","DOI":"10.1074\/jbc.M207744200","article-title":"Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection","volume":"278","author":"Ruiz-Palacios","year":"2003","journal-title":"J. Biol. Chem"},{"key":"B58","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1006\/smim.1999.0175","article-title":"M cells as ports of entry for enteroinvasive pathogens: mechanisms of interaction, consequences for the disease process","volume":"11","author":"Sansonetti","year":"1999","journal-title":"Semin. Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/mi.2012.98","article-title":"MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli","volume":"6","author":"Sheng","year":"2012","journal-title":"Mucosal Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/sj.ejhg.5200677","article-title":"MUC1 gene polymorphism in the gastric carcinogenesis pathway","volume":"9","author":"Silva","year":"2001","journal-title":"Eur. J. Hum. Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/sj.ejhg.5200978","article-title":"MUC1 polymorphism confers increased risk for intestinal metaplasia in a Colombian population with chronic gastritis","volume":"11","author":"Silva","year":"2003","journal-title":"Eur. J. Hum. Genetics"},{"key":"B62","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/glycob\/cwg028","article-title":"The contribution of tandem repeat number to the O-glycosylation of mucins","volume":"13","author":"Silverman","year":"2003","journal-title":"Glycobiology."},{"key":"B63","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/BF00292441","article-title":"Analysis of mammalian MUC1 genes reveals potential functionally important domains","volume":"6","author":"Spicer","year":"1995","journal-title":"Mamm. Genome"},{"key":"B64","doi-asserted-by":"crossref","first-page":"15099","DOI":"10.1016\/S0021-9258(18)98592-3","article-title":"Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism","volume":"266","author":"Spicer","year":"1991","journal-title":"J. Biol. Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1084\/jem.20071239","article-title":"Immune recognition of Pseudomonas aeruginosa. mediated by the IPAF\/NLRC4 inflammasome","volume":"204","author":"Sutterwala","year":"2007","journal-title":"J. Exp. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/328082a0","article-title":"The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM","volume":"328","author":"Swallow","year":"1987","journal-title":"Nature."},{"key":"B67","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0925-4439(99)00055-1","article-title":"MUC1 and cancer","volume":"1455","author":"Taylor-Papadimitriou","year":"1999","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1074\/jbc.M208326200","article-title":"Tumor necrosis factor-alpha converting enzyme\/ADAM 17 mediates MUC1 shedding","volume":"278","author":"Thathiah","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1042\/BJ20040513","article-title":"MT1-MMP mediates MUC1 shedding independent of TACE\/ADAM17","volume":"382","author":"Thathiah","year":"2004","journal-title":"Biochem. J."},{"key":"B70","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2009.02.006","article-title":"The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1","volume":"30","author":"Thomas","year":"2009","journal-title":"Immunity."},{"key":"B71","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"B72","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1165\/rcmb.2007-0336RC","article-title":"MUC1 mucin is a negative regulator of toll-like receptor signaling","volume":"38","author":"Ueno","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/S0140-6736(09)61114-4","article-title":"Pathogenesis, treatment, and prevention of pneumococcal pneumonia","volume":"374","author":"Van Der Poll","year":"2009","journal-title":"Lancet"},{"key":"B74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/gast.2002.34157","article-title":"Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori. gastritis","volume":"123","author":"Vinall","year":"2002","journal-title":"Gastroenterology."},{"key":"B75","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0006-291X(05)81390-7","article-title":"The mouse episialin (Muc1) gene and its promoter: rapid evolution of the repetitive domain in the protein","volume":"181","author":"Vos","year":"1991","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"G559","DOI":"10.1152\/ajpgi.1991.261.4.G559","article-title":"Secretagogue effects of interleukin-1 on gastric acid secretion","volume":"261","author":"Wallace","year":"1991","journal-title":"Am. J. Physiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.bbrc.2003.09.030","article-title":"Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail","volume":"310","author":"Wang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B78","doi-asserted-by":"publisher","first-page":"434","DOI":"10.4049\/jimmunol.1003143","article-title":"The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia","volume":"187","author":"Witzenrath","year":"2011","journal-title":"J. Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/0140-6736(93)91409-F","article-title":"Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori","volume":"342","author":"Wotherspoon","year":"1993","journal-title":"Lancet"},{"key":"B80","doi-asserted-by":"publisher","first-page":"12492","DOI":"10.1074\/jbc.272.19.12492","article-title":"Interaction of the DF3\/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion","volume":"272","author":"Yamamoto","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S1097-2765(00)80032-5","article-title":"Autoproteolytic activation of pro-caspases by oligomerization","volume":"1","author":"Yang","year":"1998","journal-title":"Mol. Cell"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00117\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T14:27:06Z","timestamp":1663338426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00117\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":81,"alternative-id":["10.3389\/fcimb.2019.00117"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00117","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"article-number":"117"}}