{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:04:31Z","timestamp":1790262271094,"version":"4.1.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00132","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T04:58:40Z","timestamp":1557809920000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Impact of Toxoplasma gondii Infection on Host Non-coding RNA Responses"],"prefix":"10.3389","volume":"9","author":[{"given":"Kayla L.","family":"Menard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne E.","family":"Haskins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y.","family":"Denkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/IAI.00789-18","article-title":"Downregulation of the central noradrenergic system by Toxoplasma gondii Infection","volume":"87","author":"Alsaady","year":"2019","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.chom.2012.12.003","article-title":"Combined action of nucleic acid-sensing toll-like receptors and TLR11\/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice","volume":"13","author":"Andrade","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/s41564-018-0352-y","article-title":"Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1","volume":"4","author":"Atayde","year":"2019","journal-title":"Nat. Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-immunol-041015-055459","article-title":"Immunobiology of long noncoding RNAs","volume":"35","author":"Atianand","year":"2017","journal-title":"Ann. Rev. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1084\/jem.20130103","article-title":"A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation","volume":"210","author":"Braun","year":"2013","journal-title":"J. Exp. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e1002236","DOI":"10.1371\/journal.ppat.1002236","article-title":"Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control","volume":"7","author":"Butcher","year":"2011","journal-title":"PLoS Pathog."},{"key":"B7","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/1756-3305-6-356","article-title":"STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage","volume":"6","author":"Cai","year":"2013","journal-title":"Parasit. Vectors"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.cellsig.2014.02.013","article-title":"Toxoplasma gondii inhibits apoptosis via a novel STAT3-miR-17-92-Bim pathway in macrophages","volume":"26","author":"Cai","year":"2014","journal-title":"Cell. Signal."},{"key":"B9","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.celrep.2014.02.002","article-title":"miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain","volume":"6","author":"Cannella","year":"2014","journal-title":"Cell Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/j.1365-2958.2007.05714.x","article-title":"Suicide prevention: disruption of apoptotic pathways by protozoan parasites","volume":"64","author":"Carmen","year":"2007","journal-title":"Mol. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/science.1240925","article-title":"A long noncoding RNA mediates both activation and repression of immune response genes","volume":"341","author":"Carpenter","year":"2013","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/ni.3771","article-title":"Gene regulation in the immune system by long noncoding RNAs","volume":"18","author":"Chen","year":"2017","journal-title":"Nat. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"25599","DOI":"10.18632\/oncotarget.16108","article-title":"Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection","volume":"8","author":"Cong","year":"2017","journal-title":"Oncotarget"},{"key":"B14","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","article-title":"Immune response and immunopathology during toxoplasmosis","volume":"34","author":"Dupont","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.celrep.2018.10.027","article-title":"Genetic models reveal cis and trans immune-regulatory activities for lincRNA-Cox2","volume":"25","author":"Elling","year":"2018","journal-title":"Cell Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.coi.2013.12.001","article-title":"Long noncoding RNAs in innate and adaptive immunity","volume":"26","author":"Fitzgerald","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1017\/S0031182018001105","article-title":"A new landscape of host-protozoa interactions involving the extracellular vesicles world","volume":"145","author":"Gavinho","year":"2018","journal-title":"Parasitology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"902","DOI":"10.4049\/jimmunol.167.2.902","article-title":"IFN-g overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection","volume":"167","author":"Gavrilescu","year":"2001","journal-title":"J. Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.chom.2014.01.004","article-title":"Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men","volume":"15","author":"Gazzinelli","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B20","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent upon CD4+ T cells and accompanied by overproduction of IL-12, IFN-g, and TNF-a","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/nature10887","article-title":"Modular regulatory principles of large non-coding RNAs","volume":"482","author":"Guttman","year":"2012","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/CMR.00005-17","article-title":"Toxoplasma effectors targeting host signaling and transcription","volume":"30","author":"Hakimi","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e39887","DOI":"10.7554\/eLife.39887","article-title":"Characterization of a Toxoplasma effector uncovers an alternative GSK3\/beta-catenin-regulatory pathway of inflammation","volume":"7","author":"He","year":"2018","journal-title":"Elife"},{"key":"B24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.meegid.2015.11.005","article-title":"Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection","volume":"37","author":"He","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12864-019-5458-y","article-title":"Comparison of splenocyte microRNA expression profiles of pigs during acute and chronic toxoplasmosis","volume":"20","author":"Hou","year":"2019","journal-title":"BMC Genom."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nm.2849","article-title":"MiR-23b is a safeguard against autoimmunity","volume":"18","author":"Hu","year":"2012","journal-title":"Nat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.3389\/fmicb.2018.02316","article-title":"Differential brain microRNA expression profiles after acute and chronic infection of mice with Toxoplasma gondii oocysts","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"key":"B29","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1186\/1756-3305-7-433","article-title":"Plasma microRNAs are promising novel biomarkers for the early detection of Toxoplasma gondii infection","volume":"7","author":"Jia","year":"2014","journal-title":"Parasit. Vectors"},{"key":"B30","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3347\/kjp.2016.54.2.147","article-title":"Exosomes secreted by Toxoplasma gondii-infected L6 cells: their effects on host cell proliferation and cell cycle changes","volume":"54","author":"Kim","year":"2016","journal-title":"Korean J. Parasitol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/ncb2054","article-title":"miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator","volume":"12","author":"Lagos","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3630","DOI":"10.4049\/jimmunol.1800566","article-title":"Induction of a long noncoding RNA transcript, NR_045064, promotes defense gene transcription and facilitates intestinal epithelial cell responses against Cryptosporidium infection","volume":"201","author":"Li","year":"2018","journal-title":"J. Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13071-019-3297-y","article-title":"Expression profile of microRNAs in porcine alveolar macrophages after Toxoplasma gondii infection","volume":"12","author":"Li","year":"2019","journal-title":"Parasit. Vectors"},{"key":"B34","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1017\/S003118201400167X","article-title":"Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner","volume":"142","author":"Li","year":"2015","journal-title":"Parasitology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.it.2008.04.004","article-title":"microRNAs and the immune response","volume":"29","author":"Lindsay","year":"2008","journal-title":"Trends Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13071-018-2697-8","article-title":"Microarray analysis of long non-coding RNA expression profiles uncovers a Toxoplasma-induced negative regulation of host immune signaling","volume":"11","author":"Liu","year":"2018","journal-title":"Parasit. Vectors"},{"key":"B37","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/3-540-27320-4_10","article-title":"Apoptosis and its modulation during infection with Toxoplasma gondii: molecular mechanisms and role in pathogenesis","volume":"289","author":"L\u00fcder","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"B38","first-page":"100","article-title":"Human Toxoplasma infection","volume-title":"Toxoplasma gondii. The Model Apicomplexan: Perspectives and Methods","author":"McLeod","year":"2013"},{"key":"B39","doi-asserted-by":"publisher","first-page":"15017","DOI":"10.1038\/s41598-018-33274-5","article-title":"Toxoplasma gondii manipulates expression of host long noncoding RNA during intracellular infection","volume":"8","author":"Menard","year":"2018","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1073\/pnas.1113793109","article-title":"MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.4049\/jimmunol.167.8.4574","article-title":"Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines","volume":"167","author":"Mordue","year":"2001","journal-title":"J. Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"11496","DOI":"10.1038\/s41598-017-10675-6","article-title":"Toxoplasma modulates signature pathways of human epilepsy, neurodegeneration and cancer","volume":"7","author":"Ng\u00f4","year":"2017","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2016.06.006","article-title":"Toxoplasma effector recruits the Mi-2\/NuRD complex to repress STAT1 transcription and block IFN-gamma-Dependent gene expression","volume":"20","author":"Olias","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B44","doi-asserted-by":"publisher","first-page":"28731","DOI":"10.1074\/jbc.M110.112359","article-title":"Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6","volume":"285","author":"Ong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3402\/jev.v2i0.22484","article-title":"Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation","volume":"2","author":"Pope","year":"2013","journal-title":"J. Extracell. Vesicles"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4818","DOI":"10.4049\/jimmunol.1301301","article-title":"Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin","volume":"191","author":"Raetz","year":"2013","journal-title":"J. Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1128\/IAI.01666-14","article-title":"Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury","volume":"82","author":"Rao","year":"2014","journal-title":"Infect. Immun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.micpath.2018.05.030","article-title":"miR-20a inhibition using locked nucleic acid (LNA) technology and its effects on apoptosis of human macrophages infected by Toxoplasma gondii RH strain","volume":"121","author":"Rezaei","year":"2018","journal-title":"Microb. Pathog."},{"key":"B49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1084\/jem.20100717","article-title":"Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein","volume":"208","author":"Rosowski","year":"2011","journal-title":"J. Exp. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","article-title":"Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue","volume":"445","author":"Saeij","year":"2007","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/intimm\/dxy004","article-title":"Host immune responses to Toxoplasma gondii","volume":"30","author":"Sasai","year":"2018","journal-title":"Int. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.molmed.2011.06.009","article-title":"NeurimmiRs: microRNAs in the neuroimmune interface","volume":"17","author":"Soreq","year":"2011","journal-title":"Trends Mol. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.4049\/jimmunol.1600970","article-title":"Biogenesis and transcriptional regulation of long noncoding RNAs in the human immune system","volume":"197","author":"Spurlock","year":"2016","journal-title":"J. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.meegid.2018.07.034","article-title":"Epigenetic dysregulation of host gene expression in Toxoplasma infection with specific reference to dopamine and amyloid pathways","volume":"65","author":"Syn","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0150353","DOI":"10.1371\/journal.pone.0150353","article-title":"lncRNA-RNA interactions across the human transcriptome","volume":"11","author":"Szcze\u015bniak","year":"2016","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B57","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1093\/nar\/gks151","article-title":"miR-212\/132 expression and functions: within and beyond the neuronal compartment","volume":"40","author":"Wanet","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.3389\/fimmu.2018.03066","article-title":"Extracellular vesicle-mediated communication within host-parasite interactions","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/ni1575","article-title":"Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes","volume":"9","author":"Xiao","year":"2008","journal-title":"Nat. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuroscience.2014.03.015","article-title":"MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway","volume":"268","author":"Xiao","year":"2014","journal-title":"Neuroscience"},{"key":"B61","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1756-3305-6-154","article-title":"Characterization of mouse brain microRNAs after infection with cyst-forming Toxoplasma gondii","volume":"6","author":"Xu","year":"2013","journal-title":"Parasit. Vectors"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-7046-9_1","article-title":"MicroRNAs, long noncoding RNAs, and their functions in human disease","volume":"1617","author":"Xue","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1084\/jem.20091703","article-title":"A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3","volume":"206","author":"Yamamoto","year":"2009","journal-title":"J. Exp. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to Toxoplasma gondii infection","volume":"14","author":"Yarovinsky","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e8742","DOI":"10.1371\/journal.pone.0008742","article-title":"Toxoplasma gondii infection specifically increases the levels of key host microRNAs","volume":"5","author":"Zeiner","year":"2010","journal-title":"PLoS ONE"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.7150\/thno.19646","article-title":"Decoding noncoding RNAs: role of microRNAs and long noncoding RNAs in ocular neovascularization","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat. Med."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00132\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T15:01:26Z","timestamp":1694876486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00132\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":67,"alternative-id":["10.3389\/fcimb.2019.00132"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00132","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]},"article-number":"132"}}