{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:48Z","timestamp":1790361288891,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00216","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T09:18:42Z","timestamp":1561108722000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":118,"title":["Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Anna","family":"Lundmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue O. O.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Huss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders F.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclay","family":"Yucel-Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1600-0765.2009.01250.x","article-title":"Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR","volume":"45","author":"Abiko","year":"2010","journal-title":"J. Periodont. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41522-017-0031-4","article-title":"Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries","volume":"3","author":"Belstrom","year":"","journal-title":"NPJ Biofilms Microbiomes"},{"key":"B4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jcpe.12190","article-title":"Differences in bacterial saliva profile between periodontitis patients and a control cohort","volume":"41","author":"Belstrom","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/JPER.17-0377","article-title":"Influence of periodontal treatment on subgingival and salivary microbiotas","volume":"89","author":"Belstrom","year":"2018","journal-title":"J. Periodontol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0182992","DOI":"10.1371\/journal.pone.0182992","article-title":"Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients","volume":"12","author":"Belstrom","year":"","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1600-051X.2010.01670.x","article-title":"Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis","volume":"38","author":"Buduneli","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"B9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fmicb.2015.00119","article-title":"Subgingival microbiota in health compared to periodontitis and the influence of smoking","volume":"6","author":"Camelo-Castillo","year":"2015","journal-title":"Front. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/s41396-017-0037-1","article-title":"Oral microbiota of periodontal health and disease and their changes after nonsurgical periodontal therapy","volume":"12","author":"Chen","year":"2018","journal-title":"ISME J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9053","DOI":"10.1038\/srep09053","article-title":"A filifactor alocis-centered co-occurrence group associates with periodontitis across different oral habitats","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1902\/jop.2009.090185","article-title":"Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray","volume":"80","author":"Colombo","year":"2009","journal-title":"J. Periodontol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/jcpe.12538","article-title":"Host-derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta-analysis","volume":"43","author":"de Lima","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1038\/s41598-017-03804-8","article-title":"Dysbiosis in chronic periodontitis: key microbial players and interactions with the human host","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1902\/jop.2015.140520","article-title":"Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012","volume":"86","author":"Eke","year":"2015","journal-title":"J. Periodontol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1902\/jop.2012.110676","article-title":"Advances in surveillance of periodontitis: the centers for disease control and prevention periodontal disease surveillance project","volume":"83","author":"Eke","year":"2012","journal-title":"J. Periodontol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/j.1600-0765.2012.01500.x","article-title":"Comparison of CCL28, interleukin-8, interleukin-1beta and tumor necrosis factor-alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis","volume":"48","author":"Ertugrul","year":"2013","journal-title":"J. Periodont. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/odi.12932","article-title":"Cariogenic microbiome and microbiota of the early primary dentition: a contemporary overview","volume":"25","author":"Fakhruddin","year":"2019","journal-title":"Oral Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1128\/JCM.00729-13","article-title":"A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis","volume":"51","author":"Fine","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10266-011-0042-1","article-title":"Correlations between pentraxin 3 or cytokine levels in gingival crevicular fluid and clinical parameters of chronic periodontitis","volume":"100","author":"Fujita","year":"2012","journal-title":"Odontology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e65520","DOI":"10.1371\/journal.pone.0065520","article-title":"Oral microbiome of deep and shallow dental pockets in chronic periodontitis","volume":"8","author":"Ge","year":"2013","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nrcardio.2010.120","article-title":"Prevention: reducing the risk of CVD in patients with periodontitis","volume":"7","author":"Genco","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/ismej.2011.191","article-title":"Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing","volume":"6","author":"Griffen","year":"2012","journal-title":"ISME J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fcimb.2016.00196","article-title":"Editorial: use of saliva in diagnosis of periodontitis: cumulative use of bacterial and host-derived biomarkers","volume":"6","author":"Gursoy","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1155\/2011\/621484","article-title":"Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach","volume":"30","author":"Gursoy","year":"2011","journal-title":"Dis. Markers"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1902\/jop.2013.130306","article-title":"Microbial analysis of subgingival plaque samples compared to that of whole saliva in patients with periodontitis","volume":"85","author":"Haririan","year":"2014","journal-title":"J. Periodontol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1038\/ismej.2011.41","article-title":"Transitions in bacterial communities along the 2000 km salinity gradient of the Baltic sea","volume":"5","author":"Herlemann","year":"2011","journal-title":"ISME J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e0174782","DOI":"10.1371\/journal.pone.0174782","article-title":"Relative abundance of total subgingival plaque-specific bacteria in salivary microbiota reflects the overall periodontal condition in patients with periodontitis","volume":"12","author":"Kageyama","year":"2017","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1177\/0022034510375281","article-title":"\u201cGum bug, leave my heart alone!\u201d\u2013epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis","volume":"89","author":"Kebschull","year":"2010","journal-title":"J. Dent. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0200900","DOI":"10.1371\/journal.pone.0200900","article-title":"Grading system for periodontitis by analyzing levels of periodontal pathogens in saliva","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/154405910308200503","article-title":"New bacterial species associated with chronic periodontitis","volume":"82","author":"Kumar","year":"2003","journal-title":"J. Dent. Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1600-051X.2012.01856.x","article-title":"Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants","volume":"39","author":"Kumar","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"Le Cao","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1038\/ismej.2014.28","article-title":"Phylogenetic and functional gene structure shifts of the oral microbiomes in periodontitis patients","volume":"8","author":"Li","year":"2014","journal-title":"ISME J."},{"key":"B42","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw","year":"2002","journal-title":"R News"},{"key":"B43","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3389\/fcimb.2018.00267","article-title":"The performance of an oral microbiome biomarker panel in predicting oral cavity and oropharyngeal cancers","volume":"8","author":"Lim","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e37919","DOI":"10.1371\/journal.pone.0037919","article-title":"Deep sequencing of the oral microbiome reveals signatures of periodontal disease","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS ONE"},{"key":"B45","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e10029","DOI":"10.1371\/journal.pone.0010029","article-title":"Increased throughput by parallelization of library preparation for massive sequencing","volume":"5","author":"Lundin","year":"2010","journal-title":"PLoS ONE"},{"key":"B47","doi-asserted-by":"publisher","first-page":"18475","DOI":"10.1038\/srep18475","article-title":"Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases","volume":"5","author":"Lundmark","year":"2015","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1034\/j.1600-0765.2003.00677.x","article-title":"Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis","volume":"38","author":"Mantyla","year":"2003","journal-title":"J. Periodont. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1177\/0022034515594779","article-title":"Association of synergistetes and cyclodipeptides with periodontitis","volume":"94","author":"Marchesan","year":"2015","journal-title":"J. Dent. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1399-302x.2004.00172.x","article-title":"Detection frequency of periodontitis-associated bacteria by polymerase chain reaction in subgingival and supragingival plaque of periodontitis and healthy subjects","volume":"19","author":"Mayanagi","year":"2004","journal-title":"Oral Microbiol. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e61217","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS ONE"},{"key":"B52","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1177\/0022034516634619","article-title":"Levels of candidate periodontal pathogens in subgingival biofilm","volume":"95","author":"Oliveira","year":"2016","journal-title":"J. Dent. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3109\/00016357.2015.1007480","article-title":"From the Acta Prize Lecture 2014: the periodontal-systemic connection seen from a microbiological standpoint","volume":"73","author":"Olsen","year":"2015","journal-title":"Acta Odontol. Scand."},{"key":"B54","first-page":"79","article-title":"National opinion poll on cerebrovascular accidents. Paul Padovani survey","volume":"170","author":"Padovani","year":"1986","journal-title":"Bull. Acad. Natl. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1600-0757.1997.tb00189.x","article-title":"The pathogenesis of human periodontitis: an introduction","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol. 2000"},{"key":"B56","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1177\/0022034514542468","article-title":"Newly identified pathogens associated with periodontitis: a systematic review","volume":"93","author":"Perez-Chaparro","year":"2014","journal-title":"J. Dent. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1600-0757.2011.00425.x","article-title":"The global burden of periodontal disease: towards integration with chronic disease prevention and control","volume":"60","author":"Petersen","year":"2012","journal-title":"Periodontol. 2000"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e58487","DOI":"10.1371\/journal.pone.0058487","article-title":"The dental plaque microbiome in health and disease","volume":"8","author":"Peterson","year":"2013","journal-title":"PLoS ONE"},{"key":"B59","unstructured":"R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing.2015"},{"key":"B60","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/jcpe.12038","article-title":"Salivary biomarkers of oral health: a cross-sectional study","volume":"40","author":"Rathnayake","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","author":"Rohart","year":"2017","journal-title":"bioRxiv."},{"key":"B62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fcimb.2015.00069","article-title":"Quantitative PCR analysis of salivary pathogen burden in periodontitis","volume":"5","author":"Salminen","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fcimb.2018.00124","article-title":"The subgingival microbiome of periodontal pockets with different probing depths in chronic and aggressive periodontitis: a pilot study","volume":"8","author":"Shi","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41598-018-20085-x","article-title":"Combined analysis of the salivary microbiome and host defence peptides predicts dental disease","volume":"8","author":"Simon-Soro","year":"2018","journal-title":"Sci. Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1172\/JCI19872","article-title":"Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways","volume":"113","author":"Sims","year":"2004","journal-title":"J. Clin. Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"17069","DOI":"10.1038\/nrdp.2017.69","article-title":"A quantitative point-of-care test for periodontal and dental peri-implant diseases","volume":"3","author":"Sorsa","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B68","doi-asserted-by":"publisher","first-page":"22164","DOI":"10.1038\/srep22164","article-title":"Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study","volume":"6","author":"Takeshita","year":"2016","journal-title":"Sci. Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1128\/CMR.00021-13","article-title":"Salivary biomarkers: toward future clinical and diagnostic utilities","volume":"26","author":"Yoshizawa","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1017\/erm.2013.8","article-title":"Inflammatory mediators in the pathogenesis of periodontitis","volume":"15","author":"Yucel-Lindberg","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.3389\/fmicb.2017.02144","article-title":"Relationship between gingival crevicular fluid microbiota and cytokine profile in periodontal host homeostasis","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Microbiol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00216\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T09:18:46Z","timestamp":1561108726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00216\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":72,"alternative-id":["10.3389\/fcimb.2019.00216"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00216","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,21]]},"article-number":"216"}}