{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:23:59Z","timestamp":1790364239213,"version":"4.1.0"},"reference-count":130,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/P020119\/1"],"award-info":[{"award-number":["BB\/P020119\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00261","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T10:21:17Z","timestamp":1563358877000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":66,"title":["Stress-Activated Protein Kinases in Human Fungal Pathogens"],"prefix":"10.3389","volume":"9","author":[{"given":"Alison M.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/j.1365-2958.2005.04533.x","article-title":"The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae","volume":"56","author":"Aguilera","year":"2005","journal-title":"Mol. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1099\/mic.0.023309-0","article-title":"The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans","volume":"155","author":"Alonso-Monge","year":"2009","journal-title":"Microbiology"},{"key":"B3","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1128\/JB.181.10.3058-3068.1999","article-title":"Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans","volume":"181","author":"Alonso-Monge","year":"1999","journal-title":"J. Bacteriol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1128\/EC.2.2.351-361.2003","article-title":"The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans","volume":"2","author":"Alonso-Monge","year":"2003","journal-title":"Eukaryotic Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0136932","DOI":"10.1371\/journal.pone.0136932","article-title":"Network modeling reveals cross talk of MAP kinases during adaptation to caspofungin stress in Aspergillus fumigatus","volume":"10","author":"Altwasser","year":"2015","journal-title":"PLoS ONE"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1111\/j.1462-5822.2007.00898.x","article-title":"Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicans","volume":"9","author":"Arana","year":"2007","journal-title":"Cell. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1099\/mic.0.27723-0","article-title":"The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans","volume":"151","author":"Arana","year":"2005","journal-title":"Microbiology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1128\/EC.00133-10","article-title":"Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3","volume":"10","author":"Argimon","year":"2011","journal-title":"Eukaryotic Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1128\/EC.00323-08","article-title":"Master and commander in fungal pathogens: the two-component system and the HOG signaling pathway","volume":"7","author":"Bahn","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1128\/EC.00349-07","article-title":"Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans","volume":"6","author":"Bahn","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1091\/mbc.e04-11-0987","article-title":"Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans","volume":"16","author":"Bahn","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1091\/mbc.e06-02-0113","article-title":"A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans","volume":"17","author":"Bahn","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/mmi.13461","article-title":"Opposing PKA and Hog1 signals control the post-transcriptional response to glucose availability in Cryptococcus neoformans","volume":"102","author":"Banerjee","year":"2016","journal-title":"Mol. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1111\/j.1365-2958.2004.04238.x","article-title":"Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance","volume":"53","author":"Bilsland","year":"2004","journal-title":"Mol. Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3887","DOI":"10.1128\/MCB.20.11.3887-3895.2000","article-title":"Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1","volume":"20","author":"Bilsland-Marchesan","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1126\/science.7681220","article-title":"An osmosensing signal transduction pathway in yeast","volume":"259","author":"Brewster","year":"1993","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"re7","DOI":"10.1126\/scisignal.2005458","article-title":"Hog1: 20 years of discovery and impact","volume":"7","author":"Brewster","year":"2014","journal-title":"Sci. Signal."},{"key":"B18","doi-asserted-by":"crossref","DOI":"10.1128\/9781555819583.ch21","article-title":"Stress adaptation","volume-title":"Microbiol. Spectr.","author":"Brown","year":"2017"},{"key":"B19","doi-asserted-by":"publisher","first-page":"165r","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1111\/mmi.13354","article-title":"Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence","volume":"100","author":"Bruder Nascimento","year":"2016","journal-title":"Mol. Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1091\/mbc.12.2.407","article-title":"Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway","volume":"12","author":"Buck","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jbiotec.2011.09.017","article-title":"A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity","volume":"157","author":"Buschart","year":"2012","journal-title":"J. Biotechnol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1128\/IAI.68.2.518-525.2000","article-title":"Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans","volume":"68","author":"Calera","year":"2000","journal-title":"Infect. Immun."},{"key":"B24","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1128\/IAI.67.8.4280-4284.1999","article-title":"Avirulence of Candida albicans CaHK1 mutants in a murine model of hematogenously disseminated candidiasis","volume":"67","author":"Calera","year":"1999","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fgb.2015.09.005","article-title":"Systematic gene deletion and functional characterization of histidine kinase phosphorelay receptors (HKRs) in the human pathogenic fungus Aspergillus fumigatus","volume":"84","author":"Chapeland-Leclerc","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1128\/EC.2.5.1018-1024.2003","article-title":"Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress","volume":"2","author":"Chauhan","year":"2003","journal-title":"Eukaryotic Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"42002","DOI":"10.1074\/jbc.M111.265231","article-title":"MAPKKK-independent regulation of the Hog1 stress-activated protein kinase in Candida albicans","volume":"286","author":"Cheetham","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1091\/mbc.e07-06-0581","article-title":"A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans","volume":"18","author":"Cheetham","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"B29","article-title":"The antimicrobial photodynamic inactivation resistance of Candida albicans is modulated by the Hog1 pathway and the Cap1 transcription factor","volume-title":"Med. Mycol.","author":"Chien","year":"2018"},{"key":"B30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/mmy.40.3.259.262","article-title":"fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis","volume":"40","author":"Clemons","year":"2002","journal-title":"Med. Mycol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0076-6879(07)28004-8","article-title":"Control of cell cycle in response to osmostress: lessons from yeast","volume":"428","author":"Clotet","year":"2007","journal-title":"Meth. Enzymol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.3389\/fmicb.2016.02133","article-title":"The Hog1 MAP kinase promotes the recovery from cell cycle arrest induced by hydrogen peroxide in Candida albicans","volume":"7","author":"Correia","year":"2016","journal-title":"Front. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1128\/MCB.00313-10","article-title":"Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans","volume":"30","author":"da Silva Dantas","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"14340","DOI":"10.1038\/s41598-017-14756-4","article-title":"Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen","volume":"7","author":"Day","year":"","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e1006131","DOI":"10.1371\/journal.ppat.1006131","article-title":"Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation","volume":"13","author":"Day","year":"","journal-title":"PLoS Pathog."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e01952","DOI":"10.1128\/mBio.01952-18","article-title":"Protein kinase a and high-osmolarity glycerol response pathways cooperatively control cell wall carbohydrate mobilization in Aspergillus fumigatus","volume":"9","author":"de Assis","year":"2018","journal-title":"MBio"},{"key":"B37","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/mmi.12785","article-title":"ChIP-seq reveals a role for CrzA in the Aspergillus fumigatus high-osmolarity glycerol response (HOG) signalling pathway","volume":"94","author":"de Castro","year":"2014","journal-title":"Mol. Microbiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/emboj.2009.346","article-title":"Multilayered control of gene expression by stress-activated protein kinases","volume":"29","author":"de Nadal","year":"2010","journal-title":"EMBO J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"23961","DOI":"10.1074\/jbc.M312974200","article-title":"High osmolarity glycerol (HOG) pathway-induced phosphorylation and activation of 6-phosphofructo-2-kinase are essential for glycerol accumulation and yeast cell proliferation under hyperosmotic stress","volume":"279","author":"Dihazi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/13693780500338886","article-title":"The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus","volume":"44","author":"Du","year":"2006","journal-title":"Med. Mycol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1046\/j.1365-2443.1997.d01-311.x","article-title":"Signal transduction via the histidyl-aspartyl phosphorelay","volume":"2","author":"Egger","year":"1997","journal-title":"Genes Cells"},{"key":"B42","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1128\/EC.5.2.347-358.2006","article-title":"The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans","volume":"5","author":"Eisman","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1091\/mbc.e05-06-0501","article-title":"Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans","volume":"17","author":"Enjalbert","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.3389\/fmicb.2018.03347","article-title":"The AGC kinase YpkA regulates sphingolipids biosynthesis and physically interacts with SakA MAP kinase in Aspergillus fumigatus","volume":"9","author":"Fabri","year":"2018","journal-title":"Front. Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1093\/emboj\/17.19.5606","article-title":"Regulated nucleo\/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1","volume":"17","author":"Ferrigno","year":"1998","journal-title":"EMBO J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e00142","DOI":"10.1128\/mBio.00142-13","article-title":"The fungal pathogen Aspergillus fumigatus regulates growth, metabolism, and stress resistance in response to light","volume":"4","author":"Fuller","year":"2013","journal-title":"MBio"},{"key":"B47","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.8047888","article-title":"An osmosensing signal transduction pathway in mammalian cells","volume":"265","author":"Galcheva-Gargova","year":"1994","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the Cryptococcus gattii\/Cryptococcus neoformans species complex","volume":"78","author":"Hagen","year":"2015","journal-title":"Fungal Genet. Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.fgb.2014.10.011","article-title":"The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus","volume":"73","author":"Hagiwara","year":"2014","journal-title":"Fungal Genet. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e80881","DOI":"10.1371\/journal.pone.0080881","article-title":"NikA\/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus","volume":"8","author":"Hagiwara","year":"2013","journal-title":"PLoS ONE"},{"key":"B51","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1126\/science.7914033","article-title":"A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells","volume":"265","author":"Han","year":"1994","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/jb\/mvj089","article-title":"Activation of the HOG pathway upon cold stress in Saccharomyces cerevisiae","volume":"139","author":"Hayashi","year":"2006","journal-title":"J. Biochem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1128\/AAC.00365-13","article-title":"Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans","volume":"57","author":"Hayes","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B54","doi-asserted-by":"publisher","first-page":"e02229","DOI":"10.1128\/mBio.02229-17","article-title":"Redox regulation, rather than stress-induced phosphorylation, of a Hog1 mitogen-activated protein kinase modulates its nitrosative-stress-specific outputs","volume":"9","author":"Herrero-de-Dios","year":"2018","journal-title":"MBio"},{"key":"B55","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1534\/genetics.111.128322","article-title":"The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae","volume":"188","author":"Hickman","year":"2011","journal-title":"Genetics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e1005644","DOI":"10.1371\/journal.ppat.1005644","article-title":"Neutrophil attack triggers extracellular trap-dependent candida cell wall remodeling and altered immune recognition","volume":"12","author":"Hopke","year":"2016","journal-title":"PLoS Pathog."},{"key":"B57","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s11046-012-9557-4","article-title":"HOG-MAPK signaling regulates the adaptive responses of Aspergillus fumigatus to thermal stress and other related stress","volume":"174","author":"Ji","year":"2012","journal-title":"Mycopathologia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.fgb.2012.02.001","article-title":"Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway","volume":"49","author":"Jung","year":"2012","journal-title":"Fungal Genet. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2180-13-16","article-title":"Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability","volume":"13","author":"Kaba","year":"2013","journal-title":"BMC Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3109\/13693780802552606","article-title":"Exposure to caspofungin activates Cap and Hog pathways in Candida albicans","volume":"47","author":"Kelly","year":"2009","journal-title":"Med. Mycol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fmicb.2012.00088","article-title":"Targeting the oxidative stress response system of fungi with redox-potent chemosensitizing agents","volume":"3","author":"Kim","year":"2012","journal-title":"Front. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1534\/genetics.110.118315","article-title":"Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans","volume":"185","author":"Kim","year":"2010","journal-title":"Genetics"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e18769","DOI":"10.1371\/journal.pone.0018769","article-title":"Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS ONE"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1128\/EC.00120-09","article-title":"Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways","volume":"8","author":"Ko","year":"2009","journal-title":"Eukaryotic Cell"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1111\/j.1365-2958.2004.04244.x","article-title":"Fungicide activity through activation of a fungal signalling pathway","volume":"53","author":"Kojima","year":"2004","journal-title":"Mol. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"5160","DOI":"10.1074\/jbc.M608526200","article-title":"Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1","volume":"282","author":"Lawrence","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1091\/mbc.E18-03-0185","article-title":"Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1","volume":"29","author":"Lee","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1101\/gad.229310.113","article-title":"MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators","volume":"27","author":"Lee","year":"2013","journal-title":"Genes Dev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1128\/EC.05124-11","article-title":"Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans","volume":"10","author":"Lee","year":"2011","journal-title":"Eukaryotic Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1128\/EC.00069-14","article-title":"Distinct and redundant roles of protein tyrosine phosphatases Ptp1 and Ptp2 in governing the differentiation and pathogenicity of Cryptococcus neoformans","volume":"13","author":"Lee","year":"","journal-title":"Eukaryotic Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5941\/MYCO.2014.42.2.152","article-title":"A ferroxidase, Cfo1, regulates diverse environmental stress responses of Cryptococcus neoformans through the HOG pathway","volume":"42","author":"Lee","year":"","journal-title":"Mycobiology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1099\/mic.0.27237-0","article-title":"Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene","volume":"150","author":"Li","year":"2004","journal-title":"Microbiology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/j.1567-1364.2008.00402.x","article-title":"The MAP kinase-activated protein kinase Rck2p plays a role in rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans","volume":"8","author":"Li","year":"2008","journal-title":"FEMS Yeast Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1128\/EC.00235-14","article-title":"A novel function for Hog1 stress-activated protein kinase in controlling white-opaque switching and mating in Candida albicans","volume":"13","author":"Liang","year":"2014","journal-title":"Eukaryotic Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"B76","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/369242a0","article-title":"A two-component system that regulates an osmosensing MAP kinase cascade in yeast","volume":"369","author":"Maeda","year":"1994","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ygeno.2013.06.002","article-title":"Genome-wide transcriptional profiling and enrichment mapping reveal divergent and conserved roles of Sko1 in the Candida albicans osmotic stress response","volume":"102","author":"Marotta","year":"2013","journal-title":"Genomics"},{"key":"B78","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1128\/EC.00243-13","article-title":"Two-component histidine phosphotransfer protein Ypd1 is not essential for viability in Candida albicans","volume":"13","author":"Mavrianos","year":"2014","journal-title":"Eukaryotic Cell"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e38262","DOI":"10.1371\/journal.pone.0038262","article-title":"The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus","volume":"7","author":"McCormick","year":"2012","journal-title":"PLoS ONE"},{"key":"B80","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/1758-2229.12527","article-title":"The water channel protein aquaporin 1 regulates cellular metabolism and competitive fitness in a global fungal pathogen Cryptococcus neoformans","volume":"9","author":"Meyers","year":"2017","journal-title":"Environ. Microbiol. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1365-2958.2005.04735.x","article-title":"Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators","volume":"57","author":"Missall","year":"2005","journal-title":"Mol. Microbiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"6446","DOI":"10.1128\/MCB.02205-06","article-title":"Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid","volume":"27","author":"Mollapour","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B83","first-page":"425","article-title":"Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans","volume-title":"Microbiology","author":"Nagahashi","year":"1998"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1099\/mic.0.28038-0","article-title":"The MAP kinase Mkc1p is activated under different stress conditions","volume":"151","author":"Navarro-Garcia","year":"2005","journal-title":"Candida albicans. Microbiology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1128\/EC.3.5.1111-1123.2004","article-title":"Msn2- and Msn4-like transcription factors play no obvious roles in the stress responses of the fungal pathogen Candida albicans","volume":"3","author":"Nicholls","year":"2004","journal-title":"Eukaryotic Cell"},{"key":"B86","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1471-2148-9-44","article-title":"Phylogenetic diversity of stress signalling pathways in fungi","volume":"9","author":"Nikolaou","year":"2009","journal-title":"BMC Evol. Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"e01581","DOI":"10.1128\/mBio.01581-18","article-title":"High-throughput screening identifies genes required for Candida albicans induction of macrophage pyroptosis","volume":"9","author":"O'Meara","year":"2018","journal-title":"MBio"},{"key":"B88","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1038\/sj.emboj.7601756","article-title":"The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes","volume":"26","author":"Pascual-Ahuir","year":"2007","journal-title":"EMBO J."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e12681","DOI":"10.1111\/cmi.12681","article-title":"Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakA(HOG1) and MpkC dependent","volume":"19","author":"Pereira Silva","year":"2017","journal-title":"Cell. Microbiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e1006350","DOI":"10.1371\/journal.pgen.1006350","article-title":"Metal chelation as a powerful strategy to probe cellular circuitry governing fungal drug resistance and morphogenesis","volume":"12","author":"Polvi","year":"2016","journal-title":"PLoS Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1126\/science.276.5319.1702","article-title":"Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK","volume":"276","author":"Posas","year":"1997","journal-title":"Science"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1093\/emboj\/17.5.1385","article-title":"Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator","volume":"17","author":"Posas","year":"1998","journal-title":"EMBO J."},{"key":"B93","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0092-8674(00)80162-2","article-title":"Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 \u201ctwo-component\u201d osmosensor","volume":"86","author":"Posas","year":"1996","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/fgbi.2000.1225","article-title":"The isolation of FOS-1, a gene encoding a putative two-component histidine kinase from Aspergillus fumigatus","volume":"31","author":"Pott","year":"2000","journal-title":"Fungal Genet. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"e87128","DOI":"10.1371\/journal.pone.0087128","article-title":"The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans","volume":"9","author":"Prieto","year":"2014","journal-title":"PLoS ONE"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/S1097-2765(02)00557-9","article-title":"Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI\/SNF in response to osmotic stress","volume":"9","author":"Proft","year":"2002","journal-title":"Mol. Cell"},{"key":"B97","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1091\/mbc.e08-02-0191","article-title":"Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1","volume":"19","author":"Rauceo","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1128\/EC.00178-06","article-title":"Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugars","volume":"5","author":"Reyes","year":"2006","journal-title":"Eukaryotic Cell"},{"key":"B100","doi-asserted-by":"publisher","first-page":"4845","DOI":"10.1091\/mbc.e09-01-0002","article-title":"Glucose promotes stress resistance in the fungal pathogen Candida albicans","volume":"20","author":"Rodaki","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"10611","DOI":"10.1128\/MCB.25.23.10611-10627.2005","article-title":"The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans","volume":"25","author":"Roman","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1534\/genetics.112.140863","article-title":"Response to hyperosmotic stress","volume":"192","author":"Saito","year":"2012","journal-title":"Genetics"},{"key":"B103","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11274-017-2272-z","article-title":"The yeasts phosphorelay systems: a comparative view","volume":"33","author":"Salas-Delgado","year":"2017","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"5850","DOI":"10.1128\/jb.178.19.5850-5852.1996","article-title":"The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans","volume":"178","author":"San Jose","year":"1996","journal-title":"J. Bacteriol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/mmy.39.1.69.74","article-title":"COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor","volume":"39","author":"Selitrennikoff","year":"2001","journal-title":"Med. Mycol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"e1008052","DOI":"10.1371\/journal.pgen.1008052","article-title":"The p38\/HOG stress-activated protein kinase network couples growth to division in Candida albicans","volume":"15","author":"Sellam","year":"2019","journal-title":"PLoS Genet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"e1004632","DOI":"10.1371\/journal.ppat.1004632","article-title":"A case for two-component signaling systems as antifungal drug targets","volume":"11","author":"Shor","year":"2015","journal-title":"PLoS Pathog."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1574-6968.2010.01937.x","article-title":"Stress signalling to fungal stress-activated protein kinase pathways","volume":"306","author":"Smith","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"B109","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1091\/mbc.e04-03-0181","article-title":"A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans","volume":"15","author":"Smith","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"33411","DOI":"10.1074\/jbc.M204593200","article-title":"The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast","volume":"277","author":"Smith","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.3389\/fmicb.2018.02958","article-title":"Sho1 and Msb2 play complementary but distinct roles in stress responses, sexual differentiation, and pathogenicity of Cryptococcus neoformans","volume":"9","author":"So","year":"2018","journal-title":"Front. Microbiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1091\/mbc.e12-06-0477","article-title":"Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity","volume":"24","author":"Su","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"B113","doi-asserted-by":"publisher","first-page":"ra21","DOI":"10.1126\/scisignal.2004780","article-title":"Yeast osmosensors Hkr1 and Msb2 activate the Hog1 MAPK cascade by different mechanisms","volume":"7","author":"Tanaka","year":"2014","journal-title":"Sci. Signal."},{"key":"B114","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1093\/emboj\/cdg353","article-title":"A docking site determining specificity of Pbs2 MAPKK for Ssk2\/Ssk22 MAPKKKs in the yeast HOG pathway","volume":"22","author":"Tatebayashi","year":"2003","journal-title":"EMBO J."},{"key":"B115","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1038\/ncomms7975","article-title":"Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1","volume":"6","author":"Tatebayashi","year":"2015","journal-title":"Nat. Commun."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1038\/sj.emboj.7601192","article-title":"Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway","volume":"25","author":"Tatebayashi","year":"2006","journal-title":"EMBO J."},{"key":"B117","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1128\/AAC.00889-13","article-title":"Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans","volume":"57","author":"Thomas","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B118","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1128\/IAI.70.2.985-987.2002","article-title":"Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro","volume":"70","author":"Torosantucci","year":"2002","journal-title":"Infect. Immun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/mmi.12388","article-title":"Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence","volume":"90","author":"Upadhya","year":"2013","journal-title":"Mol. Microbiol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.molcel.2004.06.021","article-title":"A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase","volume":"15","author":"Veal","year":"2004","journal-title":"Mol. Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/embor.2011.154","article-title":"Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase","volume":"12","author":"Vendrell","year":"2011","journal-title":"EMBO Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1128\/EC.00039-07","article-title":"Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway","volume":"6","author":"Vylkova","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"B123","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1128\/MCB.21.1.51-60.2001","article-title":"Ptc1, a type 2C Ser\/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1","volume":"21","author":"Warmka","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"12212","DOI":"10.1073\/pnas.0805797105","article-title":"Stress resistance and signal fidelity independent of nuclear MAPK function","volume":"105","author":"Westfall","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B125","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/mmi.12919","article-title":"High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence","volume":"96","author":"Winkelstroter","year":"2015","journal-title":"Mol. Microbiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1128\/EC.1.2.163-173.2002","article-title":"Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress","volume":"1","author":"Winkler","year":"2002","journal-title":"Eukaryotic Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.fgb.2012.01.005","article-title":"A novel dehydrin-like protein from Aspergillus fumigatus regulates freezing tolerance","volume":"49","author":"Wong Sak Hoi","year":"2012","journal-title":"Fungal Genet. Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1128\/MCB.17.3.1289","article-title":"Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases","volume":"17","author":"Wurgler-Murphy","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"B129","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1128\/JB.181.23.7243-7247.1999","article-title":"Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans","volume":"181","author":"Yamada-Okabe","year":"1999","journal-title":"J. Bacteriol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"16019","DOI":"10.1038\/nmicrobiol.2016.19","article-title":"Fungi use the SakA (HogA) pathway for phytochrome-dependent light signalling","volume":"1","author":"Yu","year":"2016","journal-title":"Nat. Microbiol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00261\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T21:37:22Z","timestamp":1610487442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00261\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":130,"alternative-id":["10.3389\/fcimb.2019.00261"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00261","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"article-number":"261"}}