{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:43:52Z","timestamp":1789987432128,"version":"4.0.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI135287"],"award-info":[{"award-number":["R21AI135287"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI130523"],"award-info":[{"award-number":["R21AI130523"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["T31-AI-07290"],"award-info":[{"award-number":["T31-AI-07290"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007349","name":"Secretaria Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["71-2012-4-CAP11-003"],"award-info":[{"award-number":["71-2012-4-CAP11-003"]}],"id":[{"id":"10.13039\/501100007349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00268","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T03:53:58Z","timestamp":1563940438000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response"],"prefix":"10.3389","volume":"9","author":[{"given":"Julia L.","family":"McKechnie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis","family":"Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcelys","family":"Pitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisseth","family":"Saenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Ara\u00faz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis L.","family":"Lanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Blish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"L\u00f3pez-Verg\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1365-2249.2006.02996.x","article-title":"NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease","volume":"143","author":"Azeredo","year":"2006"},{"key":"B2","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.chom.2016.09.006","article-title":"Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis","volume":"20","author":"Bayless","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fimmu.2014.00192","article-title":"NK cells during dengue disease and their recognition of Dengue virus-infected cells","volume":"5","author":"Beltr\u00e1n","year":"2014","journal-title":"Front. Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1086\/381501","article-title":"Major histocompatibility complex class I (MHC-I) induction by West Nile virus: involvement of 2 signaling pathways in MHC-I up-regulation","volume":"189","author":"Cheng","year":"2004","journal-title":"J. Infect. Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e00741","DOI":"10.1128\/mBio.00741-17","article-title":"Dengue virus-infected dendritic cells, but not monocytes, activate natural killer cells through a contact-dependent mechanism involving adhesion molecules","volume":"8","author":"Costa","year":"2017","journal-title":"MBio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1182\/blood-2006-06-030213","article-title":"Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation","volume":"109","author":"Coupel","year":"2007","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1005421","DOI":"10.1371\/journal.ppat.1005421","article-title":"A conserved HIV-1-derived peptide presented by HLA-E renders infected T-cells highly susceptible to attack by NKG2A\/CD94-bearing natural killer cells","volume":"12","author":"Davis","year":"2016","journal-title":"PLoS Pathog"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1039","DOI":"10.1002\/cti2.1039","article-title":"Upregulation of HLA-E by dengue and not Zika viruses","volume":"7","author":"Drews","year":"2018","journal-title":"Clin. Transl. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.virol.2008.03.028","article-title":"Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever","volume":"376","author":"Durbin","year":"2008","journal-title":"Virology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e00785","DOI":"10.1128\/JVI.00785-17","article-title":"Zika virus escapes NK cell detection by upregulating major histocompatibility complex class I molecules","volume":"91","author":"Glasner","year":"2017","journal-title":"J. Virol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.jmb.2013.11.023","article-title":"Innate immunity to Dengue virus infection and subversion of antiviral responses","volume":"426","author":"Green","year":"2014","journal-title":"J. Mol. Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"8679","DOI":"10.1074\/jbc.M112.409672","article-title":"Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells","volume":"288","author":"Heatley","year":"2013","journal-title":"J. Biol. Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7666","DOI":"10.1128\/JVI.02274-07","article-title":"Dengue virus replicon expressing the nonstructural proteins suffices to enhance membrane expression of HLA class I and inhibit lysis by human NK cells","volume":"82","author":"Hershkovitz","year":"2008","journal-title":"J. Virol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.4049\/jimmunol.174.5.2878","article-title":"Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics","volume":"174","author":"Kaiser","year":"2005","journal-title":"J. Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1086\/323603","article-title":"Transcriptional regulation of major histocompatibility complex class I by flavivirus West Nile is dependent on NF-kappa B activation","volume":"184","author":"Kesson","year":"2001","journal-title":"J. Infect. Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev.micro.62.081307.163005","article-title":"Global spread and persistence of dengue","volume":"62","author":"Kyle","year":"2008","journal-title":"Annu. Rev. Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1086\/512860","article-title":"Antibody-dependent cellular cytotoxity mediated by plasma obtained before secondary Dengue virus infections: potential involvement in early control of viral replication","volume":"195","author":"Laoprasopwattana","year":"2007","journal-title":"J. Infect. Dis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1128\/JVI.75.8.3501-3508.2001","article-title":"Human dendritic cells are activated by Dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis","volume":"75","author":"Libraty","year":"2001","journal-title":"J. Virol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1996.tb00908.x","article-title":"Flavivirus-induced up-regulation of MHC class I antigens; implications for the induction of CD8+ T-cell-mediated autoimmunity","volume":"152","author":"Lobigs","year":"1996","journal-title":"Immunol. Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1111\/imm.12928","article-title":"Defining the role of NK cells during Dengue virus infection","volume":"154","author":"Mathew","year":"2018","journal-title":"Immunology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.4049\/jimmunol.1402661","article-title":"Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry","volume":"194","author":"Mei","year":"2015","journal-title":"J. Immunol"},{"key":"B25","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1128\/JVI.75.12.5663-5671.2001","article-title":"Modulation of Transporter associated with Antigen Processing (TAP) -mediated peptide import into the endoplasmic reticulum by flavivirus infection","volume":"75","author":"Momburg","year":"2001","journal-title":"J. Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3390\/v4030397","article-title":"Innate immunity evasion by Dengue virus","volume":"4","author":"Morrison","year":"2012","journal-title":"Viruses"},{"key":"B27","first-page":"95","article-title":"HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells. Antivir","volume-title":"Ther","author":"Nattermann","year":"2005"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1189\/jlb.0208105","article-title":"Viral replication and paracrine effects result in distinct, functional responses of dendritic cells following infection with dengue 2 virus","volume":"84","author":"Nightingale","year":"2008","journal-title":"J. Leukoc. Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0004499","DOI":"10.1371\/journal.pntd.0004499","article-title":"Longitudinal analysis of natural killer cells in Dengue virus-infected patients in comparison to chikungunya and chikungunya\/Dengue virus-infected patients","volume":"10","author":"Petitdemange","year":"2016","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3389\/fimmu.2014.00209","article-title":"Control of acute Dengue virus infection by natural killer cells","volume":"5","author":"Petitdemange","year":"2014","journal-title":"Front. Immunol"},{"key":"B31","unstructured":"SeilerC.\n            KronstadL. M.\n            SimpsonL. J.\n            Le GarsM.\n            VendrameE.\n            BlishC. A.\n          Uncertainty Quantification in Multivariate Mixed Models for Mass Cytometry Data. arXiv [stat.AP]2019"},{"key":"B32","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.imlet.2014.07.010","article-title":"Inhibition of ERK and proliferation in NK cell lines by soluble HLA-E released from Japanese encephalitis virus infected cells","volume":"162","author":"Shwetank","year":"2014","journal-title":"Immunol. Lett"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e79197","DOI":"10.1371\/journal.pone.0079197","article-title":"Infection of human endothelial cells by Japanese encephalitis virus: increased expression and release of soluble HLA-E","volume":"8","author":"Shwetank","year":"2013","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jim.2016.11.005","article-title":"NK cell degranulation as a marker for measuring antibody-dependent cytotoxicity in neutralizing and non-neutralizing human sera from dengue patients","volume":"441","author":"Sun","year":"2017","journal-title":"J. Immunol. Methods"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/s41598-018-36972-2","article-title":"NK cells activated through antibody-dependent cell cytotoxicity and armed with degranulation\/IFN-\u03b3 production suppress antibody-dependent enhancement of dengue viral infection","volume":"9","author":"Sun","year":"2019","journal-title":"Sci. Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1093\/emboj\/18.15.4250","article-title":"Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94\/NKG2-A and the activating receptor CD94\/NKG2-C to HLA-E","volume":"18","author":"Val\u00e9s-G\u00f3mez","year":"1999","journal-title":"EMBO J"},{"key":"B37","unstructured":"Global Strategy for Dengue Prevention and Control 2012-20202012"},{"key":"B38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.vaccine.2012.11.015","article-title":"Immune evasion strategies of flaviviruses","volume":"31","author":"Ye","year":"2013","journal-title":"Vaccine"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T22:46:02Z","timestamp":1569192362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":38,"alternative-id":["10.3389\/fcimb.2019.00268"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00268","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/698803","asserted-by":"object"}]},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"article-number":"268"}}