{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:22:58Z","timestamp":1793780578785,"version":"4.6.1"},"reference-count":188,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00270","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T04:24:28Z","timestamp":1564547068000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":358,"title":["Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network"],"prefix":"10.3389","volume":"9","author":[{"given":"Lixin","family":"Lou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongli","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1111\/j.1462-5822.2011.01701.x","article-title":"Salmonella effectors: important players modulating host cell function during infection","volume":"13","author":"Agbor","year":"2011","journal-title":"Cell Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1046\/j.1365-2958.2003.03322.x","article-title":"AraC\/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimurium","volume":"47","author":"Akbar","year":"2003","journal-title":"Mol. Microbiol"},{"key":"B3","first-page":"85","article-title":"Genetic and environmental control of Salmonella invasion","volume":"43","author":"Altier","year":"2005","journal-title":"J. Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1046\/j.1365-2958.2000.01734.x","article-title":"Characterization of two novel regulatory genes affecting Salmonella invasion gene expression","volume":"35","author":"Altier","year":"2000","journal-title":"Mol. Microbiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.1128\/JB.185.12.3624-3635.2003","article-title":"Variation between pathogenic serovars within Salmonella pathogenicity islands","volume":"185","author":"Amavisit","year":"2003","journal-title":"J. Bacteriol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1128\/AEM.00851-10","article-title":"Inhibition of Salmonella host cell invasion by dimethyl sulfide","volume":"76","author":"Antunes","year":"2010","journal-title":"Appl. Environ. Microbiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e01838","DOI":"10.1128\/AEM.01838-17","article-title":"glnA Truncation in Salmonella enterica results in a small colony variant phenotype, attenuated host cell entry, and reduced expression of flagellin and SPI-1-associated effector genes","volume":"84","author":"Aurass","year":"2018","journal-title":"Appl. Environ. Microbiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1046\/j.1365-2958.1996.d01-1718.x","article-title":"Coordinate regulation of S. typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression","volume":"22","author":"Bajaj","year":"1996","journal-title":"Mol. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1111\/j.1462-5822.2007.01000.x","article-title":"SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion","volume":"9","author":"Bakowski","year":"2007","journal-title":"Cell Microbiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1128\/JB.182.8.2341-2344.2000","article-title":"Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells","volume":"182","author":"Bakshi","year":"2000","journal-title":"J. Bacteriol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1128\/IAI.71.3.1295-1305.2003","article-title":"HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype","volume":"71","author":"Baxter","year":"2003","journal-title":"Infect. Immun"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1128\/IAI.73.3.1377-1385.2005","article-title":"The fimYZ genes regulate Salmonella enterica serovar typhimurium invasion in addition to type 1 fimbrial expression and bacterial motility","volume":"73","author":"Baxter","year":"2005","journal-title":"Infect. Immun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1128\/IAI.02506-14","article-title":"Two-component regulators control hilA expression by controlling fimZ and hilE expression within Salmonella enterica serovar typhimurium","volume":"83","author":"Baxter","year":"2015","journal-title":"Infect. Immun"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1128\/jb.175.14.4475-4484.1993","article-title":"A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells","volume":"175","author":"Behlau","year":"1993","journal-title":"J. Bacteriol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"C939","DOI":"10.1152\/ajpcell.00413.2003","article-title":"Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD","volume":"287","author":"Bertelsen","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e00226","DOI":"10.1128\/mBio.00226-12","article-title":"Salmonella \u201csops\u201d up a preferred electron receptor in the inflamed intestine","volume":"3","author":"Bliska","year":"2012","journal-title":"MBio"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1128\/IAI.72.4.2002-2013.2004","article-title":"Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells","volume":"72","author":"Boddicker","year":"2004","journal-title":"Infect. Immun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1128\/JB.185.2.525-533.2003","article-title":"Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators","volume":"185","author":"Boddicker","year":"2003","journal-title":"J. Bacteriol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1099\/mic.0.038117-0","article-title":"Salmonella pathogenicity island 1 (SPI-1) type III secretion of SopD involves N- and C-terminal signals and direct binding to the InvC ATPase","volume":"156","author":"Boonyom","year":"2010","journal-title":"Microbiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e00429","DOI":"10.1128\/IAI.00429-18","article-title":"Methylthioadenosine suppresses Salmonella virulence","volume":"86","author":"Bourgeois","year":"2018","journal-title":"Infect. Immun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1016\/j.micinf.2006.09.008","article-title":"Salmonella typhimurium SPI-1 genes promote intestinal but not tonsillar colonization in pigs","volume":"8","author":"Boyen","year":"2006","journal-title":"Vet. Microbiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1111\/j.1462-5822.2006.00762.x","article-title":"Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2, and SipA disrupt tight junction structure and function","volume":"8","author":"Boyle","year":"2006","journal-title":"Cell Microbiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.chom.2007.02.001","article-title":"Salmonella SPI1 effector SipA persists after entry and cooperates with a SPI2 effector to regulate phagosome maturation and intracellular replication","volume":"1","author":"Brawn","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1111\/j.1365-2958.2011.07784.x","article-title":"Regulation of chaperone\/effector complex synthesis in a bacterial type III secretion system","volume":"81","author":"Button","year":"2011","journal-title":"Mol. Microbiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.3389\/fmicb.2018.01632","article-title":"Salmonella typhimurium infection leads to colonization of the mouse brain and is not completely cured with antibiotics","volume":"9","author":"Chaudhuri","year":"2018","journal-title":"Front. Microbiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.immuni.2013.11.009","article-title":"Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP","volume":"39","author":"Choi","year":"2013","journal-title":"Immunity"},{"key":"B27","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.1128\/JB.00635-10","article-title":"FliZ regulates expression of the Salmonella pathogenicity island 1 invasion locus by controlling HilD protein activity in Salmonella enterica serovar typhimurium","volume":"192","author":"Chubiz","year":"2010","journal-title":"J. Bacteriol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1046\/j.1365-2958.1997.3781740.x","article-title":"The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell","volume":"24","author":"Collazo","year":"1997","journal-title":"Mol. Microbiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.4049\/jimmunol.169.6.2846","article-title":"Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway","volume":"169","author":"Collier-Hyams","year":"2002","journal-title":"J. Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nrmicro1526","article-title":"The type III secretion injectisome","volume":"4","author":"Cornelis","year":"2006","journal-title":"Nat. Rev. Microbiol"},{"key":"B31","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1128\/JB.181.16.4949-4954.1999","article-title":"InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium","volume":"181","author":"Darwin","year":"1999","journal-title":"J. Bacteriol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1046\/j.1365-2958.2000.01772.x","article-title":"The putative invasion protein chaperone SicA acts together with InvF to activate the expression of Salmonella typhimurium virulence genes","volume":"35","author":"Darwin","year":"2000","journal-title":"Mol. Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1093\/emboj\/20.8.1850","article-title":"Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium","volume":"20","author":"Darwin","year":"2001","journal-title":"EMBO J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1139\/w10-034","article-title":"Protection of epithelial cells from Salmonella enterica serovar Enteritidis invasion by antibodies against the SPI-1 type III secretion system","volume":"56","author":"Desin","year":"2010","journal-title":"Can. J. Microbiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2180-7-3","article-title":"Systematic analysis of the regulation of type three secreted effectors in Salmonella enterica serovar Typhimurium","volume":"7","author":"Dieye","year":"2007","journal-title":"BMC Microbiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/j.1365-2958.2012.08162.x","article-title":"LeuO is a global regulator of gene expression in Salmonella enterica serovar Typhimurium","volume":"85","author":"Dillon","year":"2012","journal-title":"Mol. Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1462-5822.2004.00436.x","article-title":"The Salmonella SPI1 effector SopB stimulates nitric oxide production long after invasion","volume":"7","author":"Drecktrah","year":"2005","journal-title":"Cell Microbiol"},{"key":"B38","first-page":"743","article-title":"Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells","volume-title":"J. Leukoc. Biol","author":"Dreher","year":"2002"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e1000595","DOI":"10.1371\/journal.ppat.1000595","article-title":"Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA","volume":"5","author":"Du","year":"2009","journal-title":"PLoS Pathog"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1128\/JB.186.4.1215-1219.2004","article-title":"InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium","volume":"186","author":"Ehrbar","year":"2004","journal-title":"J. Bacteriol"},{"key":"B41","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1128\/IAI.67.8.4099-4105.1999","article-title":"Differential regulation of Salmonella typhimurium type III secreted proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional activators InvF and hilA","volume":"67","author":"Eichelberg","year":"1999","journal-title":"Infect. Immun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1365-2958.2005.04737.x","article-title":"HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium","volume":"57","author":"Ellermeier","year":"2005","journal-title":"Mol. Microbiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mib.2006.12.002","article-title":"Adaptation to the host environment: regulation of the SPI1 type III secretion system in Salmonella enterica serovar Typhimurium","volume":"10","author":"Ellermeier","year":"2007","journal-title":"Curr. Opin. Microbiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1111\/mmi.12500","article-title":"Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by the LysR-type regulator LeuO","volume":"91","author":"Espinosa","year":"2014","journal-title":"Mol. Microbiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e3829","DOI":"10.1371\/journal.pone.0003829","article-title":"Differentially evolved genes of Salmonella pathogenicity islands: insights into the mechanism of host specificity in Salmonella","volume":"3","author":"Eswarappa","year":"2008","journal-title":"PLoS ONE"},{"key":"B46","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1574-695X.2000.tb01453.x","article-title":"Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium","volume":"28","author":"Fahlen","year":"2000","journal-title":"FEMS Immunol. Med. Microbiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"14004","DOI":"10.1038\/ncomms14004","article-title":"Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA","volume":"8","author":"Fiskin","year":"2017","journal-title":"Nat. Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"34035","DOI":"10.1074\/jbc.M100609200","article-title":"SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell","volume":"276","author":"Friebel","year":"2001","journal-title":"J. Biol. Chem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1046\/j.1365-2958.1998.00684.x","article-title":"The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton","volume":"27","author":"Fu","year":"","journal-title":"Mol. Microbiol"},{"key":"B50","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1128\/JB.180.13.3393-3399.1998","article-title":"Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium","volume":"180","author":"Fu","year":"","journal-title":"J. Bacteriol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/45829","article-title":"A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion","volume":"401","author":"Fu","year":"1999","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/S0076-6879(00)25469-4","article-title":"Modulation of actin cytoskeleton by Salmonella GTPase activating protein SptP","volume":"325","author":"Gal\u00e1n","year":"2000","journal-title":"Methods Enzymol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nature05272","article-title":"Protein delivery into eukaryotic cells by type III secretion machines","volume":"444","author":"Gal\u00e1n","year":"2006","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"8754","DOI":"10.1073\/pnas.97.16.8754","article-title":"Striking a balance: modulation of the actin cytoskeleton by Salmonella","volume":"97","author":"Galan","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B55","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/j.1365-2958.1997.mmi525.x","article-title":"A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa","volume":"25","author":"Galyov","year":"1997","journal-title":"Mol. Microbiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1080\/21505594.2018.1509664","article-title":"SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells","volume":"9","author":"Garc\u00eda-Gil","year":"2018","journal-title":"Virulence"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1021\/acssynbio.6b00335","article-title":"Secretion-amplification role for Salmonella enterica translocon protein SipD","volume":"6","author":"Glasgow","year":"2017","journal-title":"ACS Synth. Biol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1471-2180-9-73","article-title":"Characterization of the expression of Salmonella Type III secretion system factor PrgI, SipA, SipB, SopE2, SpaO, and SptP in cultures and in mice","volume":"9","author":"Gong","year":"2009","journal-title":"BMC Microbiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1099\/mic.0.032318-0","article-title":"Differential expression of Salmonella type III secretion system factors InvJ, PrgJ, SipC, SipD, SopA and SopB in cultures and in mice","volume":"156","author":"Gong","year":"2010","journal-title":"Microbiology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.bbrc.2016.07.018","article-title":"Licoflavonol is an inhibitor of the type three secretion system of Salmonella enterica serovar Typhimurium","volume":"477","author":"Guo","year":"2016","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S1286-4579(01)01411-3","article-title":"Salmonella pathogenicity islands encoding type III secretion systems","volume":"3","author":"Hansen-Wester","year":"2001","journal-title":"Microbes. Infect"},{"key":"B62","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0092-8674(00)81442-7","article-title":"S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells","volume":"93","author":"Hardt","year":"1998","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1093\/emboj\/18.18.4926","article-title":"Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella","volume":"18","author":"Hayward","year":"1999","journal-title":"EMBO J"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1111\/j.1365-2958.2012.08175.x","article-title":"The coming of age of the LeuO regulator","volume":"85","author":"Hern\u00e1ndez-Lucas","year":"2012","journal-title":"Mol. Microbiol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1128\/JB.01649-07","article-title":"The LysR-type transcriptional regulator LeuO controls expression of several genes in Salmonella enterica serovar Typhi","volume":"190","author":"Hern\u00e1ndez-Lucas","year":"2008","journal-title":"J. Bacteriol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1073\/pnas.96.5.2396","article-title":"The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1","volume":"96","author":"Hersh","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B67","first-page":"379","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants","volume-title":"Microbiol. Mol. Biol. Rev","author":"Hueck","year":"1998"},{"key":"B68","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.chom.2012.01.006","article-title":"Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion","volume":"11","author":"Humphreys","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B69","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.chom.2009.01.010","article-title":"The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche","volume":"5","author":"Humphreys","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/mmi.12149","article-title":"The intestinal fatty acid propionate inhibits Salmonella invasion through the post-translational control of HilD","volume":"87","author":"Hung","year":"2013","journal-title":"Mol. Microbiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e1006429","DOI":"10.1371\/journal.ppat.1006429","article-title":"Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion","volume":"13","author":"Jiang","year":"2017","journal-title":"PLoS Pathog"},{"key":"B72","doi-asserted-by":"crossref","DOI":"10.1016\/j.resmic.2019.01.001","article-title":"LoiA directly represses lon gene expression to activate the expression of Salmonella pathogenicity island-1 genes","volume-title":"Res. Microbiol.","author":"Jiang","year":"2019"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/j.1365-2958.2004.04344.x","article-title":"The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice","volume":"54","author":"Jiang","year":"2004","journal-title":"Mol. Microbiol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e00647","DOI":"10.1128\/JB.00647-16","article-title":"The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi","volume":"199","author":"Johnson","year":"2017","journal-title":"J. Bacteriol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e00490","DOI":"10.1128\/IAI.00490-17","article-title":"Comparison of Salmonella enterica serovars typhi and typhimurium reveals typhoidal serovar-specific responses to Bile","volume":"86","author":"Johnson","year":"2018","journal-title":"Infect. Immun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1046\/j.1365-2958.1996.d01-1719.x","article-title":"Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily","volume":"22","author":"Johnston","year":"1996","journal-title":"Mol. Microbiol"},{"key":"B77","first-page":"110","article-title":"Salmonella invasion gene regulation: a story of environmental awareness","volume":"43","author":"Jones","year":"2005","journal-title":"J. Microbiol."},{"key":"B78","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1128\/IAI.66.12.5799-5804.1998","article-title":"Secreted effector proteins of Salmonella dublin act in concert to induce enteritis","volume":"66","author":"Jones","year":"1998","journal-title":"Infect. Immun"},{"key":"B79","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.chom.2008.02.016","article-title":"Salmonella AvrA coordinates suppression of host immune and apoptotic defenses via JNK pathway blockade","volume":"3","author":"Jones","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B80","doi-asserted-by":"publisher","first-page":"e1005552","DOI":"10.1371\/journal.ppat.1005552","article-title":"The Salmonella effector protein SopA modulates innate immune responses by targeting TRIM E3 ligase family members","volume":"12","author":"Kamanova","year":"2016","journal-title":"PLoS Pathog"},{"key":"B81","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1128\/jb.177.14.3965-3971.1995","article-title":"Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells","volume":"177","author":"Kaniga","year":"1995","journal-title":"J. Bacteriol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1365-2958.1996.tb02571.x","article-title":"A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium","volume":"21","author":"Kaniga","year":"1996","journal-title":"Mol. Microbiol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/cbic.201500556","article-title":"Characterization of the Shigella and Salmonella Type III secretion system tip-translocon protein-protein interaction by paramagnetic relaxation enhancement","volume":"17","author":"Kaur","year":"2016","journal-title":"Chembiochem"},{"key":"B84","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.immuni.2013.11.007","article-title":"Salmonella's masterful skill in mast cell suppression","volume":"39","author":"Kawakami","year":"2013","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"9058","DOI":"10.1074\/jbc.M412588200","article-title":"The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt","volume":"280","author":"Knodler","year":"2005","journal-title":"J. Biol. Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1034\/j.1600-0854.2003.00118.x","article-title":"Taking possession: biogenesis of the Salmonella-containing vacuole","volume":"4","author":"Knodler","year":"2003","journal-title":"Traffic"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e0190613","DOI":"10.1371\/journal.pone.0190613","article-title":"The microbiota metabolite indole inhibits Salmonella virulence: involvement of the PhoPQ two-component system","volume":"13","author":"Kohli","year":"2018","journal-title":"PLoS ONE"},{"key":"B88","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0092-8674(03)00849-3","article-title":"Temporal regulation of Salmonella virulence effector function by proteasome-dependent protein degradation","volume":"115","author":"Kubori","year":"2003","journal-title":"Cell"},{"key":"B89","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1126\/science.280.5363.602","article-title":"Supramolecular structure of the Salmonella typhimurium type III protein secretion system","volume":"280","author":"Kubori","year":"1998","journal-title":"Science"},{"key":"B90","doi-asserted-by":"publisher","first-page":"10225","DOI":"10.1073\/pnas.170128997","article-title":"Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system","volume":"97","author":"Kubori","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B91","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3389\/fmicb.2016.00421","article-title":"Red seaweeds Sarcodiotheca gaudichaudii and Chondrus crispus down regulate virulence factors of Salmonella enteritidis and induce immune responses in Caenorhabditis elegans","volume":"7","author":"Kulshreshtha","year":"2016","journal-title":"Front. Microbiol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1746-6148-8-115","article-title":"SPI-1 encoded genes of Salmonella typhimurium influence differential polarization of porcine alveolar macrophages in vitro","volume":"8","author":"Kyrova","year":"2012","journal-title":"BMC Vet. Res"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1128\/IAI.00077-09","article-title":"Salmonella enterica serovar Typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells","volume":"77","author":"Lara-Tejero","year":"2009","journal-title":"Infect. Immun"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1126\/science.1201476","article-title":"A sorting platform determines the order of protein secretion in bacterial type III systems","volume":"331","author":"Lara-Tejero","year":"2011","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1046\/j.1365-2958.2002.03268.x","article-title":"Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA\/SirA","volume":"46","author":"Lawhon","year":"2002","journal-title":"Mol. Microbiol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1371\/journal.ppat.0020011","article-title":"Genome-wide screen for Salmonella genes required for long-term systemic infection of the mouse","volume":"2","author":"Lawley","year":"2006","journal-title":"PLoS Pathog"},{"key":"B97","doi-asserted-by":"publisher","first-page":"12283","DOI":"10.1073\/pnas.97.22.12283","article-title":"A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration","volume":"97","author":"Lee","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B98","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.fm.2018.10.009","article-title":"Phages for biocontrol in foods: What opportunities for Salmonella sp. control along the dairy food chain?","volume":"78","author":"LeLi\u00e8vre","year":"2019","journal-title":"Food Microbiol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.chom.2014.12.003","article-title":"Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton","volume":"17","author":"Lhocine","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B100","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.bbrc.2018.07.151","article-title":"Global regulatory function of the low oxygen-induced transcriptional regulator LoiA in Salmonella Typhimurium revealed by RNA sequencing","volume":"503","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1128\/AAC.02421-12","article-title":"Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium","volume":"57","author":"Li","year":"2013","journal-title":"Antimicrob. Agents Chemother"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e2369","DOI":"10.1371\/journal.pone.0002369","article-title":"Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells","volume":"3","author":"Liao","year":"2008","journal-title":"PLoS ONE"},{"key":"B103","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/infdis\/jiu152","article-title":"Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization","volume":"210","author":"Lim","year":"2014","journal-title":"J. Infect. Dis"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.4014\/jmb.1305.05022","article-title":"Hfq and ArcA are involved in the stationary phase-dependent activation of Salmonella pathogenicity island 1 (SPI1) under shaking culture conditions","volume":"23","author":"Lim","year":"2013","journal-title":"J. Microbiol. Biotechnol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1093\/nar\/gkm060","article-title":"Mlc regulation of Salmonella pathogenicity island I gene expression via hilE repression","volume":"35","author":"Lim","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"B106","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1046\/j.1462-5822.2003.t01-1-00274.x","article-title":"SptP, a Salmonella typhimurium type III-secreted protein, inhibits the mitogen-activated protein kinase pathway by inhibiting Raf activation","volume":"5","author":"Lin","year":"2003","journal-title":"Cell Microbiol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"26837","DOI":"10.1074\/jbc.M116.757393","article-title":"Salmonella enteritidis effector AvrA stabilizes intestinal tight junctions via the JNK pathway","volume":"291","author":"Lin","year":"2016","journal-title":"J. Biol. Chem"},{"key":"B108","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1534\/genetics.115.178103","article-title":"Virulence gene regulation by L-arabinose in Salmonella enterica","volume":"200","author":"L\u00f3pez-Garrido","year":"2015","journal-title":"Genetics"},{"key":"B109","doi-asserted-by":"publisher","first-page":"e10505","DOI":"10.1371\/journal.pone.0010505","article-title":"Chronic effects of a Salmonella type III secretion effector protein AvrA in vivo","volume":"5","author":"Lu","year":"2010","journal-title":"PLoS ONE"},{"key":"B110","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.neo.2016.04.001","article-title":"Salmonella protein AvrA activates the STAT3 signaling pathway in colon cancer","volume":"18","author":"Lu","year":"2016","journal-title":"Neoplasia"},{"key":"B111","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1099\/mic.0.2007\/012286-0","article-title":"The posttranscriptional regulator CsrA plays a central role in the adaptation of bacterial pathogens to different stages of infection in animal hosts","volume":"154","author":"Lucchetti-Miganeh","year":"2008","journal-title":"Microbiology"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1371\/journal.ppat.0020081","article-title":"H-NS mediates the silencing of laterally acquired genes in bacteria","volume":"2","author":"Lucchini","year":"2006","journal-title":"PLoS Pathog"},{"key":"B113","doi-asserted-by":"publisher","first-page":"e1002163","DOI":"10.1371\/journal.ppat.1002163","article-title":"Crystal structure of PrgI-SipD: insight into a secretion competent state of the type three secretion system needle tip and its interaction with host ligands","volume":"7","author":"Lunelli","year":"2011","journal-title":"PLoS Pathog"},{"key":"B114","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1046\/j.1462-5822.2002.00202.x","article-title":"Salmonella enterica serovar Typhimurium effector SigD\/SopB is membrane-associated and ubiquitinated inside host cells","volume":"4","author":"Marcus","year":"2002","journal-title":"Cell Microbiol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0014-5793(01)02356-0","article-title":"A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation","volume":"494","author":"Marcus","year":"2001","journal-title":"FEBS Lett"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1126\/science.1102610","article-title":"Structural insights into the assembly of the type III secretion needle complex","volume":"306","author":"Marlovits","year":"2004","journal-title":"Science"},{"key":"B117","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/nar\/18.11.3397","article-title":"Nucleotide sequence of hns encoding the DNA-binding protein H-NS of Salmonella typhimurium","volume":"18","author":"Marsh","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1128\/JB.00806-13","article-title":"In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes","volume":"196","author":"Mart\u00ednez","year":"2014","journal-title":"J. Bacteriol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1111\/j.1365-2958.2011.07674.x","article-title":"Integration of a complex regulatory cascade involving the SirA\/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD","volume":"80","author":"Mart\u00ednez","year":"2011","journal-title":"Mol. Microbiol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e0187692","DOI":"10.1371\/journal.pone.0187692","article-title":"General response of Salmonella enterica serovar Typhimurium to desiccation: a new role for the virulence factors sopD and sseD in survival","volume":"12","author":"Maserati","year":"2017","journal-title":"PLoS ONE"},{"key":"B121","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1093\/emboj\/20.9.2131","article-title":"Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin","volume":"20","author":"McGhie","year":"2001","journal-title":"EMBO J"},{"key":"B122","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S1097-2765(04)00053-X","article-title":"Control of actin turnover by a Salmonella invasion protein","volume":"13","author":"McGhie","year":"2004","journal-title":"Mol. Cell"},{"key":"B123","doi-asserted-by":"publisher","first-page":"e00393","DOI":"10.1128\/IAI.00393-17","article-title":"SipA Activation of Caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar Typhimurium infection","volume":"85","author":"McIntosh","year":"2017","journal-title":"Infect. Immun"},{"key":"B124","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/cmdc.201600065","article-title":"Characterization of the binding of hydroxyindole, indoleacetic acid, and morpholinoaniline to the Salmonella Type III secretion system proteins SipD and SipB","volume":"11","author":"McShan","year":"2016","journal-title":"Chem. Med. Chem"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1039\/b808065h","article-title":"Mechanisms of type III protein export for bacterial flagellar assembly","volume":"4","author":"Minamino","year":"2008","journal-title":"Mol. Biosyst"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1128\/JB.183.7.2348-2358.2001","article-title":"Salmonella host cell invasion emerged by acquisition of a mosaic of separate genetic elements, including Salmonella pathogenicity island 1 (SPI1). SPI5, and sopE2","volume":"183","author":"Mirold","year":"","journal-title":"J. Bacteriol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1006\/jmbi.2001.4950","article-title":"Transfer of the Salmonella type III effector sopE between unrelated phage families","volume":"312","author":"Mirold","year":"","journal-title":"J. Mol. Biol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e60499","DOI":"10.1371\/journal.pone.0060499","article-title":"SipB-SipC complex is essential for translocon formation","volume":"8","author":"Myeni","year":"2013","journal-title":"PLoS ONE"},{"key":"B129","doi-asserted-by":"publisher","first-page":"13357","DOI":"10.1074\/jbc.M109.094045","article-title":"The C terminus of SipC binds and bundles F-actin to promote Salmonella invasion","volume":"285","author":"Myeni","year":"2010","journal-title":"J. Biol. Chem"},{"key":"B130","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1126\/science.1128794","article-title":"Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella","volume":"313","author":"Navarre","year":"2006","journal-title":"Science"},{"key":"B131","doi-asserted-by":"publisher","first-page":"14057","DOI":"10.1073\/pnas.95.24.14057","article-title":"SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase","volume":"95","author":"Norris","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B132","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1128\/IAI.71.8.4382-4388.2003","article-title":"Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18","volume":"71","author":"Obregon","year":"2003","journal-title":"Infect. Immun"},{"key":"B133","doi-asserted-by":"publisher","first-page":"6882","DOI":"10.1128\/JB.00905-07","article-title":"Role of nucleoid-associated proteins Hha and H-NS in expression of Salmonella enterica activators HilD, HilC, and RtsA required for cell invasion","volume":"189","author":"Olekhnovich","year":"2007","journal-title":"J. Bacteriol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0092-8674(92)90354-F","article-title":"The chromatin-associated protein H-NS interacts with curved DNA to influence DNA topology and gene expression","volume":"71","author":"Owen-Hughes","year":"1992","journal-title":"Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"e0203497","DOI":"10.1371\/journal.pone.0203497","article-title":"The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium","volume":"13","author":"Pardo-Est\u00e9","year":"2018","journal-title":"PLoS ONE"},{"key":"B136","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.1074\/jbc.RA117.001421","article-title":"The Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella","volume":"293","author":"Paredes-Amaya","year":"2018","journal-title":"J. Biol. Chem"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1056\/NEJMra020201","article-title":"Typhoid fever","volume":"347","author":"Parry","year":"2002","journal-title":"N. Engl. J. Med"},{"key":"B138","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1297-9716-42-16","article-title":"SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression","volume":"42","author":"Pavlova","year":"2011","journal-title":"Vet. Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"e0211430","DOI":"10.1371\/journal.pone.0211430","article-title":"Role of CsrA in stress responses and metabolism important for Salmonella virulence revealed by integrated transcriptomics","volume":"14","author":"Potts","year":"2019","journal-title":"PLoS ONE"},{"key":"B140","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1128\/IAI.68.12.6763-6769.2000","article-title":"Salmonella enterica serovar typhimurium invasion is repressed in the presence of bile","volume":"68","author":"Prouty","year":"2000","journal-title":"Infect. Immun"},{"key":"B141","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s00284-013-0307-8","article-title":"Salmonella pathogenicity island 1(SPI-1) at work","volume":"66","author":"Que","year":"2013","journal-title":"Curr. Microbiol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1128\/IAI.73.1.146-154.2005","article-title":"SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells","volume":"73","author":"Raffatellu","year":"2005","journal-title":"Infect. Immun"},{"key":"B143","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1128\/JB.181.10.3096-3104.1999","article-title":"A HilA-independent pathway to Salmonella typhimurium invasion gene transcription","volume":"181","author":"Rakeman","year":"1999","journal-title":"J. Bacteriol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1111\/j.1365-2958.2011.07639.x","article-title":"Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication","volume":"80","author":"Rodr\u00edguez-Escudero","year":"2011","journal-title":"Mol. Microbiol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"30501","DOI":"10.1074\/jbc.274.43.30501","article-title":"Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGTPases","volume":"274","author":"Rudolph","year":"1999","journal-title":"J. Biol. Chem"},{"key":"B146","doi-asserted-by":"publisher","first-page":"5767","DOI":"10.1128\/JB.00624-10","article-title":"Role of cross talk in regulating the dynamic expression of the flagellar Salmonella pathogenicity island 1 and type 1 fimbrial genes","volume":"192","author":"Saini","year":"2010","journal-title":"J. Bacteriol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.1128\/IAI.71.9.5432-5435.2003","article-title":"The small nucleoid-binding proteins H-NS, HU, and Fis affect hilA expression in Salmonella enterica serovar Typhimurium","volume":"71","author":"Schechter","year":"2003","journal-title":"Infect. Immun"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1046\/j.1365-2958.2001.02462.x","article-title":"AraC\/XylS family members, HilC and HilD, directly bind and derepress the Salmonella typhimurium hilA promoter","volume":"40","author":"Schechter","year":"2001","journal-title":"Mol. Microbiol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1046\/j.1365-2958.2000.02066.x","article-title":"The Salmonella type III secretion translocon protein SspC is inserted into the epithelial cell plasma membrane upon infection","volume":"37","author":"Scherer","year":"2000","journal-title":"Mol. Microbiol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mib.2005.12.006","article-title":"Salmonella type III secretion effectors: pulling the host cell's strings","volume":"9","author":"Schlumberger","year":"2006","journal-title":"Curr. Opin. Microbiol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e1000824","DOI":"10.1371\/journal.ppat.1000824","article-title":"Topology and organization of the Salmonella typhimurium type III secretion needle complex components","volume":"6","author":"Schraidt","year":"2010","journal-title":"PLoS Pathog"},{"key":"B152","doi-asserted-by":"publisher","first-page":"e1001002","DOI":"10.1371\/journal.ppat.1001002","article-title":"The virulence protein SopD2 regulates membrane dynamics of Salmonella-containing vacuoles","volume":"6","author":"Schroeder","year":"2010","journal-title":"PLoS Pathog"},{"key":"B153","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4161\/gmic.1.1.10950","article-title":"Salmonella SPI-1-mediated neutrophil recruitment during enteric colitis is associated with reduction and alteration in intestinal microbiota","volume":"1","author":"Sekirov","year":"2010","journal-title":"Gut Microbes"},{"key":"B154","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1128\/JB.00108-09","article-title":"Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux","volume":"191","author":"Shimada","year":"2009","journal-title":"J. Bacteriol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"15501","DOI":"10.1038\/s41598-018-33319-9","article-title":"Host lipid sensing promotes invasion of cells with pathogenic Salmonella","volume":"8","author":"Shivcharan","year":"2018","journal-title":"Sci. Rep"},{"key":"B156","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/1471-2180-8-182","article-title":"A comparison of cecal colonization of Salmonella enterica serotype Typhimurium in white leghorn chicks and Salmonella-resistant mice","volume":"8","author":"Sivula","year":"2008","journal-title":"BMC Microbiol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1194598","article-title":"Salmonella pathogenesis and processing of secreted effectors by caspase-3","volume":"330","author":"Srikanth","year":"2010","journal-title":"Science"},{"key":"B158","doi-asserted-by":"publisher","first-page":"37718","DOI":"10.1074\/jbc.M008187200","article-title":"Activation of Akt\/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD","volume":"275","author":"Steele-Mortimer","year":"2000","journal-title":"J. Biol. Chem"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1046\/j.1365-2958.2000.01933.x","article-title":"Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell","volume":"36","author":"Stender","year":"2000","journal-title":"Mol. Microbiol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1128\/JB.183.4.1159-1167.2001","article-title":"Genetic analysis of assembly of the Salmonella enterica serovar Typhimurium type III secretion-associated needle complex","volume":"183","author":"Sukhan","year":"2001","journal-title":"J. Bacteriol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/j.1365-2958.2004.04425.x","article-title":"Degradation of the HilC and HilD regulator proteins by ATP-dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expression","volume":"55","author":"Takaya","year":"2005","journal-title":"Mol. Microbiol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12866-016-0659-x","article-title":"Bifidobacterium thermophilum RBL67 impacts on growth and virulence gene expression of Salmonella enterica subsp. enterica serovar Typhimurium","volume":"16","author":"Tanner","year":"2016","journal-title":"BMC Microbiol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.cub.2004.05.050","article-title":"Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions","volume":"14","author":"Tenor","year":"2004","journal-title":"Curr. Biol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"7257","DOI":"10.1128\/JB.185.24.7257-7265.2003","article-title":"Pathways leading from BarA\/SirA to motility and virulence gene expression in Salmonella","volume":"185","author":"Teplitski","year":"2003","journal-title":"J. Bacteriol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/ncb854","article-title":"Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella","volume":"4","author":"Terebiznik","year":"2002","journal-title":"Nat. Cell Biol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"4587","DOI":"10.1128\/JB.00178-07","article-title":"Delineation of the Salmonella enterica serovar Typhimurium HilA regulon through genome-wide location and transcript analysis","volume":"189","author":"Thijs","year":"2007","journal-title":"J. Bacteriol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1007\/s00018-010-0381-z","article-title":"Post-transcriptional global regulation by CsrA in bacteria","volume":"67","author":"Timmermans","year":"2010","journal-title":"Cell. Mol. Life Sci"},{"key":"B168","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1021\/jacs.5b11575","article-title":"Antibacterial flavonoids from medicinal plants covalently inactivate type III protein secretion substrates","volume":"138","author":"Tsou","year":"2016","journal-title":"J. Am. Chem. Soc"},{"key":"B169","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.chembiol.2008.04.014","article-title":"Quantification of real-time Salmonella effector type III secretion kinetics reveals differential secretion rates for SopE2 and SptP","volume":"15","author":"Van Engelenburg","year":"2008","journal-title":"Chem. Biol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1297-9716-43-52","article-title":"Salmonella typhimurium induces SPI-1 and SPI-2 regulated and strain dependent downregulation of MHC II expression on porcine alveolar macrophages","volume":"43","author":"Van Parys","year":"2012","journal-title":"Vet. Res"},{"key":"B171","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1128\/IAI.67.4.1614-1622.1999","article-title":"PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp","volume":"67","author":"Van Velkinburgh","year":"1999","journal-title":"Infect. Immun"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1111\/cmi.12333","article-title":"The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication","volume":"16","author":"Vonaesch","year":"2014","journal-title":"Cell Microbiol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"17745","DOI":"10.1073\/pnas.1008053107","article-title":"Organization and coordinated assembly of the type III secretion export apparatus","volume":"107","author":"Wagner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/S0140-6736(13)62708-7","article-title":"Typhoid fever","volume":"385","author":"Wain","year":"2015","journal-title":"Lancet"},{"key":"B175","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1111\/j.1462-5822.2007.00960.x","article-title":"Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium","volume":"9","author":"Wall","year":"2007","journal-title":"Cell Microbiol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1046\/j.1462-5822.2000.00054.x","article-title":"The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritis","volume":"182","author":"Wood","year":"2000","journal-title":"J. Bacteriol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1046\/j.1365-2958.1996.00116.x","article-title":"SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry","volume":"22","author":"Wood","year":"1996","journal-title":"Mol. Microbiol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/pro.382","article-title":"Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA","volume":"19","author":"Worrall","year":"2010","journal-title":"Protein Sci"},{"key":"B179","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1462-5822.2011.01694.x","article-title":"The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivo","volume":"14","author":"Wu","year":"2012","journal-title":"Cell Microbiol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"882","DOI":"10.2353\/ajpath.2007.070220","article-title":"Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination","volume":"171","author":"Ye","year":"2007","journal-title":"Am. J. Pathol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"e1006925","DOI":"10.1371\/journal.ppat.1006925","article-title":"Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo","volume":"14","author":"Zhang","year":"2018","journal-title":"PLoS Pathog"},{"key":"B182","doi-asserted-by":"publisher","first-page":"38682","DOI":"10.1074\/jbc.M506309200","article-title":"Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem"},{"key":"B183","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/j.1365-2958.2006.05407.x","article-title":"The inflammation-associated Salmonella SopA is a HECT-like E3 ubiquitin ligase","volume":"62","author":"Zhang","year":"2006","journal-title":"Mol. Microbiol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bbrep.2018.04.011","article-title":"Natural compound sanguinarine chloride targets the type III secretion system of Salmonella enterica Serovar Typhimurium","volume":"14","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Rep"},{"key":"B185","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fcimb.2018.00318","article-title":"Biochanin a enhances the defense against Salmonella enterica infection through AMPK\/ULK1\/mTOR-mediated autophagy and extracellular traps and reversing SPI-1-dependent macrophage (M\u03a6) M2 polarization","volume":"8","author":"Zhao","year":"2018","journal-title":"Front. Cell Infect. Microbiol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/S1286-4579(01)01489-7","article-title":"Salmonella entry into host cells: the work in concert of type III secreted effector proteins","volume":"3","author":"Zhou","year":"2001","journal-title":"Microbes Infect"},{"key":"B187","doi-asserted-by":"publisher","first-page":"10176","DOI":"10.1073\/pnas.96.18.10176","article-title":"An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin","volume":"96","author":"Zhou","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B188","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1128\/IAI.63.10.4024-4028.1995","article-title":"Contact with cultured epithelial cells stimulates secretion of Salmonella typhimurium invasion protein InvJ","volume":"63","author":"Zierler","year":"1995","journal-title":"Infect. Immun"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00270\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T10:08:57Z","timestamp":1610705337000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00270\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":188,"alternative-id":["10.3389\/fcimb.2019.00270"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00270","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,31]]},"article-number":"270"}}