{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:47Z","timestamp":1753890527063,"version":"3.41.2"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005671","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa e \u00e0 Inova\u00e7\u00e3o Tecnol\u00f3gica do Estado de Sergipe","doi-asserted-by":"publisher","award":["019.203.02712\/2009"],"award-info":[{"award-number":["019.203.02712\/2009"]}],"id":[{"id":"10.13039\/501100005671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421060\/2018-2"],"award-info":[{"award-number":["421060\/2018-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00311","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T10:20:14Z","timestamp":1567160414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Macrophages From Subjects With Isolated GH\/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis"],"prefix":"10.3389","volume":"9","author":[{"given":"M\u00f4nica R.","family":"Barrios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane C.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalu T. A.","family":"Peres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00eds L.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A.","family":"Cazzaniga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo B.","family":"Aires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo L. L.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roque P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Salvatori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel H.","family":"Aguiar-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lia M. R.","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1210\/er.2018-00216","article-title":"Growth hormone deficiency: health and longevity","volume":"40","author":"Aguiar-Oliveira","year":"2018","journal-title":"Endocr. Rev."},{"key":"B2","first-page":"4118","article-title":"Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life","volume":"84","author":"Aguiar-Oliveira","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1210\/jc.2009-1879","article-title":"Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene","volume":"95","author":"Aguiar-Oliveira","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.yexcr.2015.05.015","article-title":"Involvement of IGF-1 and Akt in M1\/M2 activation state in bone marrow-derived macrophages","volume":"335","author":"Barrett","year":"2015","journal-title":"Exp. Cell Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"27632","DOI":"10.1038\/srep27632","article-title":"Mycobacterium leprae-induced Insulin-like Growth Factor i attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages","volume":"6","author":"Batista-Silva","year":"2016","journal-title":"Sci. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s12020-016-1061-z","article-title":"Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency","volume":"54","author":"Campos","year":"2016","journal-title":"Endocrine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0141265","DOI":"10.1371\/journal.pone.0141265","article-title":"Soluble CD40 ligand in sera of subjects exposed to leishmania infantum infection reduces the parasite load in macrophages","volume":"10","author":"de Oliveira","year":"2015","journal-title":"PLoS ONE"},{"key":"B8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s13071-016-1619-x","article-title":"Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis","volume":"9","author":"De Souza","year":"2016","journal-title":"Parasit. Vectors"},{"key":"B9","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1172\/JCI115605","article-title":"Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor","volume":"89","author":"Fu","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0001-706X(96)00633-X","article-title":"Insulin-like growth factor-1 is a growth promoting factor for Leishmania promastigotes","volume":"64","author":"Gomes","year":"1997","journal-title":"Acta Trop."},{"key":"B11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/expr.2001.4650","article-title":"Characterization of the receptor for insulin-like growth factor on Leishmania promastigotes","volume":"99","author":"Gomes","year":"2001","journal-title":"Exp. Parasitol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1046\/j.1365-2613.2000.00157.x","article-title":"Insulin-like growth factor (IGF)-I affects parasite growth and host cell migration in experimental cutaneous leishmaniasis","volume":"81","author":"Gomes","year":"2000","journal-title":"Int. J. Exp. Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1550-7408.1998.tb04548.x","article-title":"Insulin-like growth factor-I induces phosphorylation in Leishmania (Leishmania) mexicana promastigotes and amastigotes","volume":"45","author":"Gomes","year":"1998","journal-title":"J. Eukaryot. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"13211","DOI":"10.1073\/pnas.95.22.13211","article-title":"Insulin-like growth factor I is a growth-promoting factor for Leishmania promastigotes and amastigotes","volume":"95","author":"Goto","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1096-6374(03)00038-8","article-title":"Serum levels of insulin-like growth factor I and its binding proteins in health and disease","volume":"13","author":"Juul","year":"2003","journal-title":"Growth Horm. IGF Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real- time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1365-2567.2009.03136.x","article-title":"Insulin-like growth factor I messenger RNA and protein are expressed in the human lymph node and distinctly confined to subtypes of macrophages, antigen-presenting cells, lymphocytes and endothelial cells","volume":"128","author":"Oberlin","year":"2009","journal-title":"Immunology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2265.2007.03148.x","article-title":"Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene","volume":"69","author":"Oliveira","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.apjtm.2016.06.021","article-title":"Worldwide risk factors in leishmaniasis","volume":"9","author":"Oryan","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/pim.12041","article-title":"The interactions and essential effects of intrinsic insulin-like growth factor-I on Leishmania (Leishmania) major growth within macrophages","volume":"35","author":"Reis","year":"2013","journal-title":"Parasite Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1462-5822.2009.01377.x","article-title":"Mycobacterium leprae induces insulin-like growth factor and promotes survival of Schwann cells upon serum withdrawal","volume":"12","author":"Rodrigues","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1210\/jc.84.3.917","article-title":"Familial dwarfism due to a novel mutation of the growth hormone- releasing hormone receptor gene","volume":"84","author":"Salvatori","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/BF03347374","article-title":"GH response to hypoglycemia and clonidine in the GH-releasing hormone resistance syndrome","volume":"29","author":"Salvatori","year":"2006","journal-title":"J. Endocrinol. Invest."},{"key":"B24","first-page":"1447","article-title":"Glycosylated insulin-like growth factor II promoted expansion of granulocyte-macrophage colony-forming cells in serum-deprived liquid cultures of human peripheral blood cells","volume":"21","author":"Schwartz","year":"1993","journal-title":"Exp. Hematol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e0005486","DOI":"10.1371\/journal.pntd.0005486","article-title":"sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis","volume":"11","author":"Silva","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1590\/S0004-27302004000300013","article-title":"Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil","volume":"48","author":"Souza","year":"2005","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.mattod.2015.01.019","article-title":"Biomaterial based modulation of macrophage polarization: a review and suggested design principles","volume":"18","author":"Sridharan","year":"2015","journal-title":"Mater. Today"},{"key":"B28","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1365-3083.2007.01950.x","article-title":"Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal inhibition of NOS2 pathway in macrophage in vitro","volume":"66","author":"Vendrame","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"475919","DOI":"10.1155\/2014\/475919","article-title":"Insulin-like growth factor-I induces arginase activity in Leishmania amazonensis amastigote-infected macrophages through a cytokine-independent mechanism","volume":"2014","author":"Vendrame","year":"2015","journal-title":"Mediators Inflamm."},{"volume-title":"Advances in Protein Chemistry, Vol. 52, Cytokines","year":"1999","author":"Wells","key":"B30"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00311\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T03:42:12Z","timestamp":1569296532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00311\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":30,"alternative-id":["10.3389\/fcimb.2019.00311"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00311","relation":{},"ISSN":["2235-2988"],"issn-type":[{"type":"electronic","value":"2235-2988"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"article-number":"311"}}