{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:11:30Z","timestamp":1791421890237,"version":"4.3.3"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00363","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T04:28:21Z","timestamp":1571718501000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":96,"title":["Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection"],"prefix":"10.3389","volume":"9","author":[{"given":"Guilherme","family":"Loss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Martins","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Valour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Farrel","family":"Cort\u00eas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Gonzaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Bergot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Trouillet-Assant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00earome","family":"Josse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Diot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Tereza","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1159\/000327714","article-title":"Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake","volume":"3","author":"Abel","year":"2011","journal-title":"J. Innate Immun."},{"key":"B2","unstructured":"A new set of bioinformatics tools for genome projects2652\n            AlmeidaL. G. P.\n            Paix\u00e3oR.\n            SouzaR. C.\n            da CostaG. C.\n            AlmeidaD. F.\n            de VasconcelosA. T. R. de\n          15100986Genet. Mol. Res. GMR32004"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/nprot.2013.099","article-title":"Count-based differential expression analysis of RNA sequencing data using R and Bioconductor","volume":"8","author":"Anders","year":"2013","journal-title":"Nat. Protoc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/clinids\/9.6.1168","article-title":"Prosthetic valve endocarditis due to small-colony staphylococcal variants","volume":"9","author":"Baddour","year":"1987","journal-title":"Rev. Infect. Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"ftw060","DOI":"10.1093\/femspd\/ftw060","article-title":"Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus","volume":"74","author":"Beavers","year":"2016","journal-title":"Pathog. Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.2106\/00004623-200506000-00022","article-title":"Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis","volume":"87","author":"Bosse","year":"2005","journal-title":"A case report. J. Bone Joint Surg. Am."},{"key":"B8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.micinf.2014.09.009","article-title":"The induction of Staphylococcus aureus biofilm formation or Small Colony Variants is a strain-specific response to host-generated chemical stresses","volume":"17","author":"Bui","year":"2015","journal-title":"Microbes Infect."},{"key":"B9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.meegid.2015.10.011","article-title":"A full genomic characterization of the development of a stable Small Colony Variant cell-type by a clinical Staphylococcus aureus strain","volume":"36","author":"Bui","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.femsim.2004.11.010","article-title":"Iron and infection: the heart of the matter","volume":"43","author":"Bullen","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3109\/09553002.2011.622033","article-title":"Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: comparison with manual counting","volume":"87","author":"Cai","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nmeth.2474","article-title":"Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data","volume":"10","author":"Chin","year":"2013","journal-title":"Nat. Methods"},{"key":"B13","doi-asserted-by":"publisher","first-page":"16051","DOI":"10.1038\/nmicrobiol.2016.51","article-title":"Persister formation in Staphylococcus aureus is associated with ATP depletion","volume":"1","author":"Conlon","year":"2016","journal-title":"Nat. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"5222","DOI":"10.1128\/AAC.00437-10","article-title":"An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus","volume":"54","author":"Cui","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1128\/MMBR.00046-09","article-title":"ppGpp conjures bacterial virulence","volume":"74","author":"Dalebroux","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e11147","DOI":"10.1371\/journal.pone.0011147","article-title":"progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement","volume":"5","author":"Darling","year":"2010","journal-title":"PloS ONE"},{"key":"B17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s002030050635","article-title":"Methylglyoxal production in bacteria: suicide or survival?","volume":"170","author":"Ferguson","year":"1998","journal-title":"Arch. Microbiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1128\/AAC.00720-10","article-title":"Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance","volume":"55","author":"Galbusera","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B19","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/infdis\/jis772","article-title":"The RpoB H481Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus","volume":"207","author":"Gao","year":"2013","journal-title":"J. Infect. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e1000944","DOI":"10.1371\/journal.ppat.1000944","article-title":"Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection","volume":"6","author":"Gao","year":"2010","journal-title":"PLoS Pathog."},{"key":"B21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence","volume":"17","author":"Garzoni","year":"2009","journal-title":"Trends Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1003016","DOI":"10.1371\/journal.ppat.1003016","article-title":"The stringent response of Staphylococcus aureus and Its Impact on Survival after phagocytosis through the induction of intracellular PSMs expression","volume":"8","author":"Geiger","year":"2012","journal-title":"PLoS Pathog."},{"key":"B23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0966-842X(02)02403-4","article-title":"The role of the stringent response in the pathogenesis of bacterial infections","volume":"10","author":"Godfrey","year":"2002","journal-title":"Trends Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0580-9517(02)31029-8","article-title":"28 Electron microscopy in cellular microbiology: ultrastructural methods for the study of cell surface antigens and pathogenic host\u2014cell interactions","volume":"31","author":"Gounon","year":"2002","journal-title":"Methods Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJM199302113280609","article-title":"A 69-year-old woman with a sclerotic lesion of the femur and pulmonary nodules","volume":"328","author":"Greer","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.micinf.2011.11.001","article-title":"A battle for iron: host sequestration and Staphylococcus aureus acquisition","volume":"14","author":"Haley","year":"2012","journal-title":"Microbes Infect."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1093\/nar\/gku1235","article-title":"An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments","volume":"43","author":"Heyer","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"9786","DOI":"10.1073\/pnas.0402521101","article-title":"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance","volume":"101","author":"Holden","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.redox.2018.02.001","article-title":"The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus","volume":"15","author":"Imber","year":"2018","journal-title":"Redox Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1128\/IAI.70.2.631-641.2002","article-title":"Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease","volume":"70","author":"Jarraud","year":"2002","journal-title":"Infect. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4137\/MBI.S25800","article-title":"Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection","volume":"8","author":"Johns","year":"2015","journal-title":"Microbiol. Insights"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1086\/515238","article-title":"Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosis","volume":"177","author":"Kahl","year":"1998","journal-title":"J. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1128\/JCM.41.1.410-413.2003","article-title":"Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separation","volume":"41","author":"Kahl","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1128\/IAI.73.7.4119-4126.2005","article-title":"Thymidine-dependent Staphylococcus aureus small colony variants are associated with extensive changes in regulator and virulence gene expression profiles","volume":"73","author":"Kahl","year":"2005","journal-title":"Infect. Immun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1128\/CMR.00069-15","article-title":"Clinical significance and pathogenesis of staphylococcal small colony variants in persistent infections","volume":"29","author":"Kahl","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"B36","doi-asserted-by":"publisher","first-page":"6928","DOI":"10.1128\/JB.185.23.6928-6937.2003","article-title":"Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach","volume":"185","author":"Kohler","year":"2003","journal-title":"J. Bacteriol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","article-title":"A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5976","DOI":"10.1128\/JB.00592-07","article-title":"Staphylococcus aureus ArcR controls expression of the arginine deiminase operon","volume":"189","author":"Makhlin","year":"2007","journal-title":"J. Bacteriol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/S0960-9822(01)00507-3","article-title":"Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus","volume":"11","author":"Massey","year":"2001","journal-title":"Curr. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"R686","DOI":"10.1016\/S0960-9822(02)01205-8","article-title":"Antibiotic-resistant sub-populations of the pathogenic bacterium Staphylococcus aureus confer population-wide resistance","volume":"12","author":"Massey","year":"2002","journal-title":"Curr. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1128\/AAC.01213-10","article-title":"Mutational analyses of open reading frames within the vraSR operon and their roles in the cell wall stress response of Staphylococcus aureus","volume":"55","author":"McCallum","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s10096-009-0752-2","article-title":"Molecular epidemiology of Staphylococcus aureus in asymptomatic carriers","volume":"28","author":"Monecke","year":"2009","journal-title":"Eur. J. Clin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1128\/AAC.50.1.298-309.2006","article-title":"Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of Rifampin resistance genotypes in relation to clinical prevalence","volume":"50","author":"O'Neill","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e77614","DOI":"10.1371\/journal.pone.0077614","article-title":"Phenotypic variants of staphylococci and their underlying population distributions following exposure to stress","volume":"8","author":"Onyango","year":"2013","journal-title":"PloS ONE"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/cis966","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3389\/fcimb.2016.00187","article-title":"Reduced innate immune response to a Staphylococcus aureus small colony variant compared to its wild-type parent strain","volume":"6","author":"Ou","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/1471-2164-10-429","article-title":"Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance","volume":"10","author":"Pieti\u00e4inen","year":"2009","journal-title":"BMC Genomics"},{"key":"B51","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.celrep.2014.03.012","article-title":"Dual toxic-peptide-coding Staphylococcus aureus RNA under antisense regulation targets host cells and bacterial rivals unequally","volume":"7","author":"Pinel-Marie","year":"2014","journal-title":"Cell Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fcimb.2014.00099","article-title":"Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections","volume":"4","author":"Proctor","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/clinids\/20.1.95","article-title":"Persistent and relapsing infections associated with small colony variants of Staphylococcus aureus","volume":"20","author":"Proctor","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrmicro1384","article-title":"Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections","volume":"4","author":"Proctor","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e63176","DOI":"10.1371\/journal.pone.0063176","article-title":"PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts","volume":"8","author":"Rasigade","year":"2013","journal-title":"PloS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.idc.2008.10.001","article-title":"Coagulase-negative staphylococcal infections","volume":"23","author":"Rogers","year":"2009","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B59","doi-asserted-by":"publisher","first-page":"E140","DOI":"10.3390\/toxins8050140","article-title":"Toxin-antitoxin systems of Staphylococcus aureus","volume":"8","author":"Schuster","year":"2016","journal-title":"Toxins"},{"key":"B60","doi-asserted-by":"publisher","first-page":"7765","DOI":"10.1128\/JB.00774-06","article-title":"Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype","volume":"188","author":"Seggewiss","year":"2006","journal-title":"J. Bacteriol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tim.2008.11.004","article-title":"Staphylococcus aureus as an intracellular pathogen: the role of small colony variants","volume":"17","author":"Sendi","year":"2009","journal-title":"Trends Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.jocn.2005.12.006","article-title":"Reactivation of dormant lumbar methicillin-resistant Staphylococcus aureus osteomyelitis after 12 years","volume":"14","author":"Stevens","year":"2007","journal-title":"J. Clin. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e01910","DOI":"10.1128\/mBio.01910-14","article-title":"Clinical characteristics and outcomes of prosthetic joint infection caused by small colony variant staphylococci","volume":"5","author":"Tande","year":"2014","journal-title":"mBio"},{"key":"B64","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1086\/656047","article-title":"Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence","volume":"202","author":"Tuchscherr","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/emmm.201000115","article-title":"Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection","volume":"3","author":"Tuchscherr","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1128\/AAC.04359-14","article-title":"Antimicrobial activity against intraosteoblastic Staphylococcus aureus","volume":"59","author":"Valour","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B68","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1055\/s-2008-1054234","article-title":"Development of gentamicin-resistant small colony variants of Staphylococcus aureus after implantation of gentamicin beads in osteomyelitis as a possible cause of recurrence","volume":"136","author":"von Eiff","year":"1998","journal-title":"Z Orthop Ihre Grenzgeb"},{"key":"B69","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","article-title":"Iron homeostasis and the inflammatory response","volume":"30","author":"Wessling-Resnick","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1128\/AAC.46.11.3381-3385.2002","article-title":"Biological cost of Rifampin resistance from the perspective of Staphylococcus aureus","volume":"46","author":"Wichelhaus","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"B71","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijmm.2009.08.017","article-title":"The synthesis and function of the alarmone (p)ppGpp in firmicutes","volume":"300","author":"Wolz","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"W347","DOI":"10.1093\/nar\/gkr485","article-title":"PHAST: a fast phage search tool","volume":"39","author":"Zhou","year":"2011","journal-title":"Nucleic Acids Res."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00363\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T04:28:26Z","timestamp":1571718506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00363\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":72,"alternative-id":["10.3389\/fcimb.2019.00363"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00363","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]},"article-number":"363"}}