{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:02:02Z","timestamp":1790182922331,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00383","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T05:18:12Z","timestamp":1573535892000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Fungal Chitin Reduces Platelet Activation Mediated via TLR8 Stimulation"],"prefix":"10.3389","volume":"9","author":[{"given":"Jordan","family":"Leroy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis","family":"Bortolus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lecointe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Parny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogatien","family":"Charlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Jawhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.4049\/jimmunol.173.2.1313","article-title":"TNF-induced beta2 integrin activation involves Src kinases and a redox-regulated activation of p38 MAPK","volume":"173","author":"Bouaouina","year":"2004","journal-title":"J. Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27183","DOI":"10.1074\/jbc.272.43.27183","article-title":"Networking in the hemostatic system. Integrin alphaiibbeta3 binds prothrombin and influences its activation","volume":"272","author":"Byzova","year":"1997","journal-title":"J. Biol. Chem"},{"key":"B3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1128\/IAI.20.1.279-289.1978","article-title":"Candida albicans endocarditis: ultrastructural studies of vegetation formation","volume":"20","author":"Calderone","year":"1978","journal-title":"Infect. Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"20590","DOI":"10.1074\/jbc.M709334200","article-title":"Dendritic cell interaction with Candida albicans critically depends on N-linked mannan","volume":"283","author":"Cambi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13099-018-0277-2","article-title":"A decrease in anaerobic bacteria promotes Candida glabrata overgrowth while beta-glucan treatment restores the gut microbiota and attenuates colitis","volume":"10","author":"Charlet","year":"","journal-title":"Gut. Pathog."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1038\/s41598-018-21422-w","article-title":"Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response","volume":"8","author":"Charlet","year":"","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13099-017-0158-0","article-title":"Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination","volume":"9","author":"Choteau","year":"2017","journal-title":"Gut. Pathog."},{"key":"B8","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"B9","first-page":"381","article-title":"Platelet interaction with bacteria. II. Fate of the bacteria","volume":"65","author":"Clawson","year":"1971","journal-title":"Am. J. Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1182\/blood-2012-06-437392","article-title":"Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice","volume":"121","author":"Duerschmied","year":"2013","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"201846065","DOI":"10.15252\/embr.201846065","article-title":"The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size","volume":"19","author":"Fuchs","year":"2018","journal-title":"EMBO. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"Gow","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1161\/ATVBAHA.118.311787","article-title":"Focal adhesion kinases in platelet function and thrombosis","volume":"39","author":"Guidetti","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1469-7793.1999.713ad.x","article-title":"Reversible and irreversible intracellular Ca2+ spiking in single isolated human platelets","volume":"514","author":"Hussain","year":"1999","journal-title":"J. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e40648","DOI":"10.1371\/journal.pone.0040648","article-title":"Modulation of intestinal inflammation by yeasts and cell wall extracts: strain dependence and unexpected anti-inflammatory role of glucan fractions","volume":"7","author":"Jawhara","year":"2012","journal-title":"PLoS ONE"},{"key":"B16","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1086\/528990","article-title":"Colonization of mice by Candida albicans is promoted by chemically induced colitis and augments inflammatory responses through galectin-3","volume":"197","author":"Jawhara","year":"2008","journal-title":"J. Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e16594","DOI":"10.1371\/journal.pone.0016594","article-title":"Chitin modulates innate immune responses of keratinocytes","volume":"6","author":"Koller","year":"2011","journal-title":"PLoS ONE"},{"key":"B18","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000444807","article-title":"Platelet interaction with innate immune cells","volume":"43","author":"Kral","year":"2016","journal-title":"Transfus. Med. Hemother."},{"key":"B19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.chroma.2008.03.094","article-title":"Separation of chitosan oligomers by immobilized metal affinity chromatography","volume":"1194","author":"Le Devedec","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"B20","doi-asserted-by":"publisher","first-page":"H1218","DOI":"10.1152\/ajpheart.1988.254.6.H1218","article-title":"Role of platelet-activating factor in primary hemostasis","volume":"254","author":"Livio","year":"1988","journal-title":"Am. J. Physiol."},{"key":"B21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1128\/IAI.32.1.92-97.1981","article-title":"Role of surface mannan in the adherence of Candida albicans to fibrin-platelet clots formed in vitro","volume":"32","author":"Maisch","year":"1981","journal-title":"Infect. Immun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1128\/IAI.01282-10","article-title":"Recognition and blocking of innate immunity cells by Candida albicans chitin","volume":"79","author":"Mora-Montes","year":"2011","journal-title":"Infect. Immun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3712","DOI":"10.4049\/jimmunol.172.6.3712","article-title":"Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells","volume":"172","author":"Netea","year":"2004","journal-title":"J. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.3390\/ijms11125152","article-title":"Applications of chitin and its derivatives in biological medicine","volume":"11","author":"Park","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1182\/blood-2002-06-1842","article-title":"Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration","volume":"101","author":"Pluskota","year":"2003","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3109\/1040841X.2013.813904","article-title":"Candida albicans, plasticity and pathogenesis","volume":"41","author":"Poulain","year":"2015","journal-title":"Crit. Rev. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1159\/000268129","article-title":"Yeasts: neglected pathogens","volume":"27","author":"Poulain","year":"2009","journal-title":"Dig. Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1128\/IAI.68.2.570-576.2000","article-title":"Adherence of platelets to Candida species in vivo","volume":"68","author":"Robert","year":"2000","journal-title":"Infect. Immun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1002\/JLB.MR0618-213R","article-title":"Platelet TLR4 at the crossroads of thrombosis and the innate immune response","volume":"105","author":"Schattner","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1128\/CVI.00200-08","article-title":"Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan","volume":"15","author":"Sendid","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1128\/JCM.02356-12","article-title":"Strategy for overcoming serum interferences in detection of serum (1,3)-beta-D-glucans","volume":"51","author":"Sendid","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.thromres.2004.03.023","article-title":"Expression of Toll-like receptors on human platelets","volume":"113","author":"Shiraki","year":"2004","journal-title":"Thromb. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1093\/infdis\/jis743","article-title":"Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds","volume":"207","author":"Speth","year":"2013","journal-title":"J. Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"H725","DOI":"10.1152\/ajpheart.00907.2015","article-title":"Short fungal fractions of beta-1,3 glucans affect platelet activation","volume":"311","author":"Vancraeyneste","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e1004050","DOI":"10.1371\/journal.ppat.1004050","article-title":"Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation","volume":"10","author":"Wagener","year":"2014","journal-title":"PLoS Pathog."},{"key":"B36","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1160\/TH05-01-0009","article-title":"Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor","volume":"94","author":"Ward","year":"2005","journal-title":"Thromb. Haemost."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00383\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T21:29:07Z","timestamp":1612301347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00383\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":36,"alternative-id":["10.3389\/fcimb.2019.00383"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00383","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"article-number":"383"}}