{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:08:28Z","timestamp":1789924108647,"version":"4.0.1"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00420","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T09:08:25Z","timestamp":1578647305000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Dynamics and Outcome of Macrophage Interaction Between Salmonella Gallinarum, Salmonella Typhimurium, and Salmonella Dublin and Macrophages From Chicken and Cattle"],"prefix":"10.3389","volume":"9","author":[{"given":"Kaisong","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Herrero","family":"Fresno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Elmerdahl","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1128\/IAI.62.10.4602-4610.1994","article-title":"Host specificity of Salmonella infection in chickens and mice is expressed in vivo primarily at the level of the reticuloendothelial system","volume":"62","author":"Barrow","year":"1994","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1128\/IAI.66.10.4579-4587.1998","article-title":"Evolution of host adaptation in Salmonella enterica","volume":"66","author":"Baumler","year":"1998","journal-title":"Infect. Immun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5993","DOI":"10.1128\/IAI.00695-07","article-title":"Chicken cecum immune response to Salmonella enterica serovars of different levels of invasiveness","volume":"75","author":"Berndt","year":"2007","journal-title":"Infect. Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1099\/00222615-48-9-801","article-title":"Invasiveness of Salmonella serotypes Typhimurium, Choleraesuis and Dublin for rabbit terminal ileum in vitro","volume":"48","author":"Bolton","year":"1999","journal-title":"J. Med. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1016\/j.molimm.2009.06.002","article-title":"Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides","volume":"46","author":"Brownlie","year":"2009","journal-title":"Mol. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e1000538","DOI":"10.1371\/journal.ppat.1000538","article-title":"Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells","volume":"5","author":"Bruno","year":"2009","journal-title":"PLoS Pathog."},{"key":"B7","doi-asserted-by":"publisher","first-page":"010401","DOI":"10.7189\/jogh.01.010401","article-title":"Typhoid fever and paratyphoid fever: systematic review to estimate global morbidity and mortality for 2010","volume":"2","author":"Buckle","year":"2012","journal-title":"J. Glob. Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bbrc.2014.05.056","article-title":"Global impact of Salmonella type III secretion effector SteA on host cells","volume":"449","author":"Cardenal-Munoz","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0378-1135(02)00290-0","article-title":"Comparison of intestinal invasion and macrophage response of Salmonella Gallinarum and other host-adapted Salmonella enterica serovars in the avian host","volume":"92","author":"Chadfield","year":"2003","journal-title":"Vet. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.vetimm.2008.10.295","article-title":"The immunobiology of avian systemic salmonellosis","volume":"128","author":"Chappell","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1046\/j.1365-2958.1996.471410.x","article-title":"Salmonella spp. are cytotoxic for cultured macrophages","volume":"21","author":"Chen","year":"1996","journal-title":"Mol Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.vetmic.2013.04.015","article-title":"A flagellated motile Salmonella Gallinarum mutant (SG Fla+) elicits a pro-inflammatory response from avian epithelial cells and macrophages and is less virulent to chickens","volume":"165","author":"De Freitas Neto","year":"2013","journal-title":"Vet. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1128\/CMR.00066-12","article-title":"Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation","volume":"26","author":"Fabrega","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1099\/mic.0.058115-0","article-title":"Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors","volume":"158","author":"Figueira","year":"2012","journal-title":"Microbiology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1073\/pnas.86.16.6383","article-title":"Cloning and molecular characterization of genes whose products allow Salmonella Typhimurium to penetrate tissue culture cells","volume":"86","author":"Galan","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3389\/fmicb.2014.00391","article-title":"Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ","volume":"5","author":"Gal-Mor","year":"2014","journal-title":"Front. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1365-2567.2008.02814.x","article-title":"Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice","volume":"125","author":"Grant","year":"2008","journal-title":"Immunology"},{"key":"B18","volume-title":"Antigenic Formulae of the Salmonella serovars, 9th Edn.","author":"Grimont Pad","year":"2007"},{"key":"B19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrmicro1788","article-title":"Salmonellae interplay with host cells","volume":"6","author":"Haraga","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.3201\/eid2309.170136","article-title":"Epidemiology of Salmonella enterica serotype Dublin infections among humans, United States, 1968\u20132013","volume":"23","author":"Harvey","year":"2017","journal-title":"Emerging Infect. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1186\/1471-2164-14-365","article-title":"Comparative genomics of Salmonella enterica serovars Derby and Mbandaka, two prevalent serovars associated with different livestock species in the UK","volume":"14","author":"Hayward","year":"2013","journal-title":"BMC Genom."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1089\/fpd.2012.1233","article-title":"A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by prevalent poultry Salmonella serovars","volume":"9","author":"He","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e84566","DOI":"10.1371\/journal.pone.0084566","article-title":"The role of the st313-td gene in virulence of Salmonella Typhimurium ST313","volume":"9","author":"Herrero-Fresno","year":"2014","journal-title":"PLoS ONE"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1128\/IAI.74.3.1692-1698.2006","article-title":"Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection","volume":"74","author":"Higgs","year":"2006","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00552-19","article-title":"Interaction-differences of the avian host-specific Salmonella serovar Gallinarum, the host-generalist S. Typhimurium, and the cattle host-adapted S. Dublin with chicken primary macrophage. Infect Immun","author":"Huang","year":"2019"},{"key":"B26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/978-1-4939-3335-8_18","article-title":"Toll-like receptor signalling and the control of intestinal barrier function","volume":"1390","author":"Johnston","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1128\/IAI.69.9.5471-5476.2001","article-title":"Salmonella enterica serovar Gallinarum requires the Salmonella pathogenicity island 2 type III secretion system but not the Salmonella pathogenicity island 1 type III secretion system for virulence in chickens","volume":"69","author":"Jones","year":"2001","journal-title":"Infect. Immun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1099\/00221287-146-12-3217","article-title":"Differential cytokine expression in avian cells in response to invasion by Salmonella Typhimurium, Salmonella Enteritidis and Salmonella Gallinarum","volume":"12","author":"Kaiser","year":"2000","journal-title":"Microbiology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3382\/ps.2009-00420","article-title":"Prevalence and characterization of Salmonella Gallinarum in the chicken in Korea during 2000 to 2008","volume":"89","author":"Kwon","year":"2010","journal-title":"Poult. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1073\/pnas.1416707112","article-title":"Patterns of genome evolution that have accompanied host adaptation in Salmonella","volume":"112","author":"Langridge","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1080\/03079450902737771","article-title":"Functions exerted by the virulence-associated type-three secretion systems during Salmonella enterica serovar Enteritidis invasion into and survival within chicken oviduct epithelial cells and macrophages","volume":"38","author":"Li","year":"2009","journal-title":"Avian Pathol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B33","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1086\/650733","article-title":"The global burden of nontyphoidal Salmonella gastroenteritis","volume":"50","author":"Majowicz","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1017\/S1462399411001840","article-title":"Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants","volume":"13","author":"Mastroeni","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/nature13157","article-title":"Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases","volume":"509","author":"Meunier","year":"2014","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/S1286-4579(01)01480-0","article-title":"Salmonella-induced macrophage death: the role of caspase-1 in death and inflammation","volume":"3","author":"Monack","year":"2001","journal-title":"Microbes Infect."},{"key":"B37","doi-asserted-by":"publisher","first-page":"9833","DOI":"10.1073\/pnas.93.18.9833","article-title":"Salmonella Typhimurium invasion induces apoptosis in infected macrophages","volume":"93","author":"Monack","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00251-008-0340-0","article-title":"Differential mRNA expression of the avian-specific toll-like receptor 15 between heterophils from Salmonella-susceptible and -resistant chickens","volume":"61","author":"Nerren","year":"2009","journal-title":"Immunogenetics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1017\/S0950268812003007","article-title":"Within-herd prevalence of Salmonella Dublin in endemically infected dairy herds","volume":"141","author":"Nielsen","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"B40","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1297-9716-42-16","article-title":"SPI-1-encoded type III secretion system of Salmonella enterica is required for the suppression of porcine alveolar macrophage cytokine expression","volume":"42","author":"Pavlova","year":"2011","journal-title":"Vet. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0378-1135(99)00196-0","article-title":"Phagocytic uptake and killing of virulent and avirulent strains of Pasteurella multocida of capsular serotype A by chicken macrophages","volume":"72","author":"Poermadjaja","year":"2000","journal-title":"Vet. Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13567-014-0081-z","article-title":"Deciphering why Salmonella Gallinarum is less invasive in vitro than Salmonella Enteritidis","volume":"45","author":"Rossignol","year":"2014","journal-title":"Vet. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1128\/IAI.69.4.2293-2301.2001","article-title":"Salmonella enterica serovar Typhimurium induces cell death in bovine monocyte-derived macrophages by early sipB-dependent and delayed sipB-independent mechanisms","volume":"69","author":"Santos","year":"2001","journal-title":"Infect. Immun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.vetmic.2014.01.034","article-title":"Polyamines are essential for virulence in Salmonella enterica serovar Gallinarum despite evolutionary decay of polyamine biosynthesis genes","volume":"170","author":"Schroll","year":"2014","journal-title":"Vet. Microbiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.vetimm.2012.03.008","article-title":"Immune dynamics following infection of avian macrophages and epithelial cells with typhoidal and non-typhoidal Salmonella enterica serovars; bacterial invasion and persistence, nitric oxide and oxygen production, differential host gene expression, NF-kappaB signalling and cell cytotoxicity","volume":"146","author":"Setta","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.20506\/rst.19.2.1222","article-title":"Fowl typhoid and pullorum disease","volume":"19","author":"Shivaprasad","year":"2000","journal-title":"Rev. Sci. Tech."},{"key":"B47","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.smim.2018.02.008","article-title":"The intestinal complement system in inflammatory bowel disease: shaping intestinal barrier function","volume":"37","author":"Sina","year":"2018","journal-title":"Semin. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/mi.2010.66","article-title":"Intestinal macrophages and response to microbial encroachment","volume":"4","author":"Smith","year":"2011","journal-title":"Mucosal Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1005262","DOI":"10.1371\/journal.ppat.1005262","article-title":"RNA-seq brings new insights to the intra-macrophage transcriptome of Salmonella Typhimurium","volume":"11","author":"Srikumar","year":"2015","journal-title":"PLoS Pathog."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e00307","DOI":"10.1128\/IAI.00307-18","article-title":"Model of persistent Salmonella infection: Salmonella enterica serovar pullorum modulates the immune response of the chicken from a Th17-type response towards a Th2-type response","volume":"86","author":"Tang","year":"2018","journal-title":"Infect. Immun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1101\/gr.077404.108","article-title":"Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287\/91 provides insights into evolutionary and host adaptation pathways","volume":"18","author":"Thomson","year":"2008","journal-title":"Genome Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nrmicro2012","article-title":"From bench to bedside: stealth of enteroinvasive pathogens","volume":"6","author":"Tsolis","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1017\/S0950268899004379","article-title":"Host adapted serotypes of Salmonella enterica","volume":"125","author":"Uzzau","year":"2000","journal-title":"Epidemiol. Infect."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1016\/j.molimm.2010.06.006","article-title":"Molecular mechanism underlying the inflammatory complication of leptin in macrophages","volume":"47","author":"Vaughan","year":"2010","journal-title":"Mol. Immunol."},{"key":"B55","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/IAI.63.7.2755-2761.1995","article-title":"The Salmonella Dublin virulence plasmid mediates systemic but not enteric phases of salmonellosis in cattle","volume":"63","author":"Wallis","year":"1995","journal-title":"Infect. Immun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/imr.12266","article-title":"Macrophage defense mechanisms against intracellular bacteria","volume":"264","author":"Weiss","year":"2015","journal-title":"Immunol. Rev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/03079457.2016.1240866","article-title":"Salmonella enterica serovar Gallinarum: addressing fundamental questions in bacteriology sixty years on from the 9R vaccine","volume":"46","author":"Wigley","year":"2016","journal-title":"Avian Pathol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1128\/IAI.72.4.2152-2159.2004","article-title":"Rapid expression of chemokines and proinflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar Typhimurium","volume":"72","author":"Withanage","year":"2004","journal-title":"Infect. Immun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1128\/IAI.02870-14","article-title":"Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection","volume":"83","author":"Zhan","year":"2015","journal-title":"Infect. Immun."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00420\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T09:08:29Z","timestamp":1578647309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00420\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":59,"alternative-id":["10.3389\/fcimb.2019.00420"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00420","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]},"article-number":"420"}}