{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:41:47Z","timestamp":1792813307578,"version":"4.5.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81674326"],"award-info":[{"award-number":["81674326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730012"],"award-info":[{"award-number":["81730012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2019.00455","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T13:38:41Z","timestamp":1579268321000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":198,"title":["Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets"],"prefix":"10.3389","volume":"9","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjing","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11892-019-1180-z","article-title":"Fecal microbiota transplantation: a future therapeutic option for Obesity\/Diabetes?","volume":"19","author":"Aron-Wisnewsky","year":"2019","journal-title":"Curr. Diab. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11892-018-1020-6","article-title":"The gut microbiome as a target for the treatment of Type 2 Diabetes","volume":"18","author":"Aydin","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"604","DOI":"10.5694\/j.1326-5377.1989.tb136704.x","article-title":"Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?","volume":"150","author":"Borody","year":"1989","journal-title":"Med. J. Aust."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5184","DOI":"10.1038\/s41467-018-07359-8","article-title":"Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells","volume":"9","author":"Burrello","year":"2018","journal-title":"Nat. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"\u03b2-Cell deficit and increased \u03b2-cell apoptosis in humans with Type 2 Diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"B6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1136\/gutjnl-2016-313017","article-title":"European consensus conference on faecal microbiota transplantation in clinical practice","volume":"66","author":"Cammarota","year":"2017","journal-title":"Gut"},{"key":"B7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.semcancer.2017.08.005","article-title":"In vitro polyphenol effects on apoptosis: an update of literature data","volume":"46","author":"Curti","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/19490976.2017.1293224","article-title":"Fecal microbiota transplantation in metabolic syndrome: history, present and future","volume":"8","author":"de Groot","year":"2017","journal-title":"Gut Microbes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"E713","DOI":"10.1152\/ajpendo.00194.2007","article-title":"Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity","volume":"293","author":"De Taeye","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"B11","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fmicb.2017.00196","article-title":"Variable colonization after reciprocal fecal microbiota transfer between mice with low and high richness microbiota","volume":"8","author":"Ericsson","year":"2017","journal-title":"Front. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A mouse model of metabolic syndrome: insulin resistance, fatty liver and non-alcoholic fatty Pancreas Disease (NAFPD) in C57BL\/6 mice fed a high fat diet","volume":"46","author":"Fraulob","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.3390\/ijms19123720","article-title":"Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes","volume":"19","author":"Ganesan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00125-017-4523-9","article-title":"Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function","volume":"61","author":"He","year":"2018","journal-title":"Diabetologia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7046","DOI":"10.1038\/s41598-017-07335-0","article-title":"Anti-diabetic effects of clostridium butyricum CGMCC0313.1 through promoting the growth of gut butyrate-producing Bacteria in Type 2 Diabetic Mice","volume":"7","author":"Jia","year":"2017","journal-title":"Sci. Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/s41366-018-0187-x","article-title":"Konjaku flour reduces obesity in mice by modulating the composition of the gut microbiota","volume":"43","author":"Kang","year":"2018","journal-title":"Int. J. Obes."},{"key":"B17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nature10213","article-title":"Human nutrition, the gut microbiome and the immune system","volume":"474","author":"Kau","year":"2011","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3109\/1040841X.2013.837863","article-title":"Early life events influence whole-of-life metabolic health via gut microflora and gut permeability","volume":"41","author":"Kerr","year":"2015","journal-title":"Crit. Rev. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.2337\/dc17-0968","article-title":"Predicting the effect of fenofibrate on cardiovascular risk for individual patients with Type 2 Diabetes","volume":"41","author":"Koopal","year":"2018","journal-title":"Diabetes Care"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e9085","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults","volume":"5","author":"Larsen","year":"2010","journal-title":"PLoS ONE"},{"key":"B21","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/dom.13561","article-title":"Gut microbiota and obesity: an opportunity to alter obesity through fecal microbiota transplant (FMT)","volume":"21","author":"Lee","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"B22","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1080\/10408398.2018.1536646","article-title":"Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota","volume":"59","author":"Nie","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jconrel.2018.10.003","article-title":"Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury","volume":"290","author":"Park","year":"2018","journal-title":"J. Control. Release"},{"key":"B24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41419-018-0603-0","article-title":"Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment","volume":"9","author":"Ruiz","year":"2018","journal-title":"Cell Death Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1152\/physiol.00041.2015","article-title":"Linking gut microbiota and inflammation to obesity and insulin resistance","volume":"31","author":"Saad","year":"2016","journal-title":"Physiology."},{"key":"B27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/physiolgenomics.00194.2006","article-title":"A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human","volume":"29","author":"Salek","year":"2007","journal-title":"Physiol. Genomics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s00125-018-4738-4","article-title":"Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes","volume":"61","author":"Savilahti","year":"2018","journal-title":"Diabetologia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1172\/JCI79214","article-title":"Engineering the gut microbiota to treat hyperammonemia","volume":"125","author":"Shen","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B31","doi-asserted-by":"publisher","first-page":"7613","DOI":"10.1021\/acsnano.7b07643","article-title":"Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving beta-Cell Destruction","volume":"12","author":"Sun","year":"2018","journal-title":"ACS Nano"},{"key":"B32","first-page":"35","article-title":"Guiding opinions on treating experimental animals","volume":"2007","author":"The Ministry of Science and Technology","year":"2006","journal-title":"Sci. Technol. Inform. Anim. Veter."},{"key":"B33","doi-asserted-by":"publisher","first-page":"13037","DOI":"10.1038\/s41598-018-31353-1","article-title":"Gut microbiota mediates the anti-obesity effect of calorie restriction in mice","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00455\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T13:38:43Z","timestamp":1579268323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2019.00455\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":33,"alternative-id":["10.3389\/fcimb.2019.00455"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2019.00455","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]},"article-number":"455"}}