{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:39:33Z","timestamp":1790462373463,"version":"4.1.0"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1009 TP B03"],"award-info":[{"award-number":["CRC1009 TP B03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1009 TP B04"],"award-info":[{"award-number":["CRC1009 TP B04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 1884\/2-1"],"award-info":[{"award-number":["RU 1884\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 1884\/3-1"],"award-info":[{"award-number":["RU 1884\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00091","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:56:02Z","timestamp":1583481362000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":97,"title":["Secretion and Delivery of Intestinal Pathogenic Escherichia coli Virulence Factors via Outer Membrane Vesicles"],"prefix":"10.3389","volume":"10","author":[{"given":"Christian","family":"Rueter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Bielaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/j.1365-2958.2009.06618.x","article-title":"Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin","volume":"71","author":"Aldick","year":"2009","journal-title":"Mol. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.micinf.2010.05.008","article-title":"Outer membrane vesicles function as offensive weapons in host-parasite interactions","volume":"12","author":"Amano","year":"2010","journal-title":"Microbes Infect."},{"key":"B3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1365-2958.2005.04938.x","article-title":"Release of the type I secreted alpha-haemolysin via outer membrane vesicles from Escherichia coli","volume":"59","author":"Balsalobre","year":"2006","journal-title":"Mol. Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e00937","DOI":"10.1128\/AAC.00937-17","article-title":"Antibiotic-mediated modulations of outer membrane vesicles in enterohemorrhagic Escherichia coli O104:H4 and O157:H7","volume":"61","author":"Bauwens","year":"","journal-title":"Antimicrob. Agents Chemother"},{"key":"B5","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/1758-2229.12562","article-title":"Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a and cytotoxicity in Escherichia coli O157:H7 and O104:H4","volume":"9","author":"Bauwens","year":"","journal-title":"Environ. Microbiol. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.ijmm.2018.06.004","article-title":"Enterohemorrhagic Escherichia coli O157 outer membrane vesicles induce interleukin 8 production in human intestinal epithelial cells by signaling via Toll-like receptors TLR4 and TLR5 and activation of the nuclear factor NF-kappa B","volume":"308","author":"Bielaszewska","year":"2018","journal-title":"Inter. J. Med. Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1006159","DOI":"10.1371\/journal.ppat.1006159","article-title":"Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: intracellular delivery, trafficking and mechanisms of cell injury","volume":"13","author":"Bielaszewska","year":"2017","journal-title":"PLoS Pathog."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1003797","DOI":"10.1371\/journal.ppat.1003797","article-title":"Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis","volume":"9","author":"Bielaszewska","year":"2013","journal-title":"PLoS Pathog."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1000382","DOI":"10.1371\/journal.ppat.1000382","article-title":"Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles","volume":"5","author":"Bomberger","year":"2009","journal-title":"PLoS Pathog."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.bbamcr.2013.12.011","article-title":"Protein selection and export via outer membrane vesicles","volume":"1843","author":"Bonnington","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.febslet.2011.04.017","article-title":"Association of cholera toxin with Vibrio cholerae outer membrane vesicles which are internalized by human intestinal epithelial cells","volume":"585","author":"Chatterjee","year":"2011","journal-title":"FEBS Lett"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1093\/jac\/dkx131","article-title":"Acinetobacter baumannii transfers the blaNDM\u22121 gene via outer membrane vesicles","volume":"72","author":"Chatterjee","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3389\/fmicb.2015.00974","article-title":"Vesicles-mediated resistance to antibiotics in bacteria","volume":"6","author":"Chattopadhyay","year":"2015","journal-title":"Front. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/jac\/45.1.9","article-title":"Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa","volume":"45","author":"Ciofu","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1128\/AAC.02171-15","article-title":"Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on beta-lactam resistance","volume":"60","author":"Devos","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1111\/1462-2920.13793","article-title":"Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress","volume":"19","author":"Devos","year":"2017","journal-title":"Environ. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mib.2017.03.012","article-title":"Membrane vesicles and horizontal gene transfer in prokaryotes","volume":"38","author":"Domingues","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e1003620","DOI":"10.1371\/journal.ppat.1003620","article-title":"Role of the vibrio cholerae matrix protein Bap1 in cross-resistance to antimicrobial peptides","volume":"9","author":"Duperthuy","year":"2013","journal-title":"PLoS Pathog."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e00940","DOI":"10.1128\/mBio.00940-16","article-title":"LPS remodeling triggers formation of outer membrane vesicles in Salmonella","volume":"7","author":"Elhenawy","year":"2016","journal-title":"mBio"},{"key":"B20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1128\/MMBR.00031-09","article-title":"Virulence and immunomodulatory roles of bacterial outer membrane vesicles","volume":"74","author":"Ellis","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e106731","DOI":"10.1371\/journal.pone.0106731","article-title":"Outer membrane vesicles mediate transport of biologically active Vibrio cholerae cytolysin (VCC) from V. cholerae strains","volume":"9","author":"Elluri","year":"2014","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.3389\/fmicb.2017.01274","article-title":"Intestinal anti-inflammatory effects of outer membrane vesicles from Escherichia coli Nissle 1917 in DSS-experimental colitis in mice","volume":"8","author":"Fabrega","year":"2017","journal-title":"Front. Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1080\/21645515.2018.1490381","article-title":"OMV-based vaccine formulations against Shiga toxin producing Escherichia coli strains are both protective in mice and immunogenic in calves","volume":"14","author":"Fingermann","year":"2018","journal-title":"Hum. Vaccin. Immunother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/(SICI)1096-9896(199906)188:2<220::AID-PATH307>3.0.CO;2-C","article-title":"Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. uptake of released toxin and vesicles by gastric epithelium","volume":"188","author":"Fiocca","year":"1999","journal-title":"J. Pathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11908-019-0665-x","article-title":"Enterotoxigenic Escherichia coli Infections","volume":"21","author":"Fleckenstein","year":"2019","journal-title":"Curr. Infect. Dis. Rep."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1128\/AEM.04248-13","article-title":"Gene transfer potential of outer membrane vesicles of Acinetobacter baylyi and effects of stress on vesiculation","volume":"80","author":"Fulsundar","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nchembio.2083","article-title":"Membrane anchoring stabilizes and favors secretion of New Delhi metallo-\u03b2-lactamase","volume":"12","author":"Gonz\u00e1lez","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/tra.12488","article-title":"The outer membrane vesicles: secretion system type zero","volume":"18","author":"Guerrero-Mandujano","year":"2017","journal-title":"Traffic"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1111\/cmi.12172","article-title":"Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells","volume":"15","author":"Guidi","year":"2013","journal-title":"Cell. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1515\/hsz-2014-0183","article-title":"Prokaryotic membrane vesicles: new insights on biogenesis and biological roles","volume":"396","author":"Haurat","year":"2015","journal-title":"Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3389\/fcimb.2018.00132","article-title":"Immunization with Skp delivered on outer membrane vesicles protects mice against enterotoxigenic Escherichia coli challenge","volume":"8","author":"Hays","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1086\/315302","article-title":"Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5","volume":"181","author":"Hellman","year":"2000","journal-title":"J. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"12489","DOI":"10.1074\/jbc.275.17.12489","article-title":"Enterotoxigenic Escherichia coli secretes active heat-labile enterotoxin via outer membrane vesicles","volume":"275","author":"Horstman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"32538","DOI":"10.1074\/jbc.M203740200","article-title":"Bacterial surface association of heat-labile enterotoxin through lipopolysaccharide after secretion via the general secretory pathway","volume":"277","author":"Horstman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3389\/fmicb.2017.01053","article-title":"Outer Membrane Vesicles (OMVs) of gram-negative bacteria. a perspective update","volume":"8","author":"Jan","year":"2017","journal-title":"Front. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1128\/JB.177.14.3998-4008.1995","article-title":"Virulence factors are released from Pseudomonas-aeruginosa in association with membrane-vesicles during normal growth and exposure to gentamicin - A novel mechanism of enzyme-secretion","volume":"177","author":"Kadurugamuwa","year":"1995","journal-title":"J. Bacteriol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/jac\/40.5.615","article-title":"Natural release of virulence factors in membrane vesicles by Pseudomonas aeruginosa and the effect of aminoglycoside antibiotics on their release","volume":"40","author":"Kadurugamuwa","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"B38","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/j.1462-5822.2009.01404.x","article-title":"Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells","volume":"12","author":"Kaparakis","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ijmm.2005.06.009","article-title":"Enterohaemorrhagic Escherichia coli in human medicine","volume":"295","author":"Karch","year":"2005","journal-title":"Inter. J. Med. Microbiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/joim.12546","article-title":"Haemolytic uraemic syndrome","volume":"281","author":"Karpman","year":"2017","journal-title":"J. Inter. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/mpat.2001.0474","article-title":"Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin","volume":"32","author":"Kato","year":"2002","journal-title":"Microb. Pathog."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1097\/00042737-200012120-00002","article-title":"Iron influences the expression of Helicobacter pylori outer membrane vesicle-associated virulence factors","volume":"12","author":"Keenan","year":"2000","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1074\/jbc.M307628200","article-title":"Incorporation of heterologous outer membrane and periplasmic proteins into Escherichia coli outer membrane vesicles","volume":"279","author":"Kesty","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4538","DOI":"10.1038\/sj.emboj.7600471","article-title":"Enterotoxigenic escherichia coli vesicles target toxin delivery into mammalian cells","volume":"23","author":"Kesty","year":"2004","journal-title":"EMBO J"},{"key":"B45","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1574-695X.2011.00869.x","article-title":"Mouse model for hemolytic uremic syndrome induced by outer membrane vesicles of Escherichia coli O157:H7","volume":"63","author":"Kim","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"5402","DOI":"10.1038\/s41598-018-23656-0","article-title":"Outer membrane vesicles from \u03b2-lactam-resistant Escherichia coli enable the survival of \u03b2-lactam-susceptible E. coli in the presence of \u03b2-lactam antibiotics","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1128\/AEM.65.5.1843-1848.1999","article-title":"Export of virulence genes and shiga toxin by membrane vesicles of Escherichia coli O157:H7","volume":"65","author":"Kolling","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1128\/IAI.74.4.2022-2030.2006","article-title":"Active cytotoxic necrotizing factor 1 associated with outer membrane vesicles from uropathogenic Escherichia coli","volume":"74","author":"Kouokam","year":"2006","journal-title":"Infect. Immunity"},{"key":"B49","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev.micro.091208.073413","article-title":"Biological functions and biogenesis of secreted bacterial outer membrane vesicles","volume":"64","author":"Kulp","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"13252","DOI":"10.1038\/srep13252","article-title":"Virulence from vesicles: novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain","volume":"5","author":"Kunsmann","year":"2015","journal-title":"Sci. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3389\/fmicb.2015.00823","article-title":"A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles","volume":"6","author":"Leitner","year":"2015","journal-title":"Front. Microbiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/1471-2180-9-220","article-title":"Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni","volume":"9","author":"Lindmark","year":"2009","journal-title":"BMC Microbiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/jobm.201700153","article-title":"Salmonella Choleraesuis outer membrane vesicles: proteomics and immunogenicity","volume":"57","author":"Liu","year":"2017","journal-title":"J. Basic Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.resmic.2012.10.020","article-title":"Offense and defense: microbial membrane vesicles play both ways","volume":"163","author":"MacDonald","year":"2012","journal-title":"Res. Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/1471-2180-11-258","article-title":"Contribution of bacterial outer membrane vesicles to innate bacterial defense","volume":"11","author":"Manning","year":"2011","journal-title":"BMC Microbiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"402919","DOI":"10.1100\/2012\/402919","article-title":"Vesiculation from Pseudomonas aeruginosa under SOS","volume":"2012","author":"Maredia","year":"2012","journal-title":"Sci. World J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jinf.2015.05.006","article-title":"A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: a phase I clinical trial","volume":"71","author":"Marsay","year":"2015","journal-title":"J. Infect."},{"key":"B58","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.micpath.2018.02.032","article-title":"Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it","volume":"117","author":"Mirhoseini","year":"2018","journal-title":"Microb. Pathog."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(02)11721-1","article-title":"Fatal meningococcal septicaemia with \u201cblebbing\u201d meningococcus","volume":"360","author":"Namork","year":"2002","journal-title":"Lancet"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1111\/cmi.12655","article-title":"Mechanisms of outer membrane vesicle entry into host cells","volume":"18","author":"O'Donoghue","year":"2016","journal-title":"Cell. Microbiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1111\/cmi.12676","article-title":"Environmentally controlled bacterial vesicle-mediated export","volume":"18","author":"Orench-Rivera","year":"2016","journal-title":"Cell. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e11334","DOI":"10.1371\/journal.pone.0011334","article-title":"Outer membrane vesicles derived from Escherichia coli induce systemic inflammatory response syndrome","volume":"5","author":"Park","year":"2010","journal-title":"PLoS ONE"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1128\/AEM.03657-12","article-title":"New type of outer membrane vesicle produced by the Gram-negative bacterium Shewanella vesiculosa M7T: implications for DNA content","volume":"79","author":"P\u00e9rez-Cruz","year":"2013","journal-title":"Appl. Environ. Microbiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e0116896","DOI":"10.1371\/journal.pone.0116896","article-title":"Outer-inner membrane vesicles naturally secreted by gram-negative pathogenic bacteria","volume":"10","author":"P\u00e9rez-Cruz","year":"2015","journal-title":"PLoS ONE"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/S0140-6736(17)31449-6","article-title":"Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study","volume":"390","author":"Petousis-Harris","year":"2017","journal-title":"Lancet"},{"key":"B66","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.addr.2015.01.003","article-title":"Are caveolae a cellular entry route for non-viral therapeutic delivery systems?","volume":"91","author":"Rewatkar","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e00792","DOI":"10.1128\/JB.00792-17","article-title":"Vibrio cholerae outer membrane vesicles inhibit bacteriophage infection","volume":"200","author":"Reyes-Robles","year":"2018","journal-title":"J. Bacteriol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"257","DOI":"10.15698\/mic2016.06.508","article-title":"Bacterial outer membrane vesicle biogenesis: a new mechanism and its implications","volume":"3","author":"Roier","year":"2016","journal-title":"Microb. Cell."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/gut.2010.207456","article-title":"Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive escherichia coli invasion","volume":"59","author":"Rolhion","year":"2010","journal-title":"Gut"},{"key":"B70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1128\/IAI.06069-11","article-title":"Perinuclear localization of internalized outer membrane vesicles carrying active cytolethal distending toxin from Aggregatibacter actinomycetemcomitans","volume":"80","author":"Rompikuntal","year":"2012","journal-title":"Infect. Immunity"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e0134098","DOI":"10.1371\/journal.pone.0134098","article-title":"Outer membrane vesicle-mediated export of processed PrtV protease from Vibrio cholerae","volume":"10","author":"Rompikuntal","year":"2015","journal-title":"PLoS ONE"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1128\/IAI.00264-10","article-title":"Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins","volume":"78","author":"Roy","year":"2010","journal-title":"Infect. Immunity"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1128\/CVI.05217-11","article-title":"Outer membrane vesicles induce immune responses to virulence proteins and protect against colonization by enterotoxigenic Escherichia coli","volume":"18","author":"Roy","year":"2011","journal-title":"Clin. Vaccine Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1128\/AAC.00929-10","article-title":"Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a new mechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii","volume":"55","author":"Rumbo","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"B75","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.ijmm.2018.06.007","article-title":"All in-Multiple parallel strategies for intracellular delivery by bacterial pathogens","volume":"308","author":"R\u00fcter","year":"2018","journal-title":"Inter. J. Med. Microbiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1462-5822.2010.01546.x","article-title":"Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells","volume":"13","author":"Schaar","year":"2011","journal-title":"Cell. Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/jac\/dkt307","article-title":"Group a streptococci are protected from amoxicillin-mediated killing by vesicles containing beta-lactamase derived from Haemophilus influenzae","volume":"69","author":"Schaar","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"B78","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrmicro3525","article-title":"Outer-membrane vesicles from gram-negative bacteria: biogenesis and functions","volume":"13","author":"Schwechheimer","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/SHK.0b013e318250de5d","article-title":"Circulating bacterial membrane cesicles cause sepsis in rats","volume":"37","author":"Shah","year":"2012","journal-title":"Shock"},{"key":"B80","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/jac\/dku466","article-title":"Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics","volume":"70","author":"Stentz","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"B81","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/infdis\/146.4.568","article-title":"Pili and outer-membrane appendages on Neisseria meningitidis in the cerebrosinal-fluid of an infant","volume":"146","author":"Stephens","year":"1982","journal-title":"J. Infect. Dis."},{"key":"B82","doi-asserted-by":"publisher","first-page":"17434","DOI":"10.1038\/s41598-017-16363-9","article-title":"Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction","volume":"7","author":"Svennerholm","year":"2017","journal-title":"Sci. Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"S206","DOI":"10.1016\/S0924-8579(07)70656-8","article-title":"Haemophilus influenzae survival during complement-mediated attacks is promoted by Moraxella catarrhalis outer membrane vesicles","volume":"29","author":"Tan","year":"2007","journal-title":"Inter. J. Antimicrob. Agents"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0140-6736(05)74232-X","article-title":"Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome","volume":"365","author":"Tarr","year":"2005","journal-title":"Lancet"},{"key":"B85","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1128\/IAI.01980-14","article-title":"Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-kappa B activation","volume":"82","author":"Thay","year":"2014","journal-title":"Infect. Immunity"},{"key":"B86","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41579-018-0112-2","article-title":"Types and origins of bacterial membrane vesicles","volume":"17","author":"Toyofuku","year":"2019","journal-title":"Nat. Rev. Microbiol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"11220","DOI":"10.1038\/ncomms11220","article-title":"Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms","volume":"7","author":"Turnbull","year":"2016","journal-title":"Nat. Commun"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e12758","DOI":"10.1111\/cmi.12758","article-title":"Enterohaemorrhagic escherichia coli produces outer membrane vesicles as an active defence system against antimicrobial peptide LL-37","volume":"19","author":"Urashima","year":"2017","journal-title":"Cell. Microbiol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2016.04.015","article-title":"Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation","volume":"165","author":"Vanaja","year":"2016","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0092-8674(03)00754-2","article-title":"Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin","volume":"115","author":"Wai","year":"2003","journal-title":"Cell"},{"key":"B91","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1348-0421.1995.tb02228.x","article-title":"The release of outer-membrane vesicles from the strains of enterotoxigenic Escherichia coli","volume":"39","author":"Wai","year":"1995","journal-title":"Microbiol. Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.thromres.2019.03.019","article-title":"Bacteria-released outer membrane vesicles promote disseminated intravascular coagulation","volume":"178","author":"Wang","year":"2019","journal-title":"Thromb. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1574-6968.2000.tb09372.x","article-title":"Production of shiga toxin by Escherichia coli measured with reference to the membrane vesicle-associated toxins","volume":"192","author":"Yokoyama","year":"2000","journal-title":"FEMS Microbiol. Lett."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1007\/s00467-010-1522-1","article-title":"Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction","volume":"25","author":"Zoja","year":"2010","journal-title":"Pediatr. Nephrol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00091\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:56:05Z","timestamp":1583481365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00091\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,6]]},"references-count":94,"alternative-id":["10.3389\/fcimb.2020.00091"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00091","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,6]]},"article-number":"91"}}