{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:51:42Z","timestamp":1791341502926,"version":"4.3.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00159","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T12:15:52Z","timestamp":1587471352000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["An Investigation of the Effect of Transfected Defective, Ebola Virus Genomes on Ebola Replication"],"prefix":"10.3389","volume":"10","author":[{"given":"Sophie J.","family":"Smither","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Garcia-Dorival","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Eastaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Findlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Carruthers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Diane","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Molina-Par\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Hiscox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cll.2017.01.003","article-title":"Ebola virus disease: an update on epidemiology, symptoms, laboratory findings, diagnostic issues, and infection prevention and control issues for laboratory professionals","volume":"37","author":"Brown","year":"2017","journal-title":"Clin. Lab. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1006\/viro.1999.9915","article-title":"Ebola virus defective interfering particles and persistent infection","volume":"262","author":"Calain","year":"1999","journal-title":"Virology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/s0140-6736(16)31272-7","article-title":"Defective interfering genomes and Ebola virus persistence","volume":"388","author":"Calain","year":"2016","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/JVI.2.10.955-961.1968","article-title":"Defectiveness of interferon production and of rubella virus interference in a line of African green monkey kidney cells (Vero)","volume":"2","author":"Desmyter","year":"1968","journal-title":"J. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1128\/jvi.01160-10","article-title":"Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway","volume":"85","author":"Fabozzi","year":"2011","journal-title":"J. Virol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5120","DOI":"10.1021\/pr500556d","article-title":"Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function","volume":"13","author":"Garcia-Dorival","year":"2014","journal-title":"J. Proteome Res."},{"key":"B7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF01242026","article-title":"Studies on the sedimentation of influenza virus","volume":"4","author":"Gard","year":"1952","journal-title":"Arch. Gesamte Virusforsch."},{"key":"B8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/226325a0","article-title":"Defective viral particles and viral disease processes","volume":"226","author":"Huang","year":"1970","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1128\/jvi.05738-11","article-title":"Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion","volume":"86","author":"Jensen","year":"2012","journal-title":"J. Virol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e01178","DOI":"10.1128\/genomeA.01178-14","volume":"2","author":"Kuhn","year":"2014"},{"key":"B11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.antiviral.2017.12.022","article-title":"Filovirus proteins for antiviral drug discovery: structure\/function of proteins involved in assembly and budding","volume":"150","author":"Martin","year":"2018","journal-title":"Antiviral Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2217\/17460794.2.2.205","article-title":"Filovirus replication and transcription","volume":"2","author":"M\u00fchlberger","year":"2007","journal-title":"Future Virol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1186\/s12879-016-2045-6","article-title":"How severe and prevalent are Ebola and Marburg viruses? a systematic review and meta-analysis of the case fatality rates and seroprevalence","volume":"16","author":"Nyakarahuka","year":"2016","journal-title":"BMC Infect. Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"8502","DOI":"10.1128\/jvi.02600-10","article-title":"Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry","volume":"85","author":"Radoshitzky","year":"2011","journal-title":"J. Virol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent end points12","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1099\/0022-1317-73-10-2509","article-title":"Defective interfering L RNA segments of tomato spotted wilt virus retain both virus genome termini and have extensive internal deletions","volume":"73","author":"Resende Rde","year":"1992","journal-title":"J. Gen. Virol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/JVI.37.2.661-672.1981","article-title":"Structure and origin of a snapback defective interfering particle RNA of vesicular stomatitis virus","volume":"37","author":"Schubert","year":"1981","journal-title":"J. Virol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/01652176.2017.1309474","article-title":"Ebola virus - epidemiology, diagnosis, and control: threat to humans, lessons learnt, and preparedness plans - an update on its 40 year's journey","volume":"37","author":"Singh","year":"2017","journal-title":"Vet. Q."},{"key":"B19","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jviromet.2013.05.015","article-title":"Comparison of the plaque assay and 50% tissue culture infectious dose assay as methods for measuring filovirus infectivity","volume":"193","author":"Smither","year":"2013","journal-title":"J. Virol. Methods"},{"key":"B20","unstructured":"31611661Ebola Virus Disease2018"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00159\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T12:15:55Z","timestamp":1587471355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00159\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":20,"alternative-id":["10.3389\/fcimb.2020.00159"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00159","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"article-number":"159"}}