{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:08:37Z","timestamp":1790705317920,"version":"4.1.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00175","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:25:38Z","timestamp":1588652738000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir"],"prefix":"10.3389","volume":"10","author":[{"given":"Kayla A.","family":"Holder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e261","DOI":"10.1038\/mtna.2015.31","article-title":"Novel RNA duplex locks HIV-1 in a latent state via chromatin-mediated transcriptional silencing","volume":"4","author":"Ahlenstiel","year":"2015","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.yexmp.2008.03.015","article-title":"HIV-1 Vpr: mechanisms of G2 arrest and apoptosis","volume":"85","author":"Andersen","year":"2008","journal-title":"Exp. Mol. Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","article-title":"Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation","volume":"44","author":"Anderson","year":"2016","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.1182\/blood-2010-08-300954","article-title":"DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction","volume":"117","author":"Ardolino","year":"2011","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.immuni.2016.04.022","article-title":"Costimulatory and coinhibitory receptor pathways in infectious disease","volume":"44","author":"Attanasio","year":"2016","journal-title":"Immunity"},{"key":"B6","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nm.4113","article-title":"PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals","volume":"22","author":"Banga","year":"2016","journal-title":"Nat. Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12977-018-0392-7","article-title":"Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs","volume":"15","author":"Baxter","year":"2018","journal-title":"Retrovirology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3389\/fimmu.2017.00760","article-title":"NK cell exhaustion","volume":"8","author":"Bi","year":"2017","journal-title":"Front. Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/hep.26968","article-title":"T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis","volume":"59","author":"Bi","year":"2014","journal-title":"Hepatology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.virol.2014.07.034","article-title":"HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain","author":"Bolduan","year":"2014","journal-title":"Virology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/eji.200839116","article-title":"A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC","volume":"39","author":"Boles","year":"2009","journal-title":"Eur. J. Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/eji.200940234","article-title":"Colonna and N. C. f. H. Immunology, A. V. Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection","volume":"40","author":"Cella","year":"2010","journal-title":"Eur. J. Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.coi.2012.01.009","article-title":"Receptors that interact with nectin and nectin-like proteins in the immunosurveillance and immunotherapy of cancer","volume":"24","author":"Chan","year":"2012","journal-title":"Curr. Opin. Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1172\/JCI80445","article-title":"TIGIT and PD-1 impair tumor antigen-specific CD8(+) T cells in melanoma patients","volume":"125","author":"Chauvin","year":"2015","journal-title":"J. Clin. Invest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1005349","DOI":"10.1371\/journal.ppat.1005349","article-title":"TIGIT marks exhausted T cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection","volume":"12","author":"Chew","year":"2016","journal-title":"PLoS Pathog"},{"key":"B16","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/387183a0","article-title":"Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection","volume":"387","author":"Chun","year":"1997","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/nm1295-1284","article-title":"In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency","volume":"1","author":"Chun","year":"1995","journal-title":"Nat. Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3389\/fimmu.2016.00698","article-title":"Allelic polymorphism determines surface expression or intracellular retention of the human NK cell receptor KIR2DL5A (CD158f)","volume":"7","author":"Cisneros","year":"2016","journal-title":"Front. Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3389\/fimmu.2012.00289","article-title":"KIR2DL5: an orphan inhibitory receptor displaying complex patterns of polymorphism and expression","volume":"3","author":"Cisneros","year":"2012","journal-title":"Front. Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1089\/AID.2015.0375","article-title":"CD155 on HIV-infected cells is not modulated by HIV-1 Vpu and Nef but synergizes with NKG2D ligands to trigger NK cell lysis of autologous primary HIV-infected cells","volume":"33","author":"Davis","year":"2017","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"B21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/487439a","article-title":"HIV: Shock and kill","volume":"487","author":"Deeks","year":"2012","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/imr.12518","article-title":"TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy","volume":"276","author":"Dougall","year":"2017","journal-title":"Immunol. Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.4049\/jimmunol.178.7.4402","article-title":"Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets","volume":"178","author":"Estefania","year":"2007","journal-title":"J. Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1097\/QAD.0000000000001849","article-title":"Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latency","volume":"32","author":"Evans","year":"2018","journal-title":"AIDS"},{"key":"B25","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/8394","article-title":"Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy","volume":"5","author":"Finzi","year":"1999","journal-title":"Nat. Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e1005761","DOI":"10.1371\/journal.ppat.1005761","article-title":"CD4+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART","volume":"12","author":"Fromentin","year":"2016","journal-title":"PLoS Pathog"},{"key":"B28","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41467-019-08798-7","article-title":"PD-1 blockade potentiates HIV latency reversal ex vivo in CD4(+) T cells from ART-suppressed individuals","volume":"10","author":"Fromentin","year":"2019","journal-title":"Nat. Commun"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.4049\/jimmunol.172.7.3994","article-title":"Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)","volume":"172","author":"Fuchs","year":"2004","journal-title":"J. Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3389\/fimmu.2018.01072","article-title":"Coming of age: CD96 emerges as modulator of immune responses","volume":"9","author":"Georgiev","year":"2018","journal-title":"Front. Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/annonc\/mdx696","article-title":"Drastic decrease of the HIV reservoir in a patient treated with nivolumab for lung cancer","volume":"29","author":"Guihot","year":"2018","journal-title":"Ann. Oncol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41586-019-1027-4","article-title":"HIV-1 remission following CCR5Delta32\/Delta32 haematopoietic stem-cell transplantation","volume":"568","author":"Gupta","year":"2019","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e0212443","DOI":"10.1371\/journal.pone.0212443","article-title":"Interaction between nectin-1 and the human natural killer cell receptor CD96","volume":"14","author":"Holmes","year":"2019","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1074\/mcp.TIR119.001433","article-title":"A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3\/CD276 and PVR\/CD155","volume":"18","author":"Husain","year":"2019","journal-title":"Mol. Cell Proteomics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1056\/NEJMoa0802905","article-title":"Long-term control of HIV by CCR5 Delta32\/Delta32 stem-cell transplantation","volume":"360","author":"Hutter","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ccell.2014.10.018","article-title":"The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function","volume":"26","author":"Johnston","year":"2014","journal-title":"Cancer Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nbt.3467","article-title":"Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity","volume":"34","author":"Karpinski","year":"2016","journal-title":"Nat. Biotechnol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1002\/eji.201041136","article-title":"Vstm3 is a member of the CD28 family and an important modulator of T-cell function","volume":"41","author":"Levin","year":"2011","journal-title":"Eur. J. Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"aaf6517","DOI":"10.1126\/science.aaf6517","article-title":"Latency reversal and viral clearance to cure HIV-1","volume":"353","author":"Margolis","year":"2016","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nri3799","article-title":"Balancing natural killer cell activation through paired receptors","volume":"15","author":"Martinet","year":"2015","journal-title":"Nat. Rev. Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.1128\/JVI.05788-11","article-title":"The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR","volume":"86","author":"Matusali","year":"2012","journal-title":"J. Virol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-867490690-9","article-title":"Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily","volume":"56","author":"Mendelsohn","year":"1989","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e00465","DOI":"10.1128\/mBio.00465-15","article-title":"The tat inhibitor didehydro-cortistatin a prevents HIV-1 reactivation from latency","volume":"6","author":"Mousseau","year":"2015","journal-title":"mBio"},{"key":"B44","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.ccell.2014.11.016","article-title":"TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit","volume":"26","author":"Pauken","year":"2014","journal-title":"Cancer Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1182\/blood-2005-07-2696","article-title":"Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction","volume":"107","author":"Pende","year":"2006","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1084\/jem.20121932","article-title":"Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production","volume":"210","author":"Perreau","year":"2013","journal-title":"J. Exp. Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"7771","DOI":"10.1093\/nar\/gkt571","article-title":"Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells","volume":"41","author":"Qu","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3390\/cancers11060877","article-title":"DNAM-1 and the TIGIT\/PVRIG\/TACTILE axis: novel immune checkpoints for Natural Killer cell-based cancer immunotherapy","volume":"11","author":"Sanchez-Correa","year":"2019","journal-title":"Cancers"},{"key":"B49","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.immuni.2012.01.014","article-title":"Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation","volume":"36","author":"Shan","year":"2012","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","first-page":"17858","DOI":"10.1073\/pnas.0903474106","article-title":"The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity","volume":"106","author":"Stanietsky","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B51","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1073\/pnas.1120606109","article-title":"Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering","volume":"109","author":"Stengel","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B52","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nrm2457","article-title":"Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation","volume":"9","author":"Takai","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"40354","DOI":"10.1038\/srep40354","article-title":"Perturbed CD8(+) T cell TIGIT\/CD226\/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals","volume":"7","author":"Tauriainen","year":"2017","journal-title":"Sci. Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3390\/v9100295","article-title":"Expression profiles of ligands for activating natural killer cell receptors on HIV infected and uninfected CD4(+) T cells","volume":"9","author":"Tremblay-McLean","year":"2017","journal-title":"Viruses"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1099\/vir.0.055541-0","article-title":"The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway","volume":"94","author":"Vassena","year":"2013","journal-title":"J. Gen. Virol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/QAD.0000000000002488","article-title":"TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells","volume":"34","author":"Vendrame","year":"2020","journal-title":"AIDS"},{"key":"B57","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.4049\/jimmunol.165.11.6416","article-title":"Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene","volume":"165","author":"Vilches","year":"","journal-title":"J. Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.4049\/jimmunol.164.11.5797","article-title":"KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains","volume":"164","author":"Vilches","year":"","journal-title":"J. Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1002\/eji.201545480","article-title":"TIGIT expression levels on human NK cells correlate with functional heterogeneity among healthy individuals","volume":"45","author":"Wang","year":"2015","journal-title":"Eur. J. Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1158\/2326-6066.CIR-18-0442","article-title":"PVRIG and PVRL2 are induced in cancer and inhibit CD8(+) T-cell function","volume":"7","author":"Whelan","year":"2019","journal-title":"Cancer Immunol. Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"B62","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/COH.0000000000000293","article-title":"Tissue reservoirs of HIV","volume":"11","author":"Wong","year":"2016","journal-title":"Curr. Opin. HIV AIDS"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.3389\/fimmu.2019.01435","article-title":"The HIV reservoir in monocytes and macrophages","volume":"10","author":"Wong","year":"2019","journal-title":"Front. Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1002\/eji.201546094","article-title":"Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice","volume":"46","author":"Wu","year":"2016","journal-title":"Eur. J. Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nri.2017.112","article-title":"Immune checkpoint blockade in infectious diseases","volume":"18","author":"Wykes","year":"2018","journal-title":"Nat. Rev. Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00262-017-2031-x","article-title":"Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions","volume":"66","author":"Xu","year":"2017","journal-title":"Cancer Immunol. Immunother"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.3389\/fimmu.2018.02341","article-title":"Expression of the inhibitory receptor TIGIT is up-regulated specifically on NK cells with CD226 activating receptor from HIV-infected individuals","volume":"9","author":"Yin","year":"2018","journal-title":"Front. Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ni.1674","article-title":"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells","volume":"10","author":"Yu","year":"2009","journal-title":"Nat. Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41590-018-0132-0","article-title":"Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity","volume":"19","author":"Zhang","year":"2018","journal-title":"Nat. Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12977-015-0150-z","article-title":"The CRISPR\/Cas9 system inactivates latent HIV-1 proviral DNA","volume":"12","author":"Zhu","year":"2015","journal-title":"Retrovirology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1084\/jem.20150785","article-title":"Identification of CD112R as a novel checkpoint for human T cells","volume":"213","author":"Zhu","year":"2016","journal-title":"J. Exp. Med"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00175\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:25:40Z","timestamp":1588652740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00175\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":73,"alternative-id":["10.3389\/fcimb.2020.00175"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00175","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"article-number":"175"}}