{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:39:15Z","timestamp":1792024755387,"version":"4.4.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00192","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:54:55Z","timestamp":1588208095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["Carvacrol Induces Candida albicans Apoptosis Associated With Ca2+\/Calcineurin Pathway"],"prefix":"10.3389","volume":"10","author":[{"given":"Chao","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.mycmed.2014.01.063","article-title":"Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi","volume":"24","author":"Abbaszadeh","year":"2014","journal-title":"J. Mycol. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10096-010-1050-8","article-title":"Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida","volume":"30","author":"Ahmad","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/cdd.2009.219","article-title":"Apoptosis in yeast: triggers, pathways, subroutines","volume":"17","author":"Carmona-Gutierrez","year":"2010","journal-title":"Cell Death Differ."},{"key":"B4","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1128\/AAC.00551-15","article-title":"The monoterpene carvacrol generates endoplasmic reticulum stress in the pathogenic fungus Candida albicans","volume":"59","author":"Chaillot","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/jac\/dkh436","article-title":"Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model","volume":"54","author":"Chami","year":"","journal-title":"J. Antimicrob. Chemother."},{"key":"B6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1399-302X.2004.00202.x","article-title":"Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo","volume":"20","author":"Chami","year":"2005","journal-title":"Oral Microbiol. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1590\/S1413-86702004000300005","article-title":"Antifungal treatment with carvacrol and eugenol of oral candidiasis in immunosuppressed rats","volume":"8","author":"Chami","year":"","journal-title":"Braz. J. Infect. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1093\/emboj\/21.4.546","article-title":"Calcineurin is essential for survival during membrane stress in Candida albicans","volume":"21","author":"Cruz","year":"2002","journal-title":"EMBO J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40104-016-0079-7","article-title":"Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens","volume":"7","author":"Du","year":"2016","journal-title":"J. Anim Sci Biotechnol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3314\/jjmm.50.243","article-title":"Inhibitory activity of hydrosols, herbal teas and related essential oils against filament formation and the growth of Candida albicans","volume":"50","author":"Inouye","year":"2009","journal-title":"Nippon Ishinkin Gakkai Zasshi"},{"key":"B11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3389\/fcimb.2018.00445","article-title":"Antifungal activity of coumarin against Candida albicans is related to apoptosis","volume":"8","author":"Jia","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1080\/10715762.2019.1610563","article-title":"Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B","volume":"53","author":"Jia","year":"2019","journal-title":"Free Radic. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.1021\/jf0531149","article-title":"Inhibition of lipid accumulation and lipid body formation in oleaginous yeast by effective components in spices, carvacrol, eugenol, thymol, and piperine","volume":"54","author":"Kimura","year":"2006","journal-title":"J Agric. Food Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"68S","DOI":"10.1592\/phco.26.6part2.68S","article-title":"Candida resistance and its clinical relevance","volume":"26","author":"Klepser","year":"2006","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Therapy"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1007\/s00253-015-7265-y","article-title":"Mechanism of antifungal activity of antimicrobial peptide APP, a cell-penetrating peptide derivative, against Candida albicans: intracellular DNA binding and cell cycle arrest","volume":"100","author":"Li","year":"2016","journal-title":"Applied microbiology and biotechnology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/10412905.2012.754728","article-title":"Antifungal activity and mode of action of carvacrol against Candida albicans strains","volume":"25","author":"Lima","year":"2013","journal-title":"J. Essent. Oil Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1128\/EC.00271-14","article-title":"Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets","volume":"14","author":"Liu","year":"2015","journal-title":"Eukaryot. Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e15808","DOI":"10.1371\/journal.pone.0015808","article-title":"Lack of trehalose accelerates H2O2-induced candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity","volume":"6","author":"Lu","year":"2010","journal-title":"PLoS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1023\/A:1013311632207","article-title":"Antifungal activities of origanum oil against Candida albicans","volume":"228","author":"Manohar","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.3109\/13880209.2016.1172319","article-title":"Investigation of the antifungal activity of carvacrol against strains of Cryptococcus neoformans","volume":"54","author":"N\u00f3brega","year":"2016","journal-title":"Pharmac. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1590\/S1982-56762011000100001","article-title":"Thymol and carvacrol: biotransformation and antifungal activity against the plant pathogenic fungi Colletotrichum acutatum and Botryodiplodia theobromae","volume":"36","author":"Numpaque","year":"2011","journal-title":"Trop. Plant Pathol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2174\/221031550501150414095331","article-title":"Chemical components of Citrus essential oils from Brazil","volume":"5","author":"Nunes Wolffenbuttel","year":"2015","journal-title":"J. Nat. Prod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1038\/onc.2008.308","article-title":"Calcium and apoptosis: ER-mitochondria Ca 2+ transfer in the control of apoptosis","volume":"27","author":"Pinton","year":"2008","journal-title":"Oncogene"},{"key":"B25","doi-asserted-by":"publisher","first-page":"5062","DOI":"10.1128\/AAC.01050-10","article-title":"Mechanism of antifungal activity of terpenoid phenols resembles calcium stress and inhibition of the TOR pathway","volume":"54","author":"Rao","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/08927014.2012.749398","article-title":"Terpenoids of plant origin inhibit morphogenesis, adhesion, and biofilm formation by Candida albicans","volume":"29","author":"Raut","year":"2013","journal-title":"Biofouling"},{"key":"B27","doi-asserted-by":"publisher","first-page":"34528","DOI":"10.1074\/jbc.M002844200","article-title":"\u03b2-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes","volume":"275","author":"Saito","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1046\/j.1365-2958.2003.03495.x","article-title":"Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence","volume":"48","author":"Sanglard","year":"2003","journal-title":"Mol. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1128\/MMBR.00045-10","article-title":"Regulatory circuitry governing fungal development, drug resistance, and disease","volume":"75","author":"Shapiro","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/ncb894","article-title":"Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis","volume":"5","author":"Shirane","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.5455\/jice.20140503090524","article-title":"Antifungal effect of eugenol and carvacrol against foodborne pathogens Aspergillus carbonarius and Penicillium roqueforti in improving safety of fresh-cut watermelon","volume":"3","author":"\u0160imovi\u0107","year":"2014","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"7246","DOI":"10.1523\/JNEUROSCI.20-19-07246.2000","article-title":"Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury","volume":"20","author":"Springer","year":"2000","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1080\/10408398.2011.653458","article-title":"The bioactivity and toxicological actions of carvacrol","volume":"55","author":"Suntres","year":"2015","journal-title":"Crit. Rev. Food Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1007\/s00253-017-8146-3","article-title":"Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans","volume":"101","author":"Tian","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1126\/science.284.5412.339","article-title":"Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD","volume":"284","author":"Wang","year":"1999","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/art.27344","article-title":"A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis","volume":"62","author":"Wieten","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbagen.2016.12.026","article-title":"Role of potassium channels in chlorogenic acid-induced apoptotic volume decrease and cell cycle arrest in Candida albicans","volume":"1861","author":"Yun","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2561929","DOI":"10.1155\/2019\/2561929","article-title":"Interactions between cytosolic phospholipase A2 activation and mitochondrial reactive oxygen species production in the development of ventilator-induced diaphragm dysfunction","volume":"2019","author":"Zhou","year":"2019","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00192\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:54:57Z","timestamp":1588208097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00192\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":38,"alternative-id":["10.3389\/fcimb.2020.00192"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00192","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"article-number":"192"}}