{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:13Z","timestamp":1792697113126,"version":"4.5.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00334","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T04:30:44Z","timestamp":1594269044000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Human Cytomegalovirus Infections Are Associated With Elevated Biomarkers of Vascular Injury"],"prefix":"10.3389","volume":"10","author":[{"given":"Jennifer N.","family":"Styles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan R.","family":"Converse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena A.","family":"Nylander-French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill R.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Sams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hudgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey I.","family":"Egorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11882-018-0768-8","article-title":"Impact of particulate air pollution on cardiovascular health","volume":"18","author":"An","year":"2018","journal-title":"Curr. Allergy Asthma Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1086\/652438","article-title":"Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004","volume":"50","author":"Bate","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/jes.2016.86","article-title":"Systemic serum amyloid A as a biomarker for exposure to zinc and \/ or copper-containing metal fumes","volume":"28","author":"Baumann","year":"2017","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1093\/ndt\/gfm348","article-title":"Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease","volume":"22","author":"Betjes","year":"2007","journal-title":"Nephrol. Dial. Transplant"},{"key":"B5","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/EDE.0b013e31824523f0","article-title":"Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort","volume":"23","author":"Bind","year":"2012","journal-title":"Epidemiology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0021-9150(03)00097-2","article-title":"Adhesion molecules and atherosclerosis","volume":"170","author":"Blankenberg","year":"2003","journal-title":"Atherosclerosis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/rmv.655","article-title":"Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection","volume":"20","author":"Cannon","year":"2010","journal-title":"Rev. Med. Virol"},{"key":"B8","first-page":"172","article-title":"Cytomegalovirus infection in pregnancy: should all women be screened?","volume-title":"Rev. Obstet. Gynecol","author":"Carlson","year":"2010"},{"key":"B9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3390\/v10080444","article-title":"Molecular determinants and the regulation of human cytomegalovirus latency and reactivation","volume":"10","author":"Collins-Mcmillen","year":"2018","journal-title":"Viruses"},{"key":"B10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1471-2334-7-71","article-title":"Incidence of cytomegalovirus infection among the general population and pregnant women in the United States","volume":"7","author":"Colugnati","year":"2007","journal-title":"BMC Infect. Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1128\/CMR.00034-08","article-title":"Immunobiology of human cytomegalovirus : from bench to bedside","volume":"22","author":"Crough","year":"2009","journal-title":"Clin. Microbiol. Rev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev. Med. Virol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/s12879-018-3343-y","article-title":"Environmental risk factors for Toxoplasma gondii infections and the impact of latent infections on allostatic load in residents of Central North Carolina","volume":"18","author":"Egorov","year":"2018","journal-title":"BMC Infect. Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.envres.2017.07.009","article-title":"Vegetated land cover near residence is associated with reduced allostatic load and improved biomarkers of neuroendocrine, metabolic and immune functions","volume":"158","author":"Egorov","year":"2017","journal-title":"Environ. Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1080\/003655401750173968","article-title":"Circulating soluble vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in immunocompetent and renal transplant patients: correlation with cytomegalovirus disease and renal function","volume":"33","author":"Eriksson","year":"2001","journal-title":"Scand. J. Infect. Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1097\/01.TP.0000090163.48433.48","article-title":"Cytomegalovirus infection status predicts progression of heart-transplant vasculopathy","volume":"76","author":"Fateh-Moghadam","year":"2003","journal-title":"Transplantation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1161\/ATVBAHA.107.149179","article-title":"Vascular adhesion molecules in atherosclerosis","volume":"27","author":"Galkina","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/S0735-1097(02)02272-6","article-title":"The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study","volume":"40","author":"Haider","year":"2002","journal-title":"J. Am. Coll. Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1749-6632.2011.06202.x","article-title":"Socioeconomic status and smoking: a review","volume":"1248","author":"Hiscock","year":"2012","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B20","first-page":"1310","article-title":"C-reactive protein, fibrinogen, and cardiovascular disease prediction","volume-title":"N. Engl. J. Med","author":"Kaptoge","year":"2012"},{"key":"B21","doi-asserted-by":"publisher","first-page":"578","DOI":"10.5694\/mja14.00183","article-title":"Cytomegalovirus disease in immunocompetent adults","volume":"201","author":"Lancini","year":"2014","journal-title":"Med. J. Aust"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1043","DOI":"10.1002\/cti2.1043","article-title":"A. high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population","volume":"8","author":"Lee","year":"2019","journal-title":"Clin. Transl. Immunol."},{"key":"B23","first-page":"1","article-title":"Births: final data for 2007","volume":"58","author":"Martin","year":"2010","journal-title":"Nat. Vital Stat. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1086\/317624","article-title":"Reactivation and shedding of cytomegalovirus in astronauts during spaceflight","volume":"182","author":"Mehta","year":"2000","journal-title":"J. Infect. Dis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1046\/j.1365-2249.2000.01221.x","article-title":"Chemokines and soluble adhesion molecules in renal transplant recipients with cytomegalovirus infection","volume":"120","author":"Nordoy","year":"2000","journal-title":"Clin. Exp. Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s11239-011-0662-x","article-title":"Human cytomegalovirus infection and atherothrombosis","volume":"33","author":"Popovi\u0107","year":"2012","journal-title":"J. Thromb. Thrombolysis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1128\/CVI.00487-14","article-title":"Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy","volume":"21","author":"Prince","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1053\/j.spid.2004.09.011","article-title":"Congenital cytomegalovirus infection: outcome and diagnosis","volume":"16","author":"Ross","year":"2004","journal-title":"Semin. Pediatr. Infect. Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/978-3-540-77349-8_20","article-title":"Cytomegalovirus vaccine development","volume":"325","author":"Schleiss","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.psyneuen.2014.08.002","article-title":"Herpesviruses, inflammatory markers and incident depression in a longitudinal study of Detroit residents","volume":"50","author":"Simanek","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e16103","DOI":"10.1371\/journal.pone.0016103","article-title":"Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States","volume":"6","author":"Simanek","year":"2011","journal-title":"PLoS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.imlet.2014.09.011","article-title":"Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people","volume":"162","author":"Terrazzini","year":"2014","journal-title":"Immunol. Lett"},{"key":"B33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s40471-018-0166-8","article-title":"Air pollution and cardiovascular disease: a focus on vulnerable populations Worldwide","volume":"5","author":"Tibuakuu","year":"2018","journal-title":"Curr. Epidemiol. Rep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1005719","DOI":"10.1371\/journal.pcbi.1005719","article-title":"Infectious reactivation of cytomegalovirus explaining age- and sex-specific patterns of seroprevalence","volume":"13","author":"van Boven","year":"2017","journal-title":"PLoS Comput. Biol"},{"key":"B35","volume-title":"Obesity : Preventing and Managing the Global Epidemic. WHO Technical Report Series.","year":"2000"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2042-4280-4-3","article-title":"High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy","volume":"4","author":"Yaiw","year":"2013","journal-title":"Herpesviridae"},{"key":"B37","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jjcc.2008.12.007","article-title":"Inflammatory biomarkers in coronary artery disease","volume":"53","author":"Zakynthinos","year":"2009","journal-title":"J. Cardiol"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00334\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T04:30:46Z","timestamp":1594269046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00334\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":37,"alternative-id":["10.3389\/fcimb.2020.00334"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00334","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,9]]},"article-number":"334"}}