{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:03:34Z","timestamp":1781777014531,"version":"3.54.5"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00429","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T13:49:43Z","timestamp":1601041783000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Toxoplasma gondii Triggers Neutrophil Extracellular Traps Release in Dogs"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhengkai","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zedong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1128\/IAI.05730-11","article-title":"Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps","volume":"80","author":"Abi Abdallah","year":"2012","journal-title":"Infect. Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B3","volume-title":"Toxoplasmosis of Animals and Humans","author":"Dubey","year":"2010"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.ijpara.2008.03.007","article-title":"Toxoplasma gondii infection in humans and animals in the United States","volume":"38","author":"Dubey","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1007\/s00436-015-4900-6","article-title":"Toxoplasmosis in the Caribbean islands: literature review, seroprevalence in pregnant women in ten countries, isolation of viable Toxoplasma gondii from dogs from St. Kitts, West Indies with report of new T. gondii genetic types","volume":"115","author":"Dubey","year":"2016","journal-title":"Parasitol. Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ajh.24970","article-title":"A key role for Rac and Pak signaling in neutrophil extracellular traps (NETs) formation defines a new potential therapeutic target","volume":"93","author":"Gavillet","year":"2018","journal-title":"Am. J. Hematol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e01117","DOI":"10.1128\/mBio.01117-13","article-title":"Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii","volume":"5","author":"Gorfu","year":"2014","journal-title":"MBio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"103527","DOI":"10.1016\/j.dci.2019.103527","article-title":"Dolphin-derived NETosis results in rapid Toxoplasma gondii tachyzoite ensnarement and different phenotypes of NETs","volume":"103","author":"Imlau","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3347\/kjp.2015.53.4.493","article-title":"Prevalence of Toxoplasma gondii in dogs in Zhanjiang, Southern China","volume":"53","author":"Jiang","year":"2015","journal-title":"Korean J. Parasitol."},{"key":"B10","first-page":"944","article-title":"Neutrophil extracellular traps involvement in corneal fungal infection","volume":"22","author":"Jin","year":"2016","journal-title":"Mol. Vis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"107770","DOI":"10.1016\/j.exppara.2019.107770","article-title":"Toxoplasma gondii induces extracellular traps release in cat neutrophils","volume":"207","author":"Lacerda","year":"2019","journal-title":"Exp. Parasitol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1189\/jlb.1010549","article-title":"Rac2 is required for the formation of neutrophil extracellular traps","volume":"90","author":"Lim","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1017\/S0031182014001413","article-title":"Epidemiological review of Toxoplasma gondii infection in humans and animals in Portugal","volume":"141","author":"Lopes","year":"2014","journal-title":"Parasitology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.dci.2015.05.007","article-title":"NADPH oxidase, MPO, NE, ERK1\/2, p38 MAPK and Ca2+ influx are essential for Cryptosporidium parvum-induced NET formation","volume":"52","author":"Munoz-Caro","year":"","journal-title":"Dev. Comp. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13567-015-0155-6","article-title":"Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1\/2-, p38 MAP kinase- and SOCE-dependent","volume":"46","author":"Munoz-Caro","year":"","journal-title":"Vet. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.3389\/fmicb.2017.01825","article-title":"Sixty years (1957-2017) of research on Toxoplasmosis in China-an overview","volume":"8","author":"Pan","year":"2017","journal-title":"Front. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-017-2573-y","article-title":"P2X7 receptor mediates NLRP3-dependent IL-1beta secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells","volume":"11","author":"Quan","year":"2018","journal-title":"Parasit. Vectors"},{"key":"B18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.dci.2015.02.002","article-title":"Harbour seal (Phoca vitulina) PMN and monocytes release extracellular traps to capture the apicomplexan parasite Toxoplasma gondii","volume":"50","author":"Reichel","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1051\/parasite\/2017009","article-title":"Seroprevalence of Toxoplasma gondii in domestic pets from metropolitan regions of Panama","volume":"24","author":"Rengifo-Herrera","year":"2017","journal-title":"Parasite"},{"key":"B20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.chom.2012.05.015","article-title":"Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1","volume":"12","author":"Saitoh","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1007\/s00436-014-3939-0","article-title":"The apicomplexan parasite Eimeria arloingi induces caprine neutrophil extracellular traps","volume":"113","author":"Silva","year":"2014","journal-title":"Parasitol. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.semcdb.2018.03.020","article-title":"Neutrophil extracellular traps in fungal infection","volume":"89","author":"Urban","year":"2018","journal-title":"Semin. Cell Dev. Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1099\/vir.0.014613-0","article-title":"Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus","volume":"91","author":"Wardini","year":"2010","journal-title":"J. Gen. Virol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3389\/fimmu.2016.00436","article-title":"Canine neutrophil extracellular traps release induced by the apicomplexan parasite Neospora caninum in vitro","volume":"7","author":"Wei","year":"2016","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetpar.2018.06.002","article-title":"Bovine macrophage-derived extracellular traps act as early effectors against the abortive parasite Neospora caninum","volume":"258","author":"Wei","year":"","journal-title":"Vet. Parasitol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.chemosphere.2017.12.175","article-title":"The formation of canine neutrophil extracellular traps induced by sodium arsenic in polymorphonuclear neutrophils","volume":"196","author":"Wei","year":"","journal-title":"Chemosphere"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetimm.2017.05.005","article-title":"Role of NETs in the difference in host susceptibility to Toxoplasma gondii between sheep and cattle","volume":"189","author":"Yildiz","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ijvsm.2017.08.006","article-title":"A seroepidemiological survey of Toxoplasma gondii infection in referred dogs to Veterinary Hospital of Ahvaz, Iran","volume":"5","author":"Zarra-Nezhad","year":"2017","journal-title":"Int. J. Vet. Sci. Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1007\/s00436-015-4746-y","article-title":"Seroprevalence and risk factors of Toxoplasma gondii infection in stray dogs in northern China","volume":"114","author":"Zhang","year":"2015","journal-title":"Parasitol. Res."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00429\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T13:49:47Z","timestamp":1601041787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00429\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":30,"alternative-id":["10.3389\/fcimb.2020.00429"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00429","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"429"}}