{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:57:31Z","timestamp":1777535851398,"version":"3.51.4"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00477","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T06:24:30Z","timestamp":1599546270000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["ERG-Associated lncRNA (ERGAL) Promotes the Stability and Integrity of Vascular Endothelial Barrier During Dengue Viral Infection via Interaction With miR-183-5p"],"prefix":"10.3389","volume":"10","author":[{"given":"Baojia","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianfang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1111\/j.1538-7836.2008.03087.x","article-title":"Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration","volume":"6","author":"Aghajanian","year":"2008","journal-title":"J. Thromb. Haemost"},{"key":"B2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1182\/blood-2007-08-105346","article-title":"The transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin","volume":"111","author":"Birdsey","year":"2008","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1182\/blood-2011-04-350025","article-title":"The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis","volume":"119","author":"Birdsey","year":"2012","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.devcel.2014.11.016","article-title":"The endothelial transcription factor ERG promotes vascular stability and growth through Wnt\/\u03b2-Catenin signaling","volume":"32","author":"Birdsey","year":"2015","journal-title":"Dev. Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/1471-2105-14-S2-S4","article-title":"An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs","volume":"4","author":"Chang","year":"2013","journal-title":"BMC Bioinform"},{"key":"B7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.repbio.2016.07.002","article-title":"MiRNA-183-5p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting the PDCD4","volume":"16","author":"Cheng","year":"2016","journal-title":"Reprod. Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature02628","article-title":"The case for a US prospective cohort study of genes and environment","volume":"429","author":"Collins","year":"2004","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.gene.2005.06.019","article-title":"Non-coding RNAs: new players in eukaryotic biology","volume":"357","author":"Costa","year":"2005","journal-title":"Gene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.1093\/nar\/gkv703","article-title":"The microRNA-183 cluster: the family that plays together stays together","volume":"43","author":"Dambal","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res"},{"key":"B12","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/ng.2965","article-title":"Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance","volume":"46","author":"Fort","year":"2014","journal-title":"Nat. Genet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"Guzman","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3892\/or.2018.6429","article-title":"Oncogenic role of miR-183-5p in lung adenocarcinoma: a comprehensive study of qPCR, in vitro experiments and bioinformatic analysis","volume":"40","author":"He","year":"2018","journal-title":"Oncol. Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1152\/ajplung.00294.2004","article-title":"Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers","volume":"288","author":"Irwin","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0065-230X(10)07004-1","article-title":"Role of EBERs in the pathogenesis of EBV infection","volume":"107","author":"Iwakiri","year":"2010","journal-title":"Adv. Cancer Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0166-0934(02)00065-4","article-title":"An improved endothelial barrier model to investigate dengue haemorrhagic fever","volume":"104","author":"Jacobs","year":"2002","journal-title":"J. Virol. Methods"},{"key":"B18","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ccr.2014.01.030","article-title":"Viral-human chimeric transcript predisposes risk to liver cancer development and progression","volume":"25","author":"Lau","year":"2014","journal-title":"Cancer Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/bioinformatics\/btr209","article-title":"PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions","volume":"27","author":"Lin","year":"2011","journal-title":"Bioinformatics"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1096\/fj.12-213967","article-title":"XAF1 contributes to dengue virus-induced apoptosis in vascular endothelial cells","volume":"27","author":"Long","year":"2013","journal-title":"FASEB J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1128\/CMR.00035-09","article-title":"Dengue virus pathogenesis: an integrated view","volume":"22","author":"Martina","year":"2009","journal-title":"Clin. Microbiol. Rev"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1182\/blood.V98.12.3332","article-title":"Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation","volume":"98","author":"McLaughlin","year":"2010","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.yexcr.2018.12.003","article-title":"miR-183-5p functions as a tumor suppressor in lung cancer through PIK3CA inhibition","volume":"374","author":"Meng","year":"2019","journal-title":"Exp. Cell Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1083\/jcb.147.1.185","article-title":"Endothelial claudin: claudin-5\/TMVCF constitutes tight junction strands in endothelial cells","volume":"147","author":"Morita","year":"1999","journal-title":"J. Cell Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"12178","DOI":"10.1128\/JVI.01757-15","article-title":"Modulation of microRNA cluster miR-183-96-182 expression by Epstein-Barr virus latent membrane protein 1","volume":"89","author":"Oussaief","year":"2015","journal-title":"J. Virol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.jinf.2017.09.016","article-title":"Correlation of altered expression of a long non-coding RNA, NEAT1, in peripheral blood mononuclear cells with dengue disease progression","volume":"75","author":"Pandey","year":"2017","journal-title":"J. Infect"},{"key":"B28","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1128\/mBio.00206-10","article-title":"Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling","volume":"1","author":"Peng","year":"2010","journal-title":"MBio"},{"key":"B29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2015","journal-title":"Nat. Rev. Genet"},{"key":"B30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1161\/01.ATV.4.3.283","article-title":"Transport of 125I-albumin across normal and deendothelialized rabbit thoracic aorta in vivo","volume":"4","author":"Ramirez","year":"1984","journal-title":"Arteriosclerosis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1042\/BST0371248","article-title":"Regulation of angiogenesis by ETS transcription factors","volume":"37","author":"Randi","year":"2009","journal-title":"Biochem. Soc. Trans"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e0135863","DOI":"10.1371\/journal.pone.0135863","article-title":"Let-7, Mir-98 and Mir-181 as biomarkers for cancer and schizophrenia","volume":"10","author":"Rizos","year":"2015","journal-title":"PLoS ONE"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/mt.2014.29","article-title":"An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription","volume":"22","author":"Saayman","year":"2014","journal-title":"Mol. Ther"},{"key":"B34","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1067\/mai.2002.128581","article-title":"Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration","volume":"110","author":"Sedgwick","year":"2002","journal-title":"J. Allergy Clin. Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms16002","article-title":"The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability","volume":"8","author":"Shah","year":"2017","journal-title":"Nat. Commun"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1099\/jgv.0.000981","article-title":"High dengue virus load differentially modulates human microvascular endothelial barrier function during early infection","volume":"98","author":"Soe","year":"2017","journal-title":"J. Gene Virol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.yexcr.2004.07.012","article-title":"Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP","volume":"300","author":"Soma","year":"2004","journal-title":"Exp. Cell Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1128\/JVI.05903-11","article-title":"High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection","volume":"86","author":"Stark","year":"2012","journal-title":"J. Virol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/ncb1752","article-title":"Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5","volume":"10","author":"Taddei","year":"2008","journal-title":"Nat. Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1126\/science.1112014","article-title":"The transcriptional landscape of the mammalian genome","volume":"309","year":"2005","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1196\/annals.1420.016","article-title":"Regulation of endothelial junctional permeability","volume":"1123","author":"Vandenbroucke","year":"2008","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1161\/ATVBAHA.107.158014","article-title":"VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation","volume":"28","author":"Vestweber","year":"2008","journal-title":"Arterioscl. Throm. Vas. Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.tcb.2008.10.001","article-title":"Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player","volume":"19","author":"Vestweber","year":"2009","journal-title":"Trends Cell Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1007\/s00018-015-1890-6","article-title":"F-actin binding protein, anillin, regulates integrity of intercellular junctions in human epithelial cells","volume":"72","author":"Wang","year":"2015","journal-title":"Cell. Mol. Life Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e809","DOI":"10.1371\/journal.pntd.0000809","article-title":"Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during Dengue virus infection","volume":"4","author":"Wang","year":"2010","journal-title":"PLoS Negl. Trop. Dis"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1093\/nar\/gkt006","article-title":"CPAT: coding-potential assessment tool using an alignment-free logistic regression model","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.4269\/ajtmh.17-0307","article-title":"The differential expression and possible function of long noncoding rnas in liver cells infected by dengue virus","volume":"97","author":"Wang","year":"2017","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6582","DOI":"10.1074\/jbc.M111.300236","article-title":"ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5)","volume":"287","author":"Yuan","year":"2012","journal-title":"Gene J. Biol. Chem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1161\/CIRCRESAHA.108.190751","article-title":"Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene","volume":"104","author":"Yuan","year":"2009","journal-title":"Circ. Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"228","DOI":"10.13471\/j.cnki.j.sun.yat-sen.univ(med.sci).2019.0032","article-title":"Long non-coding RNA expression profile in vascular endothelial cells before and after infected by dengue virus type I(Chinese version)","volume":"42","author":"Zheng","year":"2019","journal-title":"J. Sun Yat-Sen Univ"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T06:24:34Z","timestamp":1599546274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,8]]},"references-count":52,"alternative-id":["10.3389\/fcimb.2020.00477"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00477","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,8]]},"article-number":"477"}}