{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:54:54Z","timestamp":1791924894355,"version":"4.3.4"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.00498","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T03:06:32Z","timestamp":1600743992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Non-surgical Periodontal Treatment Restored the Gut Microbiota and Intestinal Barrier in Apolipoprotein E\u2212\/\u2212 Mice With Periodontitis"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuezhen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jim.2013.05.002","article-title":"Optimization of the ligature-induced periodontitis model in mice","volume":"394","author":"Abe","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1093\/carcin\/bgs112","article-title":"Periodontal disease, porphyromonas g ingivalis serum antibody levels and orodigestive cancer mortality","volume":"33","author":"Ahn","year":"2012","journal-title":"Carcinogenesis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1038\/srep04828","article-title":"Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota","volume":"4","author":"Arimatsu","year":"2014","journal-title":"Sci. Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"033","DOI":"10.5005\/jcdp-11-2-33","article-title":"Evaluation of periodontal status in subjects with hyperlipidemia","volume":"11","author":"Awartani","year":"2010","journal-title":"J. Contemp. Dent. Pract"},{"key":"B5","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e48220","DOI":"10.1371\/journal.pone.0048220","article-title":"High-fat diet induces periodontitis in mice through lipopolysaccharides (LPS) receptor signaling: protective action of estrogens","volume":"7","author":"Blasco-Baque","year":"2012","journal-title":"PLoS ONE"},{"key":"B7","doi-asserted-by":"publisher","first-page":"S135","DOI":"10.1902\/jop.2013.1340013","article-title":"Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence","volume":"84","author":"Borgnakke","year":"2013","journal-title":"J. Periodontol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states: I","volume":"101","author":"Chiu","year":"1970","journal-title":"a morphological, hemodynamic, and metabolic reappraisal. Arch Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1902\/jop.1999.70.12.1429","article-title":"Association between periodontitis and hyperlipidemia: cause or effect?","volume":"70","author":"Cutler","year":"1999","journal-title":"J. Periodontol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1902\/jop.2008.080103","article-title":"Treatment of experimental periodontal disease by photodynamic therapy in rats with diabetes","volume":"79","author":"de Almeida","year":"2008","journal-title":"J Periodontol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrendo.2011.126","article-title":"Targeting gut microbiota in obesity: effects of prebiotics and probiotics","volume":"7","author":"Delzenne","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"B14","first-page":"36","article-title":"Effect of periodontal initial therapy on the serum level of lipid in the patients with both periodontitis and hyperlipidemia","volume":"41","author":"Duan","year":"2009","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1038\/s41467-017-01973-8","article-title":"Meta-analysis of gut microbiome studies identifies disease-specific and shared responses","volume":"8","author":"Duvallet","year":"2017","journal-title":"Nat. Commun"},{"key":"B16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1055\/s-0039-1697370","article-title":"The bi-directional relationship between periodontal disease and hyperlipidemia","volume":"2","author":"Fentoglu","year":"2008","journal-title":"Eur. J. Dent"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s00784-015-1621-2","article-title":"Effects of periodontal therapy on serum lipid profile and proinflammatory cytokines in patients with hyperlipidemia: a randomized controlled trial","volume":"20","author":"Fu","year":"2016","journal-title":"Clin. Oral Investig"},{"key":"B18","doi-asserted-by":"publisher","first-page":"G840","DOI":"10.1152\/ajpgi.00029.2015","article-title":"Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent","volume":"308","author":"Hamilton","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mSphere.00460-18","article-title":"Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome","volume":"3","author":"Kato","year":"2018","journal-title":"mSphere"},{"key":"B20","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1177\/0022034516641053","article-title":"Metabolic syndrome and periodontal disease progression in men","volume":"95","author":"Kaye","year":"2016","journal-title":"J. Dent. Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1902\/jop.2015.140589","article-title":"Association between periodontal disease and overweight and obesity: a systematic review","volume":"86","author":"Keller","year":"2015","journal-title":"J. Periodontol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1079\/BJN2002827","article-title":"Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats","volume":"89","author":"Kleessen","year":"2003","journal-title":"Br. J. Nutr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"8513","DOI":"10.3168\/jds.2019-16328","article-title":"Effects of ad libitum milk replacer feeding and butyrate supplementation on the epithelial growth and development of the gastrointestinal tract in Holstein calves","volume":"102","author":"Koch","year":"2019","journal-title":"J. Dairy Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1073\/pnas.1011383107","article-title":"Human oral, gut, and plaque microbiota in patients with atherosclerosis","volume":"108","author":"Koren","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B26","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5713\/ajas.14.0330","article-title":"Effect of Bacillus amyloliquefaciens based direct-fed microbial on performance, nutrient utilization, intestinal morphology and cecal microflora in broiler chickens","volume":"28","author":"Lei","year":"2014","journal-title":"Asian Australas J. Anim. Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B29","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1128\/CMR.13.4.547","article-title":"Systemic diseases caused by oral infection","volume":"13","author":"Li","year":"2000","journal-title":"Clin. Microbiol. Rev"},{"key":"B30","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12944-018-0811-8","article-title":"Western diet feeding influences gut microbiota profiles in apoE knockout mice","volume":"17","author":"Liu","year":"2018","journal-title":"Lipids Health Dis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1017\/S0007114508911612","article-title":"Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs","volume":"100","author":"Liu","year":"2008","journal-title":"Br. J. Nutr"},{"key":"B32","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1462-2920.2009.02066.x","article-title":"Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA: acetate CoA-transferase gene","volume":"12","author":"Louis","year":"2010","journal-title":"Environ. Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1487741","DOI":"10.1080\/20002297.2018.1487741","article-title":"Defining the gut microbiota in individuals with periodontal diseases: an exploratory study","volume":"10","author":"Louren\u03c2o","year":"2018","journal-title":"J. Oral Microbiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/1471-2105-7-371","article-title":"UniFrac \u2013 an online tool for comparing microbial community diversity in a phylogenetic context","volume":"7","author":"Lozupone","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ijfoodmicro.2016.10.019","article-title":"Lactate-and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans","volume":"241","author":"Moens","year":"2017","journal-title":"Int. J. Food Microbiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0134234","DOI":"10.1371\/journal.pone.0134234","article-title":"Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver","volume":"10","author":"Nakajima","year":"2015","journal-title":"PloS ONE"},{"key":"B37","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1600-0757.1997.tb00199.x","article-title":"Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions","volume":"14","author":"Page","year":"1997","journal-title":"Periodontology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1177\/0022034516645332","article-title":"SOCS-3 regulates alveolar bone loss in experimental periodontitis","volume":"95","author":"Papathanasiou","year":"2016","journal-title":"J. Dent. Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"404","DOI":"10.15557\/PiMR.2016.0040","article-title":"The impact of the microbiota on human health","volume":"12","author":"Rakowska","year":"2016","journal-title":"Pediatria i Med. Rodz."},{"key":"B41","doi-asserted-by":"publisher","first-page":"792","DOI":"10.5551\/jat.1644","article-title":"Lower high-density lipoprotein cholesterol is a significant and independent risk for coronary artery disease in Japanese men","volume":"16","author":"Satoh","year":"2009","journal-title":"J. Atheroscler. Thromb"},{"key":"B42","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/j.1462-2920.2007.01503.x","article-title":"Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis","volume":"10","author":"Scanlan","year":"2008","journal-title":"Environ. Microbiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e42693","DOI":"10.7554\/eLife.42693","article-title":"Extensive transmission of microbes along the gastrointestinal tract","volume":"8","author":"Schmidt","year":"2019","journal-title":"Elife"},{"key":"B44","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1902\/jop.2013.1340019","article-title":"Periodontitis and atherosclerotic cardiovascular disease: consensus report of the joint EFP\/AAPWorkshop on periodontitis and systemic diseases","volume":"84","author":"Tonetti","year":"2013","journal-title":"J. Periodontol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1111\/jre.12532","article-title":"Subgingival glycine powder air-polishing as an additional approach to nonsurgical periodontal therapy in subjects with untreated chronic periodontitis","volume":"53","author":"Tsang","year":"2018","journal-title":"J. Periodont. Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5727","DOI":"10.3390\/ijms20225727","article-title":"Low molecular seleno-aminopolysaccharides protect the intestinal mucosal barrier of rats under weaning stress","volume":"20","author":"Wen","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1411543","article-title":"Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E","volume":"258","author":"Zhang","year":"1992","journal-title":"Science"},{"key":"B49","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.archoralbio.2014.11.008","article-title":"Interrelationship between diabetes and periodontitis: role of hyperlipidemia","volume":"60","author":"Zhou","year":"2015","journal-title":"Arch. Oral Biol"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00498\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T03:06:33Z","timestamp":1600743993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.00498\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":49,"alternative-id":["10.3389\/fcimb.2020.00498"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.00498","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"article-number":"498"}}