{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:51:31Z","timestamp":1791816691639,"version":"4.3.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.545372","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T06:06:36Z","timestamp":1604297196000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Pre-Clinical Studies of Inactivated Polyvalent HFRS Vaccine"],"prefix":"10.3389","volume":"10","author":[{"given":"Tamara K.","family":"Dzagurova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra A.","family":"Siniugina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidar A.","family":"Ishmukhametov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Egorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana S.","family":"Kurashova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Balovneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A.","family":"Deviatkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr E.","family":"Tkachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana A.","family":"Leonovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny A.","family":"Tkachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"B1","first-page":"27","article-title":"Vaccine against hemorrhagic fever with renal syndrome","volume":"1","author":"Barkhaleva","year":"2011","journal-title":"Biopharmaceuticals: Prevent. Diagnosis Treat (in Russian)"},{"key":"B2","first-page":"5","article-title":"Features of the Natural Focality of Hantavirus Zoonoses","volume":"2","author":"Bernshtein","year":"2010","journal-title":"Epidemiol. Vaccine Prophylaxis (In Russian)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1016\/s0264-410x(02)00341-9","article-title":"Yeast-expressed Puumala hantavirus nucleocapsid protein induces protection in a bank vole model","volume":"20","author":"Dargeviciute","year":"2002","journal-title":"Vaccine"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6669","DOI":"10.1128\/jvi.76.13.6669-6677.2002","article-title":"Cross-protection against challenge with Puumala virus after immunization with nucleocapsid proteins from different hantaviruses","volume":"76","author":"de Carvalho Nicacio","year":"2002","journal-title":"J. Virol."},{"key":"B5","first-page":"142","article-title":"Isolation and identification of strains of Hantavirus - pathogens of HFRS in the European part of Russia","volume":"25","author":"Dzagurova","year":"2008","journal-title":"Med. Virol. (In Russian)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/jmv.2079","article-title":"Human immune response to Puumala virus glycoproteins and nucleocapsid protein expressed in mammalian cells","volume":"65","author":"Kallio-Kokko","year":"2001","journal-title":"J.\u00a0Med. Virol."},{"key":"B7","volume-title":"Cytokines","author":"Ketlinsky","year":"2008"},{"key":"B8","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3201\/eid1404.071310","article-title":"Hemorrhagic fever with renal syndrome caused by two distinct lineages of Dobrava hantavirus emerging in Russia","volume":"14","author":"Klempa","year":"2008","journal-title":"Emerg. Infect. Dis. J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.3201\/eid2112.150891","article-title":"Life-Threatening Sochi Virus Infections, Russia","volume":"21","author":"Kruger","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.vaccine.2018.12.067","article-title":"Highly homogenous tri-acylated S-LPS acts as a novel clinically applicable vaccine against Shigella flexneri 2a infection","volume":"37","author":"Ledov","year":"2019","journal-title":"Vaccine"},{"key":"B11","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/infdis\/137.3.298","article-title":"Isolation of the ethiologic agent of Korean hemorrhagic fever","volume":"137","author":"Lee","year":"1978","journal-title":"J. Infect. Dis."},{"key":"B12","first-page":"267","article-title":"Vaccines against hemorrhagic fever with renal syndrome","volume-title":"Factors in the emergence and control of rodent-borne viral diseases (hantaviral and arenal diseases)","author":"Lee","year":"1999"},{"key":"B13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.rvsc.2009.02.008","article-title":"Quantification of water buffalo (Bubalus bubalis) cytokine expression in response to inactivated foot-and-mouth disease (FMD) vaccine","volume":"87","author":"Mingala","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cyto.2015.06.017","article-title":"The interleukin (IL)-1 cytokine family\u2013Balance between agonists and antagonists in inflammatory diseases","volume":"76","author":"Palomo","year":"2015","journal-title":"Cytokine"},{"key":"B15","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.antiviral.2012.06.002","article-title":"The Syrian hamster model of hantavirus pulmonary syndrome","volume":"95","author":"Safronetz","year":"2012","journal-title":"Antiviral Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.micpath.2018.08.049","article-title":"Kinetics of Interferon gamma and Interleukin-21 response following foot and mouth disease virus infection","volume":"125","author":"Sharma","year":"2018","journal-title":"Microb. Pathog."},{"key":"B17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.31631\/2073-3046-2019-18-4-52-58","article-title":"Pre-Clinical Studies of Inactivated Polivalent Vaccine Against Hemorrhagic Fever with Renal Syndrome","volume":"18","author":"Sinyugina","year":"2019","journal-title":"Epidemiol. Vaccine Prophylaxis (In Russian)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3349\/ymj.2001.42.3.278","article-title":"Primary humoral immuno responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax): considerationof active immunization in South Korea","volume":"42","author":"Sohn","year":"2001","journal-title":"Yonsei Med. J."},{"key":"B19","first-page":"28","article-title":"Comparative analysis of epidemic outbreaks of hemorrhagic fever with renal syndrome caused by the viruses of Puumala and Dobrava\/Belgrade","volume":"4","author":"Tkachenko","year":"2005","journal-title":"Epidemiol. Vaccine Prophylaxis (in Russian)"},{"key":"B20","first-page":"14","article-title":"The epizootological and virological characteristics of a natural hantavirus infection focus in the subtropic zone of the Krasnodar territory","volume":"50","author":"Tkachenko","year":"2005","journal-title":"Voprosy Virusologii (In Russian)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.21518\/1561-5936-2015-6-47-53","article-title":"Development of an experimental technology of the vaccine for hemorrhagic fever with renal syndrome prevention","volume":"6","author":"Tkachenko","year":"2015","journal-title":"Remedium (in Russian)"},{"key":"B22","first-page":"331","article-title":"Hemorrhagic fever with renal syndrome in Russia: Successes and Challenges in the present stage. In the book \u201cBiomedicine of XXI century: achievements and perspective directions of development\u201d","author":"Tkachenko","year":"2016","journal-title":"Proc. Russian Acad. Natural Sci. Moscow"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.3201\/eid2512.181649","article-title":"Hemorrhagic Fever with Renal Syndrome, Russia","volume":"25","author":"Tkachenko","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev.iy.13.040195.001343","article-title":"Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity","volume":"13","author":"Trinchieri","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/s0264-410x(97)00172-2","article-title":"Chimaeric HBV core particles carrying a defined segment of Puumala hantavirus nucleocapsid protein evoke protective immunity in an animal model","volume":"16","author":"Ulrich","year":"1998","journal-title":"Vaccine"},{"key":"B26","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0168-1656(99)00117-0","article-title":"Newchimaeric hepatitis B virus core particles carrying hantavirus (serotype Puumala) epitopes: immunogenicity and protection against virus challenge","volume":"73","author":"Ulrich","year":"1999","journal-title":"J. Biotechnol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00167","article-title":"New insights in the immunobiology of IL-1 family members","volume":"4","author":"Veerdonk","year":"2013","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3201\/eid2202.151516","article-title":"Long term epidemiological effects of vaccination on hemorrhagic fever with renal syndrome (HFRS) in Shaanxi provincial HFRS epidemic areas","volume":"33","author":"Wang","year":"2012","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"B29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of effector CD4 T cell populations","volume":"28","author":"Zhu","year":"2009","journal-title":"Annu. Rev. Immunol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2020.545372\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T14:59:58Z","timestamp":1604501998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2020.545372\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":29,"alternative-id":["10.3389\/fcimb.2020.545372"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.545372","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]},"article-number":"545372"}}