{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:57:49Z","timestamp":1771657069787,"version":"3.50.1"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.554052","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T06:34:41Z","timestamp":1601361281000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Neurotransmitters in the Protection of Caenorhabditis Elegans for Salmonella Infection by Lactobacillus"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaozhen","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoping","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1003787","DOI":"10.1371\/journal.ppat.1003787","article-title":"Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells","volume":"9","author":"Anderson","year":"2013","journal-title":"PLoS Pathog"},{"key":"B2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.chom.2009.04.012","article-title":"Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity","volume":"5","author":"Anyanful","year":"2009","journal-title":"Cell. Host. Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.cub.2016.06.036","article-title":"Neural inhibition of dopaminergic signaling enhances immunity in a cell-non-autonomous manner","author":"Cao","year":"2016","journal-title":"Curr. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1016\/j.foodres.2011.08.017","article-title":"The intestinal microbiota and its modulation for Salmonella control in chickens","volume":"44","author":"Chambers","year":"2011","journal-title":"Food Res. Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.mib.2014.11.009","article-title":"Microbial pathogenesis and host defense in the nematode C. elegans","volume":"23","author":"Cohen","year":"2015","journal-title":"Curr. Opin. Microbiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.smim.2014.04.005","article-title":"Insights from the worm: the C. elegans model for innate immunity","volume":"26","author":"Ermolaeva","year":"2014","journal-title":"Semin. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e9487","DOI":"10.1371\/journal.pone.0009487","article-title":"The C. elegans D2-Like dopamine receptor DOP-3 decreases behavioral sensitivity to the olfactory stimulus 1-Octanol","volume":"5","author":"Ezak","year":"2010","journal-title":"PLoS ONE"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/emboj.2011.22","article-title":"Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling","volume":"30","author":"Ezcurra","year":"2011","journal-title":"EMBO J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"40695","DOI":"10.1038\/srep40695","article-title":"Antimicrobial probiotics reduce Salmonella enterica in turkey gastrointestinal tracts","volume":"7","author":"Forkus","year":"2017","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"29284","DOI":"10.1038\/srep29284","article-title":"Caenorhabditis elegans employs innate and learned aversion in response to bacterial toxic metabolites tambjamine and violacein","volume":"6","author":"Francesco","year":"2016","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1462-5822.2005.00523.x","article-title":"Caenorhabditis elegans as a model for innate immunity to pathogens","volume":"7","author":"Gravato-Nobre","year":"2010","journal-title":"Cell. Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1099\/mic.0.000709","article-title":"Salmonella infection - prevention and treatment by antibiotics and probiotic yeasts: a review","volume":"164","author":"Gut","year":"2018","journal-title":"Microbiology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.neuron.2010.11.025","article-title":"Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans","volume":"68","author":"Ha","year":"2010","journal-title":"Neuron"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6404","DOI":"10.1128\/AEM.00704-07","article-title":"Influence of lactic acid bacteria on longevity of Caenorhabditis elegans and host defense against Salmonella enterica serovar enteritidis","volume":"73","author":"Ikeda","year":"2007","journal-title":"Appl. Environ. Microb."},{"key":"B16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nri2689","article-title":"Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates","volume":"10","author":"Irazoqui","year":"2010","journal-title":"Nat. Rev. Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1016\/j.mex.2019.10.015","article-title":"Inappropriateness of RNAlater to preserve caenorhabditis elegans for RNA extraction","volume":"6","author":"Jiang","year":"2019","journal-title":"MethodsX"},{"key":"B18","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.cell.2016.01.007","article-title":"Distinct circuits for the formation and retrieval of an imprinted olfactory memory","volume":"164","author":"Jin","year":"2016","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1371\/journal.ppat.0030018","article-title":"Antifungal chemical compounds identified using a C. elegans pathogenicity assay","volume":"3","author":"Julia","year":"2007","journal-title":"PLoS Pathog."},{"key":"B20","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrd2031","article-title":"Finding function in novel targets: C. elegans as a model organism","volume":"5","author":"Kaletta","year":"2006","journal-title":"Nat. Rev. Drug Disco."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1039\/C6FO00510A","article-title":"Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection","volume":"7","author":"Kamaladevi","year":"2016","journal-title":"Food Funct."},{"key":"B22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cbpc.2015.08.004","article-title":"Lactobacillus casei stimulates phase-II detoxification system and rescues malathion-induced physiological impairments in Caenorhabditis elegans","volume":"179","author":"Kamaladevi","year":"2016","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1128\/IAI.06350-11","article-title":"Caenorhabditis elegans immune conditioning with the probiotic bacterium Lactobacillus acidophilus NCFM enhances gram-positive immune responses","volume":"80","author":"Kim","year":"2012","journal-title":"Infect. Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3920\/BM2019.0046","article-title":"Probiotics exert reciprocal effects on autophagy and interleukin-1\u03b2 expression in Salmonella-infected intestinal epithelial cells via autophagy-related 16L1 protein","volume":"10","author":"Lai","year":"2019","journal-title":"Benef Microbes"},{"key":"B25","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1242\/dev.126.24.5819","article-title":"Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene","volume":"126","author":"Lints","year":"1999","journal-title":"Development"},{"key":"B26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.it.2014.08.008","article-title":"Behavioral avoidance of pathogenic bacteria by Caenorhabditis elegans","volume":"35","author":"Meisel","year":"2014","journal-title":"Trends Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"10227","DOI":"10.1021\/acs.jafc.5b03730","article-title":"Bacillus licheniformis isolated from traditional Korean food resources enhances the longevity of Caenorhabditis elegans through serotonin signaling","volume":"63","author":"Park","year":"2015","journal-title":"J. Agr. Food Chem."},{"key":"B29","first-page":"559","article-title":"Salmonella Typhimurium DT104: a virulent and drug-resistant pathogen","volume":"39","author":"Poppe","year":"1998","journal-title":"Can. Vet. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1089\/107662902760190653","article-title":"Diversity in antimicrobial resistance and other characteristics among Salmonella Typhimurium DT104 isolates","volume":"8","author":"Poppe","year":"2002","journal-title":"Microb. Drug Resist."},{"key":"B31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1039\/B613414A","article-title":"Maze exploration and learning in C. elegans","volume":"7","author":"Qin","year":"2007","journal-title":"Lab Chip."},{"key":"B32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/sj.emboj.7600057","article-title":"Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans","volume":"23","author":"Sanyal","year":"2004","journal-title":"EMBO J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0896-6273(00)81199-X","volume":"26","author":"Sawin","year":"2000","journal-title":"C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron"},{"key":"B34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nrn.2015.26","article-title":"Dopamine reward prediction-error signalling: a two-component response","volume":"17","author":"Schultz","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s12602-018-9420-0","article-title":"Multivariate analysis of increase in life span of Caenorhabditis elegans through intestinal colonization by indigenous probiotic strains","volume":"11","author":"Sharma","year":"2019","journal-title":"Probiotics Antimicro."},{"key":"B36","first-page":"1","article-title":"Maintenance of C. elegans","volume":"11","author":"Stiernagle","year":"1999","journal-title":"Wormbook"},{"key":"B37","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/35000609","article-title":"Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant","volume":"403","author":"Sze","year":"2000","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fncel.2017.00025","article-title":"Gut microbiota: a potential regulator of neurodevelopment","volume":"11","author":"Tognini","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1371\/journal.pgen.0020183","article-title":"p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans","volume":"2","author":"Troemel","year":"2006","journal-title":"PLoS Genet"},{"key":"B40","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.immuni.2014.05.002","article-title":"Innate host defense requires TFEB-Mediated transcription of cytoprotective and antimicrobial genes","volume":"40","author":"Visvikis","year":"2014","journal-title":"Immunity"},{"key":"B41","doi-asserted-by":"publisher","first-page":"86","DOI":"10.4315\/0362-028X.JFP-10-155","article-title":"Use of Caenorhabditis elegans for preselecting Lactobacillus isolates to control Salmonella Typhimurium","volume":"74","author":"Wang","year":"2011","journal-title":"J. Food Protect."},{"key":"B42","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3390\/microorganisms7110570","article-title":"Bacteriophages as potential tools for detection and control of Salmonella spp","volume":"7","author":"Wei","year":"2019","journal-title":"in food systems. Microorganisms"},{"key":"B43","doi-asserted-by":"publisher","first-page":"9946","DOI":"10.1073\/pnas.0603791103","article-title":"A Caenorhabditis elegans tissue model of radiation-induced reproductive cell death","volume":"103","author":"Weidhaas","year":"2006","journal-title":"Proc. Natl. Acad. Sci U.S.A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.3389\/fimmu.2018.02398","article-title":"Peripheral dopamine controlled by gut microbes inhibits invariant natural killer T cell-mediated hepatitis","volume":"9","author":"Xue","year":"2018","journal-title":"Front. Immuno."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.4014\/jmb.1406.06008","article-title":"Bacillus licheniformis isolated from korean traditional food sources enhances the resistance of Caenorhabditis elegans to infection by Staphylococcus aureus","volume":"24","author":"Yun","year":"2014","journal-title":"J Microbiol Biotechnol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature04216","article-title":"Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans","volume":"438","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3389\/fimmu.2018.01745","article-title":"Cell signaling of Caenorhabditis elegans in response to enterotoxigenic Escherichia coli infection and Lactobacillus zeae protection","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e89004","DOI":"10.1371\/journal.pone.0089004","article-title":"Lactobacillus zeae protects Caenorhabditis elegans from enterotoxigenic Escherichia coli-caused death by inhibiting enterotoxin gene expression of the pathogen","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.554052\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T01:41:02Z","timestamp":1668994862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.554052\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":48,"alternative-id":["10.3389\/fcimb.2020.554052"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.554052","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"article-number":"554052"}}