{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:56:20Z","timestamp":1791654980888,"version":"4.3.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.566149","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:17:02Z","timestamp":1602825422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Lymphocyte Populations in Patients With Dobrava or Puumala orthohantavirus Infection"],"prefix":"10.3389","volume":"10","author":[{"given":"Katarina","family":"Resman Rus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja Nata\u0161a","family":"Kopitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0161a","family":"Korva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alojz","family":"Ihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Petrovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Av\u0161i\u010d-\u017dupanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8408","DOI":"10.1128\/JVI.77.15.8408-8417.2003","article-title":"Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus","volume":"77","author":"Araki","year":"2003","journal-title":"J. Virol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1086\/515185","article-title":"Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia\u2013a 10-year survey","volume":"28","author":"Avsic-Zupanc","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2217\/bmm.14.88","article-title":"Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica","volume":"9","author":"Baigildina","year":"2015","journal-title":"Biomark. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/ni1181","article-title":"Natural regulatory T cells in infectious disease","volume":"6","author":"Belkaid","year":"2005","journal-title":"Nat. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1084\/jem.20100762","article-title":"Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus","volume":"208","author":"Bjorkstrom","year":"2011","journal-title":"J. Exp. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e1004521","DOI":"10.1371\/journal.ppat.1004521","article-title":"NK cell activation in human hantavirus infection explained by virus-induced IL-15\/IL15Ralpha expression","volume":"10","author":"Braun","year":"2014","journal-title":"PLoS Pathog"},{"key":"B7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/ni714","article-title":"Specific and nonspecific NK cell activation during virus infection","volume":"2","author":"Dokun","year":"2001","journal-title":"Nat. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1003272","DOI":"10.1371\/journal.ppat.1003272","article-title":"Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis","volume":"9","author":"Gupta","year":"2013","journal-title":"PLoS Pathog"},{"key":"B9","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/infdis\/169.4.868","article-title":"Hemorrhagic fever with renal syndrome: relationship between pathogenesis and cellular immunity","volume":"169","author":"Huang","year":"1994","journal-title":"J. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1146\/annurev-immunol-032712-100001","article-title":"Control of human viral infections by natural killer cells","volume":"31","author":"Jost","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1007\/s10096-014-2176-x","article-title":"Upregulation of IFN-gamma and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome","volume":"33","author":"Khaiboullina","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.4049\/jimmunol.172.5.3297","article-title":"Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome","volume":"172","author":"Kilpatrick","year":"2004","journal-title":"J. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jinf.2013.11.007","article-title":"Regulatory T cell response correlates with the severity of human hantavirus infection","volume":"68","author":"Koivula","year":"2014","journal-title":"J. Infect."},{"key":"B14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.micinf.2008.12.016","article-title":"The hantaviral load in tissues of naturally infected rodents","volume":"11","author":"Korva","year":"2009","journal-title":"Microbes Infect."},{"key":"B15","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3390\/v11080686","article-title":"Characterization of biomarker levels in crimean-congo hemorrhagic fever and hantavirus fever with renal syndrome","volume":"11","author":"Korva","year":"2019","journal-title":"Viruses"},{"key":"B16","doi-asserted-by":"publisher","first-page":"E358","DOI":"10.1111\/1469-0691.12218","article-title":"Viral load and immune response dynamics in patients with haemorrhagic fever with renal syndrome","volume":"19","author":"Korva","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"B17","doi-asserted-by":"publisher","first-page":"11845","DOI":"10.1128\/JVI.01233-12","article-title":"Seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory T cell phenotypes","volume":"86","author":"Li","year":"2012","journal-title":"J. Virol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1093\/infdis\/173.1.38","article-title":"Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome","volume":"173","author":"Linderholm","year":"1996","journal-title":"J. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3109\/00365549309008554","article-title":"Local host response in the lower respiratory tract in nephropathia epidemica","volume":"25","author":"Linderholm","year":"1993","journal-title":"Scand. J. Infect. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"10252","DOI":"10.1128\/JVI.05548-11","article-title":"Longitudinal analysis of the human T cell response during acute hantavirus infection","volume":"85","author":"Lindgren","year":"2011","journal-title":"J. Virol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.coi.2006.05.002","article-title":"Natural killer cells as an initial defense against pathogens","volume":"18","author":"Lodoen","year":"2006","journal-title":"Curr. Opin. Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1160\/TH09-09-0640","article-title":"Hantavirus regulation of endothelial cell functions","volume":"102","author":"Mackow","year":"2009","journal-title":"Thromb. Haemost."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e1000779","DOI":"10.1371\/journal.ppat.1000779","article-title":"Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by andes hantavirus","volume":"6","author":"Manigold","year":"2010","journal-title":"PLoS Pathog"},{"key":"B24","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1046\/j.1365-2249.1999.00790.x","article-title":"Role of peripheral blood mononuclear cell (PBMC) phenotype changes in the pathogenesis of haemorrhagic fever with renal syndrome (HFRS)","volume":"115","author":"Markotic","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3389\/fimmu.2015.00432","article-title":"Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome","volume":"6","author":"Morzunov","year":"2015","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e0197661","DOI":"10.1371\/journal.pone.0197661","article-title":"Sequential assessment of clinical and laboratory parameters in patients with hemorrhagic fever with renal syndrome","volume":"13","author":"Pal","year":"2018","journal-title":"PLoS ONE"},{"key":"B27","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s00508-005-0359-2","article-title":"Hemorrhagic fever with renal syndrome in the Pomurje region of Slovenia\u2013an 18-year survey","volume":"117","author":"Pal","year":"2005","journal-title":"Wien. Klin. Wochenschr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1378\/chest.10-2791","article-title":"Presence of activated airway T lymphocytes in human puumala hantavirus disease","volume":"140","author":"Rasmuson","year":"2011","journal-title":"Chest"},{"key":"B29","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s10096-016-2592-1","article-title":"Cytotoxic immune responses in the lungs correlate to disease severity in patients with hantavirus infection","volume":"35","author":"Rasmuson","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/infdis\/jix650","article-title":"Delayed interferon type 1-induced antiviral state is a potential factor for hemorrhagic fever with renal syndrome severity","volume":"217","author":"Resman Rus","year":"2018","journal-title":"J. Infect. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1471-2172-12-65","article-title":"Cytokine expression during early and late phase of acute Puumala hantavirus infection","volume":"12","author":"Sadeghi","year":"2011","journal-title":"BMC Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1086\/527485","article-title":"Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome","volume":"197","author":"Saksida","year":"2008","journal-title":"J. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/1471-2334-11-142","article-title":"Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome","volume":"11","author":"Saksida","year":"2011","journal-title":"BMC Infect. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1006462","DOI":"10.1371\/journal.ppat.1006462","article-title":"Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways","volume":"13","author":"Scholz","year":"2017","journal-title":"PLoS Pathog"},{"key":"B35","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/clin.1996.0007","article-title":"Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: an immunohistochemical study","volume":"78","author":"Temonen","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1099\/0022-1317-74-3-515","article-title":"Susceptibility of human cells to Puumala virus infection","volume":"74","author":"Temonen","year":"1993","journal-title":"J. Gen. Virol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3390\/v3071059","article-title":"T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome","volume":"3","author":"Terajima","year":"2011","journal-title":"Viruses"},{"key":"B38","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1084\/jem.20011255","article-title":"Long-lived memory T lymphocyte responses after hantavirus infection","volume":"196","author":"Van Epps","year":"2002","journal-title":"J. Exp. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1086\/595834","article-title":"Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity","volume":"199","author":"Wang","year":"2009","journal-title":"J. Infect. Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1398-9995.1997.tb01031.x","article-title":"Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions","volume":"52","author":"Werfel","year":"1997","journal-title":"Allergy"},{"key":"B41","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s11739-011-0633-4","article-title":"Levels of HTNV-specific CD8+ T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome","volume":"8","author":"Xie","year":"2013","journal-title":"Intern. Emerg. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1365-2249.2008.03858.x","article-title":"Reduced circulating CD4+CD25+ cell populations in haemorrhagic fever with renal syndrome","volume":"156","author":"Zhu","year":"2009","journal-title":"Clin. Exp. Immunol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.566149\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:17:07Z","timestamp":1602825427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.566149\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":42,"alternative-id":["10.3389\/fcimb.2020.566149"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.566149","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"article-number":"566149"}}