{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:14:53Z","timestamp":1778228093465,"version":"3.51.4"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"DOI":"10.3389\/fcimb.2020.574584","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T06:54:26Z","timestamp":1600930466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Hemophagocytic Lymphohistiocytosis During HIV Infection in Cayenne Hospital 2012\u20132015: First Think Histoplasmosis"],"prefix":"10.3389","volume":"10","author":[{"given":"Duc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Nacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loic","family":"Epelboin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Melzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Blaizot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinan","family":"Drak Alsibai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Djossou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Couppi\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Adenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/S1473-3099(18)30354-2","article-title":"Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study","volume":"18","author":"Adenis","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mmcr.2018.01.001","article-title":"Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS)","volume":"20","author":"Asanad","year":"2018","journal-title":"Med. Mycol. Case Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1086\/379615","article-title":"Candidiasis-associated hemophagocytic lymphohistiocytosis in a patient infected with human immunodeficiency virus","volume":"37","author":"Bhatia","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/01.aids.0000199014.66139.39","article-title":"Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis","volume":"20","author":"Breton","year":"2006","journal-title":"AIDS Lond. Engl."},{"key":"B5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s12281-019-00365-3","article-title":"The manaus declaration: current situation of histoplasmosis in the Americas, Report of the II regional meeting of the international histoplasmosis advocacy group","volume":"13","author":"Caceres","year":"2019","journal-title":"Curr. Fungal Infect. Rep."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv140","article-title":"Hemophagocytic lymphohistiocytosis secondary to human immunodeficiency virus-associated histoplasmosis","author":"Castelli","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5045\/kjh.2012.47.1.77","article-title":"Histoplasmosis on bone marrow aspirate cytological examination associated with hemophagocytosis and pancytopenia in an AIDS patient","volume":"47","author":"Chandra","year":"2012","journal-title":"Korean J. Hematol."},{"key":"B8","first-page":"726","article-title":"Hemophagocytic syndrome during Histoplasma capsulatum infection","volume":"82","author":"Chemlal","year":"1997","journal-title":"Haematologica"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1086\/392512","article-title":"Hemophagocytic syndrome in a patient with acute human immunodeficiency virus infection","volume":"38","author":"Concetta","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jinf.2008.11.010","article-title":"Reconstitution inflammatory syndrome related to histoplasmosis, with a hemophagocytic syndrome in HIV infection","volume":"58","author":"De Lavaissi\u00e8re","year":"2009","journal-title":"J. Infect."},{"key":"B11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1086\/375224","article-title":"Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients","volume":"37","author":"Fardet","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0248-8663(99)80050-2","article-title":"Pancytop\u00e9nie f\u00e9brile au cours du sida: un syndrome d h\u00e9mophagocytose","volume":"19","author":"Fiszbin","year":"1998","journal-title":"Rev. M\u00e9d. Interne"},{"key":"B14","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S1130-1406(07)70063-3","article-title":"Disseminated histoplasmosis with hemophagocytic syndrome in a patient with AIDS: description of one case and review of the Spanish literature","volume":"24","author":"Gil-Brusola","year":"2007","journal-title":"Rev. Iberoam. Micol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s11046-017-0144-6","article-title":"Reconstitution inflammatory syndrome like reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a HIV patient","volume":"182","author":"G\u00f3mez-Espejo","year":"2017","journal-title":"Mycopathologia"},{"key":"B16","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrrheum.2015.179","article-title":"Macrophage activation syndrome in the era of biologic therapy","volume":"12","author":"Grom","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.diagmicrobio.2006.09.010","article-title":"Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: the role of the real-time polymerase chain reaction in the diagnosis and successful treatment with amphotericin B lipid complex","volume":"57","author":"Guiot","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.blre.2016.05.001","article-title":"Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: a systematic scoping review","volume":"30","author":"Hayden","year":"2016","journal-title":"Blood Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr. Blood Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1182\/blood-2014-01-550657","article-title":"Hemophagocytic lymphohistiocytosis and disseminated histoplasmosis","volume":"123","author":"Huang","year":"2014","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7107326","DOI":"10.1155\/2019\/7107326","article-title":"Histoplasmosis-associated hemophagocytic lymphohistiocytosis: a review of the literature","volume":"2019","author":"Jabr","year":"2019","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrneph.2009.73","article-title":"What nephrologists need to know about hemophagocytic syndrome","volume":"5","author":"Karras","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/clinids\/21.6.1463","article-title":"Reactive hemophagocytic syndrome: a new presentation of disseminated histoplasmosis in patients with AIDS","volume":"21","author":"Koduri","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1773-035X(14)72746-7","article-title":"Perturbations biologiques et immunologiques au cours des syndromes h\u00e9mophagocytaires","volume":"2014","author":"Kolopp-Sarda","year":"2014","journal-title":"Rev. Francoph. Lab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/1097-0339(200012)23:6<422::AID-DC13>3.0.CO;2-F","article-title":"Disseminated histoplasmosis with reactive hemophagocytosis: aspiration cytology findings in two cases","volume":"23","author":"Kumar","year":"2000","journal-title":"Diagn. Cytopathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1093\/cid\/civ999","article-title":"Hemophagocytic lymphohistiocytosis associated with Bartonella henselae infection in an HIV-infected patient","volume":"62","author":"Le Joncour","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1177\/0956462417753008","article-title":"Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis","volume":"29","author":"Loganantharaj","year":"2018","journal-title":"Int. J. STD AIDS"},{"key":"B28","first-page":"51","article-title":"Hemophagocytic syndrome associated with histoplasmosis in the acquired immunodeficiency syndrome: description of 3 cases and review of the literature","volume":"38","author":"Majluf-Cruz","year":"1993","journal-title":"Sangre."},{"key":"B29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1093\/cid\/ciz247","article-title":"Incidence and trends in immune reconstitution inflammatory syndrome associated with histoplasma capsulatum among people living with human immunodeficiency virus: a 20-year case series and literature review","volume":"70","author":"Melzani","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13104-020-05054-w","article-title":"HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?","volume":"13","author":"Nacher","year":"","journal-title":"BMC Res. Notes"},{"key":"B31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4269\/ajtmh.2011.10-0251","article-title":"What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis","volume":"84","author":"Nacher","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/QAD.0000000000000961","article-title":"Disseminated histoplasmosis in Central and South America, the invisible elephant: the lethal blind spot of international health organizations","volume":"30","author":"Nacher","year":"2016","journal-title":"AIDS"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e2638","DOI":"10.1371\/journal.pntd.0002638","article-title":"Risk factors for disseminated histoplasmosis in a cohort of HIV-infected patients in French Guiana","volume":"8","author":"Nacher","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e2319","DOI":"10.1371\/journal.pntd.0002319","article-title":"Disseminated histoplasmosis in HIV-infected patients in South America: a neglected killer continues on its rampage","volume":"7","author":"Nacher","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0197990","DOI":"10.1371\/journal.pone.0197990","article-title":"Modeling of the HIV epidemic and continuum of care in French Guiana","volume":"13","author":"Nacher","year":"2018","journal-title":"PLoS ONE"},{"key":"B36","unstructured":"NacherM. OuedraogoE. SuccoT. GuarmitB. DjossouF. StettlerL. HIV in French Guiana: historical review and current trends. Bull. Epid\u00e9miol. Hebd"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.7705\/biomedica.v36i2.2797","article-title":"Tratamiento exitoso de linfohistiocitosis hemofagoc\u00edtica y coagulaci\u00f3n intravascular diseminada secundarias a histoplasmosis en un paciente con HIV\/sida","volume":"36","author":"Nieto","year":"2016","journal-title":"Biom\u00e9dica"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-221264","article-title":"Safe usage of anakinra and dexamethasone to treat refractory hemophagocytic lymphohistiocytosis secondary to acute disseminated histoplasmosis in a patient with HIV\/AIDS","author":"Ocon","year":"2017","journal-title":"BMJ Case Rep."},{"key":"B39","unstructured":"SanchezA. CelayaA. K. VictorioA. 17990371Histoplasmosis-Associated Hemophagocyti Syndrome: A Case Report2007"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.12890\/2014_000099","article-title":"HIV infection presenting as haemophagocytic syndrome","author":"Silva","year":"2014","journal-title":"Eur. J. Case Rep. Intern. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.1086\/379613","article-title":"Human immunodeficiency virus\u2014associated hemophagocytosis with iron-deficiency anemia and massive splenomegaly","volume":"37","author":"Sproat","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/2325957415570740","article-title":"Hemophagocytic syndrome in the setting of AIDS and disseminated histoplasmosis: case report and a review of literature","volume":"14","author":"Subedee","year":"2015","journal-title":"J. Int. Assoc. Provid. AIDS Care"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1097\/01.qai.0000136725.92886.b8","article-title":"Hemophagocytic lymphohistiocytosis: an unusual initial presentation of acute HIV infection","volume":"37","author":"Sun","year":"2004","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"B44","unstructured":"TelferM. GulatiS. Hemophagocytic lymphohistiocytosis in a patient with disseminated histoplasmosis: a case report. J. Hosp. Med. 7(suppl 2)2012"},{"key":"B45","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00277-018-3500-9","article-title":"Hemophagocytic syndrome in patients living with HIV: a retrospective study","volume":"98","author":"Telles","year":"2019","journal-title":"Ann. Hematol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"ofv055","DOI":"10.1093\/ofid\/ofv055","article-title":"Histoplasmosis-induced hemophagocytic syndrome: a case series and review of the literature","volume":"2","author":"Townsend","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4269\/ajtmh.18-0478","article-title":"Case Report: hemophagocytic lymphohistiocytosis caused by disseminated histoplasmosis in a venezuelan patient with HIV and epstein\u2013barr virus reactivation who traveled to Japan","volume":"100","author":"Tsuboi","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B48","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0956462415585254","article-title":"HIV infection presenting proliferation of CD8+ T lymphocyte and hemophagocytic lymphohistiocytosis","volume":"27","author":"Usman","year":"2016","journal-title":"Int. J. STD AIDS"},{"key":"B49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.52964\/AMJA.0495","article-title":"A case of haemophagocytic syndrome in HIV-associated disseminated histoplasmosis","volume":"10","author":"Vaid","year":"2011","journal-title":"Acute Med."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.574584\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T05:34:42Z","timestamp":1668922482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fcimb.2020.574584\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":49,"alternative-id":["10.3389\/fcimb.2020.574584"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.574584","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"article-number":"574584"}}