{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:56:15Z","timestamp":1790787375392,"version":"4.1.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007455","name":"Skolkovo Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>PGLYRP1\/Tag-7\/PGRP-S is one of mammalian peptidoglycan recognition proteins (PGRPs). Here, we demonstrate that human recombinant PGLYRP1\/Tag-7\/PGRP-S potentiates the response of murine macrophage-like ANA-1 cells and human macrophages to facultative intracellular pathogen <jats:italic>Listeria monocytogenes<\/jats:italic>. PGLYRP1\/Tag-7\/PGRP-S binds to the surface of <jats:italic>L. monocytogenes<\/jats:italic> and other bacterial cells but has no effect on their growth in culture. While PGLYRP1\/Tag-7\/PGRP-S treatment modestly enhanced phagocytosis of bacteria by ANA-1 cells, the intracellular survival of PGLYRP1\/Tag-7\/PGRP-S treated <jats:italic>L. monocytogenes<\/jats:italic> was strongly inhibited 2\u00a0h after internalization. PGLYRP1\/Tag-7\/PGRP-S treatment of bacteria boosted oxidative burst induction and increased the level of proinflammatory cytokine IL-6 produced by ANA-1, however, these effects happened too late to be responsible for decreased intracellular survival of bacteria. Our results thus suggest that PGLYRP1\/Tag-7\/PGRP-S acts as a molecular sensor for detection of <jats:italic>L. monocytogenes<\/jats:italic> infection of mammalian cells that leads to increased killing through a mechanism(s) that remains to be defined.<\/jats:p>","DOI":"10.3389\/fcimb.2020.582803","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T04:26:25Z","timestamp":1608697585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Human Short Peptidoglycan Recognition Protein PGLYRP1\/Tag-7\/PGRP-S Inhibits Listeria monocytogenes Intracellular Survival in Macrophages"],"prefix":"10.3389","volume":"10","author":[{"given":"Darya","family":"Slonova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Posvyatenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Kibardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sysolyatina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lyssuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Ermolaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Obydennyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Gnuchev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgii","family":"Georgiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Severinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Larin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1469-0691.2009.03109.x","article-title":"Listeriosis: A resurgent foodborne infection","volume":"16","author":"Allerberger","year":"2010","journal-title":"Clin. 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