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Cell. Infect. Microbiol."],"abstract":"<jats:p>Across diverse organisms, various physiologies are profoundly regulated by mitochondrial function, which is defined by mitochondrial fusion, biogenesis, oxidative phosphorylation (OXPHOS), and mitophagy. Based on our data and significant published studies from <jats:italic>Caenorhabditis elegans<\/jats:italic>, <jats:italic>Drosophila melanogaster<\/jats:italic> and mammals, we propose that midgut mitochondria control midgut health and the health of other tissues in vector mosquitoes. Specifically, we argue that trade-offs among resistance to infection, metabolism, lifespan, and reproduction in vector mosquitoes are fundamentally controlled both locally and systemically by midgut mitochondrial function.<\/jats:p>","DOI":"10.3389\/fcimb.2020.593159","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T05:30:46Z","timestamp":1607664646000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Midgut Mitochondrial Function as a Gatekeeper for Malaria Parasite Infection and Development in the Mosquito Host"],"prefix":"10.3389","volume":"10","author":[{"given":"Shirley","family":"Luckhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Riehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.celrep.2014.01.015","article-title":"Cell-nonautonomous effects of dFOXO\/DAF-16 in aging","volume":"6","author":"Alic","year":"2014","journal-title":"Cell Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1472-6793-9-15","article-title":"Manipulating insulin signaling to enhance mosquito reproduction","volume":"9","author":"Arik","year":"2009","journal-title":"BMC Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1096\/fj.14-261479","article-title":"Increased Akt signaling in the mosquito fat body increases adult survivorship","volume":"29","author":"Arik","year":"2015","journal-title":"FASEB J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/embor.2011.157","article-title":"Mitochondria in innate immunity","volume":"12","author":"Arnoult","year":"2011","journal-title":"EMBO Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jip.2007.05.005","article-title":"Morphological evidence for proliferative regeneration of the Anopheles stephensi midgut epithelium following Plasmodium falciparum ookinete invasion","volume":"96","author":"Baton","year":"2007","journal-title":"J. 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